C Niederau

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Gaucher's disease: a review for the internist and hepatologist
    C Niederau
    Department of Medicine, St Josef Hospital Oberhausen, University of Essen, Germany
    Hepatogastroenterology 47:984-97. 2000
  2. ncbi request reprint [Diagnosis and therapy of Gaucher disease. Current recommendations of German therapy centers in the year 2000]
    C Niederau
    Klinik fur Innere Medizin, St Josef Hospital Oberhausen, Akademisches Lehrkrankenhaus, Universitat Essen
    Med Klin (Munich) 96:32-9. 2001
  3. ncbi request reprint The role of calcium in pancreatitis
    C Niederau
    Department of Internal Medicine, St Josef Hospital Oberhausen, Germany
    Hepatogastroenterology 46:2723-30. 1999
  4. ncbi request reprint [Diabetes mellitus in hemochromatosis]
    C Niederau
    Innere Abteilung, St Josef Hospital Oberhausen, Akademisches Lehrkrankenhaus der Universität Essen
    Z Gastroenterol . 1999
  5. ncbi request reprint Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin receptor antagonists
    C Niederau
    St Josef Hospital, Academic Teaching Hospital, Department of Internal Medicine, Oberhausen, Germany
    Digestion 60:69-74. 1999
  6. ncbi request reprint Prognosis of chronic hepatitis C: results of a large, prospective cohort study
    C Niederau
    Department of Medicine, Division of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Hepatology 28:1687-95. 1998
  7. ncbi request reprint Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Leich Study Group
    C Niederau
    Department of Medicine, Heinrich Heine University of Dusseldorf, Germany
    Hepatogastroenterology 45:797-804. 1998
  8. ncbi request reprint First long-term results of imiglucerase therapy of type 1 Gaucher disease
    C Niederau
    Department of Medicine, Heinrich Heine Universitat, Dusseldorf, Germany
    Eur J Med Res 3:25-30. 1998
  9. ncbi request reprint CCK-resistance in Zucker obese versus lean rats
    C Niederau
    Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
    Regul Pept 70:97-104. 1997
  10. ncbi request reprint [Diagnosis and treatment of chronic hepatitis C. Practical recommendations and new developments]
    C Niederau
    Klinik fur Innere Medizin, St Josef Hospital Oberhausen, Akademisches Lehrkrankenhaus, Universitat Essen
    Med Klin (Munich) 96:599-607. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Gaucher's disease: a review for the internist and hepatologist
    C Niederau
    Department of Medicine, St Josef Hospital Oberhausen, University of Essen, Germany
    Hepatogastroenterology 47:984-97. 2000
    ..Regression of skeletal complications is usually seen only after 3-4 years. Recently gene therapy trials, which center on autotransfusion of retrovirally transduced stem cells, have successfully been started...
  2. ncbi request reprint [Diagnosis and therapy of Gaucher disease. Current recommendations of German therapy centers in the year 2000]
    C Niederau
    Klinik fur Innere Medizin, St Josef Hospital Oberhausen, Akademisches Lehrkrankenhaus, Universitat Essen
    Med Klin (Munich) 96:32-9. 2001
    ..In 5 to 10% of the patients there are also central nervous symptoms such as myoclonic seizures, oculomotoric apraxia and a slight mental retardation...
  3. ncbi request reprint The role of calcium in pancreatitis
    C Niederau
    Department of Internal Medicine, St Josef Hospital Oberhausen, Germany
    Hepatogastroenterology 46:2723-30. 1999
    ..So far, [Ca2+]i increases were thought to represent physiological signals when they occurred as oscillations at the single cell level...
  4. ncbi request reprint [Diabetes mellitus in hemochromatosis]
    C Niederau
    Innere Abteilung, St Josef Hospital Oberhausen, Akademisches Lehrkrankenhaus der Universität Essen
    Z Gastroenterol . 1999
    ..Thus, in the future we should aim to diagnose hemochromatosis in early stages which are not associated with diabetes mellitus or liver cirrhosis...
  5. ncbi request reprint Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin receptor antagonists
    C Niederau
    St Josef Hospital, Academic Teaching Hospital, Department of Internal Medicine, Oberhausen, Germany
    Digestion 60:69-74. 1999
    ..There is also evidence that CCK antagonists have a potential therapeutic benefit. Clinical studies will evaluate their therapeutic potential for patients with AP...
  6. ncbi request reprint Prognosis of chronic hepatitis C: results of a large, prospective cohort study
    C Niederau
    Department of Medicine, Division of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Hepatology 28:1687-95. 1998
    ..The age at diagnosis therefore should play a major role in therapeutic considerations. The present data also suggest that interferon therapy has a long-term clinical benefit, although it did not reduce the risk of liver cancer...
  7. ncbi request reprint Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Leich Study Group
    C Niederau
    Department of Medicine, Heinrich Heine University of Dusseldorf, Germany
    Hepatogastroenterology 45:797-804. 1998
    ..The diagnosis of chronic viral hepatitis was based on an abnormal serum alanine aminotransferase (ALT) value (more than twice the upper value of normal), viral replication and chronic hepatitis found on liver biopsy...
  8. ncbi request reprint First long-term results of imiglucerase therapy of type 1 Gaucher disease
    C Niederau
    Department of Medicine, Heinrich Heine Universitat, Dusseldorf, Germany
    Eur J Med Res 3:25-30. 1998
    ..This case report, with 30 months' follow-up, represents the first publication of long-term results of imiglucerase therapy of type 1 Gaucher's disease in Europe...
  9. ncbi request reprint CCK-resistance in Zucker obese versus lean rats
    C Niederau
    Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
    Regul Pept 70:97-104. 1997
    ..However, the failure of the CCK-A antagonist to increase food intake questions whether any of the effects of exogenous CCK are of physiological relevance...
  10. ncbi request reprint [Diagnosis and treatment of chronic hepatitis C. Practical recommendations and new developments]
    C Niederau
    Klinik fur Innere Medizin, St Josef Hospital Oberhausen, Akademisches Lehrkrankenhaus, Universitat Essen
    Med Klin (Munich) 96:599-607. 2001
    ..Chronic hepatitis C affects more than 500,000 people in Germany and is one of the most important chronic liver diseases. A large part of liver cirrhosis and cancer as well as most liver transplantations are today caused by hepatitis C...
  11. ncbi request reprint [Therapy of chronic Hepatitis C in 2008]
    C Niederau
    Kath Kliniken Oberhausen gGmbH, Klinik fur Innere Medizin, St Josef Hospital Oberhausen, Oberhausen
    MMW Fortschr Med 150:31-4. 2008
  12. pmc Safety, tolerability and efficacy of peginterferon alpha-2a and ribavirin in chronic hepatitis C in clinical practice: The German Open Safety Trial
    Th Witthöft
    Medical Department I, Division of Gastroenterology, University Hospital Schleswig Holstein Campus Lübeck, Lubeck, Germany
    J Viral Hepat 14:788-96. 2007
    ..This investigation confirms the well-known risk-benefit ratio found in controlled studies in a clinical practice setting. The safety profile is similar and shows the highest incidence of adverse events in the first 12 weeks of treatment...
  13. ncbi request reprint [Diagnosis and clinical characteristics of Hepatitis C in 2008]
    C Niederau
    Kath Kliniken Oberhausen gGmbH, Klinik fur Innere Medizin, St Josef Hospital Oberhausen, Akad Lehrkrankenhaus der Universität Duisburg Essen, Oberhausen
    MMW Fortschr Med 150:27-30. 2008
  14. ncbi request reprint [Only 1 injection per week brings a 60% chance of healing. New therapy recommendations in chronic hepatitis C]
    C Niederau
    Klinik fur Innere Medizin, St Josef Hospital, Oberhausen
    MMW Fortschr Med 145:28-32. 2003
    ..In asymptomatic older patients with no liver fibrosis, however, in particular those with a limited chance of a sustained viral response or concomitant disease, the indication for antiviral therapy is doubtful...
  15. doi request reprint Treatment results of chronic hepatitis C genotype 5 and 6 infections in Germany
    S Mauss
    Center for HIV and Hepatogastroenterology, Dusseldorf, Germany
    Z Gastroenterol 50:441-4. 2012
    ..Sustained virological response seems to be better than for patients with genotype 1 or 4 with similar treatment duration...
  16. ncbi request reprint Epidemiology, clinical spectrum and prognosis of hemochromatosis
    C Niederau
    Dept of Medicine, Heinrich Heine University of Dusseldorf, Germany
    Adv Exp Med Biol 356:293-302. 1994
    ..041 and a frequency of heterozygotes of 0.078. Further analyses showed that some of these studies have probably underestimated the prevalence which in reality is probably two- to threefold higher than estimated by the meta-analysis...
  17. doi request reprint [New data and recommendations of antiviral therapy of chronic hepatitis B and C]
    C Niederau
    Klinik fur Innere Medizin, St Josef Hospital, Katholische Kliniken Oberhausen gGmbH, Akademisches Lehrkrankenhaus der Universität Duisburg Essen, Mülheimer Strasse 83, 46045, Oberhausen, Deutschland
    Internist (Berl) 49:1265-6, 1268-73. 2008
    ..Without such rapid response HCV-RNA needs to be checked after 12 and 24 weeks: when HCV-RNA becomes negative only after 24 weeks, a prolongation of therapy might be advisable...
  18. ncbi request reprint [Gaucher disease: MR evaluation of bone marrow features during treatment with enzyme replacement]
    L W Poll
    Institut für Diagnostische Radiologie, Heinrich Heine Universitat Dusseldorf, Germany
    Rofo 173:931-7. 2001
    ..There are only a few studies available evaluating bone disease during ERT. The aim of this study was to investigate the features of bone marrow (bm) by magnetic resonance imaging (MRI) in these patients during ERT...
  19. ncbi request reprint Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation
    S Vom Dahl
    Division of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Dusseldorf, Germany
    J Hepatol 31:741-6. 1999
    ..Based on clinical, laboratory, cytological and and biochemical findings, CESD can clearly be separated from other more frequent inherited lysosomal storage diseases, e.g. atypical forms of Gaucher disease...
  20. doi request reprint [Changes in socio-economics, quality of life and knowledge of patients with chronic hepatitis C during the Hepatitis Competence Net Project]
    C Niederau
    Katholische Kliniken Oberhausen GmbH, St Josef Hospital, Akademisches Lehrkrankenhaus der Universität Duisburg Essen, Oberhausen
    Z Gastroenterol 46:22-33. 2008
    ..A 1st questionnaire 3 1/2 years ago gathered information in 714 CHC patients all of whom now received a 2nd questionnaire which was sent back by 503 subjects (71%)...
  21. ncbi request reprint Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B
    A Erhardt
    Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Hepatology 31:716-25. 2000
    ..Our data suggest that HBV genome mutations located within the BCP are determinants of a response to IFN therapy...
  22. ncbi request reprint [Hereditary hemochromatosis]
    C Niederau
    St Josef Hospital, Oberhausen
    Internist (Berl) 44:191-205; quiz 206-7. 2003
    ..The prognosis of haemochromatosis is normal when phlebotomy therapy is started prior to manifestation of cirrhosis or diabetes. Screening strategies should be implemented to improve early detection...
  23. ncbi request reprint Clinical spectrum and management of haemochromatosis
    C Niederau
    Medizinische Klinik und Poliklinik, Abteilung für Gastroenterologie, Heinrich Heine Universitat Dusseldorf, Germany
    Baillieres Clin Haematol 7:881-901. 1994
    ..Further strategies have to evaluate the design of screening programmes in order to diagnose more patients in the precirrhotic and asymptomatic stage...
  24. ncbi request reprint [Criteria for the treatment of chronic hepatitis B and D]
    C Niederau
    St Josef Hospital Oberhausen, Klinik fur Innere Medizin, Akademisches Lehrkrankenhaus der Universität Essen, Oberhausen
    Z Gastroenterol 42:682-6. 2004
  25. ncbi request reprint [10 minute consultation:36-year-old patient with chronic hepatitis C. Is unprotected sex with the spouse still possible?]
    C Niederau
    Klinik fur Innere Medizin, St Josef Hospital Oberhausen
    MMW Fortschr Med 147:59-60. 2005