Christian Heiss

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction
    Patrick Horn
    Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Duesseldorf, Germany
    J Am Heart Assoc 2:e003764. 2013
  2. doi request reprint Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    Christian Heiss
    Division of Cardiology, University of California San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 56:218-24. 2010
  3. doi request reprint Dietary nitrate supplementation improves revascularization in chronic ischemia
    Ulrike B Hendgen-Cotta
    Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Dusseldorf, Dusseldorf, Germany
    Circulation 126:1983-92. 2012
  4. pmc Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli
    Christian Heiss
    Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    Arterioscler Thromb Vasc Biol 30:2212-8. 2010
  5. ncbi request reprint Resting microvascular resistance and conduit artery tone: relevance to endothelium-dependent flow-mediated dilation
    Thomas Lauer
    Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
    Eur J Cardiovasc Prev Rehabil 15:677-82. 2008
  6. ncbi request reprint Endothelial function, nitric oxide, and cocoa flavanols
    Christian Heiss
    Department of Medicine, Division of Cardiology, University of California, San Francisco, CA 94143 0214, USA
    J Cardiovasc Pharmacol 47:S128-35; discussion S172-6. 2006
  7. ncbi request reprint Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients
    Patrick Horn
    Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstrasse 5, Düsseldorf D 40235, Germany
    Br J Nutr 111:1245-52. 2014
  8. doi request reprint Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening
    Stefanie Keymel
    Medical Clinic I, Dept of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, RWTH University Hospital Aachen, Pauwelstrasse 30, 52074, Aachen, Germany
    Basic Res Cardiol 103:582-6. 2008
  9. doi request reprint Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0103, USA
    J Am Coll Cardiol 51:1760-71. 2008
  10. ncbi request reprint Flavanols and cardiovascular health: effects on the circulating NO pool in humans
    Jan Balzer
    Medical Clinic I, Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital RWTH Aachen, Germany
    J Cardiovasc Pharmacol 47:S122-7; discussion S172-6. 2006

Collaborators

Detail Information

Publications36

  1. pmc Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction
    Patrick Horn
    Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Duesseldorf, Germany
    J Am Heart Assoc 2:e003764. 2013
    ..As a significant proportion of MPs originate from platelets and endothelial cells, we hypothesized that MPs may harbor functional enzymes including an endothelial NO synthase (eNOS)...
  2. doi request reprint Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    Christian Heiss
    Division of Cardiology, University of California San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 56:218-24. 2010
    ....
  3. doi request reprint Dietary nitrate supplementation improves revascularization in chronic ischemia
    Ulrike B Hendgen-Cotta
    Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Dusseldorf, Dusseldorf, Germany
    Circulation 126:1983-92. 2012
    ..Whether dietary nitrate, serially reduced to nitrite by commensal bacteria in the oral cavity and subsequently to nitric oxide and other nitrogen oxides, enhances ischemia-induced remodeling of the vascular network is not known...
  4. pmc Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli
    Christian Heiss
    Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    Arterioscler Thromb Vasc Biol 30:2212-8. 2010
    ..The role of nitric oxide (NO) in CAC function is poorly understood. We hypothesized that CAC migration toward angiogenic signals is modulated by both NO synthase (NOS) expression and functional response to NO...
  5. ncbi request reprint Resting microvascular resistance and conduit artery tone: relevance to endothelium-dependent flow-mediated dilation
    Thomas Lauer
    Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
    Eur J Cardiovasc Prev Rehabil 15:677-82. 2008
    ..The significance of the interaction between microcirculation and macrocirculation in the flow-mediated dilation (FMD) is poorly understood...
  6. ncbi request reprint Endothelial function, nitric oxide, and cocoa flavanols
    Christian Heiss
    Department of Medicine, Division of Cardiology, University of California, San Francisco, CA 94143 0214, USA
    J Cardiovasc Pharmacol 47:S128-35; discussion S172-6. 2006
    ....
  7. ncbi request reprint Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients
    Patrick Horn
    Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstrasse 5, Düsseldorf D 40235, Germany
    Br J Nutr 111:1245-52. 2014
    ..Our data show that flavanols lower the levels of EMP along with higher endothelial function, lending evidence to the novel concept that flavanols may improve endothelial integrity...
  8. doi request reprint Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening
    Stefanie Keymel
    Medical Clinic I, Dept of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, RWTH University Hospital Aachen, Pauwelstrasse 30, 52074, Aachen, Germany
    Basic Res Cardiol 103:582-6. 2008
    ..We investigated whether qualitative or quantitative alterations of the endothelial progenitor cell (EPC) pool predict age-related structural vessel wall changes...
  9. doi request reprint Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0103, USA
    J Am Coll Cardiol 51:1760-71. 2008
    ..This study sought to analyze the effects of acute secondhand smoke (SHS) exposure on the number and function of endothelial progenitor cells (EPCs) over 24 h...
  10. ncbi request reprint Flavanols and cardiovascular health: effects on the circulating NO pool in humans
    Jan Balzer
    Medical Clinic I, Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital RWTH Aachen, Germany
    J Cardiovasc Pharmacol 47:S122-7; discussion S172-6. 2006
    ..This review is aimed at evaluating the suitability of quantifying this NO pool as a biomarker for cardiovascular function in humans, in particular during dietary interventions with flavonoid-rich foods...
  11. ncbi request reprint Plasma nitroso compounds are decreased in patients with endothelial dysfunction
    Christian Heiss
    Department of Cardiology, Pneumology, and Vascular Medicine, RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 47:573-9. 2006
    ..We investigated whether plasma nitros(yl)ated species (RXNOs) that mediate systemic nitric oxide (NO) bioactivity are depleted in individuals with cardiovascular risk factors and endothelial dysfunction...
  12. doi request reprint Characterization of the non-invasive assessment of the cutaneous microcirculation by laser Doppler perfusion scanner
    Stefanie Keymel
    Department of Medicine, Division of Cardiology, Pneumology, and Vascular Diseases, University Hospital, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    Microcirculation 17:358-66. 2010
    ..Here, we aimed at establishing a sensitive and valid method to measure microvascular reactivity during post-occlusive reactive hyperemia (PORH) using scanning laser Doppler perfusion imaging (LDPI) of the forearm...
  13. doi request reprint Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients
    Nicolas Amabile
    Department of Medicine, Division of Cardiology, University of California at San Francisco, San Francisco, California, USA
    J Heart Lung Transplant 28:1081-6. 2009
    ..We hypothesized that the levels of circulating EMPs and LMPs could predict outcome in these patients...
  14. doi request reprint Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
    Jan Balzer
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 51:2141-9. 2008
    ..Our goal was to test feasibility and efficacy of a dietary intervention based on daily intake of flavanol-containing cocoa for improving vascular function of medicated diabetic patients...
  15. ncbi request reprint Plasma nitrite reserve and endothelial function in the human forearm circulation
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, University Hospital Aachen, 52074 Aachen, Germany
    Free Radic Biol Med 41:295-301. 2006
    ..001). This observation suggests that nitrite changes reflect endothelial function. Assessment of local plasma nitrite during reactive hyperemia may open new avenues in the diagnosis of vascular function...
  16. doi request reprint Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function
    Christian Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital, Duesseldorf, Germany
    J Am Coll Cardiol 55:454-9. 2010
    ..This study sought to characterize the impact of hemodialysis (HD)-induced release of hemoglobin on the bioavailability of nitric oxide (NO) and endothelial function...
  17. ncbi request reprint In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco 94143 0124, USA
    Am J Physiol Heart Circ Physiol 294:H1086-93. 2008
    ..To our knowledge, this is the first integrative physiological model to reproducibly study FMD of conduit arteries in living rats...
  18. pmc Nitric oxide synthase-derived plasma nitrite predicts exercise capacity
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Br J Sports Med 41:669-73; discussion 673. 2007
    ..As NO is necessary to maintain an adequate vascular response to the increased demands of blood flow, it is believed to be important for vasodilation induced by exercise...
  19. doi request reprint Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension
    Nicolas Amabile
    Division of Cardiology, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0103, USA
    Am J Respir Crit Care Med 177:1268-75. 2008
    ..Endothelial MPs are a biological marker of dysfunctional endothelium. Vascular remodeling and endothelial dysfunction are involved in pulmonary hypertension (PH)...
  20. ncbi request reprint Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers
    Christian Heiss
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University, Duesseldorf, Germany
    J Am Coll Cardiol 46:1276-83. 2005
    ..This study was designed to assess the effect of flavanol-rich food on the circulating pool of bioactive nitric oxide (NO) and endothelial dysfunction in smokers...
  21. doi request reprint Flavanols and cardiovascular disease prevention
    Christian Heiss
    Department of Cardiology, Vascular Medicine and Pulmonology, Heinrich Heine University, Duesseldorf, Germany
    Eur Heart J 31:2583-92. 2010
    ....
  22. ncbi request reprint TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention
    Eva S Kehmeier
    Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Department of Medicine, University Hospital Aachen, 52074 Aachen, Germany
    Clin Res Cardiol 101:815-27. 2012
    ....
  23. ncbi request reprint Reduction of peripheral flow reserve impairs endothelial function in conduit arteries of patients with essential hypertension
    Thomas Lauer
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Duesseldorf, Germany
    J Hypertens 23:563-9. 2005
    ..Hypertension is associated with structural alterations in the microcirculation and a reduced endothelium-dependent dilation in conduit arteries. Both have been demonstrated to predict future cardiovascular events...
  24. pmc Characterization of macro-and microvascular function and structure in patients with type 2 diabetes mellitus
    Stefanie Keymel
    University Duesseldorf, Medical Faculty, Department of Cardiology, Pulmonology, and Vascular Diseases, University Hospital Duesseldorf Germany
    Am J Cardiovasc Dis 1:68-75. 2011
    ..Thus, we aimed at simultaneously characterizing functional, physicomechanical, and structural vascular alterations in diabetic patients using a non-invasive approach...
  25. pmc Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells
    Christian Heiss
    Department of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California 94143 0124, USA
    J Cell Physiol 215:366-73. 2008
    ..These data suggest that PTN may mediate its pro-angiogenic effects by increasing the local number of not only endothelial cells but also early EPCs at angiogenic sites...
  26. doi request reprint Predicting neurally mediated syncope based on pulse arrival time: algorithm development and preliminary results
    Christian Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    J Cardiovasc Electrophysiol 22:1042-8. 2011
    ..The circulatory adjustments to orthostatic stress occur just prior to a sudden loss of consciousness. NMS prediction would protect patients from falls or accidents...
  27. doi request reprint Dietary inorganic nitrate mobilizes circulating angiogenic cells
    Christian Heiss
    University Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology, and Vascular Medicine, Duesseldorf, Germany
    Free Radic Biol Med 52:1767-72. 2012
    ..Dietary inorganic nitrate acutely mobilizes CACs via serial reduction to nitrite and NO. The nitrate-nitrite-NO pathway could offer a novel nutritional approach for regulation of vascular regenerative processes...
  28. ncbi request reprint Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia
    Shobha Natarajan
    Division of Pediatric Cardiology, University of California San Francisco, San Francisco, CA, USA
    Am J Cardiol 103:862-6. 2009
    ....
  29. ncbi request reprint Cocoa polyphenols and inflammatory mediators
    Helmut Sies
    Institute for Biochemistry and Molecular Biology I and the Department of Medicine, Division of Cardiology, Pulmonary Diseases, and Angiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Am J Clin Nutr 81:304S-312S. 2005
    ..Adverse effects of NO metabolites, such as nitrite and peroxynitrite, were thus attenuated...
  30. ncbi request reprint Impaired progenitor cell activity in age-related endothelial dysfunction
    Christian Heiss
    Department of Cardiology, Pneumology, and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    J Am Coll Cardiol 45:1441-8. 2005
    ..We investigated whether human age-related endothelial dysfunction is accompanied by quantitative and qualitative alterations of the endothelial progenitor cell (EPC) pool...
  31. ncbi request reprint Is there a role for antioxidants in the treatment of stable angina?
    Dominik Schuler
    University Duesseldorf, Medical Faculty, Division of Cardiology, Pulmonology, and Vascular Medicine, Duesseldorf, Germany
    Curr Pharm Des 19:1601-15. 2013
    ..Taken together, there is currently not enough evidence that treatment with antioxidants per se will play a role in cardiovascular medicine...
  32. doi request reprint Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity
    Ana Rodriguez-Mateos
    Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading, United Kingdom AR M, CR, TB M, St, TWG, and JPES the Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Düsseldorf, Dusseldorf, Germany AR M and CH and the Department of Applied Sciences, Faculty of Health and Life Sciences, University of Northumbria, Newcastle upon Tyne, United Kingdom TWG
    Am J Clin Nutr 98:1179-91. 2013
    ..There are very limited data regarding the effects of blueberry flavonoid intake on vascular function in healthy humans...
  33. pmc Evidence for in vivo transport of bioactive nitric oxide in human plasma
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Clin Invest 109:1241-8. 2002
    ..Our results suggest that NO can be transported in bioactive form for significant distances along the vascular bed. Both free NO and plasma nitroso species contribute to the dilation of the downstream vasculature...
  34. doi request reprint Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation
    Ulrich Sydlik
    IUF Leibniz Research Institute for Environmental Medicine, Auf m Hennekamp 50, Duesseldorf, Germany
    Eur Respir J 41:433-42. 2013
    ..Ectoine, a compound of the highly compliant group of compatible solutes, demonstrates a reproducible and robust effect on the resolution of lung inflammation...
  35. pmc Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function
    Kranthi Pinnamaneni
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA
    Nicotine Tob Res 16:584-90. 2014
    ..In humans, SHS exposure for 30min impairs FMD. It is important to gain a better understanding of the acute effects of exposure to SHS at low concentrations and for brief periods of time...
  36. doi request reprint The potential of flavanol and procyanidin intake to influence age-related vascular disease
    Roberta R Holt
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Nutr Gerontol Geriatr 31:290-323. 2012
    ..In the current article we review a selection of these studies, and comment on some of the potential mechanisms that have been postulated to underlie the health effects of flavanol and procyanidin-rich foods...