Helmut L Haas

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Alpha 2-adrenergic receptor-mediated presynaptic inhibition of GABAergic IPSPs in rat histaminergic neurons
    David R Stevens
    Department of Neurophysiology, Heinrich Heine Universitat, Postfach 101007, D 40001 Duesseldorf, Germany
    Neuropharmacology 46:1018-22. 2004
  2. ncbi request reprint Functional diversity of ventral midbrain dopamine and GABAergic neurons
    Tatiana M Korotkova
    Institute of Neurophysiology, Heinrich Heine University, D 40001 Duesseldorf, Germany
    Mol Neurobiol 29:243-59. 2004
  3. ncbi request reprint OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling
    Sylwia Ammoun
    Department of Neuroscience, Unit of Physiology, Uppsala University, SE 75123 Uppsala, Sweden
    Mol Endocrinol 20:80-99. 2006
  4. doi request reprint Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases
    O Selbach
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Acta Physiol (Oxf) 198:277-85. 2010
  5. pmc The waking brain: an update
    Jian Sheng Lin
    INSERM U628, Integrative Physiology of Brain Arousal Systems, Claude Bernard University, 69373, Lyon, France
    Cell Mol Life Sci 68:2499-512. 2011
  6. ncbi request reprint Comparison of glycine- and GABA-evoked currents in two types of neurons isolated from the rat striatum
    O A Sergeeva
    Department of Physiology II, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosci Lett 243:9-12. 1998
  7. ncbi request reprint Functions of neuronal adenosine receptors
    H L Haas
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:375-81. 2000
  8. doi request reprint Histamine in the nervous system
    Helmut L Haas
    Institute of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Physiol Rev 88:1183-241. 2008
  9. doi request reprint Waking with the hypothalamus
    Helmut L Haas
    Department of Neurophysiology, Heinrich Heine University Dusseldorf, P O Box 101007, 40001, Dusseldorf, Germany
    Pflugers Arch 463:31-42. 2012
  10. ncbi request reprint The role of histamine and the tuberomamillary nucleus in the nervous system
    Helmut Haas
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Nat Rev Neurosci 4:121-30. 2003

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Alpha 2-adrenergic receptor-mediated presynaptic inhibition of GABAergic IPSPs in rat histaminergic neurons
    David R Stevens
    Department of Neurophysiology, Heinrich Heine Universitat, Postfach 101007, D 40001 Duesseldorf, Germany
    Neuropharmacology 46:1018-22. 2004
    ..Inputs from noradrenergic neurons of the brainstem will reduce the inhibitory actions of GABAergic inputs resulting in disinhibition of histaminergic neurons...
  2. ncbi request reprint Functional diversity of ventral midbrain dopamine and GABAergic neurons
    Tatiana M Korotkova
    Institute of Neurophysiology, Heinrich Heine University, D 40001 Duesseldorf, Germany
    Mol Neurobiol 29:243-59. 2004
    ....
  3. ncbi request reprint OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling
    Sylwia Ammoun
    Department of Neuroscience, Unit of Physiology, Uppsala University, SE 75123 Uppsala, Sweden
    Mol Endocrinol 20:80-99. 2006
    ....
  4. doi request reprint Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases
    O Selbach
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Acta Physiol (Oxf) 198:277-85. 2010
    ..Orexins/hypocretins (OX/Hcrt) are hypothalamic neuropeptides linking sleep-wakefulness, appetite and neuroendocrine control. Their role and mechanisms of action on higher brain functions, such as learning and memory, are not clear...
  5. pmc The waking brain: an update
    Jian Sheng Lin
    INSERM U628, Integrative Physiology of Brain Arousal Systems, Claude Bernard University, 69373, Lyon, France
    Cell Mol Life Sci 68:2499-512. 2011
    ..Inhibition of these waking systems by GABAergic neurons allows sleep. Over the past decades, a prominent role became evident for the histaminergic and the orexinergic neurons as a hypothalamic waking center...
  6. ncbi request reprint Comparison of glycine- and GABA-evoked currents in two types of neurons isolated from the rat striatum
    O A Sergeeva
    Department of Physiology II, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosci Lett 243:9-12. 1998
    ..GABA- and glycine- responses were additive and blocked selectively by bicuculline (1 microM) and strychnine (50 nM), respectively. These results predict the presence of alpha- and beta-subunits of the glycine receptor in the striatum...
  7. ncbi request reprint Functions of neuronal adenosine receptors
    H L Haas
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:375-81. 2000
    ....
  8. doi request reprint Histamine in the nervous system
    Helmut L Haas
    Institute of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Physiol Rev 88:1183-241. 2008
    ....
  9. doi request reprint Waking with the hypothalamus
    Helmut L Haas
    Department of Neurophysiology, Heinrich Heine University Dusseldorf, P O Box 101007, 40001, Dusseldorf, Germany
    Pflugers Arch 463:31-42. 2012
    ..This review concentrates on the more recently explored ventral route and the hypothalamus with its different regions involved in the control of the waking state...
  10. ncbi request reprint The role of histamine and the tuberomamillary nucleus in the nervous system
    Helmut Haas
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Nat Rev Neurosci 4:121-30. 2003
  11. ncbi request reprint Co-expression of non-selective cation channels of the transient receptor potential canonical family in central aminergic neurones
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurochem 85:1547-52. 2003
    ..We conclude that several TRPC channel populations exist in individual neurones and that their subunit co-expression pattern is region and cell-type specific...
  12. ncbi request reprint Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling
    O Selbach
    Department of Neurophysiology, Heinrich Heine University, Universitaetsstrasse 1 22 03 01, P O B 101007, D 40001 Dusseldorf, Germany
    Neuroscience 127:519-28. 2004
    ....
  13. pmc GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Physiology II, POB 101007, D 40001 Dusseldorf, Germany
    J Physiol 585:539-48. 2007
    ..These findings help in understanding neuropathologies accompanied by the loss of endogenous taurine, for instance in hepatic encephalopathy...
  14. ncbi request reprint Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    Neuroscience 134:1091-8. 2005
    ....
  15. ncbi request reprint Glycine receptor mediated responses in rat histaminergic neurons
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, POB 101007, D 40001, Dusseldorf, Germany
    Neurosci Lett 300:5-8. 2001
    ..5 microm) the glycine response was absent or very small. We conclude that histaminergic cells are heterogeneous with respect to their sensitivity to glycine and this correlates with their size...
  16. ncbi request reprint Histamine excites noradrenergic neurons in locus coeruleus in rats
    Tatiana M Korotkova
    Institute of Neurophysiology, Heinrich Heine University, Universitaetstrasse 1, 40225 Duesseldorf, Germany
    Neuropharmacology 49:129-34. 2005
    ..These findings underline the coordination between aminergic systems and suggest that the arousal induced by the histamine system could involve excitation of noradrenergic neurons in the locus coeruleus...
  17. ncbi request reprint Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins
    Tatiana M Korotkova
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 23:7-11. 2003
    ..In narcolepsy, in which the orexin system is disrupted, dysfunction of the orexin modulation of VTA neurons may be important in triggering attacks of cataplexy...
  18. ncbi request reprint Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 25:88-95. 2005
    ..The infrequent expression of the epsilon-subunit may be a key factor in the recently discovered central role of the tuberomamillary nucleus in anesthesia...
  19. ncbi request reprint Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline)
    Ritchie E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 22:8850-9. 2002
    ..43 and 1, respectively)...
  20. ncbi request reprint Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat
    T M Korotkova
    Institute for Neurophysiology, Heinrich Heine University, D 40001 Dusseldorf, Germany
    Eur J Neurosci 23:2677-85. 2006
    ..These findings suggest a link between the ability of neuropeptides to promote arousal and their action on VTA neurons...
  21. doi request reprint Developmental alterations of DHPG-induced long-term depression of corticostriatal synaptic transmission: switch from NMDA receptor-dependent towards CB1 receptor-dependent plasticity
    Aisa N Chepkova
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, 40001, Germany
    Pflugers Arch 459:131-41. 2009
    ..These findings are relevant for the pathophysiology and therapy of PD as they link the activation of group I mGluRs, endocannabinoid release, and striatal NO production...
  22. pmc Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models
    Christelle Anaclet
    INSERM U628, Integrated Physiology of Brain Arousal Systems, IFR19, 69373 Lyon, France
    J Neurosci 29:14423-38. 2009
    ....
  23. doi request reprint Orexins/hypocretins and aminergic systems
    K S Eriksson
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Acta Physiol (Oxf) 198:263-75. 2010
    ..This review highlights the role of these players in the control of energy administration, sleep-wake architecture, cortical activation, plasticity, and memory functions in health and disease...
  24. ncbi request reprint Orexin (hypocretin)/dynorphin neurons control GABAergic inputs to tuberomammillary neurons
    Krister S Eriksson
    Department of Neurophysiology, Heinrich Heine University Dusseldorf, Germany
    Eur J Neurosci 19:1278-84. 2004
    ..Thus, orexins excite TM neurons directly and by disinhibition, gated by dynorphin. These data might explain some of the neuropathology of narcolepsy...
  25. doi request reprint Carbenoxolone impairs LTP and blocks NMDA receptors in murine hippocampus
    Aisa N Chepkova
    Department of Neurophysiology, Heinrich Heine University, D 40001 Dusseldorf, Germany
    Neuropharmacology 55:139-47. 2008
    ..Thus the widely used gap junction uncoupler CBX acts as an antagonist at NMDA receptors and consequently impairs the induction of LTP...
  26. pmc Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    Regis Parmentier
    Department of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    J Neurosci 29:4471-83. 2009
    ..Our findings indicate a key role of the brain histamine system in TRH-induced arousal...
  27. ncbi request reprint Hypocretins: the timing of sleep and waking
    Oliver Selbach
    Department of Physiology, Heinrich Heine University, Dusseldorf, Germany
    Chronobiol Int 23:63-70. 2006
    ..Their loss causes narcolepsy, a disease conferring the inability to separate sleep and waking. Their role in appetitive behavior, stress, and memory functions is important to our understanding of addiction and compulsion...
  28. ncbi request reprint Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro
    Tatiana M Korotkova
    Institute for Neurophysiology, Heinrich Heine University, D 40001, Duesseldorf, Germany
    Neurosci Lett 320:133-6. 2002
    ..Our results suggest that histamine does not directly inhibit dopaminergic neurons in SN and VTA, but rather that this inhibition is mediated through histamine-induced excitation of GABAergic neurons...
  29. doi request reprint Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice
    Aisa Chepkova
    Department of Neurophysiology, Heinrich Heine Universitat, 40001, Dusseldorf, Germany
    Cell Mol Neurobiol 32:17-25. 2012
    ..We conclude that the absence of neuronal histamine results in subtle changes in hippocampal synaptic transmission and plasticity associated with alteration in the expression of H3 receptors...
  30. doi request reprint GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies
    Yevgenij Yanovsky
    Molecular Neurophysiology, Heinrich Heine University, 40001, Dusseldorf, Germany
    Pflugers Arch 463:187-99. 2012
    ..Thus, sleep and anaesthesia depend on different GABA(A)R types...
  31. ncbi request reprint Aminergic control of high-frequency (approximately 200 Hz) network oscillations in the hippocampus of the behaving rat
    Alexei A Ponomarenko
    Department of Neurophysiology, Heinrich Heine University, D 40001, Dusseldorf, Germany
    Neurosci Lett 348:101-4. 2003
    ..In the light of these divergent actions via different receptor subtypes the net effect of aminergic innervations will be determined by their state-dependent activities and mutual interactions as well as receptor localizations...
  32. ncbi request reprint Long-term depression of cortico-striatal synaptic transmission by DHPG depends on endocannabinoid release and nitric oxide synthesis
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine University, D 40001, Dusseldorf, Germany
    Eur J Neurosci 26:1889-94. 2007
    ..These findings are relevant for the pathophysiology of PD, as they link the overactivation of group I mGluRs and striatal NO production...
  33. ncbi request reprint Mechanisms of long-lasting enhancement of corticostriatal neurotransmission by taurine
    Aisa N Chepkova
    Institute of Neurophysiology, Heinrich Heine University, Dusseldorf, D 40001, Germany POB 101007
    Adv Exp Med Biol 583:401-10. 2006
    ..2004). Concurrent activation of M1 and PLC-coupled D1 receptors (O'Sullivan et al., 2004) can amplify Ca2+ signal via IP3- stimulated Ca2+ release from intracellular stores and stimulate PKC...
  34. ncbi request reprint Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons
    Tatiana M Korotkova
    Institute of Neurophysiology, Heinrich Heine University, Physiology II, POB 101007, Duesseldorf, Germany
    Eur J Neurosci 22:1287-93. 2005
    ..A higher Pitx3 expression level and higher coexpression of Pitx3 and CB in VTA than in SN neurons may contribute to the different vulnerability of these dopaminergic nuclei to neurodegeneration...
  35. doi request reprint Frequency of network synchronization in the hippocampus marks learning
    Alexey A Ponomarenko
    Institute of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Eur J Neurosci 27:3035-42. 2008
    ..Thus, in addition to the known replay of neuronal firing patterns during ripple oscillations, the rhythm itself appears to be modulated in an experience-specific way and represents a direct correlate of learning...
  36. ncbi request reprint GABA(A) receptor heterogeneity in histaminergic neurons
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    Eur J Neurosci 16:1472-82. 2002
    ..two gamma-subunits in one receptor. Thus, we describe here native GABAA receptor function in relation to its stoichiometry...
  37. pmc Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block
    Yevgenij Yanovsky
    Department of Neurophysiology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e42512. 2012
    ..In conclusion, UDCA enhances alertness through disinhibition, at least partially of the histaminergic system via GABA(A) receptors...
  38. doi request reprint Ammonia-induced deficit in corticostriatal long-term depression and its amelioration by zaprinast
    Aisa N Chepkova
    Department of Neurophysiology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    J Neurochem 122:545-56. 2012
    ..Zaprinast counteracts the ammonia-induced impairment of long-term corticostriatal plasticity and may thus improve fine motor skills and procedural learning in hepatic encephalopathy...
  39. ncbi request reprint Neurotransmitter-induced activation of sodium-calcium exchange causes neuronal excitation
    Krister S Eriksson
    Department of Neurophysiology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Ann N Y Acad Sci 976:405-7. 2002
  40. ncbi request reprint Drugs to interfere with orexins (hypocretins)
    Oliver Selbach
    Department of Neurophysiology, Heinrich Heine University, Dusseldorf, Germany
    Drug News Perspect 16:669-81. 2003
    ....
  41. ncbi request reprint Modafinil inhibits rat midbrain dopaminergic neurons through D2-like receptors
    T M Korotkova
    Department of Neurophysiology, Heinrich Heine Universitat, Universitatstrasse 1, D 40001 Dusseldorf, Germany
    Neuropharmacology 52:626-33. 2007
    ..Thus modafinil directly inhibits DA neurons through D2 receptors...
  42. ncbi request reprint Long-lasting enhancement of corticostriatal transmission by taurine: role of dopamine and acetylcholine
    A N Chepkova
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    Cell Mol Neurobiol 25:767-76. 2005
    ..4. Thus, dopaminergic and cholinergic mechanisms, in concert with the taurine transporter and glycine receptors, contribute critically to the induction of corticostriatal LLE(TAU)...
  43. ncbi request reprint P2Y receptor-mediated excitation in the posterior hypothalamus
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, POB 101007, D 40001 Dusseldorf, Germany
    Eur J Neurosci 24:1413-26. 2006
    ..Excitation of the wake-active TMN neurons by nucleotides and the lack of adenosine action may be important factors in sleep-wake regulation...
  44. ncbi request reprint Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Glia 55:758-71. 2007
    ..The findings further support a close interrelation between osmotic and oxidative stress in astrocytes, which may be relevant to different brain pathologies including hepatic encephalopathy...
  45. ncbi request reprint Co-ordinated expression of 5-HT2C receptors with the NCX1 Na+/Ca2+ exchanger in histaminergic neurones
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurochem 87:657-64. 2003
    ..We conclude that several exchanger-subtypes can be coexpressed in single neurones and that TM cells are heterogeneous with respect to their calcium homeostasis regulation...
  46. ncbi request reprint Taurine rescues hippocampal long-term potentiation from ammonia-induced impairment
    Aisa N Chepkova
    Department of Neurophysiology, Heinrich Heine University, POB 101007, D 40001 Dusseldorf, Germany
    Neurobiol Dis 23:512-21. 2006
    ..It is suggested that taurine may rescue the mechanisms of hippocampal synaptic plasticity by improving mitochondrial function under hyperammonemic conditions...
  47. pmc Guanidinoethyl sulphonate is a glycine receptor antagonist in striatum
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, POB 101007, D 40001 Dusseldorf, Germany
    Br J Pharmacol 137:855-60. 2002
    ..The antagonistic action of GES at inhibitory ionotropic receptors can explain its epileptogenic action. Care must be taken with the interpretation of data on GES evoked taurine release...
  48. pmc Modulation of ATP-induced currents by zinc in acutely isolated hypothalamic neurons of the rat
    Vladimir S Vorobjev
    Department of Neurophysiology, Heinrich Heine University, Duesseldorf, Germany
    Br J Pharmacol 139:919-26. 2003
    ..7. Our data suggest that zinc-induced potentiation of ATP-mediated currents is caused by the slowing of ATP dissociation from the receptor, while inhibition of ATP-induced currents is related to the suppression of ATP receptor gating...
  49. pmc L-Dopa activates histaminergic neurons
    Yevgenij Yanovsky
    Department of Neurophysiology, Heinrich Heine University, D 40001, Dusseldorf, Germany
    J Physiol 589:1349-66. 2011
    ..Taking into consideration the high density of histaminergic fibres and the histamine H3 receptor heteromerization either with D1 or with D2 receptors in the striatum, this study predicts new avenues for PD therapy...
  50. doi request reprint Histamine H3 receptors and sleep-wake regulation
    Jian Sheng Lin
    Institut National de la Sante et de la Recherche Medicale, Integrative Physiology of Brain Arousal Systems, Claude Bernard University, Lyon, France
    J Pharmacol Exp Ther 336:17-23. 2011
    ....
  51. ncbi request reprint Expression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    Neuroscience 104:1043-55. 2001
    ..We demonstrate interspecies differences and heterogeneity in expression and function of glycine receptors within the same neuronal population in the neostriatum...
  52. pmc Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Physiol 550:911-9. 2003
    ..The different mechanisms of taurine-induced synaptic plasticity may reflect the different vulnerabilities of these brain regions under pathological conditions that are accompanied by osmotic changes such as hepatic encephalopathy...
  53. ncbi request reprint AMPA receptor properties and coexpression with sodium-calcium exchangers in rat hypothalamic neurons
    O A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, POB 101007, D 40001 Dusseldorf, Germany
    Eur J Neurosci 19:957-65. 2004
    ....
  54. pmc Expression and function of P2X purinoceptors in rat histaminergic neurons
    Vladimir S Vorobjev
    Department of Neurophysiology, Heinrich Heine Universitat, POB 101007, D 40001 Dusseldorf, Germany
    Br J Pharmacol 138:1013-9. 2003
    ....
  55. ncbi request reprint High frequency (200 Hz) oscillations and firing patterns in the basolateral amygdala and dorsal endopiriform nucleus of the behaving rat
    Alexei A Ponomarenko
    Department of Physiology, Heinrich Heine University, D 40001 Dusseldorf, Germany
    Behav Brain Res 141:123-9. 2003
    ..These data suggest common principles of temporal coding in BL and EPN in certain behavioural states via short scale population synchrony though they convey signals of different modalities...
  56. ncbi request reprint Behavioural parameters in aged rats are related to LTP and gene expression of ChAT and NMDA-NR2 subunits in the striatum
    D Schulz
    Institute of Physiological Psychology, Center for Biological and Medical Research, University of Dusseldorf, Universitatsstr 1, D 40225, Dusseldorf, Germany
    Eur J Neurosci 19:1373-83. 2004
    ..Notably, the correlations found were heterogeneous amid the groups, e.g. variability in place learning was explained by variability in levels of LTP in the superior learners, but in levels of NR2A-B mRNA in the inferior group...
  57. ncbi request reprint Editing of AMPA and serotonin 2C receptors in individual central neurons, controlling wakefulness
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, POB 101007, 40001 Dusseldorf, Germany
    Cell Mol Neurobiol 27:669-80. 2007
    ....
  58. ncbi request reprint Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice
    Nanuli Doreulee
    Department of Physiology II, Heinrich Heine Universitat, POB 101007, D 40001 Dusseldorf, Germany
    Brain Res 964:159-63. 2003
    ..Impairment of NO-synthesis thus shifts striatal plasticity towards LTD. This indicates a possible involvement of eNOS from endothelia in neuronal modulation...
  59. pmc Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors
    Olga A Sergeeva
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat, 44780 Bochum, Germany
    J Biol Chem 285:23985-93. 2010
    ..In conclusion, with the help of FDDs we reveal a functional expression of beta1-containing GABA(A)Rs in the hypothalamus, offering a new tool for studies on the functional diversity of native GABA(A)Rs...
  60. ncbi request reprint Multiple GABAA receptor subtypes regulate hippocampal ripple oscillations
    A A Ponomarenko
    Department of Neurophysiology, Heinrich Heine University, D 40001 Duesseldorf, Germany
    Eur J Neurosci 20:2141-8. 2004
    ..The results suggest a differential role of GABAA receptor subtype specific inhibitory mechanisms in the mediation and fine-tuning of the network synchronization during approximately 200 Hz hippocampal oscillations...
  61. doi request reprint The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABA(A) receptors
    S R Schubring
    Heinrich Heine University, Medical Faculty, Molecular Neurophysiology, D 40225 Dusseldorf, Germany
    Neurosci Lett 506:322-6. 2012
    ..GABAergic synaptic currents displayed a faster decay under BS. Our data provide new insight into extrahepatic functions of BS revealing their neuroactive potential...
  62. ncbi request reprint Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro
    Tatiana M Korotkova
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Regul Pept 104:83-9. 2002
    ..The orexin excitation of SN reticulata cells may help to maintain their high firing rate during waking. Furthermore, the absence of orexin effects in narcolepsy may predispose affected individuals to attacks of cataplexy...
  63. doi request reprint Alterations of corticostriatal plasticity by ammonium and rescue by green tea polyphenols
    Aisa N Chepkova
    Department of Neurophysiology, Heinrich Heine University, D 40204 Düsseldorf, Germany
    Arch Biochem Biophys 536:176-82. 2013
    ..Alterations in NMDA-induced plasticity were prevented by treatment with green tea polyphenols suggesting the contribution of oxidative stress to the expression of abnormal corticostriatal plasticity. ..
  64. ncbi request reprint Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators
    Ulrich Steidl
    Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Duesseldorf, Germany
    Blood 104:81-8. 2004
    ..In conclusion, these findings suggest a molecular interrelation of neuronal and hematopoietic signaling mechanisms in humans...
  65. pmc Histidine-decarboxylase knockout mice show deficient nonreinforced episodic object memory, improved negatively reinforced water-maze performance, and increased neo- and ventro-striatal dopamine turnover
    Ekrem Dere
    Institute of Physiological Psychology, University of Dusseldorf, D 40225 Dusseldorf, Germany
    Learn Mem 10:510-9. 2003
    ....
  66. pmc Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity
    Stefan Berger
    German Cancer Research Center, Division Molecular Biology of the Cell I, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:195-200. 2006
    ..This genetic model provides important information about the consequences of a permanently altered balance between limbic MR and GR, with implications for stress-related neuroendocrine and neuropsychiatric diseases...