E Boles

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate
    E Boles
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    J Bacteriol 179:2987-93. 1997
  2. ncbi The molecular genetics of hexose transport in yeasts
    E Boles
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    FEMS Microbiol Rev 21:85-111. 1997
  3. ncbi Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae
    R Wieczorke
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Universitatsstr 1, Geb 26 12 01, D 40225, Dusseldorf, Germany
    FEBS Lett 464:123-8. 1999
  4. pmc The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast
    F Schulte
    Institut fur Mikrobiologie, Heinrich Heine Universitat, D 40225 Dusseldorf, Germany
    J Bacteriol 182:540-2. 2000
  5. ncbi Cloning and characterization of three genes (SUT1-3) encoding glucose transporters of the yeast Pichia stipitis
    T Weierstall
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Mol Microbiol 31:871-83. 1999
  6. ncbi Characterization of the essential yeast gene encoding N-acetylglucosamine-phosphate mutase
    M Hofmann
    Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Germany
    Eur J Biochem 221:741-7. 1994
  7. ncbi Glucose-dependent and -independent signalling functions of the yeast glucose sensor Snf3
    S Dlugai
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Universitatsstr 1, Geb 26 12 01, D 40225, Dusseldorf, Germany
    FEBS Lett 505:389-92. 2001
  8. ncbi The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane
    J Makuc
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Yeast 18:1131-43. 2001
  9. pmc Identification and characterization of MAE1, the Saccharomyces cerevisiae structural gene encoding mitochondrial malic enzyme
    E Boles
    Institut fur Mikrobiologie, Heinrich Heine Universitat, D 40225 Dusseldorf, Germany
    J Bacteriol 180:2875-82. 1998
  10. ncbi A family of hexosephosphate mutases in Saccharomyces cerevisiae
    E Boles
    Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Germany
    Eur J Biochem 220:83-96. 1994

Collaborators

  • T Weierstall
  • J J Heinisch
  • R Kramer
  • B Andre
  • J M Thevelein
  • M Vanoni
  • R Wieczorke
  • C Milkowski
  • S Dlugai
  • J Makuc
  • F Rolland
  • S Krampe
  • F Schulte
  • C P Hollenberg
  • I Iraqui
  • E Reifenberger
  • V Hasse
  • S Paiva
  • V Wanke
  • J Winderickx
  • L Cauwenberg
  • P Ma
  • S Hippler
  • C Leao
  • M Casal
  • M Schauen
  • J Weirich
  • J H de Winde
  • K D Breunig
  • T Miosga
  • S Vissers
  • K Freidel
  • F Bernard
  • J O De Craene
  • A Urrestarazu
  • F K Zimmermann
  • M Hofmann
  • M Ciriacy
  • N Chalwatzis
  • N Wilhelm
  • I Schaaff-Gerstenschlager
  • C Fournier
  • S Schmitt
  • C Velten
  • A Baur

Detail Information

Publications17

  1. pmc Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate
    E Boles
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    J Bacteriol 179:2987-93. 1997
    ..The results indicate that the PYK2-encoded pyruvate kinase may be used under conditions of very low glycolytic flux...
  2. ncbi The molecular genetics of hexose transport in yeasts
    E Boles
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    FEMS Microbiol Rev 21:85-111. 1997
    ..The further characterization of this multigene family of hexose transporters should help to elucidate the role of transport in yeast sugar metabolism...
  3. ncbi Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae
    R Wieczorke
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Universitatsstr 1, Geb 26 12 01, D 40225, Dusseldorf, Germany
    FEBS Lett 464:123-8. 1999
    ..However, as additional deletion of the glucose sensor gene SNF3 partially restored growth on hexoses, our data indicate the existence of even more proteins able to transport hexoses in yeast...
  4. pmc The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast
    F Schulte
    Institut fur Mikrobiologie, Heinrich Heine Universitat, D 40225 Dusseldorf, Germany
    J Bacteriol 182:540-2. 2000
    ..The mutant forms block the transduction of the Snf3- and Rgt2-mediated glucose signals upstream of the Rgt1 transcriptional regulator...
  5. ncbi Cloning and characterization of three genes (SUT1-3) encoding glucose transporters of the yeast Pichia stipitis
    T Weierstall
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Mol Microbiol 31:871-83. 1999
    ..Further investigations suggest that the Sut proteins constitute a subfamily of glucose transporters in P. stipitis, and that other and probably unrelated proteins exist additionally mediating high-affinity glucose and xylose uptake...
  6. ncbi Characterization of the essential yeast gene encoding N-acetylglucosamine-phosphate mutase
    M Hofmann
    Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Germany
    Eur J Biochem 221:741-7. 1994
    ..Our observations indicate that the different hexosephosphate mutases of S. cerevisiae have partially overlapping substrate specificities but, nevertheless, distinct physiological functions...
  7. ncbi Glucose-dependent and -independent signalling functions of the yeast glucose sensor Snf3
    S Dlugai
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Universitatsstr 1, Geb 26 12 01, D 40225, Dusseldorf, Germany
    FEBS Lett 505:389-92. 2001
    ....
  8. ncbi The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane
    J Makuc
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Yeast 18:1131-43. 2001
    ..It is concluded that the yeast monocarboxylate transporter-homologous proteins perform other functions than do their mammalian counterparts...
  9. pmc Identification and characterization of MAE1, the Saccharomyces cerevisiae structural gene encoding mitochondrial malic enzyme
    E Boles
    Institut fur Mikrobiologie, Heinrich Heine Universitat, D 40225 Dusseldorf, Germany
    J Bacteriol 180:2875-82. 1998
    ..However, since null mutants could still grow anaerobically, this function is apparently not essential...
  10. ncbi A family of hexosephosphate mutases in Saccharomyces cerevisiae
    E Boles
    Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Germany
    Eur J Biochem 220:83-96. 1994
    ..Further investigations suggest that a complex network of mutases exist in yeast which interact and can partially substitute for each other...
  11. ncbi Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression
    E Reifenberger
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Eur J Biochem 245:324-33. 1997
    ....
  12. ncbi The role of the NAD-dependent glutamate dehydrogenase in restoring growth on glucose of a Saccharomyces cerevisiae phosphoglucose isomerase mutant
    E Boles
    Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Germany
    Eur J Biochem 217:469-77. 1993
    ..Furthermore, the requirement for an increase in NADPH consumption for the suppression of the phosphoglucose isomerase defect could be met by addition of oxidizing agents which are known to reduce the level of NADPH...
  13. pmc Feedback regulation of glucose transporter gene transcription in Kluyveromyces lactis by glucose uptake
    C Milkowski
    , , D-06099 Halle, Germany
    J Bacteriol 183:5223-9. 2001
    ..These phenotypes could be partially restored by HXT gene family members from Saccharomyces cerevisiae. The results indicate that the specific responses to high but not to low glucose concentrations require a high rate of glucose uptake...
  14. pmc Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease
    I Iraqui
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    Mol Cell Biol 19:989-1001. 1999
    ..The essential role of Grr1p in this amino acid signaling pathway lends further support to the hypothesis that this protein participates in integrating nutrient availability with the cell cycle...
  15. ncbi Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site
    T Miosga
    Institut fur Mikrobiologie, Technische Hochschule Darmstadt, Federal Republic of Germany
    Yeast 11:681-9. 1995
    ..cerevisiae. Two of them have similarity to each other and belong to a family of extracellular proteins that groups mammalian SCP/Tpx-1, insects Ag3/Ag5, plants PR-1 and fungi Sc7/Sc14.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi Cloning of a second gene encoding 5-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate
    E Boles
    Institut fur Mikrobiologie und Genetik, Technische Hochschule Darmstadt, Germany
    Mol Microbiol 20:65-76. 1996
    ..Nevertheless, it can be effectively replaced by other effectors and regulatory mechanisms during growth on glucose...
  17. ncbi The role of hexose transport and phosphorylation in cAMP signalling in the yeast Saccharomyces cerevisiae
    F Rolland
    Katholieke Universiteit Leuven, Leuven-Heverlee, Flanders, Belgium
    FEMS Yeast Res 1:33-45. 2001
    ..This may indicate that intracellular acidification can boost a downstream effect that amplifies the residual signal transmitted via the hexose kinases when glucose uptake is too low...