Carsten Munk

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. Perkovic M, Norley S, Sanzenbacher R, Battenberg M, Panitz S, Coulibaly C, et al. SIVagm containing the SHIV89.6P Envelope gene replicates poorly and is non-pathogenic. Virology. 2010;399:87-97 pubmed publisher
    ..The env gene of SHIV89.6P therefore appears insufficient to confer acute pathogenicity to a non-pathogenic primate lentivirus due to poor in vivo replication. ..
  2. Osei Kuffour E, Schott K, Jaguva Vasudevan A, Holler J, Schulz W, Lang P, et al. USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1. J Virol. 2018;92: pubmed publisher
    ..Depletion of USP18 stabilizes p21 protein expression, which correlates with dephosphorylated SAMHD1 and a block to HIV-1 replication. ..
  3. Meier K, Jaguva Vasudevan A, Zhang Z, Bähr A, Kochs G, Haussinger D, et al. Equine MX2 is a restriction factor of equine infectious anemia virus (EIAV). Virology. 2018;523:52-63 pubmed publisher
    ..Thus, eMX2 may inhibit retroviral replication by a novel mechanism that differs from that of hMXB. ..
  4. Zhang Z, Gu Q, Marino D, Lee K, Kong I, Häussinger D, et al. Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?. Viruses. 2018;10: pubmed publisher
    ..We speculate that feline APOBEC3 proteins could explain some of the observed FIV cross-species transmissions described in wild Felids. ..
  5. Jaguva Vasudevan A, Bähr A, Grothmann R, Singer A, Haussinger D, Zimmermann A, et al. MXB inhibits murine cytomegalovirus. Virology. 2018;522:158-167 pubmed publisher
    ..Hence, we propose a new mode of inhibition of MCMV by MXB that is conspicuously different from that of HIV-1. ..
  6. Zhang Z, Gu Q, Jaguva Vasudevan A, Jeyaraj M, Schmidt S, Zielonka J, et al. Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C. J Virol. 2016;90:10193-10208 pubmed
    ..This finding provides a novel way to develop HIV-1 inhibitors by targeting the internal interactions of the Vif protein. ..
  7. Gu Q, Zhang Z, Cano Ortiz L, Franco A, Haussinger D, Munk C. Feline Immunodeficiency Virus Vif N-Terminal Residues Selectively Counteract Feline APOBEC3s. J Virol. 2016;90:10545-10557 pubmed publisher
    ..Our findings provide important insights for future experiments describing the FIV Vif interaction with feline APOBEC3s and also indicate that the conserved feline APOBEC3s interaction sites of FIV Vif allow FIV transmissions in Felidae. ..
  8. Hain A, Krämer M, Linka R, Nakhaei Rad S, Ahmadian M, Häussinger D, et al. IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells. Sci Rep. 2018;8:3217 pubmed publisher
  9. M nk C, Willemsen A, Bravo I. An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals. BMC Evol Biol. 2012;12:71 pubmed publisher

More Information

Publications15

  1. Munk C, Jensen B, Zielonka J, Haussinger D, Kamp C. Running loose or getting lost: how HIV-1 counters and capitalizes on APOBEC3-induced mutagenesis through its Vif protein. Viruses. 2012;4:3132-61 pubmed publisher
    ..Both experimental evidence and the substantiation of the underlying dynamics through coevolutionary models are presented as complementary views of a coevolutionary arms race. ..
  2. Bähr A, Singer A, Hain A, Vasudevan A, Schilling M, Reh J, et al. Interferon but not MxB inhibits foamy retroviruses. Virology. 2016;488:51-60 pubmed publisher
    ..IFN-β treated THP-1 and THP-1 KO MxB cells showed the same extend of restriction to FV. Together, the data demonstrate that IFN-β inhibits FV early in infection and that MxB is not a restriction factor of FV. ..
  3. Zhang Z, Gu Q, Jaguva Vasudevan A, Hain A, Kloke B, Hasheminasab S, et al. Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors. Retrovirology. 2016;13:46 pubmed publisher
    ..Together, these findings indicate a specific and different A3 evolution in cats and human. ..
  4. Jaguva Vasudevan A, Hofmann H, Willbold D, Haussinger D, Koenig B, Munk C. Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1. J Mol Biol. 2017;429:1171-1191 pubmed publisher
    ..We conclude that the enhanced enzymatic activity of A3C is insufficient to restrict HIV-1, indicating an unknown escape mechanism of HIV-1. ..
  5. Jaguva Vasudevan A, Goering W, Haussinger D, Munk C. Detection of APOBEC3 Proteins and Catalytic Activity in Urothelial Carcinoma. Methods Mol Biol. 2018;1655:97-107 pubmed publisher
    ..Here we combine independent immunoblotting with an in vitro activity assay technique, to detect and categorize specific A3s expressed in urothelial bladder cancer and other cancer cells. ..
  6. Gu Q, Zhang Z, Gertzen C, Haussinger D, Gohlke H, Munk C. Identification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5. J Virol. 2018;92: pubmed publisher
    ..While our structural model suggests that the diverse FIV and HIV-1 Vifs use conserved residues for Cullin 5 binding, FIV Vif binds Cullin 5 independently of zinc, in contrast to HIV-1 Vif. ..