Stephan Martin

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Epidemiology of complications and total treatment costs from diagnosis of Type 2 diabetes in Germany (ROSSO 4)
    S Martin
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40221 Düsseldorf, Germany
    Exp Clin Endocrinol Diabetes 115:495-501. 2007
  2. ncbi request reprint [Nonpharmacological diabetes therapy]
    Stephan Martin
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum für Diabetes Forschung an der Heinrich Heine Universität Düsseldorf, Dusseldorf, Deutschland
    Med Klin (Munich) 101:973-89; quiz 990-1. 2006
  3. ncbi request reprint [Clinical advances in diabetes]
    S Martin
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum für Diabetes Forschung an der Heinrich Heine Universität Düsseldorf, 40225 Dusseldorf
    Dtsch Med Wochenschr 131:1461-2. 2006
  4. ncbi request reprint Self-monitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study
    S Martin
    German Diabetes Clinic, German Diabetes Centre at the Heinrich Heine University, Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetologia 49:271-8. 2006
  5. ncbi request reprint [Systematic analysis of diabetic patient care in Germany]
    S Martin
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 130:1078-84. 2005
  6. doi request reprint Sfrp5 correlates with insulin resistance and oxidative stress
    Maren Carstensen
    Institute for Clinical Diabetology, German Diabetes Center, Dusseldorf, Germany
    Eur J Clin Invest 43:350-7. 2013
  7. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
  8. ncbi request reprint Low-grade inflammation, obesity, and insulin resistance in adolescents
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, 40225 Dusseldorf, Germany
    J Clin Endocrinol Metab 92:4569-74. 2007
  9. doi request reprint Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Dusseldorf, Germany
    Atherosclerosis 200:380-8. 2008
  10. pmc Immune mediators in patients with acute diabetic foot syndrome
    Christian Weigelt
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:1491-6. 2009

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Epidemiology of complications and total treatment costs from diagnosis of Type 2 diabetes in Germany (ROSSO 4)
    S Martin
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40221 Düsseldorf, Germany
    Exp Clin Endocrinol Diabetes 115:495-501. 2007
    ..To determine the occurrence of complications and treatment costs in the first 6 years from diagnosis of Type 2 diabetes in the primary care level...
  2. ncbi request reprint [Nonpharmacological diabetes therapy]
    Stephan Martin
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum für Diabetes Forschung an der Heinrich Heine Universität Düsseldorf, Dusseldorf, Deutschland
    Med Klin (Munich) 101:973-89; quiz 990-1. 2006
    ..It will also be shown that these measures will not only optimize hyperglycaemia but also all other cardiovascular risk factors...
  3. ncbi request reprint [Clinical advances in diabetes]
    S Martin
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum für Diabetes Forschung an der Heinrich Heine Universität Düsseldorf, 40225 Dusseldorf
    Dtsch Med Wochenschr 131:1461-2. 2006
  4. ncbi request reprint Self-monitoring of blood glucose in type 2 diabetes and long-term outcome: an epidemiological cohort study
    S Martin
    German Diabetes Clinic, German Diabetes Centre at the Heinrich Heine University, Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetologia 49:271-8. 2006
    ..The aim of this study was to obtain epidemiological data on self-monitoring of blood glucose (SMBG) in type 2 diabetes and to investigate the relationship of SMBG with disease-related morbidity and mortality...
  5. ncbi request reprint [Systematic analysis of diabetic patient care in Germany]
    S Martin
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 130:1078-84. 2005
  6. doi request reprint Sfrp5 correlates with insulin resistance and oxidative stress
    Maren Carstensen
    Institute for Clinical Diabetology, German Diabetes Center, Dusseldorf, Germany
    Eur J Clin Invest 43:350-7. 2013
    ..The aim of this study was to compare serum concentrations and determinants of Sfrp5, its pro-inflammatory antagonist wingless-type MMTV integration site family member (Wnt)5a and adiponectin in humans and their regulation by coffee...
  7. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
    ..Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy...
  8. ncbi request reprint Low-grade inflammation, obesity, and insulin resistance in adolescents
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, 40225 Dusseldorf, Germany
    J Clin Endocrinol Metab 92:4569-74. 2007
    ..Low-grade inflammation is associated with insulin resistance and precedes the onset of type 2 diabetes mellitus in adults, but there are no comparable data in youth...
  9. doi request reprint Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Dusseldorf, Germany
    Atherosclerosis 200:380-8. 2008
    ....
  10. pmc Immune mediators in patients with acute diabetic foot syndrome
    Christian Weigelt
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:1491-6. 2009
    ..Further studies should investigate whether an activation of the immune system precedes the development of foot ulcer and whether anti-inflammatory therapies might be effective...
  11. doi request reprint Screening for undiagnosed diabetes in patients with acute myocardial infarction
    Mark Lankisch
    German Diabetes Center, Heinrich Heine University, Dusseldorf, Germany
    Clin Res Cardiol 97:753-9. 2008
    ..g. by the acute stress reaction. The aim was to evaluate undiagnosed diabetes (DM) and impaired glucose regulation (IGR) in AMI during hospital stay and 3 months after discharge...
  12. doi request reprint Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
    Kerstin Kempf
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich, Heine University Düsseldorf, Dusseldorf, Germany
    Am J Clin Nutr 91:950-7. 2010
    ..Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress...
  13. ncbi request reprint Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 55:2340-6. 2006
    ..088). Thus, systemic concentrations of immune mediators appear to be associated with the progression to type 2 diabetes and the prevention of type 2 diabetes by lifestyle changes...
  14. pmc Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    Alexander Strom
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e33108. 2012
    ..Aim of this secondary analysis was to identify patient subgroups which differ in the decline of beta cell function during treatment with atorvastatin...
  15. doi request reprint Screening for overt diabetes by oral glucose tolerance test: stratification by fasting blood glucose and patients' age improve practicability of guidelines in cardiological routine
    Kerstin Kempf
    West German Centre of Diabetes and Health, Sana Hospital Gerresheim, Sana Clinics Düsseldorf GmbH, Dusseldorf, Germany
    Int J Cardiol 150:201-5. 2011
    ..Due to its time-consuming protocol, costs and overall inconvenience performance of OGTT is limited in cardiological routine. Thus, we aimed to identify easily available parameters that could help to reduce the numbers of OGTT needed...
  16. ncbi request reprint High prevalence of undiagnosed impaired glucose regulation and diabetes mellitus in patients scheduled for an elective coronary angiography
    M Lankisch
    Deutsche Diabetes Klinik und Institut für Biometrie und Epidemiologie, German Diabetes Center, Deutsches Diabetes Zentrum an der Heinrich Heine Universität Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Clin Res Cardiol 95:80-7. 2006
    ..The aim of this study was to investigate previously unknown glucose metabolism disorder in patients scheduled for an elective coronary angiography...
  17. pmc Residual beta cell function in newly diagnosed type 1 diabetes after treatment with atorvastatin: the Randomized DIATOR Trial
    Stephan Martin
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 6:e17554. 2011
    ..The aim of this study was to investigate the possible effect of atorvastatin on the decline of residual beta cell function in recent-onset type 1 diabetes...
  18. doi request reprint ROSSO-in-praxi: a self-monitoring of blood glucose-structured 12-week lifestyle intervention significantly improves glucometabolic control of patients with type 2 diabetes mellitus
    Kerstin Kempf
    West German Centre of Diabetes and Health, Sana Hospital Gerresheim, Sana Clinics Düsseldorf GmbH, Dusseldorf, Germany
    Diabetes Technol Ther 12:547-53. 2010
    ....
  19. doi request reprint Myocardial infarction and stroke in early years after diagnosis of type 2 diabetes: risk factors and relation to self-monitoring of blood glucose
    Stephan Martin
    German Diabetes Center, Institute for Clinical Diabetes Research, Dusseldorf, Germany
    Diabetes Technol Ther 11:234-41. 2009
    ..The natural course of macrovascular events in patients with type 2 diabetes was analyzed: what are the risk factors, and what is the relationship to the use of self-monitoring of blood glucose (SMBG)?..
  20. doi request reprint Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study
    C Herder
    Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetologia 52:433-42. 2009
    ..Physical activity and diet can attenuate systemic immune activation, but it is not known which individual components of a comprehensive lifestyle intervention are most effective in targeting subclinical inflammation...
  21. ncbi request reprint Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1
    N K van den Engel
    Clinical Department, Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany
    Blood 95:1350-5. 2000
    ..The data indicate that the expression of membranous ICAM-1 and the appearance of circulating forms in serum are independently regulated mechanisms. (Blood. 2000;95:1350-1355)..
  22. ncbi request reprint [Retrolective study design -- a new tool of evidence-based medicine]
    S Martin
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, DDZ, Leibniz Zentrum für Diabetesforschung an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 130:S86-90. 2005
  23. ncbi request reprint Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors
    S Muller
    German Diabetes Clinic, German Diabetes Research Institute at the University of Düsseldorf, Dusseldorf, Germany
    Diabetologia 45:805-12. 2002
    ..A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance...
  24. ncbi request reprint Inflammation in metabolic syndrome and type 2 diabetes: Impact of dietary glucose
    Kerstin Kempf
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Ann N Y Acad Sci 1084:30-48. 2006
    ..In case of an impaired metabolic state, however, postprandial hyperglycemia increases magnitude and duration of systemic inflammatory responses, which probably promotes the development of T2DM and of cardiovascular disease...
  25. pmc The systemic immune network in recent onset type 1 diabetes: central role of interleukin-1 receptor antagonist (DIATOR Trial)
    Hubert Kolb
    West German Centre of Diabetes and Health, Verbund Katholischer Kliniken Düsseldorf, Dusseldorf, Germany
    PLoS ONE 8:e72440. 2013
    ..The hypothesis was tested that the systemic immune milieu in recent-onset type 1 diabetes is associated with residual beta cell function and other metabolic patient characteristics...
  26. doi request reprint ROSSO-in-praxi follow-up: long-term effects of self-monitoring of blood glucose on weight, hemoglobin A1c, and quality of life in patients with type 2 diabetes mellitus
    Kerstin Kempf
    West German Centre of Diabetes and Health, Düsseldorf Catholic Hospital Group, Dusseldorf, Germany
    Diabetes Technol Ther 14:59-64. 2012
    ..So far it is unknown if this short-term intervention also has long-term effects. Therefore, participants were followed up for a mean period of 2 years...
  27. doi request reprint RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Institute at Heinrich Heine University, 40225 Dusseldorf, Germany
    Eur J Endocrinol 158:R1-5. 2008
    ....
  28. ncbi request reprint Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus
    P Hanifi-Moghaddam
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 23:156-63. 2006
    ..The hypothesis was tested in an exploratory study that individuals at high risk of developing Type 1 diabetes mellitus have altered systemic levels of cytokines and chemokines...
  29. ncbi request reprint Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates
    S Martin
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 9:637-43. 1996
    ..ICAM-1 and LFA-1 expression is seen prior to L-selectin and VCAM-1. However, adhesion molecule expression during Th1 versus Th2 cell infiltration is very similar, suggesting similar adhesion molecule requirements of the two Th subsets...
  30. ncbi request reprint Effects of somatostatin and octreotide on cytokine and chemokine production by lipopolysaccharide-activated peripheral blood mononuclear cells
    F ter Veld
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    J Endocrinol Invest 32:123-9. 2009
    ..Although somatostatin or its analogues have been shown to modulate a number of immune functions, their immunomodulatory effects are not uniform and are strongly dependent on the underlying cell system...
  31. ncbi request reprint Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 54:S11-7. 2005
    ..There is no general upregulation of chemokine production in type 2 diabetes, but rather an association of the disease with specific members of the chemokine family...
  32. ncbi request reprint Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002
    C Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, Dusseldorf, Germany
    Diabetologia 51:276-84. 2008
    ..Our aim was to investigate the triangular association between MIF genotypes, circulating MIF concentrations and incident type 2 diabetes, and to use a Mendelian randomisation approach to assess the causal role of MIF...
  33. ncbi request reprint Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4
    H Rothe
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetologia 37:1154-8. 1994
    ..Macrophages show two different functional states in insulitis; strong iNOS expression in macrophages is associated with destructive insulitis...
  34. doi request reprint ROSSO-in-praxi-international: long-term effects of self-monitoring of blood glucose on glucometabolic control in patients with type 2 diabetes mellitus not treated with insulin
    Kerstin Kempf
    West German Centre of Diabetes and Health, Düsseldorf Catholic Hospital Group, Dusseldorf, Germany
    Diabetes Technol Ther 15:89-96. 2013
    ..We analyzed whether the SMBG-structured lifestyle intervention program ROSSO-in-praxi-international can improve glucometabolic control in the short and the long term...
  35. doi request reprint [Coffee and diabetes]
    Kerstin Kempf
    Westdeutsches Diabetes und Gesundheitszentrum, Sana Krankenhaus Gerresheim, Sana Kliniken Düsseldorf GmbH, Dusseldorf, Germany
    Med Klin (Munich) 105:910-5. 2010
    ..g. chlorogenic acid, play a central role, as they can inhibit oxidative stress and inflammation in addition. In the context of lifestyle tasks coffee consumption therefore is an additional option for modifying diabetes risk...
  36. ncbi request reprint [Non-pharmacological diabetes therapy]
    Stephan Martin
    Institut für Klinische Diabetologie, Deutsches Diabetes Zentrum, Leibniz Zentrum für Diabetes Forschung an der Heinrich Heine Universität Düsseldorf
    Med Monatsschr Pharm 31:42-51. 2008
    ..Non-pharmacological interventions are a therapeutical alternative in a lot of patients or are able to reduce the amount of antidiabetic agents significantly...
  37. doi request reprint Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies
    C Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 40:722-6. 2008
    ..We conclude that gene variants of CDKAL1, PPARG, IGF2BP2, HHEX, TCF7L2, and FTO predispose to type 2 diabetes in the German KORA 500 K study population. These associations appear to be independent of BMI...
  38. doi request reprint Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder
    B Nowotny
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Horm Metab Res 42:746-53. 2010
    ..This points towards an independent effect of acute psychological stress on glucose metabolism and inflammation...
  39. ncbi request reprint Change in patients' body weight after 12 months of treatment with glimepiride or glibenclamide in Type 2 diabetes: a multicentre retrospective cohort study
    S Martin
    Clinical Department, German Diabetes Centre at the Heinrich Heine University, Auf m Hennekamp 65, 40225, Dusseldorf, Germany
    Diabetologia 46:1611-7. 2003
    ..Our study compared the effects of glimepiride or glibenclamide treatment on body weight over 12 months of treatment in patients with Type 2 diabetes in routine outpatient practice...
  40. ncbi request reprint Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity
    K Kempf
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 39:596-600. 2007
    ..Our data show a strong association between adipose tissue inflammation and ECS activation in obesity, and indicate that a pro-inflammatory state may directly activate the ECS...
  41. ncbi request reprint Development of low-dose streptozotocin-induced diabetes in ICAM-1-deficient mice
    S Martin
    Clinical Department, German Diabetes Research Institute at the Heinrich Heine University Düsseldorf
    Horm Metab Res 31:636-40. 1999
    ..These results do not support the hypothesis that ICAM-1 plays a key role during immune-mediated infiltration and destruction of pancreatic islets in LDSZ induced diabetes...
  42. ncbi request reprint Dominant role of intercellular adhesion molecule-1 in the pathogenesis of autoimmune diabetes in non-obese diabetic mice
    S Martin
    German Diabetes Centre, German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 17:109-17. 2001
    ..These results identify a dominant and non-redundant role of ICAM-1 in the development of autoimmune diabetes...
  43. ncbi request reprint [Pilot study of controlled retrospective analysis (retrolective study design) of care for type 2 diabetics since 1990]
    S Martin
    Deutsche Diabetes Klinik, Deutschen Diabetes Forschungsinstitut, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 128:1173-8. 2003
    ....
  44. ncbi request reprint Inflammation and type 2 diabetes: results from KORA Augsburg
    C Herder
    Leibniz Institute at Heinrich Heine University, German Diabetes Clinic, German Diabetes Center, Dusseldorf, Germany
    Gesundheitswesen 67:S115-21. 2005
    ....
  45. pmc Dose-dependent induction of IL-6 by plant-derived proteases in vitro
    B Rose
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at the Heinrich Heine University, Duesseldorf, Germany
    Clin Exp Immunol 143:85-92. 2006
    ..These findings might provide the mechanistic rationale for the current use of proteases in wound healing and tissue regeneration since these processes depend on IL-6 induction...
  46. ncbi request reprint Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
    C Herder
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, 40225, Dusseldorf, Germany
    Diabetologia 49:921-9. 2006
    ..We hypothesised that these chemokines may be risk factors for the development of type 2 diabetes...
  47. ncbi request reprint The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression
    K Kempf
    German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225, Dusseldorf, Germany
    J Mol Med (Berl) 85:389-96. 2007
    ..Thus, the MetS may support peripheral inflammation by sensitizing leukocytes to up-regulate proinflammatory markers in response to glucose, which in turn increases the risk for type-2 diabetes mellitus and cardiovascular disease...
  48. ncbi request reprint Prevalence of impaired glucose regulation in German school-leaving students
    C Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Dusseldorf, Germany
    Int J Obes (Lond) 31:1086-8. 2007
    ..American populations, but, nevertheless provides evidence for the necessity of public health interventions aiming at primary prevention of obesity and T2D in children and adolescents...
  49. ncbi request reprint Increased TNF-alpha and decreased TGF-beta expression in peripheral blood leukocytes after acute myocardial infarction
    K Kempf
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 38:346-51. 2006
    ..Gene expression alterations indicate a sophisticated regulation of counteracting TNF-alpha and TGF-beta cytokine expression in peripheral blood leukocytes after AMI with bias towards a pro-inflammatory situation...
  50. ncbi request reprint Performance of screening questionnaires and risk scores for undiagnosed diabetes: the KORA Survey 2000
    Wolfgang Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center at Düsseldorf University, Dusseldorf, Germany
    Arch Intern Med 165:436-41. 2005
    ..Validation of published screening questionnaires and risk scores for undiagnosed diabetes has typically not been performed in independent population samples...
  51. ncbi request reprint Chronic inflammation and hemodialysis reduce immune competence of peripheral blood leukocytes in end-stage renal failure patients
    Kerstin Knerr
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Cytokine 30:132-8. 2005
    ..This study shows by induction and stabilization of immune-relevant transcripts that chronic inflammation and hemodialysis are crucial factors for disturbed immune competence of end-stage renal failure patients...
  52. ncbi request reprint Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation
    L Reichstein
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute, Heinrich Heine University Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetologia 48:824-8. 2005
    ..We performed a controlled, randomised pilot trial to compare the effects of high-frequency external muscle stimulation (HF) with those of TENS in patients with symptomatic DSP...
  53. ncbi request reprint Evaluation of diagnostic relevance of mRNA levels in peripheral blood: predictive value for mortality in hemodialysis patients
    Reiner Füth
    German Diabetes Centre, German Diabetes Research Institute at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Cytokine 27:166-72. 2004
    ..This study shows that gene expression patterns of circulating leukocytes may present an important new diagnostic tool to predict clinical outcome in patients with inflammatory vascular diseases...
  54. ncbi request reprint Somatostatin receptor expression in peripheral blood of type 2 diabetes mellitus patients
    F ter Veld
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, and Department of General Pediatrics, University Children s Hospital, Dusseldorf, Germany
    Horm Metab Res 39:230-2. 2007
  55. ncbi request reprint Oral DNA vaccination with a plasmid encoding soluble ICAM-1 modulates cytokine expression profiles in nonobese diabetic mice
    Natasja K van den Engel
    German Diabetes Center, German Diabetes Research Institute, Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    J Mol Med (Berl) 80:301-8. 2002
    ..We conclude that oral vaccination with DNA encoding immunoregulatory molecules such as ICAM-1 and TGF-beta represents an approach for modulating the ongoing inflammatory process in the pancreas of diabetes prone NOD mice...
  56. ncbi request reprint Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002
    Barbara Thorand
    GF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 54:2932-8. 2005
    ..This association is independent of a generalized proinflammatory state, but subjects with elevated levels of several inflammatory markers seem to be particularly prone to develop type 2 diabetes...
  57. ncbi request reprint Is self-monitoring of blood glucose appropriate for all type 2 diabetic patients? The Fremantle Diabetes Study
    Hubert Kolb
    Diabetes Care 30:183-4; author reply 184-5. 2007
  58. ncbi request reprint Chemokines and incident coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    German Diabetes Clinic, Leibniz Center at Heinrich Heine University, Dusseldorf Germany
    Arterioscler Thromb Vasc Biol 26:2147-52. 2006
    ..The aim of this study was to assess whether elevated systemic levels of these chemokines precede coronary events...
  59. ncbi request reprint The DREAM trial
    Christian Herder
    Lancet 368:2049; author reply 2050-1. 2006
  60. ncbi request reprint Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:2745-51. 2006
    ....
  61. doi request reprint Interrelations between diabetes therapy, self-monitoring of blood glucose, blood glucose and non-fatal or fatal endpoints in patients with type 2 diabetes / results of a longitudinal cohort study (ROSSO 5)
    Berthold Schneider
    Institut für Biometrie, Medizinische Hochschule Hannover, Hannover, Germany
    Arzneimittelforschung 57:762-9. 2007
    ..001). SMBG-associated changes of antidiabetic therapy may contribute to the better clinical outcome of patients with SMBG...
  62. ncbi request reprint Combined activation of innate and T cell immunity for recognizing immunomodulatory properties of therapeutic agents
    Bettina Rose
    German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany
    J Leukoc Biol 75:624-30. 2004
    ....
  63. doi request reprint Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials
    Nish Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
    Lancet 372:1394-402. 2008
    ..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes...
  64. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  65. doi request reprint Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
    Anne Katrin Sjølie
    Department of Ophthalmology, Odense University Hospital, Odense, Denmark
    Lancet 372:1385-93. 2008
    ..Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes...