H G Fischer

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Cytokine responses induced by Toxoplasma gondii in astrocytes and microglial cells
    H G Fischer
    Institut für Medizinische Mikrobiologie und Virologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Eur J Immunol 27:1539-48. 1997
  2. ncbi request reprint Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brain
    H G Fischer
    Institute for Medical Microbiology and Virology, Duesseldorf, Germany
    Parasitol Res 83:637-41. 1997
  3. ncbi request reprint GRA7, an excretory 29 kDa Toxoplasma gondii dense granule antigen released by infected host cells
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine Universitat, Dusseldorf, Germany
    Mol Biochem Parasitol 91:251-62. 1998
  4. ncbi request reprint Brain dendritic cells and macrophages/microglia in central nervous system inflammation
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Duesseldorf, Germany
    J Immunol 166:2717-26. 2001
  5. ncbi request reprint Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Duesseldorf, Germany
    J Immunol 164:4826-34. 2000
  6. ncbi request reprint Attenuation of mouse-virulent Toxoplasma gondii parasites is associated with a decrease in interleukin-12-inducing tachyzoite activity and reduced expression of actin, catalase and excretory proteins
    N Nischik
    Institute for Medical Microbiology and Virology, Heinrich-Heine-University, , , Germany
    Microbes Infect 3:689-99. 2001
  7. ncbi request reprint Antigen presentation function of brain-derived dendriform cells depends on astrocyte help
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Universitatsstrasse 1, Geb 22 21, 40225 Dusseldorf, Germany
    Int Immunol 11:1265-74. 1999
  8. ncbi request reprint Toxoplasma gondii induction of interleukin-12 is associated with acute virulence in mice and depends on the host genotype
    B Schade
    Institute for Medical Microbiology and Virology, Heinrich-Heine-University, , , Germany
    Vet Parasitol 100:63-74. 2001
  9. ncbi request reprint T cell receptor specificities of Toxoplasma gondii-reactive mouse CD4+ T lymphocytes and Th1 clones
    G Reichmann
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Dusseldorf, Germany
    Med Microbiol Immunol 186:25-30. 1997

Collaborators

  • U Gross
  • B Schade
  • G Reichmann
  • N Nischik
  • K Dytnerska
  • H Dlugonska

Detail Information

Publications9

  1. ncbi request reprint Cytokine responses induced by Toxoplasma gondii in astrocytes and microglial cells
    H G Fischer
    Institut für Medizinische Mikrobiologie und Virologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Eur J Immunol 27:1539-48. 1997
    ..gondii-induced pathway of astroglia activation characterized by the release of IL-1 which may drive local inflammatory reaction both at initial infection of the brain and during reactivating toxoplasmosis...
  2. ncbi request reprint Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brain
    H G Fischer
    Institute for Medical Microbiology and Virology, Duesseldorf, Germany
    Parasitol Res 83:637-41. 1997
    ..These findings demonstrate that both glial and neuronal host cells allow T. gondii encystation in the absence of T cell-derived cytokines and imply that a brain-internal spreading of bradyzoites may sustain chronic infection...
  3. ncbi request reprint GRA7, an excretory 29 kDa Toxoplasma gondii dense granule antigen released by infected host cells
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine Universitat, Dusseldorf, Germany
    Mol Biochem Parasitol 91:251-62. 1998
    ..Thus, p29 which is named dense granule protein (GRA)7 may indicate the presence of intracellular toxoplasma...
  4. ncbi request reprint Brain dendritic cells and macrophages/microglia in central nervous system inflammation
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Duesseldorf, Germany
    J Immunol 166:2717-26. 2001
    ..These DC functionally mature upon disease onset and can differentiate from resident microglia. Their emergence, maturation, and prolonged activity within the brain might contribute to the chronicity of intracerebral Th1 responses...
  5. ncbi request reprint Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Duesseldorf, Germany
    J Immunol 164:4826-34. 2000
    ..In sum, these results demonstrate T. gondii-induced expansion and functional maturation of DC in the CNS and, thus, highlight a mechanism that may contribute to the chronicity of the host response...
  6. ncbi request reprint Attenuation of mouse-virulent Toxoplasma gondii parasites is associated with a decrease in interleukin-12-inducing tachyzoite activity and reduced expression of actin, catalase and excretory proteins
    N Nischik
    Institute for Medical Microbiology and Virology, Heinrich-Heine-University, , , Germany
    Microbes Infect 3:689-99. 2001
    ..gondii infection in vivo and parasite synthesis of actin, catalase and several excretory proteins, and thus postulate a role for these molecules in acute virulence...
  7. ncbi request reprint Antigen presentation function of brain-derived dendriform cells depends on astrocyte help
    H G Fischer
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Universitatsstrasse 1, Geb 22 21, 40225 Dusseldorf, Germany
    Int Immunol 11:1265-74. 1999
    ..In sum, these findings ascribe an immature DC phenotype to GM-CSF-grown myeloid brain cells and indicate a role for astrocytic M-CSF in maintaining their antigen presentation function...
  8. ncbi request reprint Toxoplasma gondii induction of interleukin-12 is associated with acute virulence in mice and depends on the host genotype
    B Schade
    Institute for Medical Microbiology and Virology, Heinrich-Heine-University, , , Germany
    Vet Parasitol 100:63-74. 2001
    ..gondii pathogenicity...
  9. ncbi request reprint T cell receptor specificities of Toxoplasma gondii-reactive mouse CD4+ T lymphocytes and Th1 clones
    G Reichmann
    Institute for Medical Microbiology and Virology, Heinrich Heine University, Dusseldorf, Germany
    Med Microbiol Immunol 186:25-30. 1997
    ..Thus, we describe the heterogeneity of toxoplasmic immunodominant T cell antigens including a 58-kDa group I-restricted molecule which may provide a marker for virulent isolates...