K D Kröncke

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Development and evaluation of a questionnaire to measure the perceived implementation of the mission statement of a competency based curriculum
    Thomas Rotthoff
    Deanery of study, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany
    BMC Med Educ 12:109. 2012
  2. doi request reprint Computer-based learning versus practical course in pre-clinical education: acceptance and knowledge retention
    Klaus Dietrich Kröncke
    Institute of Biochemistry and Molecular Biology I, Medical Department of the Heinrich Heine University of Düsseldorf, Dusseldorf, Germany
    Med Teach 32:408-13. 2010
  3. doi request reprint Zinc fingers as biologic redox switches?
    Klaus D Kröncke
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Antioxid Redox Signal 11:1015-27. 2009
  4. ncbi request reprint Cellular stress and intracellular zinc dyshomeostasis
    Klaus D Kröncke
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University of Dusseldorf, Universitatsstr 1, D 40225, Dusseldorf, Germany
    Arch Biochem Biophys 463:183-7. 2007
  5. ncbi request reprint Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO
    Klaus Dietrich Kröncke
    Research Group Immunobiology, Biomedical Research Center, Medical Department of the Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    J Biol Chem 277:13294-301. 2002
  6. ncbi request reprint Cysteine-Zn2+ complexes: unique molecular switches for inducible nitric oxide synthase-derived NO
    K D Kröncke
    Research Group Immunobiology, Medical Department of the Heinrich Heine University of Düsseldorf, D 40225 Dusseldorf, Germany
    FASEB J 15:2503-7. 2001
  7. ncbi request reprint Zinc finger proteins as molecular targets for nitric oxide-mediated gene regulation
    K D Kröncke
    Biomedical Research Centre, Medical Department of the Heinrich Heine University, Dusseldorf, Germany
    Antioxid Redox Signal 3:565-75. 2001
  8. ncbi request reprint Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival
    K D Kröncke
    Medical Department of the Heinrich Heine University of Düsseldorf, Germany
    Int Immunopharmacol 1:1407-20. 2001
  9. ncbi request reprint Nitric oxide inhibits the cochaperone activity of the RING finger-like protein DnaJ
    K D Kröncke
    Research Group Immunobiology, Medical Department of the Heinrich Heine University of Düsseldorf, Moorenstrasse 5, Dusseldorf, D 40225, Germany
    Nitric Oxide 5:289-95. 2001
  10. ncbi request reprint Implications of inducible nitric oxide synthase expression and enzyme activity
    K D Kröncke
    Research Group Immunobiology in the Biomedical Research Centre, Heinrich Heine University, Dusseldorf, Germany
    Antioxid Redox Signal 2:585-605. 2000

Collaborators

Detail Information

Publications16

  1. pmc Development and evaluation of a questionnaire to measure the perceived implementation of the mission statement of a competency based curriculum
    Thomas Rotthoff
    Deanery of study, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany
    BMC Med Educ 12:109. 2012
    ..We investigated to what extent the MSQ captures the construct of learning environment and how well a faculty is following--in its perception--a competency orientation in a competency-based curriculum...
  2. doi request reprint Computer-based learning versus practical course in pre-clinical education: acceptance and knowledge retention
    Klaus Dietrich Kröncke
    Institute of Biochemistry and Molecular Biology I, Medical Department of the Heinrich Heine University of Düsseldorf, Dusseldorf, Germany
    Med Teach 32:408-13. 2010
    ..Computer-based learning is a tool that, when designed appropriately, can be used to effectively meet worthy educational goals...
  3. doi request reprint Zinc fingers as biologic redox switches?
    Klaus D Kröncke
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Antioxid Redox Signal 11:1015-27. 2009
    ..Moreover, we present an overview on human diseases or disorders characterized by an intracellular Zn(2+) dyshomeostasis...
  4. ncbi request reprint Cellular stress and intracellular zinc dyshomeostasis
    Klaus D Kröncke
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University of Dusseldorf, Universitatsstr 1, D 40225, Dusseldorf, Germany
    Arch Biochem Biophys 463:183-7. 2007
    ..However, much less is known about the consequences of a disturbed intracellular Zn2+ homeostasis under these conditions. Current knowledge is reviewed here...
  5. ncbi request reprint Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO
    Klaus Dietrich Kröncke
    Research Group Immunobiology, Biomedical Research Center, Medical Department of the Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    J Biol Chem 277:13294-301. 2002
    ..The results indicate that, among the reactive species investigated, only NO. may act sufficiently gentle to be considered as a regulator and not only as an inhibitor of gene expression via zinc finger transcription factors...
  6. ncbi request reprint Cysteine-Zn2+ complexes: unique molecular switches for inducible nitric oxide synthase-derived NO
    K D Kröncke
    Research Group Immunobiology, Medical Department of the Heinrich Heine University of Düsseldorf, D 40225 Dusseldorf, Germany
    FASEB J 15:2503-7. 2001
    ..It is suggested that iNOS-derived NO acts as a signal molecule targeting cysteine-Zn2+ linkages, thus enabling cells to react toward nitrosative stress...
  7. ncbi request reprint Zinc finger proteins as molecular targets for nitric oxide-mediated gene regulation
    K D Kröncke
    Biomedical Research Centre, Medical Department of the Heinrich Heine University, Dusseldorf, Germany
    Antioxid Redox Signal 3:565-75. 2001
    ..Current knowledge about effects of NO on the cellular zinc homeostasis and on the gene-regulating activity of zinc finger transcription factors is reviewed...
  8. ncbi request reprint Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival
    K D Kröncke
    Medical Department of the Heinrich Heine University of Düsseldorf, Germany
    Int Immunopharmacol 1:1407-20. 2001
    ..These NO-mediated actions will contribute to a better understanding of the impact of inducible nitric oxide synthase (iNOS) enzyme activity during inflammatory reactions...
  9. ncbi request reprint Nitric oxide inhibits the cochaperone activity of the RING finger-like protein DnaJ
    K D Kröncke
    Research Group Immunobiology, Medical Department of the Heinrich Heine University of Düsseldorf, Moorenstrasse 5, Dusseldorf, D 40225, Germany
    Nitric Oxide 5:289-95. 2001
    ..Thus, an encounter of bacterial cells with NO can impair the protein folding activity of the bacterial chaperone system, thereby increasing bacterial susceptibility toward the defensive attack by the host...
  10. ncbi request reprint Implications of inducible nitric oxide synthase expression and enzyme activity
    K D Kröncke
    Research Group Immunobiology in the Biomedical Research Centre, Heinrich Heine University, Dusseldorf, Germany
    Antioxid Redox Signal 2:585-605. 2000
    ..Thus, the action of NO during inflammatory reactions has to be considered in the context of timing and duration of its synthesis as well as stages and specific events in inflammation...
  11. ncbi request reprint Nitric oxide: cytotoxicity versus cytoprotection--how, why, when, and where?
    K D Kröncke
    Research Group Immunobiology in the Biomedical Research Centre, Heinrich Heine University, Dusseldorf, Germany
    Nitric Oxide 1:107-20. 1997
    ..We here review the current understanding of cytotoxic versus cytoprotective effects of NO in mammalian cells and try to highlight the janus-faced properties of this important small molecule...
  12. pmc Nitric oxide inhibits endothelial IL-1[beta]-induced ICAM-1 gene expression at the transcriptional level decreasing Sp1 and AP-1 activity
    D Berendji-Grün
    Research Group Immunobiology, Medical Department, Heinrich Heine University of Dusseldorf, Germany
    Mol Med 7:748-54. 2001
    ..Nitric oxide (NO) has frequently been shown to inhibit leukocyte adherence to activated endothelium thus displaying anti-adhesive and immunosuppressive activities. A molecular mechanism contributing to this effect is described...
  13. ncbi request reprint Inactivation of zinc finger transcription factors provides a mechanism for a gene regulatory role of nitric oxide
    K D Kröncke
    Research Group Immunobiology, Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
    FASEB J 14:166-73. 2000
    ..5 mM). These findings suggest that NO has a modulatory role on transcription factors depending on their sensitivity to NO-induced stress, thus providing a mechanism for a gene regulatory function of NO...
  14. ncbi request reprint Even after UVA-exposure will nitric oxide protect cells from reactive oxygen intermediate-mediated apoptosis and necrosis
    C V Suschek
    Research Group Immunobiology, , , Germany
    Cell Death Differ 8:515-27. 2001
    ..Thus, the experiments presented demonstrate that NO exposure during or even after a ROS-mediated toxic insult fully protects from apoptosis or necrosis by maintaining membrane integrity and function...
  15. ncbi request reprint Nitric oxide induces apoptosis in mouse thymocytes
    K Fehsel
    Institute of Immunobiology, Heinrich Heine University, Dusseldorf, Germany
    J Immunol 155:2858-65. 1995
    ..Addition of dexamethasone to these cocultures did not lead to a further increase in the percentage of apoptotic thymocytes, underlining the protective effect of NO on dexamethasone-induced apoptosis...
  16. ncbi request reprint Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progression
    M V Cronauer
    Department of Urology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Oncogene 26:1875-84. 2007
    ..In summary, our findings suggest that intratumoral iNOS activity favors development of prostate cancer cells that are able to proliferate androgen receptor-independently, thereby promoting prostate tumor progression...