Marc Heidbreder

Summary

Country: Germany

Publications

  1. ncbi request reprint Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform
    Sebastian Wolfrum
    Institute for Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, Germany
    Cardiovasc Res 55:583-9. 2002
  2. ncbi request reprint Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Cardiovasc Res 78:108-15. 2008
  3. ncbi request reprint Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Biochem Biophys Res Commun 352:437-43. 2007
  4. ncbi request reprint Hypoxia rapidly activates HIF-3alpha mRNA expression
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    FASEB J 17:1541-3. 2003
  5. ncbi request reprint Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Free Radic Biol Med 38:117-24. 2005
  6. doi request reprint Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARγ target gene regulation
    Helge Müller-Fielitz
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Endocrinology 153:1103-15. 2012
  7. ncbi request reprint Calcitonin gene related peptide mediates cardioprotection by remote preconditioning
    Sebastian Wolfrum
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Regul Pept 127:217-24. 2005
  8. doi request reprint Suppression of cardiac phosphatidate phosphohydrolase 1 activity and lipin mRNA expression in Zucker diabetic fatty rats and humans with type 2 diabetes mellitus
    Christof Burgdorf
    Department of Internal Medicine II, University Hospital Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany
    Biochem Biophys Res Commun 390:165-70. 2009
  9. doi request reprint Overfeeding-induced obesity in spontaneously hypertensive rats: an animal model of the human metabolic syndrome
    Anja Miesel
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Lubeck, Germany
    Ann Nutr Metab 56:127-42. 2010
  10. ncbi request reprint Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase
    Sebastian Wolfrum
    Medical Clinic II, University of Lubeck, Germany
    J Cardiovasc Pharmacol 41:474-80. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform
    Sebastian Wolfrum
    Institute for Experimental and Clinical Pharmacology and Toxicology, Medical University of Lubeck, Germany
    Cardiovasc Res 55:583-9. 2002
    ..Furthermore, we tried to delineate the mechanisms by which RPC is transduced to the heart with respect to the possible contribution of kinins and neuronal reflexes...
  2. ncbi request reprint Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Cardiovasc Res 78:108-15. 2008
    ..Since mitogen-activated protein kinases (MAPKs) were found to be implicated in the signalling of ischaemic preconditioning (IPC), we tested the hypothesis of a contribution of these protein kinases to remote preconditioning (RPC)...
  3. ncbi request reprint Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Biochem Biophys Res Commun 352:437-43. 2007
    ..Transcriptional up-regulation of HIF-3alpha represents a typical response to in vivo hypoglycaemia and glucoprivation. These data suggest an involvement of the HIF system in metabolic derangements as for instance caused by diabetes...
  4. ncbi request reprint Hypoxia rapidly activates HIF-3alpha mRNA expression
    Marc Heidbreder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    FASEB J 17:1541-3. 2003
    ..Our results suggest that induction at the transcriptional level is a unique feature of HIF-3alpha, which therefore may represent a rapidly reacting component of the HIF system in protection against hypoxic damage...
  5. ncbi request reprint Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals
    Andreas Dendorfer
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Free Radic Biol Med 38:117-24. 2005
    ..Enhancement of superoxide activity by DFO could be demonstrated in vitro. Acute and prolonged myocardial preconditioning is triggered by DFO in response to accumulation of oxygen radicals and activation of protein kinase C...
  6. doi request reprint Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARγ target gene regulation
    Helge Müller-Fielitz
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Endocrinology 153:1103-15. 2012
    ..Because the expression of examined PPARγ target genes was not affected, we concluded that improved insulin sensitivity after long-term treatment with AT(1) blockers was not related to a PPARγ-dependent mechanism...
  7. ncbi request reprint Calcitonin gene related peptide mediates cardioprotection by remote preconditioning
    Sebastian Wolfrum
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Regul Pept 127:217-24. 2005
    ..In conclusion, CGRP protects the heart from ischemic injury and is involved in RPC, presumably by activating myocardial PKCepsilon...
  8. doi request reprint Suppression of cardiac phosphatidate phosphohydrolase 1 activity and lipin mRNA expression in Zucker diabetic fatty rats and humans with type 2 diabetes mellitus
    Christof Burgdorf
    Department of Internal Medicine II, University Hospital Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany
    Biochem Biophys Res Commun 390:165-70. 2009
    ..Insulin therapy increased both PAP(1) activity and lipin mRNA expression in diabetic patients. We conclude that suppression of cardiac PAP(1) activity/lipin expression may contribute to metabolic dysfunction of the diabetic heart...
  9. doi request reprint Overfeeding-induced obesity in spontaneously hypertensive rats: an animal model of the human metabolic syndrome
    Anja Miesel
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Lubeck, Germany
    Ann Nutr Metab 56:127-42. 2010
    ..CD-fed SHR feature leptin and insulin resistance, hypertension and obesity, thus mimicking the situation of MS patients. As such, our model is more suitable than the genetically modified rat models used to study human MS...
  10. ncbi request reprint Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase
    Sebastian Wolfrum
    Medical Clinic II, University of Lubeck, Germany
    J Cardiovasc Pharmacol 41:474-80. 2003
    ..Therefore, statins may protect the heart not only by reducing the incidence of ischemic events, but also by limiting cell damage during acute myocardial infarction...