Thomas K Hoffmann

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi [Squamous cell carcinoma of the head and neck. Principles and current concepts of immunotherapy]
    T K Hoffmann
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkrankheiten der Universität Düsseldorf
    HNO 53:285-97; quiz 298. 2005
  2. doi Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Oral Oncol 44:1100-9. 2008
  3. ncbi Aberrant cytokine expression in serum of patients with adenoid cystic carcinoma and squamous cell carcinoma of the head and neck
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Head Neck 29:472-8. 2007
  4. ncbi T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx
    Thomas K Hoffmann
    Department of Otorhinolaryngology, University of Duesseldorf, Germany
    Int J Cancer 118:1984-91. 2006
  5. ncbi [The subclavicular route for the pectoralis major myocutaneous flap]
    T K Hoffmann
    Hals Nasen Ohren Klinik, Universitätsklinik Düsseldorf, Dusseldorf
    HNO 54:523-7. 2006
  6. ncbi [Dapsone-induced agranulocytosis. The role of xenobiotic-metabolizing enzymes demonstrated by a case report]
    T K Hoffmann
    Hals Nasen Ohren Klinik, Heinrich Heine Universitat Dusseldorf
    Hautarzt 56:673-7. 2005
  7. ncbi p53 as an immunotherapeutic target in head and neck cancer
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, Dusseldorf, Germany
    Adv Otorhinolaryngol 62:151-60. 2005
  8. ncbi Targeting the immune system: novel therapeutic approaches in squamous cell carcinoma of the head and neck
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Cancer Immunol Immunother 53:1055-67. 2004
  9. doi ["An apple a day keeps the doctor away". DNA protection by polyphenols]
    T K Hoffmann
    Universitätsklinik Düsseldorf, Hals Nasen Ohren Klinik, Moorenstrasse 5, 40225 Dusseldorf
    HNO 56:750-1. 2008
  10. doi A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, Dusseldorf, Germany
    Int J Cancer 124:2589-96. 2009

Detail Information

Publications48

  1. ncbi [Squamous cell carcinoma of the head and neck. Principles and current concepts of immunotherapy]
    T K Hoffmann
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkrankheiten der Universität Düsseldorf
    HNO 53:285-97; quiz 298. 2005
    ....
  2. doi Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Oral Oncol 44:1100-9. 2008
    ..However, single alterations in the p53 pathway are not reliable predictors for the response to radio- or chemotherapy in HNSCC...
  3. ncbi Aberrant cytokine expression in serum of patients with adenoid cystic carcinoma and squamous cell carcinoma of the head and neck
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Head Neck 29:472-8. 2007
    ..Our objective was to characterize and compare cytokine profiles in the systemic circulation of patients with SCC and ACC...
  4. ncbi T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx
    Thomas K Hoffmann
    Department of Otorhinolaryngology, University of Duesseldorf, Germany
    Int J Cancer 118:1984-91. 2006
    ....
  5. ncbi [The subclavicular route for the pectoralis major myocutaneous flap]
    T K Hoffmann
    Hals Nasen Ohren Klinik, Universitätsklinik Düsseldorf, Dusseldorf
    HNO 54:523-7. 2006
    ..However, limited length and arc of rotation as well as excessive bulk can be problematic...
  6. ncbi [Dapsone-induced agranulocytosis. The role of xenobiotic-metabolizing enzymes demonstrated by a case report]
    T K Hoffmann
    Hals Nasen Ohren Klinik, Heinrich Heine Universitat Dusseldorf
    Hautarzt 56:673-7. 2005
    ..Because of the risk of severe hematologic reactions, dapsone should only be employed for solid indications and with appropriate monitoring...
  7. ncbi p53 as an immunotherapeutic target in head and neck cancer
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, Dusseldorf, Germany
    Adv Otorhinolaryngol 62:151-60. 2005
    ..It calls for modified approaches, in which altered peptide variants of the wt sequence p53 264-272 epitope are used in a vaccine in order to overcome unresponsiveness of T lymphocytes to the native epitope...
  8. ncbi Targeting the immune system: novel therapeutic approaches in squamous cell carcinoma of the head and neck
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Cancer Immunol Immunother 53:1055-67. 2004
    ..These biologic therapies, alone or in combination with conventional treatment, are likely to develop into useful future treatment options for patients with SCCHN...
  9. doi ["An apple a day keeps the doctor away". DNA protection by polyphenols]
    T K Hoffmann
    Universitätsklinik Düsseldorf, Hals Nasen Ohren Klinik, Moorenstrasse 5, 40225 Dusseldorf
    HNO 56:750-1. 2008
  10. doi A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration
    Thomas K Hoffmann
    Department of Otorhinolaryngology, Heinrich Heine University, Dusseldorf, Germany
    Int J Cancer 124:2589-96. 2009
    ..This novel mechanism for anti-EGFR mAb action may contribute to the antitumor effects of anti-EGFR mAb in vivo...
  11. ncbi Gamma-delta T-cells in patients with squamous cell carcinoma of the head and neck
    Murat Bas
    Department of Otorhinolaryngology, University of Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Oral Oncol 42:691-7. 2006
    ..The current study implies that increased frequencies of gamma/delta-T-cells in patients with SCCHN may not only be the result of tumor-host interactions but the consequence of applied treatment modalities...
  12. doi HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells
    Clarissa Anni Wild
    Department of Otorhinolaryngology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Int Immunol 24:485-94. 2012
    ..As regulatory T cells (T(reg)) play a crucial role in autoimmune diseases and tumor immune escape, the previously unexamined role of HMGB1 on the function of T(reg) is of great interest...
  13. ncbi Effects of tamoxifen on human squamous cell carcinoma lines of the head and neck
    Thomas K Hoffmann
    Department of Otorhinolaryngology Head and Neck Surgery, Heinrich Heine University, 40225 Dusseldorf, Germany
    Anticancer Drugs 13:521-31. 2002
    ..In the present in vitro system, the observed antitumor activity of high-dose TAM in SCCHN cannot be explained by estrogen antagonism, alterations of TGF-alpha/beta levels or decreased PKC activity...
  14. doi Is there a role for the Fas-/Fas-Ligand pathway in chemoresistance of human squamous cell carcinomas of the head and neck (SCCHN)?
    Karl Christoph Sproll
    Department of Maxillo and Plastic Facial Surgery, Westdeutsche Kieferklinik, Heinrich Heine University, Dusseldorf, Germany
    Oral Oncol 45:69-84. 2009
    ..In conclusion, in contrast to many other solid tumors, the Fas/FasL-system does not seem to play an exclusive role in anticancer drug mediated apoptosis in SCCHN...
  15. doi Acute arterial hemorrhage following radiotherapy of oropharyngeal squamous cell carcinoma
    Jens Greve
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Strahlenther Onkol 186:269-73. 2010
    ..Vascular erosion is a rare but life-threatening complication after radiotherapy. The authors report on acute arterial bleeding and its therapy following radiotherapy of oropharyngeal tumors...
  16. pmc The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN)
    Kathrin Scheckenbach
    Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University Dusseldorf, Germany
    J Negat Results Biomed 9:10. 2010
    ..Our purpose was to investigate the role of CHK2 germ line mutations in patients with squamous cell carcinoma of the head and neck (SCCHN)...
  17. pmc Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas
    Christoph Bergmann
    Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstrasse 55, 45127 Essen, Germany
    J Transl Med 9:139. 2011
    ....
  18. pmc Tumor immune escape by the loss of homeostatic chemokine expression
    Andor Pivarcsi
    Department of Dermatology, Heinrich Heine University, D 40255 Düsseldorf, Germany
    Proc Natl Acad Sci U S A 104:19055-60. 2007
    ..Collectively, our data identify a mechanism of skin tumors to evade host antitumor immune responses...
  19. doi Bevacizumab as a treatment option for radiation-induced cerebral necrosis
    Christiane Matuschek
    Department of Radiation Oncology, University Hospital Dusseldorf, Dusseldorf, Germany
    Strahlenther Onkol 187:135-9. 2011
    ..Our case report together with the current literature suggests bevacizumab as a treatment option for patients with symptoms and radiological signs of cerebral necrosis induced by radiotherapy...
  20. doi Survivin and epidermal growth factor receptor expression in surgically treated oropharyngeal squamous cell carcinoma
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne, Cologne, Germany
    Head Neck 30:1318-24. 2008
    ..Their correlation in oropharyngeal squamous cell carcinoma (OSCC) has not been evaluated yet...
  21. ncbi Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines
    Thomas K Hoffmann
    Department of Otorhinolaryngology Head and Neck Surgery, Heinrich Heine University, 40225 Dusseldorf, Germany
    Anticancer Drugs 13:93-100. 2002
    ..However, comparison with theoretical additive dose-response curves showed additive rather than synergistic effects for both PKC inhibitors...
  22. doi Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer
    Sokratis Trellakis
    Department of Otorhinolaryngology, University Hospital Essen, 45122 Essen, Germany
    Innate Immun 19:328-36. 2013
    ..Our data suggest that CXCL8 promotes accumulation of G-MDSC in cancer patients independent of classical colony-stimulating factors...
  23. doi Successful long-term treatment with the bradykinin B2 receptor antagonist icatibant in a patient with hereditary angioedema
    Jens Greve
    Department of Otorhinolaryngology, University Hospital Essen, University Duisburg, Essen, Germany
    Int J Dermatol 50:1294-5. 2011
    ..It is characterized by recurrent subcutaneous or submucosal edema attacks in various organs with a frequency from a few attacks to over one hundred attacks per year...
  24. doi Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease
    Sokratis Trellakis
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    Int J Cancer 129:2183-93. 2011
    ..In vitro, tumor-derived factors modulate cellular functions of PMNs and increase their inflammatory activity. Thus, the interaction between HNSCC and PMNs may contribute to host-mediated changes in the tumor microenvironment...
  25. doi A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer
    Claudia A Dumitru
    Department of Otorhinolaryngology, University of Duisburg Essen, Essen, Germany
    J Leukoc Biol 91:591-8. 2012
    ..Thus, our findings provide novel, mechanistic insights relevant for the pathophysiology of HNC and possibly, other types of cancer as well...
  26. pmc Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neck
    Thomas K Hoffmann
    Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Anticancer Res 31:3151-7. 2011
    ..We aimed to determine cyclin B1 expression in squamous cell carcinomas of the head and neck (SCCHN) and correlate it with p53 status and clinicopathological parameters...
  27. doi Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosis
    Kathrin Scheckenbach
    Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Auris Nasus Larynx 37:322-8. 2010
    ..Due to the lack of typical clinical signs, diagnosis relies on histopathology. Therapy consists of the management of predisposing factors, radical surgical intervention and systemic antifungal therapy...
  28. ncbi Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy
    Anja Muller
    Department of Radiation Oncology, Heinrich Heine University, Duesseldorf, Germany
    Int J Cancer 118:2147-57. 2006
    ....
  29. doi Development and management of severe cutaneous side effects in head-and-neck cancer patients during concurrent radiotherapy and cetuximab
    Edwin Bölke
    Department of Radiation Oncology, University of Duesseldorf, Germany
    Strahlenther Onkol 184:105-10. 2008
    ..An aggravation of the radiation-induced skin toxicity was not described. Here, however, two cases with severe skin toxicity during the combined treatment are reported...
  30. ncbi Argon plasma coagulation (APC) in palliative surgery of head and neck malignancies
    Ulrich Hauser
    Department of Otorhinolaryngology, Head and Neck Surgery, Heinrich Heine University, Duesseldorf, Germany
    Laryngoscope 112:1275-80. 2002
    ..Argon plasma coagulation (APC) represents a novel technique providing effective hemostasis and wound sealing. Thus, APC features requirements of particular interest in palliative surgery of the head and neck...
  31. doi Toll-like Receptors in Regulatory T Cells of Patients With Head and Neck Cancer
    Clarissa Anni Wild
    Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Arch Otolaryngol Head Neck Surg 136:1253-9. 2010
    ..to investigate the role of Toll-like receptor (TLR) signaling and T-regulatory (T-reg) cells in patients with head and neck squamous cell carcinoma (HNSCC)...
  32. doi Cystatin C - a fast and reliable biomarker for glomerular filtration rate in head and neck cancer patients
    Edwin Bölke
    Department of Radiation Therapy and Radiation Oncology, University of Dusseldorf, Germany
    Strahlenther Onkol 187:191-201. 2011
    ..We compared the accuracy of cystatin C- and creatinine-based equations to estimate GFR in head and neck cancer (HNC) patients receiving platinum-based radiochemotherapy...
  33. ncbi Urokinase plasminogen activator, uPAR, MMP-2, and MMP-9 in the C6-glioblastoma rat model
    Patrick J Schuler
    Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    In Vivo 26:571-6. 2012
    ..In glioblastoma multiforme (GBM), the serine protease urokinase plasminogen activator (uPA), and matrix metalloproteases (MMP-2/MMP-9) contribute to its invasive growth pattern, which is the major obstacle to successful surgical treatment...
  34. ncbi IL-31: a new link between T cells and pruritus in atopic skin inflammation
    Eniko Sonkoly
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    J Allergy Clin Immunol 117:411-7. 2006
    ..IL-31 is a novel T-cell-derived cytokine that induces severe pruritus and dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL-31 receptor A and oncostatin M receptor...
  35. pmc Potential genetic risk factors in angiotensin-converting enzyme-inhibitor-induced angio-oedema
    Murat Bas
    Department of Otorhinolaryngology, Technische Universitat Munchen, Munchen, Germany
    Br J Clin Pharmacol 69:179-86. 2010
    ..We have investigated the impact of ACE insertion/deletion (I/D) polymorphism in combination with serum ACE activity as well as the bradykinin B2 receptor 2/3 and c.C181T polymorphisms...
  36. ncbi Aural myiasis in a patient with Alzheimer's disease
    Pascal Werminghaus
    Department of Otorhinolaryngology, Heinrich Heine University Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Eur Arch Otorhinolaryngol 265:851-3. 2008
    ..Aural manifestation of myiasis may become dangerous if the petrous bone is affected. Entomological aspects, clinical characteristics, and treatment of this rare disease are reviewed...
  37. doi Surgical management of retropharyngeal abscesses
    Patrick J Schuler
    Department of Otorhinolaryngology and Head and Neck Surgery, Heinrich Heine University Hospital, Moorenstrasse 5, Duesseldorf, Germany
    Acta Otolaryngol 129:1274-9. 2009
    ....
  38. ncbi Diagnostic strategies in cervical carcinoma of an unknown primary (CUP)
    Inge Haas
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur Arch Otorhinolaryngol 259:325-33. 2002
    ..In patients with cervical CUP, blind but systematic pharyngeal biopsies, including bilateral tonsillectomy, should be performed...
  39. pmc An intronic alteration of the fibroblast growth factor 10 gene causing ALSG-(aplasia of lacrimal and salivary glands) syndrome
    Kathrin Scheckenbach
    Department of Otorhinolaryngology, Heinrich Heine University, Dusseldorf, Germany
    BMC Med Genet 9:114. 2008
    ..This phenotype represents the autosomal-dominant aplasia of lacrimal and salivary glands syndrome (ALSG). Recently, aberrations of the Fibroblast Growth Factor 10 (FGF10) gene have been identified to be causative for this disorder...
  40. ncbi Evaluation and management of angioedema of the head and neck
    Murat Bas
    Clinic of Otolaryngology, Heinrich Heine University, Dusseldorf, Germany
    Curr Opin Otolaryngol Head Neck Surg 14:170-5. 2006
    ..Unfortunately, angioedema is often unrecognized and/or incorrectly treated. To change this situation, a better understanding of angioedema and possible therapeutic approaches appears necessary...
  41. ncbi Frequencies of tetramer+ T cells specific for the wild-type sequence p53(264-272) peptide in the circulation of patients with head and neck cancer
    Thomas K Hoffmann
    University of Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 62:3521-9. 2002
    ..These findings emphasize the complexity of interactions between the tumor and the host immune system, and, thus, have particularly important implications for future p53-based immunization strategies...
  42. ncbi Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance
    Thomas K Hoffmann
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
    Clin Cancer Res 8:2553-62. 2002
    ..Fas/FasL interactions might lead to excessive turnover of T cells in the circulation and, consequently, to reduced immune competence in patients with HNC...
  43. ncbi Direct visualization of antigen-specific T cells using peptide-MHC-class I tetrameric complexes
    Norbert Meidenbauer
    Department of Hematology and Oncology, University of Regensburg, D 93053 Regensburg, Germany
    Methods 31:160-71. 2003
    ..Recently, various technical peculiarities of tetramers have led to modifications within this important immunoassay. The current manuscript details potential pitfalls and provides guidance for interpretation of results...
  44. ncbi The ability of variant peptides to reverse the nonresponsiveness of T lymphocytes to the wild-type sequence p53(264-272) epitope
    Thomas K Hoffmann
    Department of Pathology, UP Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 168:1338-47. 2002
    ....
  45. ncbi Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer
    Niklas Reimers
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Cologne, Germany
    Int J Cancer 120:1731-8. 2007
    ..HPV+/p16+ tumors tended to have decreased EGFR expression, but using both immunohistological markers has significant prognostic implications...
  46. ncbi Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck
    Daisuke Ito
    Division of Basic Research, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 120:2618-24. 2007
    ....
  47. ncbi Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck
    Thomas K Hoffmann
    Department of Pathology, Cancer Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Clin Cancer Res 8:1787-93. 2002
    ..An overall decrease in the myeloid-derived subset of DC could contribute to the failure of SCCHN patients to develop effective antitumor immune responses...
  48. ncbi Unpulsed dendritic cells induce broadly applicable anti-tumor immunity in mice
    Grzegorz Dworacki
    Division of Basic Research, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion, Suite 1 19, 5117 Centre Ave, Pittsburgh, Pennsylvania 15213, USA
    Cancer Biol Ther 4:50-6. 2005
    ..These findings highlight the potential broad applicability of unpulsed DC as a tumor vaccine...