Christiane Lex

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests
    Christiane Lex
    Department of Pediatric Respiratory Medicine, Imperial College of Science, Technology, and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 174:1286-91. 2006
  2. ncbi request reprint Value of surrogate tests to predict exercise-induced bronchoconstriction in atopic childhood asthma
    Christiane Lex
    Department of Paediatric Cardiology and Pulmonology, Heinrich Heine University, Dusseldorf, Germany
    Pediatr Pulmonol 42:225-30. 2007
  3. pmc Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, National Heart and Lung Institute, London, UK
    Respir Res 7:63. 2006
  4. ncbi request reprint Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children
    Angela Zacharasiewicz
    Department of Respiratory Pediatrics, Clinical Trials and Evaluation Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:1077-82. 2005
  5. ncbi request reprint Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma?
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
    Pediatr Pulmonol 42:298-303. 2007
  6. ncbi request reprint Is a two-week trial of oral prednisolone predictive of target lung function in pediatric asthma?
    Christiane Lex
    Department of Respiratory Paediatrics, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Pediatr Pulmonol 39:521-7. 2005
  7. ncbi request reprint Markers of airway inflammation in primary ciliary dyskinesia studied using exhaled breath condensate
    Nadwa Zihlif
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 41:509-14. 2006
  8. ncbi request reprint Effect of inhalation times on exhaled NO
    Angela Zacharasiewicz
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom
    Pediatr Pulmonol 38:335-8. 2004
  9. ncbi request reprint Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern
    Christiane Lex
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:318-24. 2005
  10. ncbi request reprint Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesia
    Nadwa Zihlif
    Department of Paediatric Respiratory Medicine, Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:551-7. 2005

Detail Information

Publications11

  1. ncbi request reprint Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests
    Christiane Lex
    Department of Pediatric Respiratory Medicine, Imperial College of Science, Technology, and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 174:1286-91. 2006
    ....
  2. ncbi request reprint Value of surrogate tests to predict exercise-induced bronchoconstriction in atopic childhood asthma
    Christiane Lex
    Department of Paediatric Cardiology and Pulmonology, Heinrich Heine University, Dusseldorf, Germany
    Pediatr Pulmonol 42:225-30. 2007
    ..In conclusion, eNO measurements, symptom questionnaires and most efficiently a combination of both surrogate tests can be used as time-saving methods to exclude EIB in atopic childhood asthma...
  3. pmc Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, National Heart and Lung Institute, London, UK
    Respir Res 7:63. 2006
    ..The aim of this study was to evaluate the relationship between cysLTs in EBC and another marker of airway remodeling, reticular basement membrane (RBM) thickening, in endobronchial biopsies in children...
  4. ncbi request reprint Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children
    Angela Zacharasiewicz
    Department of Respiratory Pediatrics, Clinical Trials and Evaluation Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Am J Respir Crit Care Med 171:1077-82. 2005
    ..38; confidence interval, 1.06-1.81) were significant predictors of failed reduction. These findings suggest that monitoring airway inflammation may be useful in optimizing treatment in children with asthma...
  5. ncbi request reprint Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma?
    Christiane Lex
    Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
    Pediatr Pulmonol 42:298-303. 2007
    ..25 [0-91]%) or the "non-eosinophilic" group (27.5 [0-96] vs. 44 [9-96]%). In conclusion children with difficult asthma may benefit clinically from high-dose systemic corticosteroids even in the absence of sputum eosinophilia...
  6. ncbi request reprint Is a two-week trial of oral prednisolone predictive of target lung function in pediatric asthma?
    Christiane Lex
    Department of Respiratory Paediatrics, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Pediatr Pulmonol 39:521-7. 2005
    ..5-39.9) vs. 1.4 (0.0-4.8) cells/mm2, P = 0.018). In conclusion, a 2-week course of prednisolone is not necessarily predictive of "target" lung function. Definitions such as PAL should be regularly reviewed on individual basis...
  7. ncbi request reprint Markers of airway inflammation in primary ciliary dyskinesia studied using exhaled breath condensate
    Nadwa Zihlif
    Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 41:509-14. 2006
    ..The mechanism of airway neutrophilia is unclear, but is unlikely to be related to increased production of LTB4, at least in stable PCD patients...
  8. ncbi request reprint Effect of inhalation times on exhaled NO
    Angela Zacharasiewicz
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom
    Pediatr Pulmonol 38:335-8. 2004
    ..The inhalation maneuver does not influence eNO measurements using the variable expiratory flow technique...
  9. ncbi request reprint Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell pattern
    Christiane Lex
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:318-24. 2005
    ..Raised nitric oxide is only poorly predictive of sputum eosinophilia in these children...
  10. ncbi request reprint Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesia
    Nadwa Zihlif
    Department of Paediatric Respiratory Medicine, Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 39:551-7. 2005
    ..693, P < 0.002), but not percent FEV(1) or eNO. Stable PCD children have increased cough frequency and neutrophilic airway inflammation. In conclusion, cough frequency correlated with sputum neutrophils but not with FEV1 or eNO...
  11. ncbi request reprint Repeatability of sodium and chloride in exhaled breath condensates
    Angela Zacharasiewicz
    Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Pediatr Pulmonol 37:273-5. 2004
    ..The wide use of EBC is more likely to depend on the development of highly sensitive and reproducible assays, rather than further refinements of the collection technique...