Affiliation: Heinrich Heine University
Hanggi D, Turowski B, Beseoglu K, Yong M, Steiger H. Intra-arterial nimodipine for severe cerebral vasospasm after aneurysmal subarachnoid hemorrhage: influence on clinical course and cerebral perfusion. AJNR Am J Neuroradiol. 2008;29:1053-60 pubmed publisher
..Nevertheless the efficacy of IAN is temporary. Therefore, the search for more effective treatment strategies to reduce critical vasospasm and to improve cerebral perfusion must be continued. ..
Hänggi D, Beseoglu K, Turowski B, Steiger H. Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy. Clin Neurol Neurosurg. 2008;110:784-90 pubmed publisher
..The results of the study are therefore encouraging, and further experimental and clinical trials should be carried out so as to investigate the efficacy of intrathecal nimodipine lavage in vasospasm therapy. ..
Hänggi D, Steiger H, Vajkoczy P. The Role of MCA-STA Bypass Surgery After COSS and JET: The European Point of View. Acta Neurochir Suppl. 2014;119:77-8 pubmed publisher
..JAMA 306:1983-1992, 2011).The goal of this article is to give the European point of view after COSS and JET on behalf of the Cerebrovascular Section of the European Association of Neurological Surgeons (EANS). ..
HÃ¤nggi D, Etminan N, MacDonald R, Steiger H, Mayer S, Aldrich F, et al
. NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage. Neurocrit Care. 2015;23:274-84 pubmed publisher
..Here, we describe a Phase 1/2a multicenter, controlled, randomized, open-label, dose escalation study to determine the MTD and assess the safety and tolerability of EG-1962 in patients with aSAH. ..
Hänggi D, Etminan N, Steiger H. The impact of microscope-integrated intraoperative near-infrared indocyanine green videoangiography on surgery of arteriovenous malformations and dural arteriovenous fistulae. Neurosurgery. 2010;67:1094-103; discussion 1103-4 pubmed publisher
..This simple and safe real-time method is a useful additional tool that can potentially lower the surgical risk in complex AVMs and help avoid missed residuals. ..
Hänggi D, Steiger H. The influence of cisternal and ventricular lavage on cerebral vasospasm in patients suffering from subarachnoid hemorrhage: analysis of effectiveness. Acta Neurochir Suppl. 2011;110:95-8 pubmed publisher
..As a consequence a prospective randomized study would be of great interest. ..
H nggi D, Perrin J, Eicker S, Beseoglu K, Etminan N, Kamp M, et al
. Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage. PLoS ONE. 2012;7:e42597 pubmed publisher
..Local delivery of high-dose nimodipine prolonged-release microparticles at high concentration resulted in significant reduction in angiographic vasospasm after experimental SAH and with no histological signs for matrix toxicity...
Hänggi D, Liersch J, Turowski B, Yong M, Steiger H. The effect of lumboventricular lavage and simultaneous low-frequency head-motion therapy after severe subarachnoid hemorrhage: results of a single center prospective Phase II trial. J Neurosurg. 2008;108:1192-9 pubmed publisher
..No obvious effect could be found on the rate of angiographic vasospasm. ..