A Heidland

Summary

Country: Germany

Publications

  1. ncbi Neuromuscular electrostimulation techniques: historical aspects and current possibilities in treatment of pain and muscle waisting
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    Clin Nephrol 79:S12-23. 2013
  2. ncbi The contribution of Rudolf Virchow to the concept of inflammation: what is still of importance?
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Germany
    J Nephrol 19:S102-9. 2006
  3. ncbi Mass-screening for early detection of renal disease: benefits and limitations of self-testing for proteinuria
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Nephrol 22:249-54. 2009
  4. ncbi Beginning of modern concept of inflammation: the work of Friedrich Daniel von Recklinghausen and Julius Friedrich Cohnheim
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Nephrol 22:71-9. 2009
  5. doi Mechanisms of acute uremic encephalopathy: early activation of Fos and Fra-2 gene products in different nuclei/areas of the rat brain
    August Heidland
    Department of Internal Medicine, University of Wuerzburg, Wuerzburg, Germany
    J Ren Nutr 20:S44-50. 2010
  6. doi Karl Peter's fundamental contribution to the structural organization of the kidney
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Nephrol 24:S51-7. 2011
  7. pmc Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation
    A Heidland
    Department of Internal Medicine, University of Wurzburg, Hans Brandmann Weg 1, D 97080 Wurzburg, Germany
    Heart 90:1269-74. 2004
  8. ncbi Relation between different treatment modalities and genomic damage of end-stage renal failure patients
    K Kobras
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 29:10-7. 2006
  9. ncbi Advanced glycation end products and the progressive course of renal disease
    A Heidland
    Department of Internal Medicine and Physiologische Chemie I, University of Wurzburg, Germany
    Am J Kidney Dis 38:S100-6. 2001
  10. doi Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists
    N Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Horm Metab Res 42:458-65. 2010

Collaborators

Detail Information

Publications39

  1. ncbi Neuromuscular electrostimulation techniques: historical aspects and current possibilities in treatment of pain and muscle waisting
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    Clin Nephrol 79:S12-23. 2013
    ..In controlled clinical studies electrical myostimulation (EMS) has been shown to be effective against the sarcopenia of patients with chronic congestive heart disease, diabetes, chronic obstructive pulmonary disease and ESRD...
  2. ncbi The contribution of Rudolf Virchow to the concept of inflammation: what is still of importance?
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Germany
    J Nephrol 19:S102-9. 2006
    ..This hypothesis has recently been corroborated by numerous studies and may have therapeutic consequences. Virchow contributed to nearly all aspects of human pathology and championed the cause of social medicine...
  3. ncbi Mass-screening for early detection of renal disease: benefits and limitations of self-testing for proteinuria
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Nephrol 22:249-54. 2009
    ..Chronic kidney diseases are of growing importance for our health system. With regard to the high number of undetected cases, screening programs provide opportunities for an early to detect and treat patients...
  4. ncbi Beginning of modern concept of inflammation: the work of Friedrich Daniel von Recklinghausen and Julius Friedrich Cohnheim
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Nephrol 22:71-9. 2009
    ..In the last few decades, experimental and clinical studies using modern techniques have fully confirmed and extended these basic observations made by von Recklinghausen and Cohnheim more than 100 years ago...
  5. doi Mechanisms of acute uremic encephalopathy: early activation of Fos and Fra-2 gene products in different nuclei/areas of the rat brain
    August Heidland
    Department of Internal Medicine, University of Wuerzburg, Wuerzburg, Germany
    J Ren Nutr 20:S44-50. 2010
    ..This suggests the involvement of the toxic effects of uranium as a result of its accumulation in the brain...
  6. doi Karl Peter's fundamental contribution to the structural organization of the kidney
    August Heidland
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Nephrol 24:S51-7. 2011
    ..Furthermore, Peter gave a detailed description of the principal zones of the human kidney: the cortex, the outer medulla with outer and inner stripes, and the inner medulla...
  7. pmc Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation
    A Heidland
    Department of Internal Medicine, University of Wurzburg, Hans Brandmann Weg 1, D 97080 Wurzburg, Germany
    Heart 90:1269-74. 2004
    ....
  8. ncbi Relation between different treatment modalities and genomic damage of end-stage renal failure patients
    K Kobras
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 29:10-7. 2006
    ..Patients with end-stage renal disease display enhanced genomic damage. We investigated the relation between genomic damage and different treatment modalities...
  9. ncbi Advanced glycation end products and the progressive course of renal disease
    A Heidland
    Department of Internal Medicine and Physiologische Chemie I, University of Wurzburg, Germany
    Am J Kidney Dis 38:S100-6. 2001
    ....
  10. doi Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists
    N Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Horm Metab Res 42:458-65. 2010
    ....
  11. ncbi High-tone external muscle stimulation in end-stage renal disease: effects on symptomatic diabetic and uremic peripheral neuropathy
    A Klassen
    Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany
    J Ren Nutr 18:46-51. 2008
    ....
  12. ncbi Advanced glycation end products impair protein turnover in LLC-PK1: amelioration by trypsin
    G Xiang
    Department of Internal Medicine, Institute of Physiological Chemistry, , , Germany
    Kidney Int Suppl 78:S53-7. 2001
    ..Since these alterations were abrogated by coincubation with trypsin, an interference of this serine protease with the AGE-binding proteins on cell surfaces is assumed...
  13. doi Renal research in 19th century Germany
    Eberhard Ritz
    Department of Internal Medicine, Division of Nephrology, University Heidelberg, Germany
    Am J Kidney Dis 55:1121-9. 2010
    ....
  14. ncbi [Incidence and spectrum of malignant disease among dialysis patients in North Bavaria]
    M Teschner
    Kuratorium für Dialyse und Nierentransplantation, Wurzburg, Germany
    Dtsch Med Wochenschr 127:2497-502. 2002
    ..Since this topic has to date received only minimal attention in Germany, we undertook a multi-centric analysis (8 dialysis centres) in North Bavaria in order to address the occurrence of malignant diseases in end-stage renal failure...
  15. ncbi Franz Volhard and Theodor Fahr: achievements and controversies in their research in renal disease and hypertension
    A Heidland
    Department of Internal Medicine, University of Wuerzburg, Germany
    J Hum Hypertens 15:5-16. 2001
    ..Additionally, Volhard made crucial advances in cardiology and pneumology. Journal of Human Hypertension (2001) 15, 5-16..
  16. ncbi Homocysteine exerts genotoxic and antioxidative effects in vitro
    K Fink
    Institute of Pharmacology and Toxicology, University of Wuerzburg, Versbacherstrasse 9, 97078 Wuerzburg, Germany
    Toxicol In Vitro 21:1402-8. 2007
    ..Elevated Hcy levels--usually indicative of cardiovascular events--correlated with the genomic damage in cross-sectional studies. Therefore we investigated the genotoxic effects of Hcy in vitro...
  17. ncbi Pilot study for comparison of reticulocyte-micronulei with lymphocyte-micronuclei in human biomonitoring
    H Stopper
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacherstr 9, D 97080 Wurzburg, Germany
    Toxicol Lett 156:351-60. 2005
    ..The latter reflects a more rapid reduction of genomic damage after an acute exposure...
  18. ncbi New approaches for the treatment of genomic damage in end-stage renal disease
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    J Ren Nutr 18:127-33. 2008
    ..A major cause of DNA damage is oxidative stress, which may be induced by various uremic toxins, including advanced glycation end products (AGEs), as well as by activation of the renin-angiotensin system...
  19. doi Reduction of the genomic damage level in haemodialysis patients by folic acid and vitamin B12 supplementation
    Helga Stopper
    Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D 97078 Wuerzburg, Germany
    Nephrol Dial Transplant 23:3272-9. 2008
    ..The aim of this study was to analyse whether this supplementation can also lower the genomic damage in PBL of haemodialysis patients. This may ultimately help to reduce cancer incidence in renal patients...
  20. ncbi Genotoxicity of advanced glycation end products in mammalian cells
    Helga Stopper
    Department of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, D 97078, Wurzburg, Germany
    Cancer Lett 190:151-6. 2003
    ..It is concluded that AGEs induce genotoxicity in tubule cells, which may be involved in the enhanced cancer development in advanced kidney diseases...
  21. ncbi Genotoxicity of advanced glycation end products: involvement of oxidative stress and of angiotensin II type 1 receptors
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Ann N Y Acad Sci 1043:685-95. 2005
    ..We were able to identify important participants in AGE-induced DNA damage: ROS, NF-kappaB, and Ang II, as well as modulators to prevent this DNA damage: antioxidants, DMF, and AT1 antagonists...
  22. ncbi Georg Ganter--a pioneer of peritoneal dialysis and his tragic academic demise at the hand of the Nazi regime
    Markus Teschner
    Kuratorium for Dialysis and Kidney Transplantation, Wurzburg, Germany
    J Nephrol 17:457-60. 2004
    ..In spite of these limited experiences, Ganter was convinced of the superiority of his method over the troublesome hemodialysis therapy and recommended its broader clinical application...
  23. ncbi Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Renal Physiol 292:F1427-34. 2007
    ..The present findings support our hypothesis that ANG II causes DNA damage via ANG II type 1 receptor binding and subsequent formation of oxidative stress...
  24. ncbi Plasma levels of advanced glycation end products during haemodialysis, haemodiafiltration and haemofiltration: potential importance of dialysate quality
    Andrea Gerdemann
    Physiologische Chemie l, Biozentrum, Am Hubland, Wurzburg, Germany
    Nephrol Dial Transplant 17:1045-9. 2002
    ..Advanced glycation end products (AGEs) accumulate in patients with end-stage renal disease (ESRD). The aim of this study was to investigate the potential influence of different modalities of renal replacement therapies on plasma AGE levels...
  25. ncbi Genomic damage and circulating AGE levels in patients undergoing daily versus standard haemodialysis
    Evangelia Fragedaki
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacherstr 9, D 97080 Wurzburg, Germany
    Nephrol Dial Transplant 20:1936-43. 2005
    ..Patients with end-stage renal failure, whether on conservative or haemodialysis therapy, have a high incidence of DNA damage. It is not known if improved control of the uraemic state by daily haemodialysis (DHD) reduces DNA lesions...
  26. ncbi Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis - amelioration by liver transplantation
    Katarina Sebekova
    Institute of Preventive and Clinical Medicine, Commenius University Medical School, Limbova 14, 833 01, Bratislava, Slovakia
    J Hepatol 36:66-71. 2002
    ..Thus, in advanced liver disease an accumulation of advanced glycation end products (AGEs) in circulation might occur, due to the reduction of effective liver mass...
  27. ncbi Association of metabolic syndrome risk factors with selected markers of oxidative status and microinflammation in healthy omnivores and vegetarians
    Katarina Sebekova
    Research Base of Slovak Medical University, Bratislava, Slovakia
    Mol Nutr Food Res 50:858-68. 2006
    ..The vegetarian diet seems to exert beneficial effects on MetS RFs associated microinflammation. Whether the vegetarian diet may counteract the deleterious effects of elevated AOPPs and AGEs, remains to be elucidated...
  28. ncbi Effects of a diet rich in advanced glycation end products in the rat remnant kidney model
    Katarina Sebekova
    Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic
    Am J Kidney Dis 41:S48-51. 2003
    ..Although bioactivity of orally absorbed MRPs has been shown in both experimental and human studies, its relevance in renal insufficiency still is unclear...
  29. ncbi Functional hyperhomocysteinemia in healthy vegetarians: no association with advanced glycation end products, markers of protein oxidation, or lipid peroxidation after correction with vitamin B(12)
    Katarina Sebekova
    Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovakia
    Clin Chem 49:983-6. 2003
  30. ncbi Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis
    Naila Ahmed
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Central Campus, Colchester, Essex CO4 3SQ, UK
    J Hepatol 41:913-9. 2004
    ..We investigated the hepatic extraction of glycated, oxidised and nitrosated proteins in vivo...
  31. ncbi Genomic damage in chronic renal failure--potential therapeutic interventions
    Helga Stopper
    Department of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany
    J Ren Nutr 15:81-6. 2005
    ..Moreover, an improved uremic state by daily hemodialysis ameliorated the genomic damage in lymphocytes, as compared to patients on conventional hemodialysis...
  32. ncbi Renal effects of oral maillard reaction product load in the form of bread crusts in healthy and subtotally nephrectomized rats
    Katarina Sebekova
    Slovak Medical University, Institute of Preventive and Clinical Medicine, Limbova 14, 833 03 Bratislava, Slovakia
    Ann N Y Acad Sci 1043:482-91. 2005
    ..6 +/- 0.2 [P < 0.01]). Plasma creatinine or creatinine clearance were not affected significantly. In conclusion, our data suggests that long-term consumption of a diet rich in MRPs may lead to damage of the kidneys...
  33. ncbi Dietary bread crust advanced glycation end products bind to the receptor for AGEs in HEK-293 kidney cells but are rapidly excreted after oral administration to healthy and subtotally nephrectomized rats
    Veronika Somoza
    German Research Center for Food Chemistry, Lichtenbergstrasse 4, 85748 Garching, Germany
    Ann N Y Acad Sci 1043:492-500. 2005
    ..Although renal insufficiency in the NX rats was reflected by proteinuria, the renal handling of CML and, presumably, other AGEs was not impaired...
  34. ncbi Increased protein glycation in cirrhosis and therapeutic strategies to prevent it
    Naila Ahmed
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Ann N Y Acad Sci 1043:718-24. 2005
    ..Therapeutic strategies to decrease dicarbonyl compounds may be beneficial, such as dicarbonyl scavengers, glutathione repleting agents, and high-dose thiamine therapy...
  35. ncbi Effect of different hemodialysis regimens on genomic damage in end-stage renal failure
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Semin Nephrol 26:28-32. 2006
    ..In the DHD patients there also was a significant decrease of the plasma concentrations of urea and the advanced glycation end products imidazolone A, carboxymethyllysine, and of advanced glycation end product-associated fluorescence...
  36. ncbi Serum carboxymethyllysine predicts mortality in hemodialysis patients
    Zoltan Wagner
    Second Department of Medicine, Nephrological Center, University of Pecs, Pecs, Germany
    Am J Kidney Dis 47:294-300. 2006
    ..The aim of the present study is to test whether serum level of the AGE carboxymethyllysine (CML) predicts all-cause or cardiovascular mortality in hemodialysis patients...
  37. ncbi Serum growth factors in hemodialyzed patients
    Leszek Paczek
    Transplantation Institute, Warsaw School of Medicine, Warsaw, Poland
    Artif Organs 28:314-6. 2004
    ..Differences in PDGF concentrations in serum of control group and hemodialyzed patients were not statistically significant. The strong correlation between TGF-beta1 and PDGF in serum of both studied groups of patients was demonstrated...
  38. ncbi Renal disease in obesity: the need for greater attention
    Przemyslaw Rutkowski
    Department of Nephrology, Transplantology, and Internal Diseases, Medical University of Gdansk, Poland
    J Ren Nutr 16:216-23. 2006
    ..In the presence of glomerulopathy and/or hypertension, angiotensin converting enzyme inhibitors or angiotensin II type I receptor blockers are the drugs of choice to improve glomerular hyperfiltration...
  39. ncbi Genomic damage in end-stage renal failure: potential involvement of advanced glycation end products and carbonyl stress
    Helga Stopper
    Institute of Pharmacology and Toxicology, University of Wurzburg, Germany
    Semin Nephrol 24:474-8. 2004
    ..In vitro, incubation of tubulus cells with various AGEs and methylglyoxal induces DNA damage, which is suppressed by antioxidants. This underlines the role played by oxidative stress in DNA damage...