R Freynhagen

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens
    Rainer Freynhagen
    Klinik fur Anaesthesiologie, Universitatsklinikum Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Pain 115:254-63. 2005
  2. ncbi request reprint The effect of mirtazapine in patients with chronic pain and concomitant depression
    R Freynhagen
    Department of Anesthesiology, University of Dusseldorf, Germany
    Curr Med Res Opin 22:257-64. 2006
  3. ncbi request reprint [Effectiveness and time to onset of pregabalin in patients with neuropathic pain]
    R Freynhagen
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf
    Schmerz 20:285-8, 290-2. 2006
  4. ncbi request reprint Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine
    R Freynhagen
    Department of Anaesthesiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Int J Clin Pract 61:1989-96. 2007
  5. ncbi request reprint Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients
    A Koch
    Department of Anesthesiology, Heinrich Heine University of Dusseldorf, 40225, Dusseldorf, Moorenstr 5, Germany
    Inflamm Res 56:32-7. 2007
  6. doi request reprint Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats
    Uta Muth-Selbach
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf, Moorenstr 5, Postfach 101007, 40225 Dusseldorf, Germany
    Brain Res Bull 79:63-8. 2009
  7. ncbi request reprint Regeneration of baroafferents after implantation into different vessels
    Markus F Stevens
    Department of Anesthesiology, University Hospital Dusseldorf, Dusseldorf, Germany
    J Peripher Nerv Syst 12:40-9. 2007
  8. pmc Efficacy and safety of lacosamide in painful diabetic neuropathy
    Dan Ziegler
    nstitute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, and the Department of Metabolic Diseases, University Hospital, Dusseldorf, Germany
    Diabetes Care 33:839-41. 2010
  9. ncbi request reprint Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats
    Rainer Freynhagen
    Klinik fur Anaesthesiologie, Moorenstrasse 5, Universitatsklinikum Dusseldorf, D 40225 Dusseldorf, Germany
    Brain Res Bull 69:168-73. 2006
  10. ncbi request reprint Increase in skin temperature after spinal anesthesia in infants
    Martin Jetzek-Zader
    Department of Anesthesiology, University of Dusseldorf, Dusseldorf, Germany
    Reg Anesth Pain Med 31:519-22. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens
    Rainer Freynhagen
    Klinik fur Anaesthesiologie, Universitatsklinikum Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Pain 115:254-63. 2005
    ..Pregabalin dosing aimed at optimal balance of efficacy and tolerability provides significant pain relief and may reduce risks for AEs and therapy discontinuation...
  2. ncbi request reprint The effect of mirtazapine in patients with chronic pain and concomitant depression
    R Freynhagen
    Department of Anesthesiology, University of Dusseldorf, Germany
    Curr Med Res Opin 22:257-64. 2006
    ..To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study...
  3. ncbi request reprint [Effectiveness and time to onset of pregabalin in patients with neuropathic pain]
    R Freynhagen
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf
    Schmerz 20:285-8, 290-2. 2006
    ..The data from a previously published 12-week randomised, double-blind, placebo-controlled multicentre study on the efficacy and safety of pregabalin were analyzed for time to onset of analgesic action with neuropathic pain...
  4. ncbi request reprint Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine
    R Freynhagen
    Department of Anaesthesiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Int J Clin Pract 61:1989-96. 2007
    ..We aimed to investigate pregabalin, a gamma-aminobutyric acid (GABA)-analogue, in a wide range of pregabalin naive patients with treatment refractory NeP...
  5. ncbi request reprint Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients
    A Koch
    Department of Anesthesiology, Heinrich Heine University of Dusseldorf, 40225, Dusseldorf, Moorenstr 5, Germany
    Inflamm Res 56:32-7. 2007
    ..To document this, we investigated whether a range of cytokines and NO were detectable in the plasma of chronic pain patients and whether cytokine and NO levels correlated with pain severity...
  6. doi request reprint Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats
    Uta Muth-Selbach
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf, Moorenstr 5, Postfach 101007, 40225 Dusseldorf, Germany
    Brain Res Bull 79:63-8. 2009
    ....
  7. ncbi request reprint Regeneration of baroafferents after implantation into different vessels
    Markus F Stevens
    Department of Anesthesiology, University Hospital Dusseldorf, Dusseldorf, Germany
    J Peripher Nerv Syst 12:40-9. 2007
    ....
  8. pmc Efficacy and safety of lacosamide in painful diabetic neuropathy
    Dan Ziegler
    nstitute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, and the Department of Metabolic Diseases, University Hospital, Dusseldorf, Germany
    Diabetes Care 33:839-41. 2010
    ..To evaluate efficacy and safety of lacosamide compared with placebo in painful diabetic polyneuropathy...
  9. ncbi request reprint Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats
    Rainer Freynhagen
    Klinik fur Anaesthesiologie, Moorenstrasse 5, Universitatsklinikum Dusseldorf, D 40225 Dusseldorf, Germany
    Brain Res Bull 69:168-73. 2006
    ..As R(-)-mirtazapine exerts the antinociceptive activity of the racemic mixture it may be a putative candidate for an enantioselective use as analgesic...
  10. ncbi request reprint Increase in skin temperature after spinal anesthesia in infants
    Martin Jetzek-Zader
    Department of Anesthesiology, University of Dusseldorf, Dusseldorf, Germany
    Reg Anesth Pain Med 31:519-22. 2006
    ..Thus, the authors evaluated sympathetic block primarily by measurement of skin temperature and secondarily by determination of noninvasive blood pressure as an indirect sign of sympatholysis...
  11. ncbi request reprint Screening of neuropathic pain components in patients with chronic back pain associated with nerve root compression: a prospective observational pilot study (MIPORT)
    Rainer Freynhagen
    Department of Anesthesiology, Heinrich Heine University, Universitatsklinikum Dusseldorf, Germany
    Curr Med Res Opin 22:529-37. 2006
    ..We also aimed to assess the usefulness of handheld computers (PDAs) in data collection...
  12. ncbi request reprint The evaluation of neuropathic components in low back pain
    Rainer Freynhagen
    Department of Anaesthesiology, Critical Care Medicine, Pain Therapy and Palliative Care, Benedictus Krankenhaus Tutzing, Bahnhofstrasse 5, Tutzing 82327, Germany
    Curr Pain Headache Rep 13:185-90. 2009
    ..In connection with the specific instance of back pain (one of the single most costly disorders in many industrialized nations), neuropathic pain components are a significant cost factor...
  13. doi request reprint Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system
    Uta Muth-Selbach
    Department of Anesthesiology, University of Duesseldorf, Germany
    Eur J Pharmacol 613:68-73. 2009
    ....
  14. ncbi request reprint Imaging pain modulation by subanesthetic S-(+)-ketamine
    Till Sprenger
    Neurologische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    Anesth Analg 103:729-37. 2006
    ..This part of the anterior cingulate cortex (midcingulate cortex) has been linked with the affective pain component that underlines the potency of ketamine in modulating affective pain processing...
  15. ncbi request reprint Pregabalin for relief of neuropathic pain associated with diabetic neuropathy: a randomized, double-blind study
    Thomas Tölle
    Neurologic Clinic, Technical University of Munich, Germany
    Eur J Pain 12:203-13. 2008
    ..0263 vs placebo). Pregabalin was well tolerated at all dosages; adverse events were generally mild to moderate. Number needed to harm (discontinuation because of adverse events) was 10.3 for pregabalin 600 mg/day...
  16. ncbi request reprint Switching from reservoir to matrix systems for the transdermal delivery of fentanyl: a prospective, multicenter pilot study in outpatients with chronic pain
    Rainer Freynhagen
    Departments of Anesthesiology, University of Dusseldorf, Dusseldorf, Germany
    J Pain Symptom Manage 30:289-97. 2005
    ..Reservoir and matrix systems appear to have comparable efficacy and safety so that outpatients can be switched directly from the reservoir to the matrix system without difficulties and new dose titration...
  17. doi request reprint Paper versus electronic rating scales for pain assessment: a prospective, randomised, cross-over validation study with 200 chronic pain patients
    Uwe Junker
    Klinikum Remscheid, Abteilung Spezielle Schmerztherapie und Palliativmedizin, Germany
    Curr Med Res Opin 24:1797-806. 2008
    ....
  18. ncbi request reprint painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain
    Rainer Freynhagen
    Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Curr Med Res Opin 22:1911-20. 2006
    ....
  19. ncbi request reprint Pseudoradicular and radicular low-back pain--a disease continuum rather than different entities? Answers from quantitative sensory testing
    Rainer Freynhagen
    Department of Anesthesiology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Pain 135:65-74. 2008
    ..The spatial incongruence of pain and sensory loss in pseudoradicular pain, however, may also indicate that the two are not causally related...
  20. ncbi request reprint Using screening tools to identify neuropathic pain
    Michael I Bennett
    Clinical Teaching and Research Unit, St Gemma s Hospice, 329 Harrogate Road, Leeds LS17 6QD, UK
    Pain 127:199-203. 2007