Jean Krutmann

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Photodamage: pathophysiology - new concepts
    Jean Krutmann
    Institut für Umweltmedizinische Forschung IUF an der Heinrich Heine Universität GmbH, Dusseldorf, Germany
    Eur J Dermatol 12:XV-XVI. 2002
  2. ncbi request reprint Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences
    Mark Berneburg
    Molecular Oncology and Aging, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany
    J Invest Dermatol 125:213-20. 2005
  3. doi request reprint Role of mitochondria in photoaging of human skin: the defective powerhouse model
    Jean Krutmann
    IUF, Duesseldorf, Germany
    J Investig Dermatol Symp Proc 14:44-9. 2009
  4. doi request reprint Sun exposure: what molecular photodermatology tells us about its good and bad sides
    Jean Krutmann
    IUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    J Invest Dermatol 132:976-84. 2012
  5. ncbi request reprint Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin
    Mark Berneburg
    Molecular Oncology and Aging, Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    J Invest Dermatol 122:1277-83. 2004
  6. ncbi request reprint Ultraviolet-free phototherapy
    Jean Krutmann
    Environmental Health Research Institute, Heinrich Heine University of Düsseldorf GmbH, Germany
    Photodermatol Photoimmunol Photomed 21:59-61. 2005
  7. ncbi request reprint [Premature skin aging by ultraviolet radiation and other environmental hazards. The molecular basis]
    J Krutmann
    Institut für Umweltmedizinische Forschung an der Heinrich Heine Universität gGmbH, Dusseldorf
    Hautarzt 54:809-17. 2003
  8. ncbi request reprint [Antibodies and oxidative stress]
    J Krutman
    Institut fur Umweltmedizinische Forschung, Heinrich Heine Universität Düsseldorf gGmbH, Dusseldorf
    Hautarzt 54:300-1. 2003
  9. doi request reprint [Actives. A central component of modern light protection]
    J Krutmann
    Institut fur Umweltmedizinische Forschung, Heinrich Heine Universität Düsseldorf gGmbH, Auf m Hennekamp 50, 40225 Dusseldorf
    Hautarzt 60:294-300. 2009
  10. ncbi request reprint [Functional food for the skin]
    J Krutmann
    Institut fur Umweltmedizinische Forschung, Heinrich Heine Universitat Dusseldorf
    Hautarzt 57:280. 2006

Detail Information

Publications81

  1. ncbi request reprint Photodamage: pathophysiology - new concepts
    Jean Krutmann
    Institut für Umweltmedizinische Forschung IUF an der Heinrich Heine Universität GmbH, Dusseldorf, Germany
    Eur J Dermatol 12:XV-XVI. 2002
  2. ncbi request reprint Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences
    Mark Berneburg
    Molecular Oncology and Aging, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany
    J Invest Dermatol 125:213-20. 2005
    ..These data indicate that increase of the energy precursor creatine protects from functionally relevant, aging-associated mutations of mitochondrial DNA...
  3. doi request reprint Role of mitochondria in photoaging of human skin: the defective powerhouse model
    Jean Krutmann
    IUF, Duesseldorf, Germany
    J Investig Dermatol Symp Proc 14:44-9. 2009
    ..Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 44-49; doi:10.1038/jidsymp.2009.1...
  4. doi request reprint Sun exposure: what molecular photodermatology tells us about its good and bad sides
    Jean Krutmann
    IUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    J Invest Dermatol 132:976-84. 2012
    ....
  5. ncbi request reprint Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin
    Mark Berneburg
    Molecular Oncology and Aging, Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    J Invest Dermatol 122:1277-83. 2004
    ..Thus, mtDNA mutations are induced in the human skin by repetitive UV exposure. In addition, these mutations seem to represent long-term in-vivo biomarkers for actinic damage in the human skin...
  6. ncbi request reprint Ultraviolet-free phototherapy
    Jean Krutmann
    Environmental Health Research Institute, Heinrich Heine University of Düsseldorf GmbH, Germany
    Photodermatol Photoimmunol Photomed 21:59-61. 2005
    ..On the other hand, UV radiation is a complete carcinogen and as a consequence, UV phototherapy is usually not used for the long-term management of children and young adults and in combination with topical or systemic immunosuppressants...
  7. ncbi request reprint [Premature skin aging by ultraviolet radiation and other environmental hazards. The molecular basis]
    J Krutmann
    Institut für Umweltmedizinische Forschung an der Heinrich Heine Universität gGmbH, Dusseldorf
    Hautarzt 54:809-17. 2003
    ..Based on our current understanding of the molecular biological basis of the effects of environmental hazards, this overview aims at listing the most important findings which contribute to aging of the skin...
  8. ncbi request reprint [Antibodies and oxidative stress]
    J Krutman
    Institut fur Umweltmedizinische Forschung, Heinrich Heine Universität Düsseldorf gGmbH, Dusseldorf
    Hautarzt 54:300-1. 2003
  9. doi request reprint [Actives. A central component of modern light protection]
    J Krutmann
    Institut fur Umweltmedizinische Forschung, Heinrich Heine Universität Düsseldorf gGmbH, Auf m Hennekamp 50, 40225 Dusseldorf
    Hautarzt 60:294-300. 2009
    ..The best example for this group is antioxidants. Currently other new active cosmetic ingredients or actives are being developed that can reduce UV-induced skin damage in a variety of ways...
  10. ncbi request reprint [Functional food for the skin]
    J Krutmann
    Institut fur Umweltmedizinische Forschung, Heinrich Heine Universitat Dusseldorf
    Hautarzt 57:280. 2006
  11. ncbi request reprint Mechanisms of ultraviolet (UV) B and UVA phototherapy
    J Krutmann
    Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    J Investig Dermatol Symp Proc 4:70-2. 1999
    ..Special emphasis will be given on studies that have identified previously unrecognized immunosuppressive/anti-inflammatory principles of UV phototherapy...
  12. ncbi request reprint Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis
    J Krutmann
    Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    J Dermatol Sci 23:S22-6. 2000
    ....
  13. ncbi request reprint [Photocarcinogenesis]
    J Krutmann
    Klinische und Experimentelle Photodermatologie, Hautklinik der Heinrich Heine Universität, Dusseldorf
    Praxis (Bern 1994) 90:297-9. 2001
    ..Extreme caution is advised before treating XP patients with radiotherapy. Determining the complementation group and radiosensitivity prior to treatment is recommended...
  14. ncbi request reprint Therapeutic photoimmunology: photoimmunological mechanisms in photo(chemo)therapy
    J Krutmann
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    J Photochem Photobiol B 44:159-64. 1998
    ..UVB and UVA radiation can exert essentially identical immunomodulatory effects, which result, however, from different photobiological mechanisms...
  15. ncbi request reprint New developments in photoprotection of human skin
    J Krutmann
    Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Skin Pharmacol Appl Skin Physiol 14:401-7. 2001
    ....
  16. ncbi request reprint Pre- and probiotics for human skin
    Jean Krutmann
    Institut fur Umweltmedizinische Forschung at Heinrich Heine University, Düsseldorf gGmbH, Auf m Hennekamp 50, D 4025 Düsseldorf, Germany
    J Dermatol Sci 54:1-5. 2009
    ..This review will briefly summarize our current understanding of the cutaneous microbiota and summarize existing information on pre- and probiotic strategies for skin...
  17. ncbi request reprint The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression
    Nicole Rockel
    Institut fur umweltmedizinische Forschung IUF an der Heinrich Heine Universitat Dusseldorf gGmbH, Dusseldorf, Germany
    J Immunol 179:3604-12. 2007
    ..Thus, similar to nucleotide excision repair, taurine uptake is critically involved in photoprotection of the skin...
  18. pmc Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes
    Katharina Röck
    Institut für Pharmakologie and Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat Dusseldorf, Germany
    J Biol Chem 287:20056-69. 2012
    ....
  19. pmc Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity
    Marc Majora
    Institut fuer Umweltmedizinische Forschung, Heinrich Heine University Duesseldorf gGmbH, Auf m Hennekamp 50, Duesseldorf, Germany
    Am J Pathol 175:1019-29. 2009
    ..Accordingly, increased LOX expression was also observed in vivo in photoaged human and mouse skin. Therefore, mtDNA deletions in human fibroblasts may lead to functional and structural alterations of the skin...
  20. pmc Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation
    Henrike Peuschel
    IUF Leibniz Institut für umweltmedizinische Forschung, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Part Fibre Toxicol 9:48. 2012
    ..Furthermore, we aimed to identify the molecular target of ectoine, a biophysical active substance which we described to prevent carbon nanoparticle-induced lung inflammation...
  21. pmc Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodeling
    Katharina Röck
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, 40225 Dusseldorf, Germany
    J Biol Chem 286:18268-76. 2011
    ..Therefore, a novel mechanism is presented how proteolytic collagen cleavage may inhibit HA synthesis in dermal fibroblasts during extrinsic skin aging...
  22. ncbi request reprint Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis
    Susanne Grether-Beck
    Institut fuer Umweltmedizinische Forschung at the Heinrich Heine University Duesseldorf gGmbH, Duesseldorf, Germany
    J Invest Dermatol 125:545-53. 2005
    ....
  23. ncbi request reprint Cellular response to infrared radiation involves retrograde mitochondrial signaling
    Peter Schroeder
    Institut für Umweltmedizinische Forschung at the Heinrich Heine University Düsseldorf gGmbH, Auf m Hennekamp 50, D 40225 Duesseldorf, Germany
    Free Radic Biol Med 43:128-35. 2007
    ..Thus, IRA, in contrast to UV, elicits a retrograde signaling response in human skin...
  24. ncbi request reprint Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin
    Peter Schroeder
    Institut fur Umweltmedizinische Forschung, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Invest Dermatol 128:2297-303. 2008
    ..Our results support the concept that disruption of mt integrity, for example, by UV-induced mtDNA mutagenesis, is of pathogenetic relevance for photoaging of human skin...
  25. doi request reprint Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)
    Christine Götz
    Leibniz Institut für Umweltmedizinische Forschung IUF, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Exp Dermatol 21:358-63. 2012
    ..Altogether, these data help to better understand skin metabolism and expand the knowledge of in vitro alternatives used for dermatotoxicity testing...
  26. pmc Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression
    Susanne Grether-Beck
    Institut fuer Umweltmedizinische Forschung, Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    J Invest Dermatol 132:1561-72. 2012
    ....
  27. doi request reprint Airborne particle exposure and extrinsic skin aging
    Andrea Vierkötter
    Institut für umweltmedizinische Forschung an der Heinrich Heine Universität Düsseldorf gGmbH, Dusseldorf, Germany
    J Invest Dermatol 130:2719-26. 2010
    ..These results indicate that particle pollution might influence skin aging as well...
  28. ncbi request reprint [Photodamage and photoaging--prevention and treatment]
    Susanne Grether-Beck
    Institut für Umweltmedizinische Forschung an der Heinrich Heine Universität gGmbH, Dusseldorf, Germany
    J Dtsch Dermatol Ges 3:S19-25. 2005
    ..New developments of therapeutic interventions including DNA repair enzymes will be discussed...
  29. ncbi request reprint Mitochondrial cytochrome c release mediates ceramide-induced activator protein 2 activation and gene expression in keratinocytes
    Susanne Grether-Beck
    Cell Biology, Institut fuer Umweltmedizinische Forschung, Heinrich Heine University gGmbH, Auf m Hennekamp 50, D 40225 Duesseldorf, Germany
    J Biol Chem 278:47498-507. 2003
    ..Mitochondria thus have a previously unrecognized function in signaling ceramide-induced transcription factor activation and gene regulation...
  30. doi request reprint Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1
    Nicole Buechner
    Molecular Cell and Aging Research, Institut fuer Umweltmedizinische Forschung at the University of Duesseldorf gGmbH, Auf m Hennekamp 50, 40225 Duesseldorf, Germany
    Exp Gerontol 43:633-7. 2008
    ..Thus, Trx may serve as an important contributor to an "anti-aging therapeutic cocktail"...
  31. doi request reprint Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing
    Susanne Grether-Beck
    Institut fur umweltmedizinische Forschung IUF, Heinrich Heine University Düsseldorf gGmbH, Dusseldorf, Germany
    Exp Dermatol 17:771-9. 2008
    ..These observations explain at least some of the beneficial effects of bathing in the Blue Lagoon and provide a scientific basis for the use of Blue Lagoon extracts in cosmetic and/or medical products...
  32. doi request reprint Infrared radiation-induced matrix metalloproteinase in human skin: implications for protection
    Peter Schroeder
    Cell Biology Molecular Ageing Research, Institut fuer Umweltmedizinische Forschung, Heinrich Heine University Düsseldorf gGmbH, Duesseldorf, Germany
    J Invest Dermatol 128:2491-7. 2008
    ..Thus, IRA irradiation most likely promotes premature skin aging and topical application of appropriate antioxidants represents an effective photoprotective strategy...
  33. doi request reprint Infrared A radiation influences the skin fibroblast transcriptome: mechanisms and consequences
    Christian Calles
    Institut fuer Umweltmedizinische Forschung IUF, Cell Biology Molecular Aging Research, Auf m Hennekamp 50, Duesseldorf, Germany
    J Invest Dermatol 130:1524-36. 2010
    ..Our results identify IRA as an environmental factor with relevance for skin homeostasis and photoaging...
  34. doi request reprint Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression
    Julia Tigges
    IUF Leibniz Research Institute for Environmental Medicine, Heinrich Heine University, Dusseldorf, Germany
    J Invest Dermatol 133:87-96. 2013
    ..These data clearly indicate that repressed CYP1 activity in NHDFs is not causally related to AhRR expression, which may serve a different, yet unknown, biological function...
  35. doi request reprint Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
    Alessandra Marini
    IUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    Exp Dermatol 21:140-6. 2012
    ..We demonstrate that PKEK has the capacity to reduce UVB-induced skin pigmentation and may be suited to serve as a skin tone-modulating agent in cosmetic products...
  36. ncbi request reprint Sunbed use induces the photoaging-associated mitochondrial common deletion
    Verena Reimann
    Institut fur Umweltmedizinische Forschung, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Invest Dermatol 128:1294-7. 2008
    ..44-8.89) of the Common Deletion in buttock skin samples after sunbed use. Participants with previous sunbed use showed no increase. This study indicates that sunbed use may contribute to mtDNA deletion-associated skin photoaging...
  37. doi request reprint The Aryl hydrocarbon receptor is involved in UVR-induced immunosuppression
    Fatemeh Navid
    Department of Dermatology, University Kiel, Kiel, Germany
    J Invest Dermatol 133:2763-70. 2013
    ..Activation of the AhR might represent an alternative to modulate the immune system in a similar manner like UVR but without causing the adverse effects of UVR, including DNA damage. ..
  38. pmc Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins
    Peter Arne Gerber
    Department of Dermatology, University of Dusseldorf, Dusseldorf, Germany
    PLoS ONE 8:e63949. 2013
    ..Some of these novel uncharacterized skin genes may represent potential biomarkers or drug targets for the development of future diagnostics or therapeutics. ..
  39. pmc Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging
    York Kamenisch
    Department of Dermatology, Eberhard Karls University, D 72076 Tuebingen, Germany
    J Exp Med 207:379-90. 2010
    ....
  40. pmc Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA
    Ilaria Dalla Rosa
    Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich Heine University, Medical School, D 40225 Dusseldorf, Germany
    Nucleic Acids Res 37:6414-28. 2009
    ..We propose that adaptation of this domain to different chromatin environments in nuclei and mitochondria has driven evolutional development and conservation of organelle-restricted topoisomerase I paralogs in vertebrates...
  41. ncbi request reprint Functions of the aryl hydrocarbon receptor in the skin
    Charlotte Esser
    Leibniz Research Institute for Environmental Medicine IUF, Auf m Hennekamp 50, 40225, Dusseldorf, Germany
    Semin Immunopathol 35:677-91. 2013
    ..We also discuss the existing evidence that AHR antagonists or AHR ligands may be used for the prevention and/or treatment of skin disease. ..
  42. ncbi request reprint Cutaneous effects of infrared radiation: from clinical observations to molecular response mechanisms
    Stefan M Schieke
    Institut fuer Umweltmedizinische Forschung IUF an der Heinrich Heine Universitaet gGmbH, Auf m Hennekamp 50, D 40225 Duesseldorf, Germany
    Photodermatol Photoimmunol Photomed 19:228-34. 2003
    ..This previously unrecognized molecular 'IR response' shows that IR radiation is capable of specifically interfering with cellular functions and provides a molecular basis for biological effects of IR on human skin...
  43. doi request reprint Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation
    Ulrich Sydlik
    IUF Leibniz Research Institute for Environmental Medicine, Auf m Hennekamp 50, Duesseldorf, Germany
    Eur Respir J 41:433-42. 2013
    ..Ectoine, a compound of the highly compliant group of compatible solutes, demonstrates a reproducible and robust effect on the resolution of lung inflammation...
  44. doi request reprint Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes
    Christine Götz
    Leibniz Institut für Umweltmedizinische Forschung IUF, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Exp Dermatol 21:364-9. 2012
    ..We conclude from our studies that 3D epidermal models, like the EPI-200 employed here, are superior over monolayer cultures in mimicking human skin xenobiotic metabolism and thus better suited for dermatotoxicity testing...
  45. doi request reprint Photoprotection against UVAR: effective triterpenoids require a lipid raft stabilizing chemical structure
    Mirko Bayer
    Caesar and Loretz GmbH, Hilden, Germany Institute of Pharmaceutical Biology, University of Duesseldorf, Duesseldorf, Germany
    Exp Dermatol 20:955-8. 2011
    ..This effect depends on the structure of the molecule, because its isomer ursolic acid also integrates within the rafts without inhibiting ceramide formation and upregulation of gene expression...
  46. doi request reprint The aryl hydrocarbon receptor mediates UVB radiation-induced skin tanning
    Bettina Jux
    Leibniz Institute for Environmental Medical Research IUF, Dusseldorf, Germany
    J Invest Dermatol 131:203-10. 2011
    ..Thus, the environmental signal sensor AhR links solar UVB radiation to skin pigmentation...
  47. ncbi request reprint Singlet oxygen-induced attenuation of growth factor signaling: possible role of ceramides
    Stefan M Schieke
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Free Radic Res 38:729-37. 2004
    ....
  48. doi request reprint The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing
    Andrea Vierkötter
    Institut fur umweltmedizinische Forschung IUF, Dusseldorf, Germany
    J Dermatol Sci 53:207-11. 2009
    ..Such an ideal score, however, does currently not exist...
  49. doi request reprint The role of near infrared radiation in photoaging of the skin
    Peter Schroeder
    Institut fuer Umweltmedizinische Forschung, Heinrich Heine University Düsseldorf gGmbH, Auf m Hennekamp 50, D 40225 Duesseldorf, Germany
    Exp Gerontol 43:629-32. 2008
    ..As part of natural sunlight, IRA significantly contributes to extrinsic skin aging. This article reviews the cutaneous effects of IRA-radiation, the underlying molecular mechanisms and the available protective strategies...
  50. ncbi request reprint Ultraviolet B radiation-induced immunosuppression: molecular mechanisms and cellular alterations
    Nicole Schade
    Institut fur umweltmedizinische Forschung IUF, Institute for Environmental Medical Research at the Heinrich Heine University Duesseldorf gGmbH, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Photochem Photobiol Sci 4:699-708. 2005
    ....
  51. ncbi request reprint Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
    Agatha Schwarz
    Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
    Nat Cell Biol 4:26-31. 2002
    ..Our results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines...
  52. ncbi request reprint 'To repair or not to repair - no longer a question': repair of mitochondrial DNA shielding against age and cancer
    Mark Berneburg
    Molecular Oncology and Aging, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany
    Exp Dermatol 15:1005-15. 2006
    ..According to recent data, mitochondria possess functional repair mechanisms such as base excision repair, double-strand break repair and mismatch repair, yet nucleotide excision repair has so far not been detected...
  53. ncbi request reprint Repair of mitochondrial DNA in aging and carcinogenesis
    Mark Berneburg
    Molecular Oncology and Aging, Department of Dermatology, Eberhard Karls University, Liebermeisterstrasse 25, D 72076 Tubingen, Germany
    Photochem Photobiol Sci 5:190-8. 2006
    ..The role of these defence mechanisms in the removal of mitochondrial DNA damage and the link to aging and carcinogenesis-associated processes are discussed in this review...
  54. ncbi request reprint Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly
    Ulrich Ranft
    Institut für Umweltmedizinische Forschung IUF an der Heinrich Heine Universität Düsseldorf, Dusseldorf, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Environ Res 109:1004-11. 2009
    ..The associations were adjusted for potential confounders using regression analysis. These results indicate that chronic exposure to traffic-related PM may be involved in the pathogenesis of AD...
  55. ncbi request reprint The hallmarks of fibroblast ageing
    Julia Tigges
    Leibniz Research Institute for Environmental Medicine IUF, Dusseldorf, Germany
    Mech Ageing Dev 138:26-44. 2014
    ..iv) The ageing process of dermal fibroblasts in their physiological tissue environment has only been partially elucidated, although these cells have been a preferred model of cell ageing in vitro for decades. ..
  56. ncbi request reprint Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation
    Faiza Kalfalah
    Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich Heine University, Med Faculty, Dusseldorf, Germany
    Exp Gerontol 56:59-68. 2014
    ....
  57. pmc Six genes associated with the clinical phenotypes of individuals with deficient and proficient DNA repair
    Tobias Gremmel
    Institut für Umweltmedizinische Forschung at the Heinrich Heine University gGmbH, Auf m Hennekamp 50, D 40225 Dusseldorf, Germany
    Transl Oncogenomics 3:1-13. 2008
    ..Thus, it is possible to identify a small gene subset associated with clinical severity of XP patients also applicable to individuals with no known DNA repair defects...
  58. pmc Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases
    Guang Dai
    Molekulare Pharmakologie, Institut für Pharmakologie and Klinische Pharmakologie, Universitätsklinkum Düsseldorf, Dusseldorf, Germany
    Am J Pathol 171:1451-61. 2007
    ..In conclusion, chronic UVB irradiation induces loss of HA from the dermis, thereby contributing to the quiescent phenotype of dermal fibroblasts...
  59. pmc Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain
    Damien van Berlo
    Institut für umweltmedizinische Forschung an der Heinrich Heine Universität Düsseldorf gGmbH, Dusseldorf, Germany
    Arch Toxicol 84:553-62. 2010
    ..Our study shows that a single, short-term inhalation exposure to DEE triggers region-specific gene expression changes in rat brain to an extent comparable to those observed in the lung...
  60. doi request reprint Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas
    Ursula Kramer
    Institut für Umweltmedizinische Forschung at the Heinrich Heine University Auf m Hennekamp 50, Dusseldorf 40225, Germany
    J Dermatol Sci 56:99-105. 2009
    ..Traffic-related air pollution (TAP) impairs respiratory health and could influence the development of allergies, as was demonstrated in urban areas with relatively high pollution. Whether eczema is affected by TAP was rarely investigated...
  61. ncbi request reprint Cutaneous lymphatic malformations in disappearing bone (Gorham-Stout) disease: a novel clue to the pathogenesis of a rare syndrome
    Daniela Bruch-Gerharz
    Department of Dermatology, Bethesda Krankenhaus Duisburg
    J Am Acad Dermatol 56:S21-5. 2007
    ..Although bone and soft tissue lesions are the most frequent manifestations of Gorham-Stout disease, skin lesions can occur and may provide a clue to the pathogenesis of this rare syndrome...
  62. doi request reprint Photoprotection of human skin beyond ultraviolet radiation
    Susanne Grether-Beck
    IUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    Photodermatol Photoimmunol Photomed 30:167-74. 2014
    ..In this regard we will particularly focus on the use of topical antioxidants and the challenges that result from the task of showing their efficacy...
  63. ncbi request reprint Analysis of cytokine profiles in human skin
    Jean Krutmann
    Institut fur umweltmedizinische Forschung IUF, Heinrich Heine University, Dusseldorf, Germany
    Methods Mol Biol 215:23-7. 2003
  64. ncbi request reprint The interaction of UVA and UVB wavebands with particular emphasis on signalling
    Jean Krutmann
    Institut fur umweltmedizinische Forschung IUF, Heinrich Heine Universität Düsseldorf gGmbH, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Prog Biophys Mol Biol 92:105-7. 2006
    ..Our results indicate that the two distinct stress responses elicited by UVA or UVB interact with each other, producing a "third" response that is different from either alone and cannot be explained by a simple addition of effects...
  65. pmc Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation
    Ellen Fritsche
    Institut fur umweltmedizinische Forschung IUF, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 104:8851-6. 2007
    ..The role of the AhR in the UVB stress response was confirmed in vivo by studies employing AhR KO mice...
  66. ncbi request reprint The osmolyte strategy of normal human keratinocytes in maintaining cell homeostasis
    Ulrich Warskulat
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Düsseldorf gGmbH, Auf m Hennekamp 50, D 40225 Dusseldorf, Germany
    J Invest Dermatol 123:516-21. 2004
    ..These studies demonstrate that NHK possess an osmolyte strategy, which is important for their capacity to maintain cell volume homeostasis and seems to be part of their response to UV radiation...
  67. doi request reprint Adaptive and maladaptive responses in skin: mild heat exposure protects against UVB-induced photoaging in mice
    Thomas Haarmann-Stemmann
    IUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    J Invest Dermatol 133:868-71. 2013
    ..This newly identified heat-mediated process of adaptation to UVB radiation exposure opens new opportunities to slow extrinsic skin aging...
  68. doi request reprint The AhR-Nrf2 pathway in keratinocytes: on the road to chemoprevention?
    Thomas Haarmann-Stemmann
    Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
    J Invest Dermatol 132:7-9. 2012
    ..This newly identified AhR-Nrf2 pathway opens up new opportunities to prevent and treat inflammatory skin diseases...
  69. ncbi request reprint UVA-1 Phototherapy
    Renz Mang
    Department of Dermatology, Heinrich Heine University Düsseldorf gGmbH, Auf m Hennekamp 50, D 40225 Dusseldorf, Germany
    Photodermatol Photoimmunol Photomed 21:103-8. 2005
  70. ncbi request reprint Cutaneous vascular malformations in disappearing bone (Gorham-Stout) disease
    Daniela Bruch-Gerharz
    Department of Dermatology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    JAMA 289:1479-80. 2003
  71. doi request reprint The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation
    Ulrich Sydlik
    Institut fur Umweltmedizinische Forschung, Dusseldorf, Germany
    Am J Respir Crit Care Med 180:29-35. 2009
    ..Because this kind of exposure in modern societies is often unavoidable, a strategy of molecular prevention on an individual level could help to prevent inflammation-derived secondary diseases...
  72. ncbi request reprint Recommendation: daily sun protection in the prevention of chronic UV-induced skin damage
    Peter Elsner
    J Dtsch Dermatol Ges 5:166-73. 2007
  73. ncbi request reprint Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation
    Jörg Eicker
    Institut für Umweltmedizinische Forschung gGmbH at the Heinrich Heine University, Auf m Hennekamp 40, D 40225 Dusseldorf, Germany
    Photochem Photobiol Sci 2:655-9. 2003
    ....
  74. ncbi request reprint Response of severe psoriasis to infliximab
    Ranz Mang
    Dermatology 204:156-7. 2002
  75. ncbi request reprint Infrared-A radiation-induced matrix metalloproteinase 1 expression is mediated through extracellular signal-regulated kinase 1/2 activation in human dermal fibroblasts
    StefanM Schieke
    Institut für Umweltmedizinische Forschung IUF an der Heinrich Heine Universität gGmbH, Auf m Hennekamp 50, D 40225 Duesseldorf, Germany
    J Invest Dermatol 119:1323-9. 2002
    ..This previously unrecognized property of infrared-A points to its possible role in the photoaging of human skin...
  76. ncbi request reprint Sunscreens with an absorption maximum of > or =360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts
    Gabriele Vielhaber
    Symrise GmbH and Co KG, Muhlenfeldstr 1, D 37603, Holzminden, Germany
    Photochem Photobiol Sci 5:275-82. 2006
    ....
  77. ncbi request reprint The expression of matrix metalloproteinase-1 mRNA induced by ultraviolet A1 (340-400 nm) is phototherapy relevant to the glutathione (GSH) content in skin fibroblasts of systemic sclerosis
    Lei Yin
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Dermatol 30:173-80. 2003
    ..These data support the concept that clinical responses to UVA1 radiation are influenced by the antioxidative state of the patients' skin...
  78. ncbi request reprint Different susceptibility of malignant versus nonmalignant human T cells toward ultraviolet A-1 radiation-induced apoptosis
    Ritsuko Yamauchi
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Invest Dermatol 122:477-83. 2004
    ....
  79. ncbi request reprint [Xeroderma pigmentosum: children of the moon]
    Yared Herouy
    Universitäts Hautklinik, Albert Ludwigs Universitat, Freiburg
    J Dtsch Dermatol Ges 1:191-8. 2003
    ..Transfection of an intact repair gene which specifically codes for the missing repair protein could open new possibilities in the therapy of xeroderma pigmentosum...
  80. ncbi request reprint Concepts in molecular dermatotoxicology
    Hans F Merk
    Department of Dermatology and Allergology, RWTH Aachen, Aachen, Germany
    Exp Dermatol 15:692-704. 2006
    ..From this knowledge, novel concepts for skin protection have been developed. Here, we provide a brief overview of some of the most exciting and intriguing concepts in molecular dermatotoxicology...
  81. ncbi request reprint Molecular crosstalk of the ultraviolet a and ultraviolet B signaling responses at the level of mitogen-activated protein kinases
    Stefan M Schieke
    J Invest Dermatol 124:857-9. 2005