R E Brown

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Physiol 515:777-86. 1999
  2. ncbi request reprint The physiology of brain histamine
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Prog Neurobiol 63:637-72. 2001
  3. ncbi request reprint Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Neuropharmacology 40:457-9. 2001
  4. ncbi request reprint Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling
    O Selbach
    Department of Neurophysiology, Heinrich Heine University, Universitaetsstrasse 1 22 03 01, P O B 101007, D 40001 Dusseldorf, Germany
    Neuroscience 127:519-28. 2004
  5. ncbi request reprint Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat
    T M Korotkova
    Institute for Neurophysiology, Heinrich Heine University, D 40001 Dusseldorf, Germany
    Eur J Neurosci 23:2677-85. 2006
  6. ncbi request reprint Mice deficient in endothelial nitric oxide synthase exhibit a selective deficit in hippocampal long-term potentiation
    R I Wilson
    Institut fur Neurophysiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Neuroscience 90:1157-65. 1999
  7. pmc Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins
    R E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, VA Medical Center Brockton, Research 151C, 940, Belmont Street, Brockton, MA 02301, USA
    Neuroscience 143:739-55. 2006
  8. ncbi request reprint Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus
    K S Eriksson
    Institute for Neurophysiology, , , Germany
    J Neurosci 21:9273-9. 2001
  9. ncbi request reprint Defective hippocampal mossy fiber long-term potentiation in endothelial nitric oxide synthase knockout mice
    N Doreulee
    , , , Germany
    Synapse 41:191-4. 2001
  10. ncbi request reprint Visual detection, pattern discrimination and visual acuity in 14 strains of mice
    A A Wong
    Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, NS, Canada
    Genes Brain Behav 5:389-403. 2006

Collaborators

Detail Information

Publications21

  1. pmc On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Physiol 515:777-86. 1999
    ..Histamine H3 receptors and adenosine A1 receptors act upon a common final effector to cause presynaptic inhibition...
  2. ncbi request reprint The physiology of brain histamine
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Prog Neurobiol 63:637-72. 2001
    ..A role for the neuronal histamine system as a danger response system is proposed...
  3. ncbi request reprint Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Neuropharmacology 40:457-9. 2001
    ..The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy...
  4. ncbi request reprint Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling
    O Selbach
    Department of Neurophysiology, Heinrich Heine University, Universitaetsstrasse 1 22 03 01, P O B 101007, D 40001 Dusseldorf, Germany
    Neuroscience 127:519-28. 2004
    ....
  5. ncbi request reprint Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat
    T M Korotkova
    Institute for Neurophysiology, Heinrich Heine University, D 40001 Dusseldorf, Germany
    Eur J Neurosci 23:2677-85. 2006
    ..These findings suggest a link between the ability of neuropeptides to promote arousal and their action on VTA neurons...
  6. ncbi request reprint Mice deficient in endothelial nitric oxide synthase exhibit a selective deficit in hippocampal long-term potentiation
    R I Wilson
    Institut fur Neurophysiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Neuroscience 90:1157-65. 1999
    ..These results support a selective role for endothelial nitric oxide synthase in long-term potentiation, but also demonstrate that nitric oxide synthase is not involved in this process under all conditions...
  7. pmc Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins
    R E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, VA Medical Center Brockton, Research 151C, 940, Belmont Street, Brockton, MA 02301, USA
    Neuroscience 143:739-55. 2006
    ..Some or all carbachol-excited neurons are presumably REM-on neurons...
  8. ncbi request reprint Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus
    K S Eriksson
    Institute for Neurophysiology, , , Germany
    J Neurosci 21:9273-9. 2001
    ..These results suggest a functional connection between the two populations of hypothalamic neurons and that they may cooperate in the regulation of rapid-eye-movement sleep and feeding...
  9. ncbi request reprint Defective hippocampal mossy fiber long-term potentiation in endothelial nitric oxide synthase knockout mice
    N Doreulee
    , , , Germany
    Synapse 41:191-4. 2001
    ..Thus, eNOS is not directly involved in mfLTP, but lack of eNOS during development leads to a deficit downstream of adenylyl cyclase...
  10. ncbi request reprint Visual detection, pattern discrimination and visual acuity in 14 strains of mice
    A A Wong
    Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, NS, Canada
    Genes Brain Behav 5:389-403. 2006
    ..Because many behavioral tasks for rodents rely on visual cues, we suggest that the visual abilities of mice should be evaluated before they are tested in commonly used visuo-spatial learning and memory tasks...
  11. pmc Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers
    P Mattjus
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Biochemistry 39:1067-75. 2000
    ..Based on these and other experiments, we conclude that the transfer process follows first-order kinetics and that the off-rate of the transfer protein from the donor vesicle surface is the rate-limiting step in the transfer process...
  12. ncbi request reprint A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse
    Q J Yan
    Department of Neurology, St Luke s Roosevelt Institute for Health Sciences, Columbia University, New York, NY, USA
    Genes Brain Behav 3:337-59. 2004
    ..Finally, a molecular examination of the fmr1-tm1Cgr mouse shows that, contrary to common belief, it is not a molecular null. Implications of this finding for interpretation of the phenotype are discussed...
  13. pmc Cloning and expression of glycolipid transfer protein from bovine and porcine brain
    X Lin
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 275:5104-10. 2000
    ..Reverse transcriptase-PCR analyses of mRNA levels supported the Northern blot results...
  14. ncbi request reprint Strain differences in activity and emotionality do not account for differences in learning and memory performance between C57BL/6 and DBA/2 mice
    J Podhorna
    Department of Psychology Dalhousie University Halifax, Nova Scotia, Canada B3H 4J1
    Genes Brain Behav 1:96-110. 2002
    ..Nonetheless, the importance of using complete behavioural test batteries should be stressed to ensure that strain differences in learning and memory tasks are not confounded by non-cognitive factors...
  15. ncbi request reprint Marked differences in olfactory sensitivity and apparent speed of forebrain neuroblast migration in three inbred strains of mice
    A W Lee
    Department of Psychology, Dalhousie University, B3H 4J1, Halifax, NS, Canada
    Neuroscience 118:263-70. 2003
    ..Perhaps more importantly, the results point to an opportunity to identify genes that regulate olfactory function and neuroblast behavior...
  16. ncbi request reprint Male and female C57BL/6 mice respond differently to diazepam challenge in avoidance learning tasks
    J Podhorna
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Pharmacol Biochem Behav 72:13-21. 2002
    ..This study also suggests that cognitive effects of BZs in rodents could be sex dependent and highlight the importance of using both sexes in studies on behavioral effects of psychoactive drugs...
  17. ncbi request reprint Effects of chronic and acute methylphenidate hydrochloride (Ritalin) administration on locomotor activity, ultrasonic vocalizations, and neuromotor development in 3- to 11-day-old CD-1 mouse pups
    M R Penner
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, B3H 4J1
    Dev Psychobiol 39:216-28. 2001
    ....
  18. ncbi request reprint Tyrosine hydroxylase protein content in the medulla oblongata of the foetal sheep brain increases in response to acute but not chronic hypoxia
    M B Adams
    Department of Physiology, The University of Adelaide, Adelaide, SA 5005, Australia
    Neurosci Lett 316:63-6. 2001
    ....
  19. ncbi request reprint Cholinergic medial septum neurons do not degenerate in aged 129/Sv control or p75(NGFR)-/-mice
    N L Ward
    Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, N S, Canada
    Neurobiol Aging 21:125-34. 2000
    ..Alternatively, p75(NGFR) -/- mice may have developed compensatory mechanisms in response to the absence of p75(NGFR)...
  20. ncbi request reprint The mechanism of spontaneous firing in histamine neurons
    D R Stevens
    Department of Physiology, Heinrich-Heine-University, P.O.B. 101007, D-40001 Dusseldorf, Germany
    Behav Brain Res 124:105-12. 2001
    ..The amount of calcium entering during the action potential will determine the duration of the AHP and thus, the firing rate...
  21. ncbi request reprint Selective retrieval of jimpy mutant pups over normal male littermates by lactating female B6CBACa-Aw-J/A-Ta jp mice
    V J Bolivar
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Genet 25:75-80. 1995
    ..We are thus left with the paradox that the mother appears to "prefer" the mutant pup to the normal littermate, despite its smaller size, reduced ultrasonic vocalization rate, and compromised fitness...