Doreen M Floss
Affiliation: Heinrich Heine University
Floss D, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, et al
. Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases. Mol Biol Cell. 2016;27:2301-16 pubmed publisher
..In addition, our data demonstrate that association of Jak2 with IL-23R is mandatory for IL-12 and/or IL-23 signaling, whereas Tyk2 seems to be dispensable. ..
SchrÃ¶der J, Moll J, Baran P, GrÃ¶tzinger J, Scheller J, Floss D. Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor Î²1 via site II and induces p19/interleukin 23 receptor interaction via site III. J Biol Chem. 2015;290:359-70 pubmed publisher
..Furthermore, our data help to explain why p40 is an antagonist of IL-23 and IL-12 signaling and show that site II of p19 is dispensable for IL-23 signaling. ..
Floss D, SchrÃ¶der J, Franke M, Scheller J. Insights into IL-23 biology: From structure to function. Cytokine Growth Factor Rev. 2015;26:569-78 pubmed publisher
..Therefore, we focused on IL-23 receptor complex assembly, signal transduction and functional relevance of IL-23R SNPs in the context of IL-23-inhibitory principles. ..
Floss D, Schonberg M, Franke M, Horstmeier F, Engelowski E, Schneider A, et al
. IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling. Sci Rep. 2017;7:15172 pubmed publisher
..In summary, our receptor shuffling approach highlights an interchangeable, modular domain structure among IL-6- and IL-12-type cytokine receptors and enabled synthetic IL-35 and IL-39 signaling. ..