Herder Christian

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
  2. pmc Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years before diagnosis of type 2 diabetes: Whitehall II prospective cohort study
    Maren Carstensen
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes 59:1222-7. 2010
  3. pmc Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells
    Maren Carstensen
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany German Center for Diabetes Research DZD, Dusseldorf, Germany
    PLoS ONE 9:e85906. 2014
  4. pmc Association between Traffic-Related Air Pollution, Subclinical Inflammation and Impaired Glucose Metabolism: Results from the SALIA Study
    Tom Teichert
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    PLoS ONE 8:e83042. 2013
  5. ncbi request reprint Adiponectin and bariatric surgery: associations with diabetes and cardiovascular disease in the Swedish Obese Subjects Study
    Christian Herder
    Corresponding author Christian Herder
    Diabetes Care 37:1401-9. 2014
  6. doi request reprint Anti-inflammatory cytokines and risk of type 2 diabetes
    C Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes Obes Metab 15:39-50. 2013
  7. pmc Association of subclinical inflammation with polyneuropathy in the older population: KORA F4 study
    Christian Herder
    Corresponding author Christian Herder
    Diabetes Care 36:3663-70. 2013
  8. pmc Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Diabetes Care 36:1703-11. 2013
  9. ncbi request reprint Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
    C Herder
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, 40225, Dusseldorf, Germany
    Diabetologia 49:921-9. 2006
  10. ncbi request reprint Hypoadiponectinemia and proinflammatory state: two sides of the same coin?: results from the Cooperative Health Research in the Region of Augsburg Survey 4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:1626-31. 2006

Collaborators

Detail Information

Publications84

  1. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
    ..Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy...
  2. pmc Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years before diagnosis of type 2 diabetes: Whitehall II prospective cohort study
    Maren Carstensen
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes 59:1222-7. 2010
    ..We used repeated measurements to characterize IL-1Ra trajectories in individuals who developed type 2 diabetes...
  3. pmc Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells
    Maren Carstensen
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany German Center for Diabetes Research DZD, Dusseldorf, Germany
    PLoS ONE 9:e85906. 2014
    ..Sfrp5 did not act on hSkMC. Therefore, the cellular actions of Sfrp5 seem to depend on the type of tissue as well as its inflammatory and metabolic state. ..
  4. pmc Association between Traffic-Related Air Pollution, Subclinical Inflammation and Impaired Glucose Metabolism: Results from the SALIA Study
    Tom Teichert
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    PLoS ONE 8:e83042. 2013
    ..Therefore, we assessed the associations between air pollution, circulating immune mediators and impaired glucose metabolism...
  5. ncbi request reprint Adiponectin and bariatric surgery: associations with diabetes and cardiovascular disease in the Swedish Obese Subjects Study
    Christian Herder
    Corresponding author Christian Herder
    Diabetes Care 37:1401-9. 2014
    ..The aim of this study was to analyze the associations between systemic levels of adiponectin and the aforementioned outcomes in a population with severe obesity at high risk of diabetes and cardiovascular events...
  6. doi request reprint Anti-inflammatory cytokines and risk of type 2 diabetes
    C Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes Obes Metab 15:39-50. 2013
    ..Thus, further research is required to better understand the causal role of proinflammatory cytokines, hypoadiponectinaemia and the upregulation of anti-inflammatory proteins before the onset of type 2 diabetes. ..
  7. pmc Association of subclinical inflammation with polyneuropathy in the older population: KORA F4 study
    Christian Herder
    Corresponding author Christian Herder
    Diabetes Care 36:3663-70. 2013
    ..Inflammatory processes have been implicated in the pathogenesis of diabetic distal sensorimotor polyneuropathy (DSPN), but their possible relationship has not been assessed at the population level...
  8. pmc Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Diabetes Care 36:1703-11. 2013
    ..We wanted to investigate whether circulating concentrations of proinflammatory immune mediators and adiponectin in diabetic patients are associated with incident cardiovascular events...
  9. ncbi request reprint Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002
    C Herder
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, 40225, Dusseldorf, Germany
    Diabetologia 49:921-9. 2006
    ..We hypothesised that these chemokines may be risk factors for the development of type 2 diabetes...
  10. ncbi request reprint Hypoadiponectinemia and proinflammatory state: two sides of the same coin?: results from the Cooperative Health Research in the Region of Augsburg Survey 4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:1626-31. 2006
    ..The major aim of this cross-sectional study was to investigate the interdependence of hypoadiponectinemia and low-grade systemic inflammation...
  11. ncbi request reprint Constitutive and regulated expression and secretion of interferon-gamma-inducible protein 10 (IP-10/CXCL10) in human adipocytes
    C Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Int J Obes (Lond) 31:403-10. 2007
    ..This study investigates whether IP-10 is expressed in human adipocytes and whether its release is regulated by body mass index (BMI) or immunological stimuli...
  12. ncbi request reprint Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 55:2340-6. 2006
    ..088). Thus, systemic concentrations of immune mediators appear to be associated with the progression to type 2 diabetes and the prevention of type 2 diabetes by lifestyle changes...
  13. ncbi request reprint Association of systemic concentrations of macrophage migration inhibitory factor with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg, Survey 4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:368-71. 2006
    ....
  14. ncbi request reprint Prevalence of impaired glucose regulation in German school-leaving students
    C Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Dusseldorf, Germany
    Int J Obes (Lond) 31:1086-8. 2007
    ..American populations, but, nevertheless provides evidence for the necessity of public health interventions aiming at primary prevention of obesity and T2D in children and adolescents...
  15. pmc Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Dusseldorf, Germany
    Diabetes Care 32:421-3. 2009
    ..The aim of this study was to investigate whether baseline systemic levels of IL-1Ra are associated with incident type 2 diabetes during more than 10 years of follow-up...
  16. ncbi request reprint Low-grade inflammation, obesity, and insulin resistance in adolescents
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, 40225 Dusseldorf, Germany
    J Clin Endocrinol Metab 92:4569-74. 2007
    ..Low-grade inflammation is associated with insulin resistance and precedes the onset of type 2 diabetes mellitus in adults, but there are no comparable data in youth...
  17. doi request reprint Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies
    C Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 40:722-6. 2008
    ..We conclude that gene variants of CDKAL1, PPARG, IGF2BP2, HHEX, TCF7L2, and FTO predispose to type 2 diabetes in the German KORA 500 K study population. These associations appear to be independent of BMI...
  18. doi request reprint Genetics of type 2 diabetes: pathophysiologic and clinical relevance
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Germany
    Eur J Clin Invest 41:679-92. 2011
    ..Recent genome-wide association studies enlarged our knowledge about the genetic background of type 2 diabetes...
  19. ncbi request reprint Systemic monocyte chemoattractant protein-1 concentrations are independent of type 2 diabetes or parameters of obesity: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Eur J Endocrinol 154:311-7. 2006
    ..Since MCP-1 is produced by adipocytes and has been postulated to be involved in macrophage infiltration into adipose tissue, we wanted to test whether serum MCP-1 levels were correlated with T2D or obesity...
  20. ncbi request reprint Inflammation and type 2 diabetes: results from KORA Augsburg
    C Herder
    Leibniz Institute at Heinrich Heine University, German Diabetes Clinic, German Diabetes Center, Dusseldorf, Germany
    Gesundheitswesen 67:S115-21. 2005
    ....
  21. doi request reprint Interleukin-6 in the prediction of primary cardiovascular events in diabetes patients: results from the ESTHER study
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Atherosclerosis 216:244-7. 2011
    ..Thus, we investigated whether IL-6 is associated with incident primary cardiovascular events and improves risk prediction in diabetes patients...
  22. ncbi request reprint Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 54:S11-7. 2005
    ..There is no general upregulation of chemokine production in type 2 diabetes, but rather an association of the disease with specific members of the chemokine family...
  23. ncbi request reprint The diabetes epidemic in the elderly population in Western Europe: data from population-based studies
    W Rathmann
    Leibniz Institute at the Heinrich Heine University, Institute of Biometrics and Epidemiology, German Diabetes Center, Dusseldorf, Germany
    Gesundheitswesen 67:S110-4. 2005
    ..Comparative studies on the predictive values of obesity, physical activity, and nutrition and possible interactions with genetic markers in European populations are of interest in the future...
  24. ncbi request reprint Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002
    C Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, Dusseldorf, Germany
    Diabetologia 51:276-84. 2008
    ..Our aim was to investigate the triangular association between MIF genotypes, circulating MIF concentrations and incident type 2 diabetes, and to use a Mendelian randomisation approach to assess the causal role of MIF...
  25. doi request reprint Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the MONICA/KORA studies
    K Kempf
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Institute for Diabetes Research at Heinrich Heine University Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 118:184-9. 2010
    ..35 [1.59; 3.46] versus AT/TT). This association appears to be independent of obesity. Our finding corroborates previous studies that suggested a link between the novel adipokine vaspin and glucose metabolism...
  26. doi request reprint Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study
    C Herder
    Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetologia 52:433-42. 2009
    ..Physical activity and diet can attenuate systemic immune activation, but it is not known which individual components of a comprehensive lifestyle intervention are most effective in targeting subclinical inflammation...
  27. ncbi request reprint Effects of somatostatin and octreotide on cytokine and chemokine production by lipopolysaccharide-activated peripheral blood mononuclear cells
    F ter Veld
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    J Endocrinol Invest 32:123-9. 2009
    ..Although somatostatin or its analogues have been shown to modulate a number of immune functions, their immunomodulatory effects are not uniform and are strongly dependent on the underlying cell system...
  28. ncbi request reprint Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000
    W Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center at Heinrich Heine University, Dusseldorf, Germany
    Int J Obes (Lond) 31:770-6. 2007
    ..In men, high adiponectin concentrations were related to a lower risk of myocardial infarction, whereas no association with cardiovascular events was found in women...
  29. ncbi request reprint The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression
    K Kempf
    German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225, Dusseldorf, Germany
    J Mol Med (Berl) 85:389-96. 2007
    ..Thus, the MetS may support peripheral inflammation by sensitizing leukocytes to up-regulate proinflammatory markers in response to glucose, which in turn increases the risk for type-2 diabetes mellitus and cardiovascular disease...
  30. doi request reprint Prediction models for incident type 2 diabetes mellitus
in the older population: KORA S4/F4 cohort study
    W Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf
    Diabet Med 27:1116-23. 2010
    ....
  31. doi request reprint Beneficial effects of external muscle stimulation on glycaemic control in patients with type 2 diabetes
    B Rose
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Center at Heinrich Heine University, Duesseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:577-81. 2008
    ..Taken together, hfEMS might represent an additional treatment option for patients with type 2 diabetes not being able to exercise...
  32. doi request reprint Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients
    Fatma Ulgen
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Arch Physiol Biochem 116:57-62. 2010
    ..However, controversial data exist regarding the association of serum levels of RBP4 with insulin resistance in humans. Obesity confers a major risk to develop insulin resistance...
  33. ncbi request reprint Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder
    B Nowotny
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Horm Metab Res 42:746-53. 2010
    ..This points towards an independent effect of acute psychological stress on glucose metabolism and inflammation...
  34. ncbi request reprint Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity
    K Kempf
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 39:596-600. 2007
    ..Our data show a strong association between adipose tissue inflammation and ECS activation in obesity, and indicate that a pro-inflammatory state may directly activate the ECS...
  35. ncbi request reprint Association of humoral immunity to human Hsp60 with the IL-6 gene polymorphism C-174G in patients with type 2 diabetes and controls
    A Mostafazadeh
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Horm Metab Res 37:257-63. 2005
    ..This finding may contribute to an understanding of the relationship between the -174C allele and increased risk of atherosclerosis...
  36. ncbi request reprint Increased TNF-alpha and decreased TGF-beta expression in peripheral blood leukocytes after acute myocardial infarction
    K Kempf
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 38:346-51. 2006
    ..Gene expression alterations indicate a sophisticated regulation of counteracting TNF-alpha and TGF-beta cytokine expression in peripheral blood leukocytes after AMI with bias towards a pro-inflammatory situation...
  37. ncbi request reprint Is inflammation a causal chain between low socioeconomic status and type 2 diabetes? Results from the KORA Survey 2000
    Wolfgang Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Epidemiol 21:55-60. 2006
    ..In conclusion, inflammation appears not to play a major role linking low SES and type 2 diabetes in the elderly population...
  38. pmc Immune mediators in patients with acute diabetic foot syndrome
    Christian Weigelt
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:1491-6. 2009
    ..Further studies should investigate whether an activation of the immune system precedes the development of foot ulcer and whether anti-inflammatory therapies might be effective...
  39. doi request reprint Neuropad: evaluation of three cut-off points of sudomotor dysfunction for early detection of polyneuropathy in recently diagnosed diabetes
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabet Med 28:1412-5. 2011
    ..To examine the sensitivity and specificity of three cut-off points of Neuropad for the diagnosis of distal symmetric polyneuropathy and small-fibre dysfunction in patients within the first year after diagnosis of diabetes...
  40. doi request reprint Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study
    M Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Intern Med 271:43-50. 2012
    ..Myeloperoxidase (MPO) is a marker of oxidative stress. We prospectively investigated whether an increased serum concentration of MPO is associated with an increased risk of incident coronary heart disease (CHD)...
  41. pmc Dose-dependent induction of IL-6 by plant-derived proteases in vitro
    B Rose
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at the Heinrich Heine University, Duesseldorf, Germany
    Clin Exp Immunol 143:85-92. 2006
    ..These findings might provide the mechanistic rationale for the current use of proteases in wound healing and tissue regeneration since these processes depend on IL-6 induction...
  42. pmc Impact of early psychosocial factors (childhood socioeconomic factors and adversities) on future risk of type 2 diabetes, metabolic disturbances and obesity: a systematic review
    Teresa Tamayo
    Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    BMC Public Health 10:525. 2010
    ..Finally, we assumed that obesity might be a mediator for the association of childhood adversities with diabetes incidence. Therefore, we carried out a second review on obesity, applying a similar search strategy...
  43. ncbi request reprint Somatostatin receptor expression in peripheral blood of type 2 diabetes mellitus patients
    F ter Veld
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, and Department of General Pediatrics, University Children s Hospital, Dusseldorf, Germany
    Horm Metab Res 39:230-2. 2007
  44. doi request reprint The CB-1 receptor antagonist rimonabant modulates the interaction between adipocytes and pancreatic beta-cells in vitro
    F Ulgen
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 119:41-6. 2011
    ..Rimonabant decreases insulin levels in vivo. This effect can either be explained by improving insulin sensitivity or by effects on beta-cells including the modulation of adipocyte - beta-cell interactions...
  45. doi request reprint Biomarkers for the prediction of type 2 diabetes and cardiovascular disease
    C Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Clin Pharmacol Ther 90:52-66. 2011
    ....
  46. ncbi request reprint Association of impaired glucose metabolism in morbid obesity with hypoadiponectinaemia
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S64-9. 2008
    ..As obesity is the major risk factor for T2DM it is not clear why many patients with morbid obesity remain normoglycaemic and if this protection can be attributed to a lower grade of inflammation or higher adiponectin levels...
  47. pmc Residual beta cell function in newly diagnosed type 1 diabetes after treatment with atorvastatin: the Randomized DIATOR Trial
    Stephan Martin
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 6:e17554. 2011
    ..The aim of this study was to investigate the possible effect of atorvastatin on the decline of residual beta cell function in recent-onset type 1 diabetes...
  48. ncbi request reprint Enhanced proinflammatory response to endotoxin after priming of macrophages with lead ions
    Stefanie B Flohé
    German Diabetes Research Institute, University of Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    J Leukoc Biol 71:417-24. 2002
    ..In conclusion, lead ions prime BMMphi for enhanced proinflammatory cytokine secretion in response to LPS, likely by activation of protein kinase C and subsequent synthesis of an unidentified mediator...
  49. ncbi request reprint Impaired glucose regulation and type 2 diabetes in children and adolescents
    Kerstin Kempf
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Institute at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes Metab Res Rev 24:427-37. 2008
    ..However, the assessment of the relevance of risk factors and of incidence or prevalence estimates in youth is complicated by methodological issues that are also discussed...
  50. ncbi request reprint Effects of a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin, given at post-puberty, in senescent mice
    Charlotte Esser
    Institute of Environmental Research gGmbH, University of Dusseldorf, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Toxicol Lett 157:89-98. 2005
    ..In conclusion, our data suggest that a single dose of TCDD in young mice is correlated to activated secondary lymphoid tissues and high IgM titers. Both findings are congruent with a weakened immune system...
  51. ncbi request reprint Inflammation in metabolic syndrome and type 2 diabetes: Impact of dietary glucose
    Kerstin Kempf
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Ann N Y Acad Sci 1084:30-48. 2006
    ..In case of an impaired metabolic state, however, postprandial hyperglycemia increases magnitude and duration of systemic inflammatory responses, which probably promotes the development of T2DM and of cardiovascular disease...
  52. doi request reprint Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
    Kerstin Kempf
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich, Heine University Düsseldorf, Dusseldorf, Germany
    Am J Clin Nutr 91:950-7. 2010
    ..Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress...
  53. ncbi request reprint Combined activation of innate and T cell immunity for recognizing immunomodulatory properties of therapeutic agents
    Bettina Rose
    German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany
    J Leukoc Biol 75:624-30. 2004
    ....
  54. ncbi request reprint Adiponectin and cardiovascular mortality: evidence for "reverse epidemiology"
    W Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center at Heinrich Heine University, Dusseldorf, Germany
    Horm Metab Res 39:1-2. 2007
  55. ncbi request reprint Macrophage inhibitory cytokine-1 is increased in individuals before type 2 diabetes diagnosis but is not an independent predictor of type 2 diabetes: the Whitehall II study
    Maren Carstensen
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Eur J Endocrinol 162:913-7. 2010
    ..We hypothesized that decreased concentrations of MIC-1 would be associated with higher risk of developing type 2 diabetes...
  56. ncbi request reprint Chemokines and incident coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    German Diabetes Clinic, Leibniz Center at Heinrich Heine University, Dusseldorf Germany
    Arterioscler Thromb Vasc Biol 26:2147-52. 2006
    ..The aim of this study was to assess whether elevated systemic levels of these chemokines precede coronary events...
  57. doi request reprint Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes
    Christian Pfleger
    Institute for Clinical Diabetes Research at German Diabetes Centre, Leibniz Institute at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 57:929-37. 2008
    ....
  58. doi request reprint RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Institute at Heinrich Heine University, 40225 Dusseldorf, Germany
    Eur J Endocrinol 158:R1-5. 2008
    ....
  59. pmc Traffic-related air pollution and incident type 2 diabetes: results from the SALIA cohort study
    Ursula Kramer
    Institut fur umweltmedizinische Forschung IUF, Leibniz Center at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Environ Health Perspect 118:1273-9. 2010
    ..Cross-sectional and ecological studies indicate that air pollution may be a risk factor for type 2 diabetes, but prospective data are lacking...
  60. ncbi request reprint Evaluation of diagnostic relevance of mRNA levels in peripheral blood: predictive value for mortality in hemodialysis patients
    Reiner Füth
    German Diabetes Centre, German Diabetes Research Institute at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Cytokine 27:166-72. 2004
    ..This study shows that gene expression patterns of circulating leukocytes may present an important new diagnostic tool to predict clinical outcome in patients with inflammatory vascular diseases...
  61. pmc Transforming growth factor-beta1 and incident type 2 diabetes: results from the MONICA/KORA case-cohort study, 1984-2002
    Christian Herder
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes Care 32:1921-3. 2009
    ..This study aimed to assess whether levels of circulating transforming growth factor-beta1 (TGF-beta1)-a central, mainly immunosuppressive, and anti-inflammatory cytokine-were associated with incident type 2 diabetes...
  62. doi request reprint Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Dusseldorf, Germany
    Atherosclerosis 200:380-8. 2008
    ....
  63. ncbi request reprint IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4
    Harald Grallert
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Germany
    Exp Gerontol 41:737-45. 2006
    ..The association with height seems to be the central factor indicating an influence of IL-6 on growth through impaired bone metabolism. However, the complex relationships need further investigation...
  64. ncbi request reprint Sex differences in the relation of body composition to markers of inflammation
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Atherosclerosis 184:216-24. 2006
    ..It has been suggested that low-grade systemic inflammation is associated with obesity and that this association might be modified by sex...
  65. ncbi request reprint Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markers
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 26:194-9. 2006
    ..Furthermore, we analyzed their correlation with various acute-phase proteins, inflammation-associated cytokines, and an adhesion molecule...
  66. ncbi request reprint Production and release of macrophage migration inhibitory factor from human adipocytes
    Thomas Skurk
    Else Kröner Fresenius Centre for Nutritional Medicine, Technical University Munich, Hochfeldweg 1, D 85350 Freising Weihenstephan
    Endocrinology 146:1006-11. 2005
    ..We therefore analyzed whether human adipocytes produce MIF, in the search of candidate mediators of macrophage infiltration of obese adipose tissue...
  67. ncbi request reprint Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002
    Barbara Thorand
    GF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 54:2932-8. 2005
    ..This association is independent of a generalized proinflammatory state, but subjects with elevated levels of several inflammatory markers seem to be particularly prone to develop type 2 diabetes...
  68. ncbi request reprint The proatherogenic cytokine interleukin-18 is secreted by human adipocytes
    Thomas Skurk
    Else Kroner Fresenius Center for Nutritional Medicine, Technical University Munich, D 85350 Weihenstephan, Germany
    Eur J Endocrinol 152:863-8. 2005
    ..The aim of our study was to investigate whether human adipocytes produce IL-18...
  69. ncbi request reprint Critical evaluation of models to identify individuals with insulin resistance
    Wolfgang Rathmann
    Diabetes Care 28:1833. 2005
  70. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  71. pmc Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    BMC Med Genet 9:9. 2008
    ..Since several studies have suggested that type 2 diabetes might be associated with changes in the innate immune response, we sought to investigate the association between genetic variants in the TLR4 gene and incident type 2 diabetes...
  72. doi request reprint The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study
    Anna Maija Tolppanen
    Department of Clinical Nutrition and Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Genet Med 10:536-44. 2008
    ..Our objective was to investigate the genetic associations of the single nucleotide polymorphisms of the TNMD gene with the serum levels of systemic immune mediators...
  73. ncbi request reprint APOA5 variants and metabolic syndrome in Caucasians
    Harald Grallert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    J Lipid Res 48:2614-21. 2007
    ..Furthermore, the data suggest a different mechanism of APOA5 impact on MetS in Caucasians, as variant c.56C>G (not analyzed in the Japanese study) and not -1131T>C, as in the Japanese subjects, was associated with MetS...
  74. ncbi request reprint Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin
    Giuseppe Murdolo
    The Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy at Goteborg University, S 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 92:2688-95. 2007
    ..The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in obesity-associated chronic inflammation, insulin resistance, and atherosclerosis...
  75. ncbi request reprint Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Barbara Thorand
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Diabetes Care 30:854-60. 2007
    ..Therefore, the aim of this study was to compare associations of markers of inflammation with type 2 diabetes risk between men and women...
  76. ncbi request reprint Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg
    Eva Maria Sedlmeier
    Institute of Epidemiology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Eur J Endocrinol 156:377-85. 2007
    ..The present study investigated the association of nine MCP-1 single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors...
  77. ncbi request reprint Calpain-10 variants and haplotypes are associated with polycystic ovary syndrome in Caucasians
    Caren Vollmert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Am J Physiol Endocrinol Metab 292:E836-44. 2007
    ..557, P=0.0011). By investigating a broad panel of CAPN10 variants, our results pointed to an allele dose-dependent association of UCSNP-56 and ins/del-19 with PCOS...
  78. ncbi request reprint Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:2745-51. 2006
    ....
  79. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  80. ncbi request reprint Relationship between adipocyte size and adipokine expression and secretion
    Thomas Skurk
    Else Kröner Fresenius Centre for Nutritional Medicine, Technical University Munich, Am Forum 5, D 85350 Freising Weihenstephan, Germany
    J Clin Endocrinol Metab 92:1023-33. 2007
    ..This secretory function is considered to provide the basis for obesity-related complications such as type 2 diabetes and atherosclerosis...
  81. ncbi request reprint The DREAM trial
    Christian Herder
    Lancet 368:2049; author reply 2050-1. 2006
  82. ncbi request reprint Circulating levels of interleukin-18 independent of body fat and fat-free mass: results from the MONICA/KORA study
    Christian Herder
    Diabetes Care 29:174-5. 2006
  83. ncbi request reprint Sustained expansion and transgene expression of coagulation factor VIII-transduced cord blood-derived endothelial progenitor cells
    Christian Herder
    Institute for Transfusion Medicine and Immunohematology, Red Cross Blood Donor Service Baden Württemberg Hessen, Sandhofstr 1, 60528 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 23:2266-72. 2003
    ..In this study, we tested the capacity of cord blood-derived endothelial progenitor cells (CBECs) for FVIII expression on stable lentiviral transduction...
  84. ncbi request reprint Heat shock protein 60 elicits abnormal response in macrophages of diabetes-prone non-obese diabetic mice
    Thure Adler
    German Diabetes Research Institute at the Heinrich Heine University, Auf m Hennekamp 65, D 40225 Dusseldorf, Germany
    Biochem Biophys Res Commun 294:592-6. 2002
    ....