Research Topics
Species | A ErhardtSummaryAffiliation: Heinrich Heine University Country: Germany Publications
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Detail Information
Publications
Response to antiviral treatment in patients infected with hepatitis B virus genotypes E-HAndreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
J Med Virol 81:1716-20. 2009..Lower rates of response to IFN-alpha in patients with HBV genotype G might be related to the frequent occurrence of double infection...
[Iron as comorbid factor in chronic hepatitis C]Andreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf
Med Klin (Munich) 98:685-91. 2003..Thus, HFE mutations and liver iron stores seem to be important comorbid factors in chronic hepatitis C. Screening for iron parameters and HFE mutations should be considered in patients with hepatitis C...
[Transient elastography for diagnosing liver cirrhosis]A Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf
Dtsch Med Wochenschr 131:2765-9. 2006..Detection of liver cirrhosis has numerous implications because of the potential sequelae of cirrhosis. Transient elastography (Fibroscan), was evaluated as a novel, non-invasive means of assessing cirrhosis by measuring liver stiffness...
HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosisAndreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
J Hepatol 38:335-42. 2003..The impact of heterozygous HFE mutations on the course of chronic hepatitis C and iron indices was studied...
[Update hepatitis D]Andreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf
Med Klin (Munich) 101:127-34. 2006..Pegylated interferons, a prolongation of treatment beyond 12 months, combination therapies with ribavirin and prenylation inhibitors are possibly new therapeutic options in chronic hepatitis C...
[Hepatocellular carcinoma: rising incidence of hepatitis C virus-associated cases at a university clinic in Germany]A Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologiem, Germany
Dtsch Med Wochenschr 127:2665-8. 2002..The aim of the present, retrospective study was to determine changes in the incidence rates and risk factors for HCC in Germany based on the data of a single center...
Treatment of chronic hepatitis delta with pegylated interferon-alpha2bAndreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany
Liver Int 26:805-10. 2006..Chronic hepatitis D is difficult to treat. The present pilot study investigated the efficacy and tolerability of pegylated (PEG)-interferon (IFN)-alpha2b in chronic hepatitis D...
HFE mutations in idiopathic dilated cardiomyopathyAndreas Erhardt
Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Duesseldorf, Germany
Med Klin (Munich) 101:135-8. 2006..The present study investigated, whether mutations of the hemochromatosis (HFE) gene might be etiologic and disease-modifying factors in idiopathic dilated cardiomyopathy..
Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype DA Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
Gut 54:1009-13. 2005..Current interferon alfa (IFN) treatment of chronic hepatitis B has limited efficacy. The role of hepatitis B virus (HBV) genotypes for response to IFN was investigated...
Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell lineAndreas Erhardt
Klinik fur Gastroenterologie, Hepatologie, und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
Virology 292:272-84. 2002..This was accompanied by an activation of c-Jun and ATF-2, but not Elk-1 and c-Fos. Furthermore, AP-1 activation was independent of c-Fos. Full-length and N(c)-truncated HCV core proteins exerted similar effects...
A seropneumothorax?Andreas Erhardt
Department of Internal Medicine, Heinrich Heine Universitat, 40225, Dusseldorf, Germany
Lancet 359:578. 2002
Successful treatment of hepatitis B virus associated polyarteritis nodosa with a combination of prednisolone, alpha-interferon and lamivudineA Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektologie, Heinrich Heine University, Dusseldorf Germany
J Hepatol 33:677-83. 2000..The present protocol of short-term prednisolone administration combined with alpha-interferon and lamivudine was effective for the treatment of HBV-related polyarteritis nodosa and may be a promising new therapeutic approach...
Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis BA Erhardt
Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
Hepatology 31:716-25. 2000..Our data suggest that HBV genome mutations located within the BCP are determinants of a response to IFN therapy...
Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatmentAndreas Erhardt
Klinik fur Gastroenterologie, Hepatologie and Infektiologie, Universitätsklinik Düsseldorf, Dusseldorf, Germany
Antivir Ther 14:23-32. 2009..BILB 1941 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase in vitro...
Combination therapy of active HBsAg vaccination and interferon-alpha in interferon-alpha nonresponders with chronic hepatitis BT Heintges
Department of Gastroenterology, Hepatology and Infectious Diseases, , Germany
Dig Dis Sci 46:901-6. 2001..This combination therapy seems to offer a new and promising approach for patients with chronic hepatitis B virus infection...
[Current treatment of hepatitis C virus infection]J Lörke
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf
Dtsch Med Wochenschr 130:1773-7. 2005..Because the optimal treatment strategy for patients with an acute hepatitis C infection is still unclear, these patients should be included in clinical studies...
Trimodal therapy in squamous cell carcinoma of the esophagusC Matuschek
Klinik für Strahlentherapie und Radiologische Onkologie, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
Eur J Med Res 16:437-44. 2011..In the future, early response evaluation and molecular biological tests could be important diagnostic tools in influencing the treatment decisions of ESCC patients...
Therapy outcome in patients with chronic hepatitis C: role of therapy supervision by expert hepatologistsA Sagir
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Moorenstr, Dusseldorf, Germany
J Viral Hepat 14:633-8. 2007..015). Patients with unfavourable genotypes 1 and 4 or with advanced liver damage benefit from HCV therapy supervision by a specialist, probably because of less frequent treatment interruptions or dose reductions...
Prognosis of chronic hepatitis C: results of a large, prospective cohort studyC Niederau
Department of Medicine, Division of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
Hepatology 28:1687-95. 1998..The age at diagnosis therefore should play a major role in therapeutic considerations. The present data also suggest that interferon therapy has a long-term clinical benefit, although it did not reduce the risk of liver cancer...
Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitisKalliopi Zachou
Department of Gastroenterology, Hepatology and Endocrinology, Hanover Medical School, Hanover, Germany
Liver Int 30:430-7. 2010..ii) Biochemical parameters did not accurately indicate the stage and grade of liver disease in chronic HDV and thus liver biopsy seems to remain the major tool for the evaluation of delta hepatitis patients...
Combination treatment of IFNalpha2b and ribavirin in patients with chronic hepatitis C and persistently normal ALTsAndreas Erhardt
, Hepatologie und Infektiologie, , , Germany
Dig Dis Sci 48:921-5. 2003..Treatment was discontinued in 3 patients due to side effects. Interferon (IFN) ribavirin combination therapy is effective in patients with normal ALTs and appears superior to IFN monotherapy...
[Increasing number and improved survival of patients with hepatocellular carcinoma from 1988 to 2007: data of a German university clinic]A Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf
Z Gastroenterol 49:720-7. 2011..The aim of the present study was to determine changes of clinical-epidemiological parameters and survival rates during two decades...
Do insulin-like growth factor associated proteins qualify as a tumor marker? Results of a prospective study in 163 cancer patientsC Matuschek
Department of Radiation Therapy and Radiooncology, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat, Duesseldorf, Germany
Eur J Med Res 16:451-6. 2011..It has never been evaluated, if the IGF-system can serve as a tumor marker in neoplasms...
Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infectionI Mederacke
Department of Gastroenterology, Hannover Medical School, Hannover, Germany
J Viral Hepat 19:387-95. 2012..Combination treatment of PegIFNα-2a+ADV in chronic hepatitis B/D co-infection did not lead to any further impairment of kidney function...
[HIV-HBV-coinfection--diagnosis and therapy]S Koch
, Hepatologie und Infektiologie, , Moorenstrasse 5,
Dtsch Med Wochenschr 131:1873-7. 2006
Sunitinib induced pyoderma gangrenosum-like ulcerationsS Akanay-Diesel
Universitatsklinikum Dusseldorf, Heinrich Heine Universitat, Duesseldorf, Germany
Eur J Med Res 16:491-4. 2011..Here, we demonstrate that pyoderma gangrenosum-like ulcers may represent a serious side effect of sunitinib-based anti-cancer treatment...
Induction of autoimmune hepatitis by pegylated interferon alfa-2b in chronic hepatitis CJulia Lörke
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat, Dusseldorf, Germany
Clin Gastroenterol Hepatol 2:xx. 2004
Cholestatic liver diseases from child to adult: the diversity of MDR3 diseaseR Kubitz
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf
Z Gastroenterol 49:728-36. 2011..Even the same mutation may be associated with varying disease progression...
Retrospective analysis of chronic hepatitis D in a West German University Clinic over two decades: migratory pattern, prevalence and clinical outcomeA Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum der Heinrich Heine Universität Düsseldorf
Z Gastroenterol 48:813-7. 2010..Epidemiology, clinical features and long term-course of chronic hepatitis D were addressed in a non-endemic Central European area...
[Diagnosis of focal liver lesions in cirrhotic patients: comparison of contrast-enhanced ultrasound using sulphur hexafluoride (SF6) microbubbles and MRI using Gd-EOB-DTPA]D Blondin
Institut fur Radiologie, Heinrich Heine Universitat Dusseldorf
Z Gastroenterol 49:23-9. 2011..The diagnostic accuracies of contrast-enhanced sonography and hepatobiliary contrast-enhanced MRI of the liver in evaluating focal liver lesions in patients with liver cirrhosis were compared...
Plasma levels of vitamin E and carotenoids are decreased in patients with Nonalcoholic Steatohepatitis (NASH)Andreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
Eur J Med Res 16:76-8. 2011..Oxidative stress is suggested to play an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The present study was aimed to compare plasma levels of antioxidants in patients suffering from NASH and healthy controls...
Relapse to prior therapy is the most important factor for the retreatment response in patients with chronic hepatitis C virus infectionAbdurrahman Sagir
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Dusseldorf, Germany
Liver Int 27:954-9. 2007..In this report, we investigated response rates to combination therapy [standard IFN-alpha or PEG-IFN-alpha and ribavirin] in patients who relapsed or failed in prior therapy...
SEN virus does not affect treatment response in hepatitis C virus coinfected patients but SEN virus response depends on SEN virus DNA concentrationAbdurrahman Sagir
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitatsklinikum Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
World J Gastroenterol 10:1893-7. 2004..To clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-alpha) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination therapy on SENV...
SEN virus seroprevalence in HIV positive patients: association with immunosuppression and HIV-replicationAbdurrahman Sagir
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, der Universitätsklinik Düsseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
J Clin Virol 33:183-7. 2005..The results were correlated with clinical markers such as HIV stage, CD4 cell count, HIV-RNA positivity, HAART or the transmission mode in HIV infected individuals...
SEN virus has an adverse effect on the survival of HIV-positive patientsAbdurrahman Sagir
Clinic for Gastroenterology, Hepatology and Infections bInstitute of Virology, University of Dusseldorf, Dusseldorf, Germany
AIDS 19:1091-6. 2005..Patients infected with HIV are often coinfected with other viruses...
The German guideline for the management of hepatitis B virus infection: short versionM Cornberg
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
J Viral Hepat 15:1-21. 2008
SEN virus infectionAbdurrahman Sagir
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
Rev Med Virol 14:141-8. 2004..Data for other acute and chronic liver diseases are sparse. Further studies are needed to define the pathogenesis and clinical importance of SEN-V infection...
New multi protein patterns differentiate liver fibrosis stages and hepatocellular carcinoma in chronic hepatitis C serum samplesThomas Göbel
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
World J Gastroenterol 12:7604-12. 2006....
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tractC Matuschek
Klinik für Strahlentherapie und Radiologische Onkologie, Heinrich Heine Universitat Dusseldorf, Germany
Eur J Med Res 16:265-74. 2011..In addition, there are no standard recommendations for adjuvant chemotherapy or chemoradiation after R0 resection and adequate lymph node dissection...
IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3Johannes G Bode
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Medizinische Klinik der Heinrich Heine Universität, 40255 Düsseldorf, Germany
FASEB J 17:488-90. 2003..These IFN-antagonistic properties of the HCV core protein may be part of the molecular basis of IFN-alpha unresponsiveness in about one-half of chronically infected HCV-patients...
Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damageAbdurrahman Sagir
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Dusseldorf, Germany
Hepatology 47:592-5. 2008..CONCLUSION: Transient elastography frequently yields pathologically high values in patients with acute liver damage and is unsuitable for detecting cirrhosis/fibrosis in these patients...
Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphataseErwin Daniel Brenndörfer
Department of Gastroenterology, Hepatology and Infectiology, University Hospital, Heinrich Heine University of Dusseldorf, Germany
Hepatology 49:1810-20. 2009..Hence, therapeutic targeting of NS3/4A may not only disturb viral replication by blocking the processing of the viral polyprotein but also exerts unforeseen indirect antiviral effects, further diminishing viral replication...
Cloning and molecular characterization of human high affinity antibody fragments against Hepatitis C virus NS3 helicaseKathi Tessmann
Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstr. 5, 40225, , Germany
J Virol Methods 103:75-88. 2002..Employing vectors for transduction of the encoding cDNA into infected cells might be a novel gene therapy strategy for intracellular immunization against chronic HCV infection...
Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patientsHolger Hinrichsen
Medizinische Universitatsklinik, Kiel, Germany
Gastroenterology 127:1347-55. 2004..BILN 2061 is a potent and specific inhibitor of HCV serine protease in vitro. Preclinical toxicology data and studies in healthy volunteers supported the administration of BILN 2061 to patients with HCV infection...
HFE gene mutations and iron metabolism in Wilson's diseaseAndreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie des Universitätsklinikums Düsseldorf, Klinik für Neurologie des Universitätsklinikums Düsseldorf
Liver 22:474-8. 2002..There is increasing evidence for an interaction between iron and copper metabolism...
Mating frequency influences nectar amino acid preference of Pieris napiJovanne Mevi-Schutz
Department of Integrative Biology, Section of Conservation Biology NLU, University of Basel, St Johanns Vorstadt 10, CH 4056 Basel, Switzerland
Proc Biol Sci 271:153-8. 2004..These results indicate a versatile response of females to nectar amino acids, depending on their nutritional status; they may even switch their source of amino acids between adult feeding and nuptial gifts...
Budesonide-induced acute hepatitis in an HIV-positive patient with ritonavir as a co-medicationAbdurrahman Sagir
AIDS 16:1191-2. 2002
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramidePhilipp A Lang
Institute of Physiology University of Tübingen, 72076 Tubingen, Germany
Nat Med 13:164-70. 2007..Our data suggest a previously unidentified mechanism for liver cirrhosis and anemia in Wilson disease...
Genotype-specific response of a lycaenid herbivore to elevated carbon dioxide and phosphorus availability in calcareous grasslandMarcel Goverde
Department of Integrative Biology, Section of Conservation Biology, University of Basel, St Johanns Vorstadt 10, 4056, Basel, Switzerland
Oecologia 139:383-91. 2004..As far as we know this is the first finding of a genotype-specific response of an insect herbivore to elevated CO2 which suggests genetic shifts in insect life history traits in response to elevated CO2...
