M Kelm

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi Nitric oxide metabolism and breakdown
    M Kelm
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Moorenstrasse 5, D 40225, Dusseldorf, Germany
    Biochim Biophys Acta 1411:273-89. 1999
  2. ncbi Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway
    M Kelm
    Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
    Cardiovasc Res 41:765-72. 1999
  3. ncbi Sympathetic hyperactivity influences chemosensor function in patients with end-stage renal disease
    C Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, University Duesseldorf, Duesseldorf, Germany
    Eur J Med Res 14:151-5. 2009
  4. ncbi Additive effect of coexistent type 2 diabetes and arterial hypertension on endothelial dysfunction in resistance arteries of human forearm vasculature
    M Preik
    Department of Medicine, Heinrich Heine University Dusseldorf, Germany
    Angiology 51:545-54. 2000
  5. ncbi Impaired red blood cell deformability in patients with coronary artery disease and diabetes mellitus
    S Keymel
    University Düsseldorf, Medical Faculty, Department of Cardiology, Pulmonology, and Vascular Diseases, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 43:760-5. 2011
  6. ncbi Vagal heart rate control in patients with atrial fibrillation: impact of tonic activation of peripheral chemosensory function in heart failure
    T Drexel
    Department of Medicine, University Hospital Duesseldorf, Duesseldorf, Germany
    Adv Exp Med Biol 755:287-97. 2013
  7. ncbi Unmasking the Janus face of myoglobin in health and disease
    U B Hendgen-Cotta
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Dusseldorf, Dusseldorf, Germany
    J Exp Biol 213:2734-40. 2010
  8. ncbi Intracoronary dipyridamole reduces the incidence of abrupt vessel closure following PTCA: a prospective randomised trial
    M P Heintzen
    School of Internal Medicine, Department of Cardiology, Pneumology and Angiology, Heinrich Heine University, Moorenstr 5, D 40225 Dusseldorf, Germany
    Heart 83:551-6. 2000
  9. ncbi [Lifestyle modification programs protecting cardiovascular health in Germany and Sweden. A qualitative interview study]
    C Meyer
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf, Medizinische Fakultat, Moorenstrasse 5, Dusseldorf, Germany
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:213-20. 2011
  10. ncbi Modulation of peripheral chemoreflex by neurohumoral adaptations after kidney transplantation
    T Rassaf
    Heinrich Heine University Duesseldorf, Department of Medicine, Moorenstr 5, 40225 Duesseldorf, Germany
    Eur J Med Res 15:83-7. 2010

Collaborators

Detail Information

Publications25

  1. ncbi Nitric oxide metabolism and breakdown
    M Kelm
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Moorenstrasse 5, D 40225, Dusseldorf, Germany
    Biochim Biophys Acta 1411:273-89. 1999
    ..Increasing knowledge on the complex metabolism of NO in vivo will lead to the development of new therapeutic strategies to enhance bioactivity of NO via modulation of its metabolism...
  2. ncbi Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway
    M Kelm
    Department of Medicine, Heinrich Heine University, Dusseldorf, Germany
    Cardiovasc Res 41:765-72. 1999
    ..Therefore, we aimed to work out a reliable biochemical index to assess endothelial NO formation in human circulation...
  3. ncbi Sympathetic hyperactivity influences chemosensor function in patients with end-stage renal disease
    C Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, University Duesseldorf, Duesseldorf, Germany
    Eur J Med Res 14:151-5. 2009
    ..This may in part explain the high cardiovascular mortality in these patients. Chemosensory function is involved in autonomic cardiovascular control and is mechanistically linked to the sympathetic tone...
  4. ncbi Additive effect of coexistent type 2 diabetes and arterial hypertension on endothelial dysfunction in resistance arteries of human forearm vasculature
    M Preik
    Department of Medicine, Heinrich Heine University Dusseldorf, Germany
    Angiology 51:545-54. 2000
    ....
  5. ncbi Impaired red blood cell deformability in patients with coronary artery disease and diabetes mellitus
    S Keymel
    University Düsseldorf, Medical Faculty, Department of Cardiology, Pulmonology, and Vascular Diseases, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 43:760-5. 2011
    ..In patients with CAD, diabetes mellitus leads to an impairment of RBC deformability which might contribute to increased morbidity of diabetic patients with CAD...
  6. ncbi Vagal heart rate control in patients with atrial fibrillation: impact of tonic activation of peripheral chemosensory function in heart failure
    T Drexel
    Department of Medicine, University Hospital Duesseldorf, Duesseldorf, Germany
    Adv Exp Med Biol 755:287-97. 2013
    ..6 vs. 0.5±1.2 ms/mmHg; p<0.05). In conclusion, our data suggest that tonic activation of excitatory chemoreceptor afferents contributes to a low vagal tone in heart failure patients with a history of AF (Clinical Trials NCT01262508)...
  7. ncbi Unmasking the Janus face of myoglobin in health and disease
    U B Hendgen-Cotta
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Dusseldorf, Dusseldorf, Germany
    J Exp Biol 213:2734-40. 2010
    ..Furthermore, the impact of myoglobin on parasite infection, rhabdomyolysis, hindlimb and liver ischemia, angiogenesis and tumor growth are considered...
  8. ncbi Intracoronary dipyridamole reduces the incidence of abrupt vessel closure following PTCA: a prospective randomised trial
    M P Heintzen
    School of Internal Medicine, Department of Cardiology, Pneumology and Angiology, Heinrich Heine University, Moorenstr 5, D 40225 Dusseldorf, Germany
    Heart 83:551-6. 2000
    ..To investigate the effect of intracoronary dipyridamole on the incidence of abrupt vessel closure, myocardial infarction, necessity for bypass grafting, and death following percutaneous transluminal coronary angioplasty (PTCA)...
  9. ncbi [Lifestyle modification programs protecting cardiovascular health in Germany and Sweden. A qualitative interview study]
    C Meyer
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf, Medizinische Fakultat, Moorenstrasse 5, Dusseldorf, Germany
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:213-20. 2011
    ....
  10. ncbi Modulation of peripheral chemoreflex by neurohumoral adaptations after kidney transplantation
    T Rassaf
    Heinrich Heine University Duesseldorf, Department of Medicine, Moorenstr 5, 40225 Duesseldorf, Germany
    Eur J Med Res 15:83-7. 2010
    ..Enhanced sympathetic activation is common in end-stage renal disease and kidney transplantation has been shown to improve cardiorespiratory reflex measures of autonomic function...
  11. ncbi Comparative evaluation of thermodilution and gated blood pool method for determination of right ventricular ejection fraction at rest and during exercise
    S M Perings
    Department of Medicine, Division of Cardiology, Pulmonary Disease and Angiology, Heinrich Heine University Dusseldorf, Germany
    Cardiology 95:161-3. 2001
    ..Therefore, the aim of the present study was a comparative evaluation of RVEF(TD) with the established gated blood pool method (RVEF(GBP)) under exercise conditions...
  12. ncbi The nitric oxide-induced reduction in cardiac energy supply is not due to inhibition of creatine kinase
    U K Decking
    Department of Physiology Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Cardiovasc Res 51:313-21. 2001
    ..Since inhibition of creatine kinase (CK) by NO-induced nitrosylation has been proposed as a possible mechanism of action, we measured the flux through CK in the intact heart...
  13. ncbi L-arginine preferentially dilates stenotic segments of coronary arteries thereby increasing coronary flow
    T Lauer
    Division of Cardiology, Pulmonology, and Vascular Medicine, Department of Medicine, University Hospital RWTH Aachen, Aachen, Germany
    J Intern Med 264:237-44. 2008
    ..3 mg) preferentially dilates stenotic coronary artery segments (CS) subsequently increasing poststenotic coronary blood flow (CBF) in patients with coronary artery disease (CAD)...
  14. ncbi [Acute coronary syndrome: unstable angina and myocardial infarction]
    M Kelm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Medizinische Klinik und Poliklinik B, Heinrich Heine Universitat Dusseldorf
    Internist (Berl) 46:265-74. 2005
    ..Moreover, to prevent left ventricular remodelling ACE-inhibitors, angiotension 2-receptor antagonists, and beta-blocker are indicated...
  15. ncbi [Intensive care in cardiovascular medicine -- acute coronary syndrome]
    M G Hennersdorf
    , Pneumologie und Angiologie, ,
    Dtsch Med Wochenschr 130:677-82. 2005
  16. ncbi [Hypertensive heart disease and microangiopathy]
    M Kelm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Medizinische Klinik und Poliklinik B, Heinrich Heine Universitat Dusseldorf
    Internist (Berl) 44:793-4, 797-805. 2003
    ..The primary therapeutic target is, apart from lowering blood pressure, to reverse cardiac manifestations of arterial hypertension using specific therapeutic algorithms...
  17. ncbi [Duplex ultrasound determination of shunt volume in iatrogenic arteriovenous fistulas after heart catheterization]
    S M Perings
    Medizinische Klinik und Poliklinik B Klinik für Kardiologie, Angiologie und Pneumologie Moorenstrasse 5 40225 Düsseldorf, Germany
    Z Kardiol 91:481-6. 2002
    ..To determine the shunt volume of iatrogenic arteriovenous fistula (AVF) following arterial puncture of the groin and to evaluate its impact on natural history and clinical outcome...
  18. ncbi Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin
    F T Ruschitzka
    Institute of Physiology, University of Zurich Irchel, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:11609-13. 2000
    ..In conclusion, we here unequivocally demonstrate that endothelial NO maintains normotension, prevents cardiovascular dysfunction, and critically determines survival in vivo under conditions of increased hematocrit...
  19. ncbi The role of intracardiac echocardiography in interventional electrophysiology
    C Knackstedt
    Department of Cardiology, RWTH University Aachen, Aachen, Germany
    Minerva Cardioangiol 55:755-70. 2007
    ..Even more, new therapy strategies have been evaluated based on ICE and it has also been used in the setting of three- dimensional imaging and image integration...
  20. ncbi Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction
    E A Liehn
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    J Cell Mol Med 12:496-506. 2008
    ....
  21. ncbi [Perioperative therapy with antiplatelet agents]
    W Lepper
    Medizinische Klinik I, Kardiologie, Pulmonologie und Angiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen
    Anaesthesist 56:592-8. 2007
    ..Especially patients with intracoronary stents are at threat when the dual platelet therapy is interrupted before complete endothelialization of the stent...
  22. ncbi The Sirolimus-eluting coronary stent in daily routine practice in Germany: trends in indications over the years. Results from the prospective multi-centre German Cypher Stent Registry
    Ralf Zahn
    Med Klinik 8, Kardiologie Angiologie Internistische Intensivmedizin, Klinikum Nürnberg Süd, Breslauer Strasse 201, 90471, Nurnberg, Germany
    Clin Res Cardiol 96:548-56. 2007
    ..Due to limited budgets in Germany, no special reimbursement has been given for their use and therefore they were mainly used in selected patients...
  23. ncbi [Cypher stent: the German registry. Results of the German prospective multicenter registry on Cypher]
    R Zahn
    Herzzentrum, Kardiologie, Ludwigshafen, Allemagne
    Ann Cardiol Angeiol (Paris) 53:36s-39s. 2004
  24. ncbi "Real life" use of sirolimus-eluting coronary stents in Germany. Results from the prospective multi-centre German Cypher Registry
    R Zahn
    Herzzentrum Ludwigshafen, Kardiologie, Bremserstrasse 79, 67063 Ludwigshafen, Germany
    Z Kardiol 93:287-94. 2004
    ..Therefore, actual clinical practice may be very different to RCT...
  25. ncbi Sirolimus-eluting stent treatment for isolated proximal left anterior descending artery stenoses. Results from the prospective multi-center German Cypher Registry
    A A Khattab
    Herzzentrum Segeberger Kliniken GmbH, Am Kurpark 1, 23795 Bad Segeberg, Germany
    Z Kardiol 94:187-92. 2005
    ..Therefore, we compared patients from the German Cypher Registry treated with SES for isolated proximal LAD lesions with those stented for isolated lesions in the proximal LCX or RCA...