Michael Brehm

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Stem cell therapy in postinfarction chronic coronary heart disease
    Michael Brehm
    Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University, Dusseldorf, Germany
    Nat Clin Pract Cardiovasc Med 3:S101-4. 2006
  2. ncbi request reprint [Myocardial disease in viral infections. Myocarditis--cardiomyopathy]
    Michael Brehm
    Medizinische Klinik B, Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf
    Med Klin (Munich) 101:36-9. 2006
  3. ncbi request reprint [Myocardial infarct trial of Düsseldorf. Short- and long-term results after intracoronary stem cell transplantation in acute and chronic myocardial infarction]
    Michael Brehm
    Medizinische Klinik B, Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf
    Med Klin (Munich) 101:193-4. 2006
  4. ncbi request reprint [Successful therapy of patients in therapy-resistant cardiogenic shock with intracoronary, autologous bone marrow stem cell transplantation]
    M Brehm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf, Germany
    Dtsch Med Wochenschr 132:1944-8. 2007
  5. ncbi request reprint [Inflammatory cardiac diseases by primary extracardial diseases]
    M Brehm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Internist (Berl) 49:27-33. 2008
  6. doi request reprint [Stem cell therapy in acute myocardial infarction]
    M Brehm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Moorenstrasse 5, Dusseldorf, Germany
    Internist (Berl) 49:1068-78. 2008
  7. doi request reprint Therapeutic potential of stem cells in elderly patients with cardiovascular disease
    M Brehm
    Department of Cardiology, Pneumology and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    Exp Gerontol 43:1024-32. 2008
  8. doi request reprint Enhanced mobilization of CD34(+) progenitor cells expressing cell adhesion molecules in patients with STEMI
    Michael Brehm
    Division of Cardiology, Pneumology and Angiology, Department of Medicine, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Clin Res Cardiol 98:477-86. 2009
  9. pmc Effects of exercise training on mobilization and functional activity of blood-derived progenitor cells in patients with acute myocardial infarction
    Michael Brehm
    Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University, Moorenstr 5, 40 225 Düsseldorf, Germany
    Eur J Med Res 14:393-405. 2009
  10. ncbi request reprint Stem cells--clinical application and perspectives
    Michael Brehm
    Internal Clinic B, Department of Cardiology, University of Duesseldorf, Germany
    Herz 27:611-20. 2002

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Stem cell therapy in postinfarction chronic coronary heart disease
    Michael Brehm
    Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University, Dusseldorf, Germany
    Nat Clin Pract Cardiovasc Med 3:S101-4. 2006
    ..These results show that functional and metabolic regeneration of infarcted and chronically avital tissue can be achieved in humans using transplantation of bone-marrow-derived cells...
  2. ncbi request reprint [Myocardial disease in viral infections. Myocarditis--cardiomyopathy]
    Michael Brehm
    Medizinische Klinik B, Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf
    Med Klin (Munich) 101:36-9. 2006
    ..Thus, new possibilities arise for assessment of the disease prognosis and the strategy of specific immunosuppressive, immunomodulating and antiviral therapy...
  3. ncbi request reprint [Myocardial infarct trial of Düsseldorf. Short- and long-term results after intracoronary stem cell transplantation in acute and chronic myocardial infarction]
    Michael Brehm
    Medizinische Klinik B, Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf
    Med Klin (Munich) 101:193-4. 2006
    ..These results demonstrate that functional and metabolic regeneration of infarcted and chronically avital tissue can be released in humans by bone marrow-derived cell transplantation...
  4. ncbi request reprint [Successful therapy of patients in therapy-resistant cardiogenic shock with intracoronary, autologous bone marrow stem cell transplantation]
    M Brehm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf, Germany
    Dtsch Med Wochenschr 132:1944-8. 2007
    ..A 64-year-old man with known coronary 3-vessel disease (CAD) who had sustained an anterior myocardial infarction 14 years ago was admitted with signs of acute left heart failure associated with another anterior myocardial infarction...
  5. ncbi request reprint [Inflammatory cardiac diseases by primary extracardial diseases]
    M Brehm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Internist (Berl) 49:27-33. 2008
    ....
  6. doi request reprint [Stem cell therapy in acute myocardial infarction]
    M Brehm
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Moorenstrasse 5, Dusseldorf, Germany
    Internist (Berl) 49:1068-78. 2008
    ....
  7. doi request reprint Therapeutic potential of stem cells in elderly patients with cardiovascular disease
    M Brehm
    Department of Cardiology, Pneumology and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    Exp Gerontol 43:1024-32. 2008
    ..In this concised paper the current understanding of stem cell therapy and early clinical experiences are discussed and related to the application of stem cells in elderly patients with myocardial ischemia...
  8. doi request reprint Enhanced mobilization of CD34(+) progenitor cells expressing cell adhesion molecules in patients with STEMI
    Michael Brehm
    Division of Cardiology, Pneumology and Angiology, Department of Medicine, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Clin Res Cardiol 98:477-86. 2009
    ....
  9. pmc Effects of exercise training on mobilization and functional activity of blood-derived progenitor cells in patients with acute myocardial infarction
    Michael Brehm
    Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University, Moorenstr 5, 40 225 Düsseldorf, Germany
    Eur J Med Res 14:393-405. 2009
    ..This may be related in part to a mobilization of bone marrow-derived circulating progenitor cells (CPCs) as well as an enhanced vascularisation...
  10. ncbi request reprint Stem cells--clinical application and perspectives
    Michael Brehm
    Internal Clinic B, Department of Cardiology, University of Duesseldorf, Germany
    Herz 27:611-20. 2002
    ..The quest for suitable donor cells has prompted research into the use of both embryonic stem cells and adult somatic stem cells...
  11. ncbi request reprint [Effects of exercise training on mobilization of BM-CPCs and migratory capacity as well as LVEF after AMI]
    Ramazan Gökmen Turan
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf
    Med Klin (Munich) 101:198-201. 2006
    ..In this study, the influence of physical training on the mobilization and the migratory activity of the BM-CPCs as well as on the left ventricular function (LVEF) after AMI was examined...
  12. ncbi request reprint Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study
    Bodo E Strauer
    Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University, Dusseldorf, Germany
    J Am Coll Cardiol 46:1651-8. 2005
    ..Stem cell therapy may be useful in chronic myocardial infarction (MI); this is conceivable, but not yet demonstrated in humans...
  13. ncbi request reprint [Transplantation of autologous adult bone marrow stem cells in patients with severe peripheral arterial occlusion disease]
    Thomas Bartsch
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf
    Med Klin (Munich) 101:195-7. 2006
    ..For many patients with severe peripheral arterial occlusion disease (PAOD) an interventional or surgical treatment is not feasible. The regenerative potential of adult autologous mononuclear stem cells could contribute to neoangiogenesis...
  14. doi request reprint Accumulation of VEGFR-2+/CD133+ cells and decreased number and impaired functionality of CD34+/VEGFR-2+ cells in patients with SLE
    Petra Ebner
    Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Rheumatology (Oxford) 49:63-72. 2010
    ..Endothelial progenitor cells (EPCs) have the ability to restore endothelial integrity. The aim of this study was to determine whether the number and function of EPCs are altered in SLE...
  15. ncbi request reprint Autologous mononuclear stem cell transplantation in patients with peripheral occlusive arterial disease
    Thomas Bartsch
    Division of Cardiology, Pneumology, and Angiology, Department of Internal Medicine, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Cardiovasc Nurs 21:430-2. 2006
    ..We analyzed the clinical benefit of combined intraarterial and intramuscular transplantation of adult autologous mononuclear bone marrow stem cells in patients with lower-limb peripheral occlusive arterial disease...
  16. doi request reprint The BALANCE Study: clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction
    Muhammad Yousef
    Department of Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    J Am Coll Cardiol 53:2262-9. 2009
    ....
  17. ncbi request reprint [Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction]
    B E Strauer
    , Pneumologie und Angiologie, Germany
    Dtsch Med Wochenschr 126:932-8. 2001
    ..The therapeutic effects may be ascribed to stem cell-associated myocardial regeneration and neovascularisation...
  18. ncbi request reprint [Rapid healing of a therapy-refractory diabetic foot after transplantation of autologous bone marrow stem cells]
    Thomas Bartsch
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Dusseldorf
    Med Klin (Munich) 100:676-80. 2005
    ..In these cases the regenerative potential of adult autologous mononuclear stem cells could serve as causal therapy...
  19. ncbi request reprint Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy
    Bodo Schwartzkopff
    Department of Cardiology, Angiology and Pneumology, Heinrich Heine University Dusseldorf, Moorenstrasse 5, Germany
    Eur J Heart Fail 4:439-4. 2002
    ..In the present study, serological markers of collagen metabolism were investigated...
  20. ncbi request reprint [Stem cell therapy in acute myocardial infarction]
    Bodo E Strauer
    Klinik ftir Kardiologie, Pneumologie und Angiologie, Universitat Dusseldorf
    Med Klin (Munich) 98:14-8. 2003
    ..The therapeutic effect may be attributed to bone marrow cell-associated myocardial regeneration and neovascularization...
  21. ncbi request reprint Increased cardiac mRNA expression of matrix metalloproteinase-1 (MMP-1) and its inhibitor (TIMP-1) in DCM patients
    F Picard
    Department of Cardiology, Angiology and Pneumology, Heinrich Heine University Dusseldorf, Germany
    Clin Res Cardiol 95:261-9. 2006
    ..The MMP-1 overexpression is mainly found in moderately dilated DCM hearts (group II) indicating the dynamic process of LV dilation and the importance of collagenases in the early phase of LV remodeling...
  22. ncbi request reprint Therapeutic potentials of stem cells in cardiac diseases
    B E Strauer
    Department of Cardiology, Pneumology and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    Minerva Cardioangiol 57:249-67. 2009
    ..Further indications are non-ischemic cardiomyopathy (dilatative cardiomyopathy) and heart failure due to hypertensive heart disease...
  23. ncbi request reprint [ Update 2001. Myocarditis--cardiomyopathy]
    B E Strauer
    Medizinische Klinik und Poliklinik B, Universitat Dusseldorf
    Med Klin (Munich) 96:608-25. 2001
    ..This has prognostic implications and helps for the decision of a specific immunosuppressive, immunomodulatory and antiviral therapy...
  24. doi request reprint The therapeutic potential of stem cells in heart disease
    B E Strauer
    Department of Cardiology, Pneumology and Vascular Medicine, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Cell Prolif 41:126-45. 2008
    ..Further indications are non-ischemic cardiomyopathy (dilative cardiomyopathy) and heart failure due to hypertensive heart disease...
  25. ncbi request reprint Factors influencing spontaneous mobilization of CD34+ and CD133+ progenitor cells after myocardial infarction
    R G Turan
    Laboratory of Stem Cell Transplantation and Molecular Cardiology, Division of Cardiology, Pneumology and Angiology, Heinrich Heine University, Moorenstrasse 6, Duesseldorf, Germany
    Eur J Clin Invest 37:842-51. 2007
    ..The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends on cardiovascular risk factors (CVRFs), age of patients, infarct associated inflammatory markers, and left ventricular function after AMI...
  26. ncbi request reprint Transplantation of autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (the TAM-PAD study)
    T Bartsch
    Department of Medicine, Division of Cardiology Pneumology and Angiology, Heinrich Heine University Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Clin Res Cardiol 96:891-9. 2007
    ..The TAM-PAD study is the first one to analyze combined intraarterial and intramuscular BMC transplantation in its acute and long-term effects...
  27. ncbi request reprint [Potentials and limitations of stem cell therapy in myocardial disease]
    T Zeus
    Universitatsklinikum Dusseldorf, Medizinische Klinik und Poliklinik, Klinik fur Kardiologie, Pneumologie und Angiologie, Moorenstrasse 5, 40225 Dusseldorf
    Z Kardiol 94:IV/100-01. 2005
    ..These results demonstrate that functional and metabolic regeneration of infarcted myocardium can be safely realized in humans by bone marrow mononuclear cell transplantation...
  28. ncbi request reprint Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease
    B Schwartzkopff
    Department of Cardiology, Pneumology and Angiology, Heinrich Heine University, Dusseldorf, Germany
    Hypertension 36:220-5. 2000
    ..These findings indicate the beneficial reparative effects of ACE inhibition on coronary microcirculation in hypertensive heart disease...
  29. ncbi request reprint Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    Bodo E Strauer
    Department of Medicine, Division of Cardiology, Heinrich Heine University of Dusseldorf, Germany
    Circulation 106:1913-8. 2002
    ..For this reason, we analyzed 10 patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI...
  30. ncbi request reprint Detection of enteroviral RNA (poliovirus types 1 and 3) in endomyocardial biopsies from patients with ventricular tachycardia and survivors of sudden cardiac death
    Rolf Michael Klein
    Division of Cardiology, Pneumology and Angiology, Heinrich Heine University Dusseldorf, Germany
    Scand J Infect Dis 34:746-52. 2002
    ..In summary, these findings raise the possibility that enteroviruses, such as poliovirus types 1 and 3, may be involved in the pathogenesis of ventricular tachycardia and sudden cardiac death...
  31. ncbi request reprint [Therapy with adult stem cells in myocardial infarct]
    M Brehm
    Medizinische Klinik und Poliklinik B, Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat, Moorenstrasse 5, 40225 Dusseldorf
    Internist (Berl) 43:S96-8. 2002
  32. ncbi request reprint [Five years' experience with autologous intracoronary stem cell transplantation. Current status and perspectives]
    C M Schannwell
    Medizinische Klinik und Poliklinik B, Universitat Dusseldorf, Moorenstrasse 5, 40225, Germany
    Internist (Berl) 47:1087-8, 1090-2. 2006
  33. ncbi request reprint [Intra-arterial and intramuscular transplantation of adult, autologous bone marrow stem cells. Novel treatment for therapy-refractory peripheral arterial occlusive disease]
    T Bartsch
    Klinik fur Kardiologie, Pneumologie und Angiologie, Heinrich Heine Universitat Dusseldorf
    Dtsch Med Wochenschr 131:79-83. 2006
    ..The patient's walking distance was only 100 meters. It was therefore decided to do a combined intraarterial and intramuscular transplantation of stem cells into the right limb...
  34. ncbi request reprint Intracoronary autologous bone marrow cell transplantation beneficially modulates heart rate variability
    Per Otto Schueller
    Int J Cardiol 119:398-9. 2007
    ..After three to twelve months of follow up, patients receiving stem cells showed a significant increase of HRV parameters that have been linked to cardiovascular prognosis...