Doreen M Floss


Affiliation: Heinrich Heine University
Country: Germany


  1. Floss D, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, et al. Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases. Mol Biol Cell. 2016;27:2301-16 pubmed publisher
    ..In addition, our data demonstrate that association of Jak2 with IL-23R is mandatory for IL-12 and/or IL-23 signaling, whereas Tyk2 seems to be dispensable. ..
  2. Schröder J, Moll J, Baran P, Grötzinger J, Scheller J, Floss D. Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III. J Biol Chem. 2015;290:359-70 pubmed publisher
    ..Furthermore, our data help to explain why p40 is an antagonist of IL-23 and IL-12 signaling and show that site II of p19 is dispensable for IL-23 signaling. ..
  3. Floss D, Schröder J, Franke M, Scheller J. Insights into IL-23 biology: From structure to function. Cytokine Growth Factor Rev. 2015;26:569-78 pubmed publisher
    ..Therefore, we focused on IL-23 receptor complex assembly, signal transduction and functional relevance of IL-23R SNPs in the context of IL-23-inhibitory principles. ..
  4. Floss D, Schonberg M, Franke M, Horstmeier F, Engelowski E, Schneider A, et al. IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling. Sci Rep. 2017;7:15172 pubmed publisher
    ..In summary, our receptor shuffling approach highlights an interchangeable, modular domain structure among IL-6- and IL-12-type cytokine receptors and enabled synthetic IL-35 and IL-39 signaling. ..