D Haussinger

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Stellate cells from rat pancreas are stem cells and can contribute to liver regeneration
    Claus Kordes
    Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    PLoS ONE 7:e51878. 2012
  2. pmc Onwards and upwards: European Journal of Medical Research continues as an open access publication
    Stefan Busch
    BioMed Central, 236 Gray s Inn Road, London, WC1X 8HB, UK
    Eur J Med Res 17:1. 2012
  3. pmc Toponomics method for the automated quantification of membrane protein translocation
    Olga Domanova
    Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany
    BMC Bioinformatics 12:370. 2011
  4. doi request reprint Osmosensing and osmosignaling in the liver
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Wien Med Wochenschr 158:549-52. 2008
  5. pmc Intrahepatic type II gall bladder perforation by a gall stone in a CAPD patient
    T Göbel
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Eur J Med Res 16:213-6. 2011
  6. ncbi request reprint Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Neurochem Int 47:64-70. 2005
  7. ncbi request reprint Pathogenesis of hepatic encephalopathy
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology und Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Gastroenterol Hepatol 17:S256-9. 2002
  8. ncbi request reprint Kurt Jungermann: a pioneer in liver research
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Anat Rec A Discov Mol Cell Evol Biol 280:807. 2004
  9. ncbi request reprint Neural control of hepatic osmolytes and parenchymal cell hydration
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Anat Rec A Discov Mol Cell Evol Biol 280:893-900. 2004
  10. ncbi request reprint Molecular aspects of medicine: from experimental to clinical hepatology
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Medizinische Universitätsklinik Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Dusseldorf 40225, Germany
    Mol Aspects Med 25:221-360. 2004

Collaborators

Detail Information

Publications158 found, 100 shown here

  1. pmc Stellate cells from rat pancreas are stem cells and can contribute to liver regeneration
    Claus Kordes
    Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    PLoS ONE 7:e51878. 2012
    ..These findings demonstrate that PSC have stem cell characteristics and can contribute to the regeneration of injured organs through differentiation across tissue boundaries...
  2. pmc Onwards and upwards: European Journal of Medical Research continues as an open access publication
    Stefan Busch
    BioMed Central, 236 Gray s Inn Road, London, WC1X 8HB, UK
    Eur J Med Res 17:1. 2012
    ..The conversion to open access opens up the potential for the journal to become a leading, globally visible title in the field of general medicine over the coming years...
  3. pmc Toponomics method for the automated quantification of membrane protein translocation
    Olga Domanova
    Fraunhofer Institute for Applied Information Technology FIT, Schloss Birlinghoven, Sankt Augustin, Germany
    BMC Bioinformatics 12:370. 2011
    ..For validation, the cholestatic liver state was compared to the normal biological state...
  4. doi request reprint Osmosensing and osmosignaling in the liver
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Wien Med Wochenschr 158:549-52. 2008
    ..This article briefly summarizes some aspects of our own work on osmosignaling and osmosensing; for indepth surveys the reader is refered to recent reviews [1-6]...
  5. pmc Intrahepatic type II gall bladder perforation by a gall stone in a CAPD patient
    T Göbel
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Eur J Med Res 16:213-6. 2011
    ..Abdominal imaging like ultrasound or CT-scan are important tools for immediate diagnose of gall bladder perforation...
  6. ncbi request reprint Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Neurochem Int 47:64-70. 2005
    ..This review focuses on the involvement of astrocyte swelling in protein tyrosine nitration and potential consequences in the setting of HE...
  7. ncbi request reprint Pathogenesis of hepatic encephalopathy
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology und Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Gastroenterol Hepatol 17:S256-9. 2002
    ..Several proteins, which are nitrated in response to ammonia, benzodiazepines, hypoosmotic astrocyte swelling or inflammatory cytokines have been identified, including glutamine synthetase and the peripheral type benzodiazepine receptor...
  8. ncbi request reprint Kurt Jungermann: a pioneer in liver research
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Anat Rec A Discov Mol Cell Evol Biol 280:807. 2004
  9. ncbi request reprint Neural control of hepatic osmolytes and parenchymal cell hydration
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Anat Rec A Discov Mol Cell Evol Biol 280:893-900. 2004
    ....
  10. ncbi request reprint Molecular aspects of medicine: from experimental to clinical hepatology
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Medizinische Universitätsklinik Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Dusseldorf 40225, Germany
    Mol Aspects Med 25:221-360. 2004
  11. ncbi request reprint Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis
    Dieter Haussinger
    Department of Gastroenterology, Hepatology and Infectology, Universitatsklinikum Dusseldorf, Germany
    Gastroenterology 124:1476-87. 2003
    ..This study investigates the sensing and upstream signaling events of TUDC-induced choleresis...
  12. doi request reprint Pathogenetic mechanisms of hepatic encephalopathy
    D Haussinger
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Gut 57:1156-65. 2008
    ..The potential of therapies targeting downstream pathophysiological events in HE has not yet been explored, but offers novel potential sites of therapeutic intervention...
  13. ncbi request reprint [Hepatic encephalopathy]
    D Haussinger
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf
    Z Gastroenterol 40:43-5. 2002
  14. doi request reprint Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity
    Dieter Haussinger
    Heinrich Heine University Dusseldorf, Clinic for Gastroenterology, Hepatology, and Infectiology, Dusseldorf, Germany
    Curr Opin Clin Nutr Metab Care 13:87-92. 2010
    ..Description of the role of oxidative stress in the pathogenesis of cerebral ammonia toxicity and hepatic encephalopathy...
  15. ncbi request reprint The hepatocyte integrin system and cell volume sensing
    D Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Acta Physiol (Oxf) 187:249-55. 2006
    ....
  16. ncbi request reprint Glutamine metabolism and signaling in the liver
    Dieter Haussinger
    Heinrich Heine University Dusseldorf, Clinic for Gastroenterology, Hepatology and Infectiology, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Front Biosci 12:371-91. 2007
    ..This review summarizes recent progress in the understanding of glutamine metabolism and signal transduction, which provides further rationale for the use of glutamine as a therapeutic tool...
  17. ncbi request reprint [Hepatic encephalopathy]
    D Haussinger
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf
    Praxis (Bern 1994) 91:957-63. 2002
    ..Recognition and rigorous treatment of these precipitating factors is the most important measure in HE therapy, which may be augmented by dietary and medical approaches...
  18. ncbi request reprint [Hepatic encephalopathy]
    D Haussinger
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf
    Praxis (Bern 1994) 95:1543-9. 2006
    ..Diagnosis and rigorous treatment of these precipitating factors is the most important therapeutic measure, which is supported by dietary and drug treatment...
  19. doi request reprint Osmotic regulation of bile acid transport, apoptosis and proliferation in rat liver
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Dusseldorf, Dusseldorf
    Cell Physiol Biochem 28:1089-98. 2011
    ..This review summarizes our own work on the understanding of how osmosensing and osmosignaling integrate into the overall context of bile acid transport, growth factor signaling and the execution of apoptotic programs...
  20. ncbi request reprint Hyperosmotic induction of the mitogen-activated protein kinase phosphatase MKP-1 in H4IIE rat hepatoma cells
    F Schliess
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine Universitat, Dusseldorf, Germany
    Arch Biochem Biophys 351:35-40. 1998
    ....
  21. ncbi request reprint [Epidemiology of primary drug resistance in chronically HIV-infected patients in Nordrhein-Westfalen, Germany, 2001-2005]
    M Oette
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf
    Dtsch Med Wochenschr 132:977-82. 2007
    ..Primary resistance is associated with reduced efficacy of antiretroviral therapy (ART). We determined the prevalence of primary resistance in Nordrhein-Westfalen, Germany...
  22. ncbi request reprint Anisoosmotic regulation of the Nopp140 mRNA in H4IIE rat hepatoma cells and primary hepatocytes
    U Warskulat
    Medizinische Universitätsklinik der Heinrich Heine Universität Düsseldorf, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Germany
    FEBS Lett 452:259-62. 1999
    ..Because Nopp140 is involved in the regulation of transcriptional activity it could play a role in the osmosignalling pathway towards gene expression in H4IIE cells and hepatocytes...
  23. ncbi request reprint Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver
    F Schliess
    Heinrich Heine Universitat, Klinik fur Gastroenterologie, Hepatologie, und Infektiologie, Dusseldorf, Germany
    Gastroenterology 113:1306-14. 1997
    ..Tauroursodeoxycholate (TUDCA) is widely used in the treatment of cholestatic liver disease. The purpose of this study was to elucidate molecular mechanisms underlying its beneficial effect...
  24. ncbi request reprint Release of osmolytes induced by phagocytosis and hormones in rat liver
    M Wettstein
    Clinic for Gastroenterology, Hepatology, and Infectious Disease, Heinrich Heine University, 40255 Düsseldorf, Germany
    Am J Physiol Gastrointest Liver Physiol 278:G227-33. 2000
    ..This mechanism may be used to compensate for the increase in cell volume induced by the ingestion of phagocytosable material. The physiological significance of hormone-induced osmolyte release remains to be evaluated...
  25. ncbi request reprint [New approaches in the treatment of hepatitis B]
    A Sagir
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf, Duesseldorf
    Dtsch Med Wochenschr 129:1203-8. 2004
  26. ncbi request reprint SEN Virus infection in HIV/HCV coinfected patients
    A Sagir
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Eur J Med Res 13:495-9. 2008
    ..The influence of SEN Virus (SENV) on the outcome of HCV therapy in HIV/HCV coinfected patients who underwent combination therapy with pegylated interferon (PEG-IFN) and ribavirin is unclear...
  27. ncbi request reprint Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Glia 55:758-71. 2007
    ..The findings further support a close interrelation between osmotic and oxidative stress in astrocytes, which may be relevant to different brain pathologies including hepatic encephalopathy...
  28. ncbi request reprint [Current trends and research emphasis. Epidemiology, resistance testing, vaccination strategies]
    M Oette
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum, Moorenstrasse 5, D 40225 Dusseldorf
    MMW Fortschr Med 144:73-6. 2002
  29. ncbi request reprint [HIV-HBV-coinfection--diagnosis and therapy]
    S Koch
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf
    Dtsch Med Wochenschr 131:1873-7. 2006
  30. ncbi request reprint Evaluation of safety and efficacy of rosiglitazone in the treatment of HIV-associated lipodystrophy syndrome
    T Feldt
    Clinic of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Infection 34:55-61. 2006
    ..Currently, an effective therapy is not available. There is some evidence that the drug class of thiazolidindiones might be effective in the treatment of LDS...
  31. ncbi request reprint Glutamine and cell signaling in liver
    D Haussinger
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    J Nutr 131:2509S-14S; discussion 2523S-4S. 2001
    ..Here, the glutamine-induced p38(MAPK) activation mediates the inhibition of autophagic proteolysis at the level of autophagosome formation...
  32. ncbi request reprint CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Germany
    J Biol Chem 279:10364-73. 2004
    ..Apparently, CD95-tyrosine phosphorylation and nitration are mutually exclusive. The data identify critical tyrosine residues of CD95 as another target of the anti-apoptotic action of NO...
  33. doi request reprint Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts
    Ulrich Warskulat
    Department of Gastroenterology, Hepatology and Infectiology, Dusseldorf, Germany
    Exp Dermatol 17:1031-6. 2008
    ..These data indicate that taurine accumulation seems to be part of the fibroblast response to UVA radiation and may protect against UVA-induced Il-6 overexpression...
  34. ncbi request reprint Atazanavir for treatment of HIV infection in clinical routine: efficacy, pharmacokinetics and safety
    T Feldt
    Clinic for Gastroenterology, Hepatology, and Infectious Diseases, University Clinic of Düsseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
    Eur J Med Res 10:7-10. 2005
    ..Atazanavir (ATV) is a novel protease inhibitor that has been recently introduced into therapy of HIV infection. Currently there is little data on ATV therapy from daily practice...
  35. ncbi request reprint Impact of rosiglitazone treatment on the bioavailability of antiretroviral compounds in HIV-positive patients
    M Oette
    Clinic for Gastroenterology, Hepatology, and Infectious Diseases, University Clinic Düsseldorf, Moorenstr 5, 40225 Dusseldorf
    J Antimicrob Chemother 56:416-9. 2005
    ..The insulin-sensitizer rosiglitazone is under investigation for therapy of HIV-associated lipodystrophy syndrome (LDS). Little is known about pharmacological interactions with antiretroviral (ARV) drugs...
  36. ncbi request reprint The osmolyte strategy of normal human keratinocytes in maintaining cell homeostasis
    Ulrich Warskulat
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Düsseldorf gGmbH, Auf m Hennekamp 50, D 40225 Dusseldorf, Germany
    J Invest Dermatol 123:516-21. 2004
    ..These studies demonstrate that NHK possess an osmolyte strategy, which is important for their capacity to maintain cell volume homeostasis and seems to be part of their response to UV radiation...
  37. ncbi request reprint Chronic liver disease is triggered by taurine transporter knockout in the mouse
    Ulrich Warskulat
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    FASEB J 20:574-6. 2006
    ..In conclusion, taurine deficiency due to defective taurine transport triggers chronic liver disease, which may involve mitochondrial dysfunction...
  38. pmc Loss of ability to self-heal malaria upon taurine transporter deletion
    Denis Delic
    Division of Molecular Parasitology, Department of Biology, and Biologisch Medizinisches Forschungszentrum, Heinrich Heine University, Universitatsstr 1, Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Infect Immun 78:1642-9. 2010
    ..chabaudi-parasitized erythrocytes and expedites increases in systemic TNF-alpha, IL-1beta, and ammonia levels, presumably contributing to multiorgan failure in P. chabaudi-infected taut-/- mice...
  39. doi request reprint Ammonia triggers exocytotic release of L-glutamate from cultured rat astrocytes
    Boris Gorg
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Glia 58:691-705. 2010
    ..It is concluded that ammonia triggers a prostanoid- and Ca(2+)-dependent glutamate exocytosis, which is essential for induction of ammonia-induced RNA oxidation...
  40. ncbi request reprint [Transient elastography for diagnosing liver cirrhosis]
    A Erhardt
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf
    Dtsch Med Wochenschr 131:2765-9. 2006
    ..Detection of liver cirrhosis has numerous implications because of the potential sequelae of cirrhosis. Transient elastography (Fibroscan), was evaluated as a novel, non-invasive means of assessing cirrhosis by measuring liver stiffness...
  41. ncbi request reprint [Hepatic encephalopathy--diagnostics]
    M Wettstein
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf
    Dtsch Med Wochenschr 128:2654-7. 2003
  42. ncbi request reprint Cortical origin of mini-asterixis in hepatic encephalopathy
    L Timmermann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 58:295-8. 2002
    ..The corticomuscular coupling demonstrates the involvement of M1 in asterixis and may reflect a pathologically slowed and synchronized motor cortical drive...
  43. pmc Maraviroc in treatment-experienced patients with HIV-1 infection - experience from routine clinical practice
    S Reuter
    Clinic for Gastroenterology, Hepatology and Infectious, University Hospital, Dusseldorf, Germany
    Eur J Med Res 15:231-7. 2010
    ..Few data are available about the efficacy of maraviroc (MVC) during routine use. We characterized indications for MVC use and the efficacy of MVC in clinical practice...
  44. ncbi request reprint Role of p38(MAPK) in cell volume regulation of perfused rat liver
    S Vom Dahl
    Div of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine Universitat, Dusseldorf, Germany
    Cell Physiol Biochem 11:285-94. 2001
    ..The findings suggest that swelling-induced activation of p38(MAPK), but not of Erks and PI-3-kinase, is involved in RVD in liver, whereas p38(MAPK) is apparently not involved in the net K(+) release induced by oxidative stress...
  45. ncbi request reprint Successful treatment of hepatitis B virus associated polyarteritis nodosa with a combination of prednisolone, alpha-interferon and lamivudine
    A Erhardt
    Klinik fur Gastroenterologie, Hepatologie und Infektologie, Heinrich Heine University, Dusseldorf Germany
    J Hepatol 33:677-83. 2000
    ..The present protocol of short-term prednisolone administration combined with alpha-interferon and lamivudine was effective for the treatment of HBV-related polyarteritis nodosa and may be a promising new therapeutic approach...
  46. ncbi request reprint Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Germany
    FASEB J 17:731-3. 2003
    ..This provides a signal for CD95 membrane trafficking and DISC formation...
  47. doi request reprint CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Gastroenterology 134:1494-506. 2008
    ..The underlying mechanisms and the function of the CD95 system in quiescent HSCs, however, are unknown...
  48. ncbi request reprint Light deprivation slows but does not prevent the loss of photoreceptors in taurine transporter knockout mice
    K Rascher
    Department of Anatomy II, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Vision Res 44:2091-100. 2004
    ..Conclusions: Cell differentiation is not seriously affected by the lack of a functional taurine transporter but mature photoreceptor cells do not survive without an intact transporter, even in the dark...
  49. ncbi request reprint Visceral leishmaniasis presenting as subcutaneous nodules in a HIV-positive patient
    K Göbels
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Eur J Clin Microbiol Infect Dis 22:329-31. 2003
  50. ncbi request reprint Prognosis of chronic hepatitis C: results of a large, prospective cohort study
    C Niederau
    Department of Medicine, Division of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Hepatology 28:1687-95. 1998
    ..The age at diagnosis therefore should play a major role in therapeutic considerations. The present data also suggest that interferon therapy has a long-term clinical benefit, although it did not reduce the risk of liver cancer...
  51. ncbi request reprint Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    Neuroscience 134:1091-8. 2005
    ....
  52. ncbi request reprint Identification of osmosensitive and ammonia-regulated genes in rat astrocytes by Northern blotting and differential display reverse transcriptase-polymerase chain reaction
    U Warskulat
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    J Hepatol 35:358-66. 2001
    ..The hepatic encephalopathy (HE) is in part the result of astrocyte swelling with alterations of glial function. Detoxification of ammonia may be one mechanism by which astrocyte swelling is triggered in HE...
  53. ncbi request reprint Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Duesseldorf, Germany
    Gastroenterology 125:839-53. 2003
    ..Hydrophobic bile acids induce CD95-dependent hepatocyte apoptosis...
  54. ncbi request reprint The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression
    Nicole Rockel
    Institut fur umweltmedizinische Forschung IUF an der Heinrich Heine Universitat Dusseldorf gGmbH, Dusseldorf, Germany
    J Immunol 179:3604-12. 2007
    ..Thus, similar to nucleotide excision repair, taurine uptake is critically involved in photoprotection of the skin...
  55. ncbi request reprint Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Hepatology 36:602-14. 2002
    ..Hyperosmotic hepatocyte shrinkage induces CD95 trafficking to the plasma membrane, which involves JNK-, PKA-, and PKC-dependent mechanisms and sensitizes hepatocytes toward CD95L-mediated apoptosis...
  56. doi request reprint RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia
    Freimut Schliess
    Heinrich Heine Universitat Dusseldorf, Klinik fur Gastroenterologie, Hepatologie, und Infektiologie, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Metab Brain Dis 24:119-34. 2009
    ..RNA oxidation offers a novel explanation for multiple disturbances of neurotransmitter systems and gene expression and the cognitive deficits observed in hepatic encephalopathy...
  57. ncbi request reprint Prevention of bile acid-induced apoptosis by betaine in rat liver
    Dirk Graf
    Department of Gastroenterology, Hepatology and Infectiology, Medizinische Einrichtungen der Heinrich Heine Universitat, Dusseldorf, Germany
    Hepatology 36:829-39. 2002
    ..In conclusion, this study identifies betaine as a potent protectant against bile acid-induced apoptosis in vivo and in vitro, and its antiapoptotic action largely resides on an inhibition of the proapoptotic mitochondrial pathway...
  58. ncbi request reprint Mini-asterixis in hepatic encephalopathy induced by pathologic thalamo-motor-cortical coupling
    L Timmermann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 61:689-92. 2003
    ..HE patients showed thalamo-motor-cortical coupling at a significantly lower frequency than the coupling in control subjects. The pathologic motor cortical drive in HE probably results from altered thalamocortical oscillatory coupling...
  59. ncbi request reprint Capreomycin in the treatment of atypical mycobacterial disease in HIV-positive patients
    K Göbels
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur J Clin Microbiol Infect Dis 21:563-5. 2002
  60. doi request reprint [Increasing number and improved survival of patients with hepatocellular carcinoma from 1988 to 2007: data of a German university clinic]
    A Erhardt
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf
    Z Gastroenterol 49:720-7. 2011
    ..The aim of the present study was to determine changes of clinical-epidemiological parameters and survival rates during two decades...
  61. ncbi request reprint Therapy outcome in patients with chronic hepatitis C: role of therapy supervision by expert hepatologists
    A Sagir
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Moorenstr, Dusseldorf, Germany
    J Viral Hepat 14:633-8. 2007
    ..015). Patients with unfavourable genotypes 1 and 4 or with advanced liver damage benefit from HCV therapy supervision by a specialist, probably because of less frequent treatment interruptions or dose reductions...
  62. ncbi request reprint Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy
    Dieter Haussinger
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, D 40225, Dusseldorf, Germany
    Metab Brain Dis 20:285-94. 2005
    ..The pathobiochemical relevance of astrocytic PTN for the development of HE symptoms remains to be established...
  63. ncbi request reprint c-Jun-N-terminal kinase dependent membrane targeting of CD95 in rat hepatic stellate cells
    Alexandra Cariers
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Germany
    Cell Physiol Biochem 12:179-86. 2002
    ..The effect of CD95 ligand (CD95L) and cycloheximide (CHX) on CD95 membrane targeting and apoptosis was studied in activated, cultured rat hepatic stellate cells (HSC)...
  64. pmc Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy
    Boris Gorg
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Hepatology 52:256-65. 2010
    ....
  65. ncbi request reprint Taurine supplementation induces multidrug resistance protein 2 and bile salt export pump expression in rats and prevents endotoxin-induced cholestasis
    Anja Muhlfeld
    Clinic for Gastroenterology, Hepatology and Infectiology, Universitatsklinikum Dusseldorf, Moorenstrasse 5, Germany
    Arch Biochem Biophys 413:32-40. 2003
    ..The data show that oral supplementation of taurine induces Mrp2 and Bsep expression and may prevent LPS-induced cholestasis...
  66. ncbi request reprint Combination treatment of IFNalpha2b and ribavirin in patients with chronic hepatitis C and persistently normal ALTs
    Andreas Erhardt
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Dig Dis Sci 48:921-5. 2003
    ..Treatment was discontinued in 3 patients due to side effects. Interferon (IFN) ribavirin combination therapy is effective in patients with normal ALTs and appears superior to IFN monotherapy...
  67. pmc Specific targeting of hepatitis C virus core protein by an intracellular single-chain antibody of human origin
    Juliane Karthe
    Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Dusseldorf, Germany
    Hepatology 48:702-12. 2008
    ..Therefore, scFv42C may represent a novel anti-HCV agent, which acts by sequestering core protein and attenuating core protein-mediated pathogenesis...
  68. ncbi request reprint TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex
    Johannes G Bode
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Medizinische Klinik der Heinrich Heine Universität, Dusseldorf, Germany
    J Immunol 171:257-66. 2003
    ..Furthermore, activation of p38 mitogen-activated protein kinase is shown to be essential for the inhibitory effect of TNF-alpha on IL-6 signaling and TNF-alpha-dependent recruitment of SHP2 to gp130...
  69. ncbi request reprint Hyperosmotic activation of the CD95 death receptor system
    R Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Acta Physiol (Oxf) 187:199-203. 2006
    ..The findings not only provide a mechanistic explanation for the high susceptibility of dehydrated cells for apoptosis, but also give insight into the role of AVD...
  70. ncbi request reprint Socioepidemiological data on hepatitis delta in a German university clinic--increase in patients from Eastern Europe and the former Soviet Union
    A Erhardt
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum der Heinrich Heine Universität Düsseldorf
    Z Gastroenterol 41:523-6. 2003
    ..The aim of the present study was the socioepidemiological characterization of patients with hepatitis delta, in order to identify patients at risk for hepatitis delta...
  71. ncbi request reprint Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B
    A Erhardt
    Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Hepatology 31:716-25. 2000
    ..Our data suggest that HBV genome mutations located within the BCP are determinants of a response to IFN therapy...
  72. ncbi request reprint Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells
    R Kubitz
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Hepatology 34:340-50. 2001
    ..The data suggest that retargeting of canalicular MRP2 to the basolateral membrane due to PKC activation may represent a novel mechanism that may contribute to cholestasis...
  73. ncbi request reprint Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity
    M Schmitt
    Medizinische Universitatsklinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Hepatology 33:509-18. 2001
    ..3) Ca(2+)-depletion induces cholestasis by disruption of occludin-determined tight junctional permeability, whereas internalization of canalicular transporters play a minor role...
  74. ncbi request reprint [Current treatment of hepatitis C virus infection]
    J Lörke
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf
    Dtsch Med Wochenschr 130:1773-7. 2005
    ..Because the optimal treatment strategy for patients with an acute hepatitis C infection is still unclear, these patients should be included in clinical studies...
  75. doi request reprint Retrospective analysis of chronic hepatitis D in a West German University Clinic over two decades: migratory pattern, prevalence and clinical outcome
    A Erhardt
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum der Heinrich Heine Universität Düsseldorf
    Z Gastroenterol 48:813-7. 2010
    ..Epidemiology, clinical features and long term-course of chronic hepatitis D were addressed in a non-endemic Central European area...
  76. ncbi request reprint Glucagon-induced expression of the MAP kinase phosphatase MKP-1 in rat hepatocytes
    F Schliess
    Klinik für Gastroenterologie und Infektiologie, Medizinische Einrichtungen der Heinrich Heine Universitat, Dusseldorf, Germany
    Gastroenterology 118:929-36. 2000
    ..Glucagon exerts pleiotropic effects on liver function, but the underlying signal transduction is incompletely understood. We investigated the effect of glucagon on the mitogen-activated protein (MAP) kinase phosphatase MKP-1 expression...
  77. doi request reprint [Pre-exposure prophylaxis in HIV--a vision or soon a reality?]
    S Reuter
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf
    Dtsch Med Wochenschr 134:2582-4. 2009
    ..Paramount questions from the fields of epidemiology, behavioural science, logistics, health politics and ethics should be answered in advance...
  78. ncbi request reprint Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells
    Christine Schafer
    Clinic for Gastroenterology, Hepatology, and Infectiology, Dusseldorf, Germany
    Am J Physiol Gastrointest Liver Physiol 292:G1089-98. 2007
    ..The osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally lead to metabolic alterations that depend on the availability of betaine-derived methyl groups...
  79. ncbi request reprint Bile salt-induced apoptosis involves NADPH oxidase isoform activation
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Gastroenterology 129:2009-31. 2005
    ..Hydrophobic bile salts trigger a rapid oxidative stress response as an upstream event of CD95 activation and hepatocyte apoptosis...
  80. ncbi request reprint Osmosensing by integrins in rat liver
    Freimut Schliess
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Methods Enzymol 428:129-44. 2007
    ..These findings define a novel role of integrins in insulin and glutamine signaling and set an example for mechanotransduction as an integral part of overall growth factor and nutrient signaling...
  81. pmc Activation of integrins by urea in perfused rat liver
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Dusseldorf, D 40225 Dusseldorf, Germany
    J Biol Chem 285:29348-56. 2010
    ..It is concluded that urea at high concentrations affects hepatic metabolism through direct activation of the α(5)β(1) integrin system...
  82. ncbi request reprint Fluorescence resonance energy transfer analysis of proapoptotic CD95-EGF receptor interactions in Huh7 cells
    Andrea Eberle
    Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Hepatology 41:315-26. 2005
    ..In conclusion, we identify EGFR-CD95 interaction and phosphorylation of critical CD95 tyrosine residues as important early events in hyperosmotic and CD95L-induced CD95 activation and apoptosis induction...
  83. ncbi request reprint Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised
    Ulrich Warskulat
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    FASEB J 18:577-9. 2004
    ..The present study identifies taurine transport as a crucial factor for the maintenance of skeletal muscle function and total exercise capacity, while cardiac muscle apparently can compensate for the loss of taurine...
  84. doi request reprint Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes
    Caroline Kruczek
    Clinic for Gastroenterology, Hepatology and Infectiology, Düsseldorf Heinrich Heine University, Dusseldorf, Germany
    Glia 57:79-92. 2009
    ..Whereas Zn2+-dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development...
  85. ncbi request reprint Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells
    Claus Kordes
    Clinic of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Biochem Biophys Res Commun 367:116-23. 2008
    ..The findings demonstrate that beta-catenin-dependent Wnt signaling maintains the quiescent state of HSC and, similar to stem and progenitor cells, influences their developmental fate...
  86. doi request reprint Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo
    Boris Gorg
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Hepatology 48:567-79. 2008
    ..Neuronal and astroglial RNA oxidation increases also in vital mouse brain slices treated with ammonia and TNF-alpha, respectively...
  87. ncbi request reprint Protein kinase C induces endocytosis of the sodium taurocholate cotransporting polypeptide
    Claudia Stross
    Dept of Gastroenterology, Hepatology and Infectiology, Heinrich Heine Univ of Düsseldorf, Germany
    Am J Physiol Gastrointest Liver Physiol 299:G320-8. 2010
    ..In conclusion, Ca(2+)-dependent PKCs induce vesicular retrieval of Ntcp, thereby reducing bile salt uptake. This mechanism may protect hepatocytes from toxic intracellular bile salt concentrations...
  88. ncbi request reprint Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes
    Freimut Schliess
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    FASEB J 16:739-41. 2002
    ..The production of reactive nitrogen intermediates and protein tyrosine nitration may alter astrocyte function and contribute to ammonia neurotoxicity...
  89. ncbi request reprint [Hepatic encephalopathy--therapy]
    M Wettstein
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf
    Dtsch Med Wochenschr 128:2658-60. 2003
  90. ncbi request reprint [Hepatic encephalopathy--case report]
    J Hemker
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf
    Dtsch Med Wochenschr 128:2653. 2003
  91. doi request reprint Hepatosplenic morbidity due to Schistosoma mansoni in schoolchildren on Ukerewe Island, Tanzania
    Tarik El Scheich
    Department of Paediatric Cardiology, University Children s Hospital, Heinrich Heine University, Duesseldorf, Germany
    Parasitol Res 110:2515-20. 2012
    ..Non-specific ultrasonographic abnormalities including hepatosplenomegaly and portal vein dilatation were seen frequently but the fraction attributable to schistosomiasis is difficult to assess...
  92. doi request reprint [Epidemiological and clinical characteristics of patients with echinococcosis - management in an infectiological service in Germany]
    A Orhun
    Tropenmedizinische Ambulanz, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat Dusseldorf, Germany
    Dtsch Med Wochenschr 137:1039-44. 2012
    ..Cystic echinococcosis (CE) is a widespread zoonosis. Difficulties in patient care were investigated in order to improve the clinical management of CE patients...
  93. ncbi request reprint Osmotic regulation of the heat shock response in H4IIE rat hepatoma cells
    F Schliess
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine Universitat, Dusseldorf, Germany
    FASEB J 13:1557-64. 1999
    ..The osmodependence of the H4IIE cell response to heat differs from that recently found in primary rat hepatocytes. The data are discussed in terms of cellular adaption mechanisms and their physiological relevance...
  94. pmc TB or not TB? Difficulties in the diagnosis of tuberculosis in HIV-negative immigrants to Germany
    D D Singh
    Tropenmedizinische Ambulanz, Universitatsklinikum Dusseldorf, Moorenstr 5, Dusseldorf, Germany
    Eur J Med Res 16:381-4. 2011
    ..Immigrants to Germany and their children are at particular risk for tuberculosis (TB). -..
  95. ncbi request reprint Clinical efficacy of L-ornithine-L-aspartate in the management of hepatic encephalopathy
    G Kircheis
    Department of Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Metab Brain Dis 17:453-62. 2002
    ..The therapy had little side effects, increasing with higher intravenously administered dosages, and was well tolerated after oral and parenteral administration...
  96. ncbi request reprint Cell hydration and mTOR-dependent signalling
    F Schliess
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, and San Francisco Hospital, Department for Internal Medicine, Cologne, Germany
    Acta Physiol (Oxf) 187:223-9. 2006
    ....
  97. ncbi request reprint Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation
    S Vom Dahl
    Division of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Dusseldorf, Germany
    J Hepatol 31:741-6. 1999
    ..Based on clinical, laboratory, cytological and and biochemical findings, CESD can clearly be separated from other more frequent inherited lysosomal storage diseases, e.g. atypical forms of Gaucher disease...
  98. doi request reprint Motor impairment in liver cirrhosis without and with minimal hepatic encephalopathy
    M Butz
    Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Dusseldorf, Germany
    Acta Neurol Scand 122:27-35. 2010
    ..Manifest hepatic encephalopathy (HE) goes along with motor symptoms such as ataxia, mini-asterixis, and asterixis. The relevance of motor impairments in cirrhotics without and with minimal HE (mHE) is still a matter of debate...
  99. ncbi request reprint Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells
    Richard Fischer
    Department of Gastroenterology, Hepatology and Infectiology, Medizinische Einrichtungen der Heinrich Heine Universitat, Dusseldorf, Germany
    Gastroenterology 123:845-61. 2002
    ..Hepatic stellate cells play an important role in liver fibrogenesis, and hepatic stellate cell death may be involved in the termination of this response...
  100. ncbi request reprint Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice
    Birgit Heller-Stilb
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    FASEB J 16:231-3. 2002
    ..In particular, the retinal involvement identifies the taurine transporter as an important factor for the development and maintenance of normal retinal functions and morphology...
  101. ncbi request reprint Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis
    Verena Keitel
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Hepatology 41:1160-72. 2005
    ..Upregulation of MRP4, but not of MRP3, might represent an important escape mechanism for bile salt extrusion in PFIC...