Gerd Meyer zu Horste

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. doi request reprint Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurobiol Dis 37:483-90. 2010
  2. doi request reprint Active immunization induces toxicity of diphtheria toxin in diphtheria resistant mice--implications for neuroinflammatory models
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Immunol Methods 354:80-4. 2010
  3. pmc Expression of antigen processing and presenting molecules by Schwann cells in inflammatory neuropathies
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Glia 58:80-92. 2010
  4. doi request reprint Quinpramine--a promising compound for treating immune-mediated demyelination of the nervous system
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Drug News Perspect 23:287-94. 2010
  5. pmc Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules
    Gerd Meyer zu Horste
    Department of Neurology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 6:e21223. 2011
  6. doi request reprint Matrix metalloproteinase-2 is involved in myelination of dorsal root ganglia neurons
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University, Moorenstrasse, Dusseldorf, Germany
    Glia 57:479-89. 2009
  7. doi request reprint Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve
    Parastoo Jangouk
    Department of Neurology, Research Group for Clinical and Experimental Neuroimmunology, Heinrich Heine University, Dusseldorf, Germany
    Glia 57:1765-74. 2009
  8. doi request reprint Intravenous immunoglobulins in the treatment of immune neuropathies
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Curr Opin Neurol 21:555-62. 2008
  9. doi request reprint Autoantibody-mediated dysfunction of sympathetic neurons in guillain-barre syndrome
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf, Germany
    Arch Neurol 67:203-10. 2010
  10. ncbi request reprint The immunocompetence of Schwann cells
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Muscle Nerve 37:3-13. 2008

Collaborators

Detail Information

Publications24

  1. doi request reprint Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurobiol Dis 37:483-90. 2010
    ..Thus, antigen presentation may be a pathological function of Schwann cells exacerbating nerve damage in inflammatory neuropathies...
  2. doi request reprint Active immunization induces toxicity of diphtheria toxin in diphtheria resistant mice--implications for neuroinflammatory models
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Immunol Methods 354:80-4. 2010
    ....
  3. pmc Expression of antigen processing and presenting molecules by Schwann cells in inflammatory neuropathies
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Glia 58:80-92. 2010
    ..Taken together, our data suggest antigen processing and presentation as a possible function of Schwann cells that may contribute to (auto)immune responses within peripheral nerves...
  4. doi request reprint Quinpramine--a promising compound for treating immune-mediated demyelination of the nervous system
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Drug News Perspect 23:287-94. 2010
    ..This article summarizes available treatment options in MS and explains why the candidate compound quinpramine may transfer from bench to bedside in the near future...
  5. pmc Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules
    Gerd Meyer zu Horste
    Department of Neurology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 6:e21223. 2011
    ..Quinpramine exerted its anti-proliferatory effect on antigen presenting cells, but not on responder T cells. Our data suggest that quinpramine represents a candidate pharmaceutical for inflammatory neuropathies...
  6. doi request reprint Matrix metalloproteinase-2 is involved in myelination of dorsal root ganglia neurons
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University, Moorenstrasse, Dusseldorf, Germany
    Glia 57:479-89. 2009
    ..Endogenous or exogenous modulation of MMP-2 activity may be a relevant target to enhance regeneration in demyelinating diseases of the PNS...
  7. doi request reprint Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve
    Parastoo Jangouk
    Department of Neurology, Research Group for Clinical and Experimental Neuroimmunology, Heinrich Heine University, Dusseldorf, Germany
    Glia 57:1765-74. 2009
    ..Hence, during the process of myelin formation, ADAM10 is highly upregulated and appears to be critically involved in axonal outgrowth that is a requirement for myelination in the peripheral nerve...
  8. doi request reprint Intravenous immunoglobulins in the treatment of immune neuropathies
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Curr Opin Neurol 21:555-62. 2008
    ..The aim of this review is to describe the value of high-dose polyclonal intravenous immunoglobulins as a treatment option in autoimmune disorders affecting the peripheral nervous system...
  9. doi request reprint Autoantibody-mediated dysfunction of sympathetic neurons in guillain-barre syndrome
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf, Germany
    Arch Neurol 67:203-10. 2010
    ..To investigate a pathologic immune response to autonomic nerve fibers in Guillain-Barré syndrome (GBS)...
  10. ncbi request reprint The immunocompetence of Schwann cells
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Muscle Nerve 37:3-13. 2008
    ..This review summarizes current knowledge on the interaction of Schwann cells with the immune system, which is involved in diseases of the peripheral nervous system...
  11. doi request reprint Recovery of the T-cell repertoire in CIDP by IV immunoglobulins
    Anne K Mausberg
    Department of Neurology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Neurology 80:296-303. 2013
    ..To investigate changes in the T-cell repertoire in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) without and with treatment of IV immunoglobulins (IVIg)...
  12. doi request reprint CD73 is expressed on invading T lymphocytes in the inflamed peripheral nerve
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heinl University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Muscle Nerve 40:287-9. 2009
    ..Endothelial cells in the peripheral nerve did not express CD73. Our findings support the concept that CD73 is involved in lymphocyte entry into the inflamed nervous system. Muscle Nerve 40: 287-289, 2009...
  13. doi request reprint Natalizumab affects the T-cell receptor repertoire in patients with multiple sclerosis
    Clemens Warnke
    From the Department of Neurology C W, A K M, M S, T D, L N, G M z H, H P H, B C K and Institute for Virology O A, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany and the Department of Clinical Neuroscience C W, A F H, Karolinska Institutet, Stockholm, Sweden
    Neurology 81:1400-8. 2013
    ....
  14. ncbi request reprint Role of nitric oxide as mediator of nerve injury in inflammatory neuropathies
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    J Neuropathol Exp Neurol 66:305-12. 2007
    ....
  15. pmc Erythropoietin ameliorates rat experimental autoimmune neuritis by inducing transforming growth factor-β in macrophages
    Anne K Mausberg
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    PLoS ONE 6:e26280. 2011
    ..Further studies are warranted to elaborate the clinical usefulness of EPO for treating immune-mediated neuropathies in affected patients...
  16. doi request reprint Natalizumab treatment in a patient with chronic inflammatory demyelinating polyneuropathy
    Christian Wolf
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Arch Neurol 67:881-3. 2010
    ..To study clinical and paraclinical effects of natalizumab in a patient with chronic inflammatory demyelinating polyneuropathy (CIDP)...
  17. doi request reprint Plasma exchange in immune-mediated neuropathies
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Curr Opin Neurol 21:547-54. 2008
    ..Plasma exchange is frequently used for treatment of immune-mediated neuropathies. Here, we review the current value of plasma exchange in the treatment of different forms of immune-mediated neuropathies and discuss latest developments...
  18. doi request reprint The clinical value of therapeutic plasma exchange in multifocal motor neuropathy
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University of Dusseldorf, Germany
    J Neurol Sci 271:34-9. 2008
    ..We set out to elucidate possible reasons for this apparent contradiction...
  19. doi request reprint Autoimmune diseases of the peripheral nervous system
    Bernd C Kieseier
    Clinical and Experimental Neuroimmunology, Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Autoimmun Rev 11:191-5. 2012
    ..Clearly, prospective controlled clinical trials are warranted before making firm conclusions on the feasibility of these innovative therapeutic approaches for treating immune-mediated disease of the peripheral nerve...
  20. doi request reprint Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential
    Rebecca Noack
    Department of Neurology, University of Dusseldorf, D 40225 Dusseldorf, Germany
    Hum Mol Genet 21:150-62. 2012
    ..Thus, our results suggest that the potential GST GDAP1 is implicated in the control of the cellular GHS content and mitochondrial activity, suggesting an involvement of oxidative stress in the pathogenesis of CMT4A...
  21. pmc Review of teriflunomide and its potential in the treatment of multiple sclerosis
    Clemens Warnke
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Neuropsychiatr Dis Treat 5:333-40. 2009
    ..With an emphasis on teriflunomide, the active metabolite of an immunosuppressant approved for the treatment of rheumatoid arthritis since 1998, a number of oral treatment options for patients with MS are discussed...
  22. doi request reprint The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Neurobiol Dis 42:1-8. 2011
    ..Future studies are needed to develop axon protective therapy in CMT1A which may be combined with therapeutic strategies aimed at downregulation of toxic PMP22 overexpression...
  23. doi request reprint Bacterial flagellin and diphtheria toxin co-stimulate IL-17-producing thymocytes
    Andreas Weber
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Cytokine 64:221-6. 2013
    ....
  24. ncbi request reprint From bench to bedside--experimental rationale for immune-specific therapies in the inflamed peripheral nerve
    Gerd Meyer zu Horste
    Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Nat Clin Pract Neurol 3:198-211. 2007
    ..We will summarize successful therapeutic trials in human autoimmune neuropathies to provide a vantage point for the transfer of experimental treatment strategies to clinical practice in immune-mediated diseases of the peripheral nerve...