Daniel Hänggi

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. doi Primary epileptogenic unruptured intracranial aneurysms: incidence and effect of treatment on epilepsy
    Daniel Hänggi
    Department of Neurosurgery, University Hospital Dusseldorf, Dusseldorf, Germany
    Neurosurgery 66:1161-5. 2010
  2. doi NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage
    Daniel Hänggi
    Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225, Dusseldorf, Germany
    Neurocrit Care 23:274-84. 2015
  3. pmc Radiobiology of radiosurgery for the central nervous system
    Antonio Santacroce
    Departments of Radiation Oncology and Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Biomed Res Int 2013:362761. 2013
  4. doi The Role of MCA-STA Bypass Surgery After COSS and JET: The European Point of View
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, Dusseldorf, 40225, Germany
    Acta Neurochir Suppl 119:77-8. 2014
  5. pmc Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e42597. 2012
  6. doi Monitoring and detection of vasospasm II: EEG and invasive monitoring
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Neurocrit Care 15:318-23. 2011
  7. doi The impact of microscope-integrated intraoperative near-infrared indocyanine green videoangiography on surgery of arteriovenous malformations and dural arteriovenous fistulae
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Neurosurgery 67:1094-103; discussion 1103-4. 2010
  8. doi The influence of cisternal and ventricular lavage on cerebral vasospasm in patients suffering from subarachnoid hemorrhage: analysis of effectiveness
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, 40225, Dusseldorf, Germany
    Acta Neurochir Suppl 110:95-8. 2011
  9. doi A multimodal concept in patients after severe aneurysmal subarachnoid hemorrhage: results of a controlled single centre prospective randomized multimodal phase I/II trial on cerebral vasospasm
    D Hanggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Cent Eur Neurosurg 70:61-7. 2009
  10. doi Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Moorenstrasse 5, Geb 13 71, 40225 Dusseldorf, Germany
    Clin Neurol Neurosurg 110:784-90. 2008

Detail Information

Publications85

  1. doi Primary epileptogenic unruptured intracranial aneurysms: incidence and effect of treatment on epilepsy
    Daniel Hänggi
    Department of Neurosurgery, University Hospital Dusseldorf, Dusseldorf, Germany
    Neurosurgery 66:1161-5. 2010
    ..Seizures as the unique initial manifestation of unruptured intracranial aneurysms have rarely been documented and not systematically described until now...
  2. doi NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage
    Daniel Hänggi
    Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225, Dusseldorf, Germany
    Neurocrit Care 23:274-84. 2015
    ..Thus, we propose to administer EG-1962 to humans in order to assess safety and tolerability and determine a dose to investigate efficacy in subsequent clinical studies...
  3. pmc Radiobiology of radiosurgery for the central nervous system
    Antonio Santacroce
    Departments of Radiation Oncology and Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Biomed Res Int 2013:362761. 2013
    ..A review of the literature about radiobiology of radiosurgery for the central nervous system is presented. ..
  4. doi The Role of MCA-STA Bypass Surgery After COSS and JET: The European Point of View
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, Dusseldorf, 40225, Germany
    Acta Neurochir Suppl 119:77-8. 2014
    ..JAMA 306:1983-1992, 2011).The goal of this article is to give the European point of view after COSS and JET on behalf of the Cerebrovascular Section of the European Association of Neurological Surgeons (EANS). ..
  5. pmc Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e42597. 2012
    ..To investigate the effect of locally applied nimodipine prolonged-release microparticles on angiographic vasospasm and secondary brain injury after experimental subarachnoid hemorrhage (SAH)...
  6. doi Monitoring and detection of vasospasm II: EEG and invasive monitoring
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Neurocrit Care 15:318-23. 2011
    ....
  7. doi The impact of microscope-integrated intraoperative near-infrared indocyanine green videoangiography on surgery of arteriovenous malformations and dural arteriovenous fistulae
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Neurosurgery 67:1094-103; discussion 1103-4. 2010
    ..Microscope-based intraoperative near-infrared indocyanine green (ICG) videoangiography is useful as an adjunct to intra- or postoperative digital subtraction angiography (DSA) in aneurysm surgery...
  8. doi The influence of cisternal and ventricular lavage on cerebral vasospasm in patients suffering from subarachnoid hemorrhage: analysis of effectiveness
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, 40225, Dusseldorf, Germany
    Acta Neurochir Suppl 110:95-8. 2011
    ..Aim of the present analysis was to review and summarize all documented clinical studies using cisternal or ventricular lavage to prevent vasospasm...
  9. doi A multimodal concept in patients after severe aneurysmal subarachnoid hemorrhage: results of a controlled single centre prospective randomized multimodal phase I/II trial on cerebral vasospasm
    D Hanggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Cent Eur Neurosurg 70:61-7. 2009
    ..The present clinical prospective randomized phase I/II study was initiated in order to analyze the prophylactic effect of intracisternal lysis in combination with kinetic treatment followed by intrathecal nimodipine lavage...
  10. doi Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Moorenstrasse 5, Geb 13 71, 40225 Dusseldorf, Germany
    Clin Neurol Neurosurg 110:784-90. 2008
    ..In the current prospective study, we attempted the intrathecal lavage administration of nimodipine in cases of severe cerebral vasospasm that were refractory to medical and endovascular therapy...
  11. doi The effect of lumboventricular lavage and simultaneous low-frequency head-motion therapy after severe subarachnoid hemorrhage: results of a single center prospective Phase II trial
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg 108:1192-9. 2008
    ....
  12. ncbi Results of direct and indirect revascularisation for adult European patients with Moyamoya angiopathy
    D Hanggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurochir Suppl 103:119-22. 2008
    ..Exact definition of long-term benefits would require a multicentric study. EMS appears to be of questionable value in the adult European population...
  13. doi Symptomatic vertebral artery conflicts to the medulla oblongata and microsurgical treatment options: review of the literature
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Neurosurg Rev 32:143-8; discussion 148-9. 2009
    ..In conclusion the present review tries to provide an overview of the existent data on the variety of clinical, radiological and surgical features in patients with symptomatic vascular brainstem compression...
  14. doi C-Port Flex-A-assisted automated anastomosis for high-flow extracranial-intracranial bypass surgery in patients with symptomatic carotid artery occlusion: a feasibility study. Clinical article
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg 111:181-7. 2009
    ..The goal of the current study was to define the feasibility and safety of this method for high-flow extracranial-intracranial (EC-IC) bypass surgery in a clinical series...
  15. doi Intra-arterial nimodipine for severe cerebral vasospasm after aneurysmal subarachnoid hemorrhage: influence on clinical course and cerebral perfusion
    D Hanggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    AJNR Am J Neuroradiol 29:1053-60. 2008
    ..The goal of the present study was to investigate the clinical effect and cerebral perfusion after IAN in patients with severe vasospasm refractory to hemodynamic treatment...
  16. doi Spontaneous intracerebral haemorrhage in adults: a literature overview
    D Hanggi
    Department of Neurosurgery, University Hospital, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurochir (Wien) 150:371-9; discussion 379. 2008
    ..Nevertheless, management still remains controversial. The purpose of the present review is to summarise the clinical data and derive a current updated management concept as a result...
  17. pmc Age of collagen in intracranial saccular aneurysms
    Nima Etminan
    From the Department of Neurosurgery N E, K B, H J S, D H and Institute of Forensic Medicine C M, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany Institute for Physiological Chemistry and Pathobiochemistry, Westfalian Wilhelms University, Munster, Germany R D, P B Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, CA B A B Department of Epidemiology, University of Iowa J C T Department of Neurology, Mayo Clinic, Rochester, MN R D B Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada R L M and Department of Surgery, University of Toronto, Toronto, Ontario, Canada R L M
    Stroke 45:1757-63. 2014
    ..We used (14)C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries to investigate this further...
  18. doi Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients
    Marcel A Kamp
    Klinik für Neurochirurgie, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosurgery 70:65-73; discussion 73-4. 2012
    ..Near-infrared indocyanine green (ICG) fluorescence angiography was introduced for visualizing vessel patency intraoperatively. However, quantitative information has not been available...
  19. doi Routine management of volume status after aneurysmal subarachnoid hemorrhage
    Stefan Wolf
    Department of Neurosurgery, Charite Campus Virchow, Freie Universitat Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Neurocrit Care 15:275-80. 2011
    ..In contrast, there is evidence for harm using overly aggressive hydration...
  20. doi Prospective, randomized, open-label phase II trial on concomitant intraventricular fibrinolysis and low-frequency rotation after severe subarachnoid hemorrhage
    Nima Etminan
    Department of Neurosurgery and Institute for Diagnostic and Interventional Radiology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Stroke 44:2162-8. 2013
    ....
  21. doi Dose-related efficacy of a continuous intracisternal nimodipine treatment on cerebral vasospasm in the rat double subarachnoid hemorrhage model
    Daniel Hänggi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany daniel haenggi uniduesseldorf de
    Neurosurgery 64:1155-9; discussion 1159-61. 2009
    ..Intracisternal continuous therapy is a concept in the treatment of cerebral vasospasm after subarachnoid hemorrhage. The purpose of the current study was to investigate the effect of intracisternal nimodipine after induced vasospasm...
  22. doi Perfusion CT in patients with spontaneous lobar intracerebral hemorrhage: effect of surgery on perihemorrhagic perfusion
    Nima Etminan
    Department of Neurosurgery, University of Dusseldorf, Medical Faculty, Dusseldorf, Germany
    Stroke 43:759-63. 2012
    ..The aim of the present study was to investigate cerebral hemodynamics in patients requiring surgical treatment for lobar intracerebral hemorrhage...
  23. doi The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage: interim analysis of safety, clot clearance rate and delayed cerebral ischemia
    Sven O Eicker
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurochir Suppl 114:323-8. 2012
    ....
  24. doi Intraoperative Doppler and Duplex sonography in cerebral aneurysm surgery
    Hi Jae Heiroth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Br J Neurosurg 25:586-90. 2011
    ..The goal of the present study was to analyse the feasibility of intraoperative B-mode Duplex ultrasound in combination with Doppler sonography (DDS) to evaluate this issue...
  25. doi The transorbital keyhole approach: early and long-term outcome analysis of approach-related morbidity and cosmetic results. Technical note
    Kerim Beseoglu
    Department of Neurosurgery, Universitätsklinik Düsseldorf, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurosurg 114:852-6. 2011
    ..The authors evaluated approach-related morbidity and cosmetic results in their patients to determine the rate of complications and compared this to published reports of similar approaches...
  26. pmc Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid
    Daniel Hänggi
    From the Department of Neurosurgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany D H, N E Neurological Surgery, University of Maryland Medical Center, Baltimore F A Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany H J S Institute for Critical Care Medicine and Department of Neurosurgery, Mount Sinai Hospital, New York S A M, J M Neurological Critical Care, Washington University School of Medicine, St Louis, MO M N D Department of Neurosurgery, University of Florida, Gainesville B L H Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical Research and Li Ka Shing Knowledge Institute, Department of Surgery, University of Toronto, Canada R L M and Edge Therapeutics, Berkeley Heights, NJ R L M, H J F
    Stroke . 2016
    ....
  27. pmc Double-barrel extracranial-intracranial bypass surgery followed by endovascular carotid artery occlusion in a patient with an extracranial giant internal carotid artery aneurysm due to Ehlers-Danlos syndrome
    Jason Michael Perrin
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurointerv Surg 5:e40. 2013
    ....
  28. doi Early CT perfusion measurement after aneurysmal subarachnoid hemorrhage: a screening method to predict outcome?
    Marcel A Kamp
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurochir Suppl 114:329-32. 2012
    ..The goal of the present study is to analyze the predictive impact of early CT-based perfusion measurement (CTP) on clinical outcome in patients suffering from aneurysmal SAH...
  29. pmc Exploring the age of intracranial aneurysms using carbon birth dating: preliminary results
    Nima Etminan
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Stroke 44:799-802. 2013
    ..In particular, it is unknown whether collagen in ruptured aneurysms undergoes more rapid turnover than in unruptured aneurysms.(14)C birth dating of collagen could be used to address this question...
  30. doi Impact of the moon on cerebral aneurysm rupture
    Marcel A Kamp
    Department for Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Acta Neurochir (Wien) 155:1525-30. 2013
    ..Therefore, the present study investigates the influence of the lunar cycle on the incidence of aneurysmal rupture, the initial clinical presentation, and the amount of subarachnoid blood...
  31. doi Coiling of a carotid cavernous sinus fistula via microsurgical venotomy: recommendation of a combined neurosurgical and endovascular approach
    Hi Jae Heiroth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurointerv Surg 5:e7. 2013
    ..In such cases it remains a challenge to find an alternative route for complete treatment...
  32. doi Early perfusion computerized tomography imaging as a radiographic surrogate for delayed cerebral ischemia and functional outcome after subarachnoid hemorrhage
    Nima Etminan
    Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Stroke 44:1260-6. 2013
    ..Therefore, we investigated the relation of early cerebral perfusion-computerized tomography and clot volume with radiological events of delayed cerebral ischemia and clinical outcome in patients with aneurysmal subarachnoid hemorrhage...
  33. doi Fatal aneurysmal subarachnoid haemorrhage: causes of 30-day in-hospital case fatalities in a large single-centre historical patient cohort
    Kerim Beseoglu
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    Clin Neurol Neurosurg 115:77-81. 2013
    ..This analysis investigates the in-hospital causes of death (CODs) within 30 days of admission in patients suffering from a SAH...
  34. doi Factors predicting recurrence of chronic subdural haematoma: the influence of intraoperative irrigation and low-molecular-weight heparin thromboprophylaxis
    Yasemin Tahsim-Oglou
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    Acta Neurochir (Wien) 154:1063-7; discussion 1068. 2012
    ..The current analysis was initiated to determine management-related risk factors for recurrence, i.e. postoperative low-molecular-weight heparin thromboprophylaxis, and the importance of rinsing the subdural space...
  35. doi Intracranial carotid artery stent placement causes delayed severe intracranial hemorrhage in a patient with moyamoya disease
    Sven Eicker
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurointerv Surg 3:160-2. 2011
    ..The case history is presented of a patient with MMD with delayed severe intracranial and subarachnoid hemorrhage following intracranial carotid artery stent placement...
  36. doi The impact of early perfusion CT measurement after extracranial-intracranial bypass surgery: results of a pilot study
    Sven O Eicker
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurochir Suppl 112:25-9. 2011
    ..The purpose of this study is to evaluate early perfusion computerized tomography (PCT) after revascularization to assess the hemodynamic balance...
  37. doi Emergency embolectomy for embolic occlusion of the middle cerebral artery-review of the literature and two illustrative cases
    Nima Etminan
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Neurosurg Rev 34:21-8. 2011
    ..Nevertheless, the decision-making process must be made critically, fast and based on factors such as vessel occlusion time, sufficient collateral flow, occlusion site and thrombus origin...
  38. pmc The impact of fluorescence guidance on spinal intradural tumour surgery
    Sven O Eicker
    Department of Neurosurgery, Heinrich Heine University, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Eur Spine J 22:1394-401. 2013
    ..Extension of this technique for resection of meningiomas and cerebral metastasis has been recently evaluated. Aim of the present study is to evaluate the impact of fluorescence-guided surgery in spinal tumor surgery...
  39. pmc Cerebral aneurysms: formation, progression, and developmental chronology
    Nima Etminan
    Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Transl Stroke Res 5:167-73. 2014
    ..Here, we review the current data on cerebral aneurysm formation and progression as well as a novel approach to investigate the developmental chronology of cerebral aneurysms...
  40. doi Evidence for direct impairment of neuronal function by subarachnoid metabolites following SAH
    Marcel A Kamp
    Department of Neurosurgery, University Hospital, Heinrich Heine University, Dusseldorf, Moorenstraße 5, D 40225, Dusseldorf, Germany
    Acta Neurochir (Wien) 155:255-60. 2013
    ..Therefore, this mini-review will discuss recent evidence for a direct influence of subarachnoid blood and its metabolites on neuronal function...
  41. doi Malignant potential of skull base versus non-skull base meningiomas: clinical series of 1,663 cases
    Jan Frederick Cornelius
    Neurochirurgische Klinik, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat, Moorenstrasse 5, 40229, Dusseldorf, Germany
    Acta Neurochir (Wien) 155:407-13. 2013
    ..The purpose of this survey was to analyse epidemiological risk factors such as sex, age and location for a higher grade (WHO grade II/III) meningioma in a large surgical series...
  42. doi The impact of hypertension and nicotine on the size of ruptured intracranial aneurysms
    Nima Etminan
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurol Neurosurg Psychiatry 82:4-7. 2011
    ....
  43. pmc Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage
    Tomoyuki Ogawa
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Cereb Blood Flow Metab 31:2231-42. 2011
    ..59±23.48 μm (11R-HO-1) versus 270.08±14.66 μm (11R-fused enhanced green fluorescent protein), 252.05±13.95 μm (saline), P<0.01)...
  44. pmc Evaluation of a murine single-blood-injection SAH model
    Marcel A Kamp
    Department for Neurosurgery, Medical Faculty, Heinrich Heine University, Dusseldorf, Moorenstraße 5, D 40225 Dusseldorf, Germany Institute for Neurophysiology, Medical Faculty, University of Cologne, Robert Koch Str 39, D 50931 Köln, Germany
    PLoS ONE 9:e114946. 2014
    ..Therefore, murine single-blood-injection SAH model is suitable for pathophysiological and further molecular analysis following SAH. ..
  45. doi Long-term impact of perfusion CT data after subarachnoid hemorrhage
    Christian Mathys
    Department of Diagnostic and Interventional Radiology, University Düsseldorf, Medical Faculty, Moorenstr 5, 40225, Dusseldorf, Germany
    Neuroradiology 55:1323-31. 2013
    ..The purpose of this study was to assess the prognostic impact of PCT parameters after SAH on the long-term outcome of patients...
  46. doi Quality of life and socio-professional reintegration after mild traumatic brain injury
    Kerim Beseoglu
    Department of Neurosurgery, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Br J Neurosurg 27:202-6. 2013
    ..Some patients do not fully recover from mTBI and experience neurocognitive impairment and reduction in quality of life. We evaluated the influence of structural brain damage on QoL and employment status (ES) after mTBI...
  47. doi Dependence of subarachnoid hemorrhage on climate conditions: a systematic meteorological analysis from the dusseldorf metropolitan area
    Kerim Beseoglu
    Department of Neurosurgery, University Hospital Dusseldorf, Dusseldorf, Germany
    Neurosurgery 62:1033-8; discussion 1038-9. 2008
    ..The present study was initiated to determine whether specific meteorological conditions are related to the occurrence of SAH in the mild climatic zone of North Rhine Westphalia...
  48. pmc Full-endoscopic cervical arcocristectomy for the treatment of spinal stenosis: results of a cadaver study
    Sven O Eicker
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Eur Spine J 21:2487-91. 2012
    ..A posterior approach is often recommended in patients with multilevel dorsal cervical compression. Aim of the present experimental study was to evaluate the feasibility of a full-endoscopic arcocristectomy in a cadaver study...
  49. doi Prognostic factors for the outcome of surgical and conservative treatment of symptomatic spinal cord cavernous malformations: a review of a series of 20 patients
    Hans Jakob Steiger
    Department of Neurosurgery, University Hospital, Heinrich Heine University, Dusseldorf, Germany
    Neurosurg Focus 29:E13. 2010
    ..In this study, the authors present a review of a series of 20 intramedullary spinal cord cavernous malformations (SCCMs) with particular focus on MR imaging and prognostic factors...
  50. doi Efficacy of 5-aminolevulinic acid based photodynamic therapy in pituitary adenomas-experimental study on rat and human cell cultures
    Lisa Margarete Neumann
    Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Photodiagnosis Photodyn Ther 14:77-83. 2016
    ..5-aminolevulinic acid based photodynamic therapy (5-ALA based PDT) showed promising results for malignant gliomas. The present study examined the efficacy of 5-ALA PDT in vitro on benign pituitary adenoma cell cultures...
  51. ncbi Relief of epilepsy and headache and quality of life after microsurgical treatment of unruptured brain AVM-audit of a single-center series and comprehensive review of the literature
    Benjamin Rohn
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosurg Rev . 2016
    ..Patients admitted with headache as the chief complaint appear to fare worse than patients with epileptogenic or incidental AVMs...
  52. doi Uptake and tracer kinetics of O-(2-(18)F-fluoroethyl)-L-tyrosine in meningiomas: preliminary results
    Jan F Cornelius
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Eur J Nucl Med Mol Imaging 42:459-67. 2015
    ..The aim of this study was to explore (18)F-FET kinetics and tumour-to-background contrast in meningiomas of various histologies...
  53. doi Perioperative measures to improve outcome after subarachnoid hemorrhage-revisiting the concept of secondary brain injury
    Hans Jakob Steiger
    Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, Geb 13 71, D 40225, Dusseldorf, Germany
    Acta Neurochir Suppl 120:211-6. 2015
    ..Furthermore, efforts for a better understanding of the variations of the calcium channels and the interplay between the different types of calcium channels should be made. ..
  54. doi The extent of the perihemorrhagic perfusion zone correlates with hematoma volume in patients with lobar intracerebral hemorrhage
    Kerim Beseoglu
    Department of Neurosurgery, Medical Faculty, Heinrich Heine Universitat Dusseldorf, Moorenstraße 5, 40225, Dusseldorf, Germany
    Neuroradiology 56:535-41. 2014
    ..This study investigates the size of the perihemorrhagic zone (PHZ) in patients with lobar ICH in relation to hematoma volume during the course of treatment using perfusion CT (PCT)...
  55. doi Multidisciplinary consensus on assessment of unruptured intracranial aneurysms: proposal of an international research group
    Nima Etminan
    From the Department of Neurosurgery N E, K B, D Hänggi, H J S, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany Department of Neurosurgery, Emory Stroke Center, Emory University School of Medicine, Atlanta, GA D L B Department of Neurosurgery, The Mount Sinai Health System, New York, NY J B Departments of Neurology R D B and Neurologic Surgery G L, Mayo Clinic, Rochester, MN Department of Neurological Surgery, Columbia University, New York, NY E S C Mallinckrodt Institute of Radiology, Washington University School of Medicine Barnes Jewish Hospital, St Louis, MO C P D Departments of Neurosurgery D Hasan and Epidemiology J C T, University of Iowa, Iowa City Department of Clinical Neurosciences, University of Helsinki, Helsinki, Finland S J Department of Neurosurgery, Tokyo Women s Medical University Medical Center East, Tokyo, Japan H K Neurosurgery Unit, Department of Clinical Neurosciences, Cambridge University Hospitals Trust, University of Cambridge, Cambridge, UK P J K Sir Charles Gairdner Hospital, Western Australia N K Neurosurgery NeuroCenter, Kuopio University Hospital, University of Eastern Finland, Finland T K Department of Neurological Surgery
    Stroke 45:1523-30. 2014
    ....
  56. doi Traumatic brain injuries in illustrated literature: experience from a series of over 700 head injuries in the Asterix comic books
    Marcel A Kamp
    Department for Neurosurgery, Heinrich Heine University Dusseldorf, Moorenstraße 5, 40225, Dusseldorf, Germany
    Acta Neurochir (Wien) 153:1351-5; discussion 1355. 2011
    ..The goal of the present study was to analyze the epidemiology and specific risk factors of traumatic brain injury (TBI) in the Asterix illustrated comic books. Among the illustrated literature, TBI is a predominating injury pattern...
  57. doi Cardiac phenomena during kainic-acid induced epilepsy and lamotrigine antiepileptic therapy
    Maxine Dibué
    Institute for Neurophysiology, University of Cologne, Robert Koch Strase 39, D 50931 Cologne, Germany Center for Molecular Medicine Cologne CMMC, University of Cologne, Robert Koch Strase 39, D 50931 Cologne, Germany Department of Neurosurgery, University Hospital, Heinrich Heine University, Dusseldorf, Moorenstraße 5, D 40225 Dusseldorf, Germany Electronic address
    Epilepsy Res 108:666-74. 2014
    ..We therefore investigated cardiac parameters during kainic-acid (KA) induced experimental epilepsy and antiepileptic treatment with lamotrigine (LTG)...
  58. pmc The impact of experimental preconditioning using vascular endothelial growth factor in stroke and subarachnoid hemorrhage
    Sven Oliver Eicker
    Department of Neurosurgery, Heinrich Heine University, Medical Faculty, 40225 Dusseldorf, Germany Department of Neurosurgery, University Medical Center, Hamburg Eppendorf, 20246 Hamburg, Germany
    Stroke Res Treat 2013:948783. 2013
    ..05) and saline-treated group (P = 0.09). The present study demonstrates the preconditioning impact of systemic intramuscular VEGF injection in animals after major stroke and induced severe vasospasm after SAH...
  59. doi Secretory meningiomas: systematic analysis of epidemiological, clinical, and radiological features
    Marcel Alexander Kamp
    Department of Neurosurgery, Heinrich Heine University Dusseldorf, Moorenstraße 5, 40225, Dusseldorf, Germany
    Acta Neurochir (Wien) 153:457-65. 2011
    ..The objective of the present study is a systematic, retrospective analysis of epidemiological, clinical, and radiological features of secretory meningiomas to predict potential patterns prior to surgery to reduce associated morbidity...
  60. doi Modulation of migratory activity and invasiveness of human glioma spheroids following 5-aminolevulinic acid-based photodynamic treatment. Laboratory investigation
    Nima Etminan
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg 115:281-8. 2011
    ..Besides direct phototoxicity, additional mechanisms may contribute. Therefore, the authors studied the influence of ALA/PDT on glioblastoma's migratory and invasive behavior in a human glioma cell spheroid model...
  61. doi Retrograde venonidal microsurgical obliteration of brain stem AVM: a clinical feasibility study
    Hans Jakob Steiger
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurochir (Wien) 151:1617-22. 2009
    ....
  62. doi Can systematic analysis of morbidity and mortality reduce complication rates in neurosurgery?
    Hans Jakob Steiger
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    Acta Neurochir (Wien) 152:2013-9. 2010
    ....
  63. doi Early fatal hemorrhage after endovascular cerebral aneurysm treatment with a flow diverter (SILK-Stent): do we need to rethink our concepts?
    Bernd Turowski
    Institute of Radiology Neuroradiology, University of Duesseldorf, Duesseldorf, Germany
    Neuroradiology 53:37-41. 2011
    ..All available data were reviewed and beside hemodynamic factors instability of the intra-aneurysmal thrombus is discussed as a possible cofactor leading to this disastrous event...
  64. pmc A Site-Specific, Sustained-Release Drug Delivery System for Aneurysmal Subarachnoid Hemorrhage
    Daniel Hänggi
    Department of Neurosurgery, University Medical Center Mannheim, Ruprecht Karls University Heidelberg, Germany, Mannheim, Germany
    Neurotherapeutics 13:439-49. 2016
    ..This therapeutic approach shows promise for improving outcome after SAH and may have broader applicability for similar diseases that are confined to body cavities or spaces, are self-limited, and lack effective treatments...
  65. doi Microsurgical resection of Spetzler-Martin grades 1 and 2 unruptured brain arteriovenous malformations results in lower long-term morbidity and loss of quality-adjusted life-years (QALY) than conservative management--results of a single group series
    Hans Jakob Steiger
    Department of Neurosurgery, Heinrich Heine Universitat, Moorenstr 5, Geb 10 54, 40225, Dusseldorf, Germany
    Acta Neurochir (Wien) 157:1279-87. 2015
    ..The therapeutic benefits of microsurgery for unruptured brain AVM remain unclear...
  66. doi Real-time ultrasound guidance for ventricular catheter placement in pediatric cerebrospinal fluid shunts
    Thomas Beez
    Department of Neurosurgery, Medical Faculty, Heinrich Heine Universitat, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Childs Nerv Syst 31:235-41. 2015
    ..The goal of this study was to analyze the impact of intraoperative real-time ultrasound on catheter positioning and outcome in children...
  67. doi Intrathecal application of the nimodipine slow-release microparticle system eg-1962 for prevention of delayed cerebral ischemia and improvement of outcome after aneurysmal subarachnoid hemorrhage
    Nima Etminan
    Department of Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstr 5, 40225, Dusseldorf, Germany
    Acta Neurochir Suppl 120:281-6. 2015
    ....
  68. doi The relation of early hypernatremia with clinical outcome in patients suffering from aneurysmal subarachnoid hemorrhage
    Kerim Beseoglu
    Department of Neurosurgery, Medical Faculty, Heinrich Heine Universitat Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany Electronic address
    Clin Neurol Neurosurg 123:164-8. 2014
    ..However, the correlation of acute dysnatremia and early brain injury (EBI) remains unclear. We investigated the early course and prognostic relevance of changes in serum sodium concentrations and its relation to EBI after aSAH...
  69. doi Evaluation of post-operative complications associated with repeat resection and BCNU wafer implantation in recurrent glioblastoma
    Maria Angela Samis Zella
    Department of Neurosurgery, Heinrich Heine University Hospital Dusseldorf, Medical Faculty, Moorenstraße 5, 40225, Dusseldorf, Germany
    Acta Neurochir (Wien) 156:313-23. 2014
    ..A retrospective investigation was conducted of surgical complications in a cohort of these patients treated at a single institution...
  70. doi Custom-tailored minimally invasive partial C2-corpectomy for ventrally located intramedullary cavernous malformation
    Sven O Eicker
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Neurosurg Rev 36:487-91. 2013
    ..Additionally, the hereby-described approach is not related to cervical instability...
  71. pmc Calcium and potassium channels in experimental subarachnoid hemorrhage and transient global ischemia
    Marcel A Kamp
    Department for Neurosurgery, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany Institute for Neurophysiology, University of Cologne, Robert Koch Strase 39, 50931 Cologne, Germany
    Stroke Res Treat 2012:382146. 2012
    ..Here, changes in calcium and potassium channel expression and function in animal models of subarachnoid hemorrhage and transient global ischemia are systematically reviewed and their clinical significance discussed...
  72. doi Primary spinal marginal zone lymphoma: case report and review of the literature
    Sebastian A Ahmadi
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Neurosurgery 71:E495-508; discussion E508. 2012
    ..There is no consensus on the optimal adjuvant treatment modalities for intracranial primary MZLs. To date, no case of spinal primary MZL has been reported...
  73. pmc 360-degree osteosynthesis via a posterolateral transpedicular approach in high-risk patients
    Sven O Eicker
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, Dusseldorf, Germany
    Eur Spine J 21:1207-13. 2012
    ..In order to reduce cardiopulmonary complications, the efficacy of a posterolateral transpedicular approach for 360-degree fusion was investigated...
  74. pmc Cerebral angiopathies as a cause of ischemic stroke in children: differential diagnosis and treatment options
    Hans Jakob Steiger
    Neurochirurgische Klinik, Universitäts klinikum der Heinrich Heine Universität, Dusseldorf, Germany
    Dtsch Arztebl Int 107:851-6. 2010
    ..Ischemic stroke in children can present with an epileptic seizure or be initially asymptomatic. The median time to diagnosis is 24 hours...
  75. doi Symptomatic intracystic hemorrhage in pineal cysts. Report of 3 cases
    Sevgi Sarikaya-Seiwert
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurosurg Pediatr 4:130-6. 2009
    ..The authors' cases confirm that MR imaging can identify intracystic hemorrhage by a characteristic fluid-fluid interface. Their experience suggests that microsurgical resection of cysts may be an effective and curative treatment option...
  76. doi Epilepsy and headache after resection of cerebral arteriovenous malformations
    Hans Jakob Steiger
    Department of Neurosurgery, Heinrich Heine Universitat, Moorenstr 5, Geb 13 71, Dusseldorf, D 40225, Germany
    Acta Neurochir Suppl 119:113-5. 2014
    ..In conclusion, the long-term treatment results regarding chronic epilepsy and chronic headache need further study and optimization. ..
  77. ncbi Custom-tailored transdural anterior transpetrosal approach to ventral pons and retroclival regions
    Hans Jakob Steiger
    Department of Neurosurgery, Heinrich Heine University Medical School, Dusseldorf, Germany
    J Neurosurg 104:38-46. 2006
    ..The use of a custom-tailored transdural anterior transpetrosal approach can potentially avoid these pitfalls...
  78. doi A cylindrical extracranial cranial base neurinoma of the hypoglossal nerve: a rare tumor with a rare localization: case report
    Hi Jae Heiroth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Neurosurgery 65:E212-3; discussion E213. 2009
    ..The isolated extracranial localization of the neurinoma of the hypoglossal nerve adjacent to the cranial base as described in this case report is extremely rare...
  79. doi Positron emission tomography imaging of meningioma in clinical practice: review of literature and future directions
    Jan Frederick Cornelius
    Neurochirurgische Klinik, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosurgery 70:1033-41; discussion 1042. 2012
    ..We discuss and illustrate the potential role of PET imaging in the clinical management of meningiomas. Finally, we indicate current limitations and outline directions for future research...
  80. doi Diversity of presynaptic calcium channels displaying different synaptic properties
    Marcel A Kamp
    Department f Neurosurgery, University Hospital, Heinrich Heine University, Dusseldorf, MoorenstraBe 5, D 40225, Dusseldorf, Germany
    Rev Neurosci 23:179-90. 2012
    ....
  81. doi Long-term outcome and quality of life after nonaneurysmal subarachnoid hemorrhage
    Kerim Beseoglu
    Department of Neurosurgery, Heinrich Heine University Dusseldorf, 40225 Dusseldorf, Germany
    Acta Neurochir (Wien) 152:409-16. 2010
    ..The outcome of pmSAH is commonly regarded as good, although often outcome is not analyzed using standardized tools of outcome measurement. In this study we focused on the patient's quality of life after nonaneurysmal SAH...
  82. doi Nonenhanced ECG-gated time-resolved 4D steady-state free precession (SSFP) MR angiography (MRA) for assessment of cerebral collateral flow: comparison with digital subtraction angiography (DSA)
    Rotem Shlomo Lanzman
    Department of Radiology, University Hospital Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Eur Radiol 21:1329-38. 2011
    ..To evaluate a nonenhanced time-resolved 4D SSFP MRA for dynamic visualization of intracranial collateral blood flow...
  83. doi Preoperative localization of spinal and peripheral pathologies for surgery by computed tomography-guided placement of a specialized needle system
    Philipp Slotty
    Neurosurgery Clinic, Heinrich Heine University, Dusseldorf, Germany
    Neurosurgery 66:784-7. 2010
    ..The goal was to reduce intraoperative localization error and radiation exposure to patients and operating room personnel...
  84. doi Solitary spinal epidural cavernous angiomas in children presenting with acute neurological symptoms caused by hemorrhage
    Sevgi Sarikaya-Seiwert
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg Pediatr 5:89-93. 2010
    ..Microsurgical resection of these cavernous malformations is an effective and curative treatment option...
  85. doi Treatment of experimental cerebral vasospasm by protein transduction of heme oxygenase 1 (HO-1) conjugated to a residue of 11 arginines
    Tomoyuki Ogawa
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurochir Suppl 112:111-3. 2011
    ..HO-1 has known vascular relaxing properties. We examined the transduction efficacy and antispastic therapeutic effect of 11R fused HO-1 protein in cerebral arteries...