Research Topics
| Christiane LexSummaryAffiliation: Heinrich Heine University Country: Germany Publications
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Detail Information
Publications
Airway eosinophilia in children with severe asthma: predictive values of noninvasive testsChristiane Lex
Department of Pediatric Respiratory Medicine, Imperial College of Science, Technology, and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, Sydney Street, London SW3 6NP, UK
Am J Respir Crit Care Med 174:1286-91. 2006..4%. CONCLUSIONS: There was moderate agreement between both Fe(NO) and sputum eosinophils and BAL eosinophils. There was good NPV, but only poor PPV for these markers for mucosal eosinophilia...- Value of surrogate tests to predict exercise-induced bronchoconstriction in atopic childhood asthmaChristiane Lex
Department of Paediatric Cardiology and Pulmonology, Heinrich Heine University, Dusseldorf, Germany
Pediatr Pulmonol 42:225-30. 2007..In conclusion, eNO measurements, symptom questionnaires and most efficiently a combination of both surrogate tests can be used as time-saving methods to exclude EIB in atopic childhood asthma... 
Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot studyChristiane Lex
Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, National Heart and Lung Institute, London, UK
Respir Res 7:63. 2006..The aim of this study was to evaluate the relationship between cysLTs in EBC and another marker of airway remodeling, reticular basement membrane (RBM) thickening, in endobronchial biopsies in children...- Clinical use of noninvasive measurements of airway inflammation in steroid reduction in childrenAngela Zacharasiewicz
Department of Respiratory Pediatrics, Clinical Trials and Evaluation Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Am J Respir Crit Care Med 171:1077-82. 2005..38; confidence interval, 1.06-1.81) were significant predictors of failed reduction. These findings suggest that monitoring airway inflammation may be useful in optimizing treatment in children with asthma... - Does sputum eosinophilia predict the response to systemic corticosteroids in children with difficult asthma?Christiane Lex
Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, United Kingdom
Pediatr Pulmonol 42:298-303. 2007..25 [0-91]%) or the "non-eosinophilic" group (27.5 [0-96] vs. 44 [9-96]%). In conclusion children with difficult asthma may benefit clinically from high-dose systemic corticosteroids even in the absence of sputum eosinophilia... - Is a two-week trial of oral prednisolone predictive of target lung function in pediatric asthma?Christiane Lex
Department of Respiratory Paediatrics, Imperial College of Science, Technology and Medicine at the Royal Brompton Hospital and National Heart and Lung Institute, London, UK
Pediatr Pulmonol 39:521-7. 2005..5-39.9) vs. 1.4 (0.0-4.8) cells/mm2, P = 0.018). In conclusion, a 2-week course of prednisolone is not necessarily predictive of "target" lung function. Definitions such as PAL should be regularly reviewed on individual basis... - Markers of airway inflammation in primary ciliary dyskinesia studied using exhaled breath condensateNadwa Zihlif
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
Pediatr Pulmonol 41:509-14. 2006..The mechanism of airway neutrophilia is unclear, but is unlikely to be related to increased production of LTB4, at least in stable PCD patients... - Effect of inhalation times on exhaled NOAngela Zacharasiewicz
Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom
Pediatr Pulmonol 38:335-8. 2004..The inhalation maneuver does not influence eNO measurements using the variable expiratory flow technique... - Sputum induction in children with difficult asthma: safety, feasibility, and inflammatory cell patternChristiane Lex
Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
Pediatr Pulmonol 39:318-24. 2005..Raised nitric oxide is only poorly predictive of sputum eosinophilia in these children... - Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesiaNadwa Zihlif
Department of Paediatric Respiratory Medicine, Imperial School of Medicine at National Heart and Lung Institute, Royal Brompton Hospital, London, UK
Pediatr Pulmonol 39:551-7. 2005..693, P < 0.002), but not percent FEV(1) or eNO. Stable PCD children have increased cough frequency and neutrophilic airway inflammation. In conclusion, cough frequency correlated with sputum neutrophils but not with FEV1 or eNO... - Repeatability of sodium and chloride in exhaled breath condensatesAngela Zacharasiewicz
Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK
Pediatr Pulmonol 37:273-5. 2004..The wide use of EBC is more likely to depend on the development of highly sensitive and reproducible assays, rather than further refinements of the collection technique...