Thomas Hehlgans

Summary

Country: Germany

Publications

  1. pmc The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
    Thomas Hehlgans
    Institute of Medical Microbiology, University of Dusseldorf, Germany
    Immunology 115:1-20. 2005
  2. ncbi request reprint Lymphotoxin-beta receptor immune interaction promotes tumor growth by inducing angiogenesis
    Thomas Hehlgans
    Department of Pathology Tumor Immunology, University of Regensburg, D 93042 Regensburg, Germany
    Cancer Res 62:4034-40. 2002
  3. ncbi request reprint Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes
    Michaela Jungbeck
    Institute of Immunology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Mol Immunol 45:34-41. 2008
  4. pmc Involvement of the lectin pathway of complement activation in antimicrobial immune defense during experimental septic peritonitis
    Michaela Windbichler
    Department of Immunology, University of Regensburg, F J Strauss Allee, D 93042 Regensburg, Germany
    Infect Immun 72:5247-52. 2004
  5. ncbi request reprint Lymphotoxin-beta receptor activation by activated T cells induces cytokine release from mouse bone marrow-derived mast cells
    Peter Stopfer
    Department of Immunology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    J Immunol 172:7459-65. 2004
  6. ncbi request reprint Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells
    Thomas Hehlgans
    Department of Pathology, Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany
    Eur Cytokine Netw 14:103-7. 2003
  7. ncbi request reprint The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5210-8. 2003
  8. ncbi request reprint The TNF-TNF receptor system
    Thomas Hehlgans
    Department of Pathology Tumor Immunology, University of Regensburg, D 93042 Regensburg, Germany
    Biol Chem 383:1581-5. 2002
  9. pmc Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria
    Benjamin Stoelcker
    Institute of Pathology Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany
    Infect Immun 70:5857-9. 2002
  10. doi request reprint Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3
    Johann Röhrl
    Institute of Immunology University of Regensburg, D 93042 Regensburg, Germany
    J Biol Chem 283:5414-9. 2008

Collaborators

  • Klaus Pfeffer
  • S Ehlers
  • Christoph Holscher
  • Daniela N Männel
  • Peter Stopfer
  • Michaela Jungbeck
  • Johann Röhrl
  • Michaela Windbichler
  • Benjamin Stoelcker
  • Frauke Bataille
  • Joost J Oppenheim
  • Sergei A Nedospasov
  • De Yang
  • Bernd Echtenacher
  • Jens C Jensenius
  • Wilhelm Schwaeble
  • Karin Weigl
  • Georges E Grau
  • Horst Bluethmann

Detail Information

Publications10

  1. pmc The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
    Thomas Hehlgans
    Institute of Medical Microbiology, University of Dusseldorf, Germany
    Immunology 115:1-20. 2005
    ..Molecular and cellular mechanisms that demonstrate a therapeutic potential by targeting individual receptors or ligands for the treatment of chronic inflammatory or autoimmune diseases are discussed...
  2. ncbi request reprint Lymphotoxin-beta receptor immune interaction promotes tumor growth by inducing angiogenesis
    Thomas Hehlgans
    Department of Pathology Tumor Immunology, University of Regensburg, D 93042 Regensburg, Germany
    Cancer Res 62:4034-40. 2002
    ..Thus, LTbetaR activation on tumor cells by activated host lymphocytes can initiate a novel proangiogenic pathway leading to organized tumor tissue development...
  3. ncbi request reprint Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes
    Michaela Jungbeck
    Institute of Immunology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Mol Immunol 45:34-41. 2008
    ..Thus, activation of LTbetaR by LTalphabeta mainly expressed on T lymphocytes is crucial for the down regulation of the inflammatory response in this experimental model...
  4. pmc Involvement of the lectin pathway of complement activation in antimicrobial immune defense during experimental septic peritonitis
    Michaela Windbichler
    Department of Immunology, University of Regensburg, F J Strauss Allee, D 93042 Regensburg, Germany
    Infect Immun 72:5247-52. 2004
    ..Our results demonstrate a long-lasting depletion of MBL-A and MBL-C from serum during microbial infection and underline the importance of both the lectin and the alternative pathways for antimicrobial immune defense...
  5. ncbi request reprint Lymphotoxin-beta receptor activation by activated T cells induces cytokine release from mouse bone marrow-derived mast cells
    Peter Stopfer
    Department of Immunology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    J Immunol 172:7459-65. 2004
    ..These data clearly show that LTbetaR expressed on mast cells can transduce a costimulatory signal in T cell-dependent mast cell activation...
  6. ncbi request reprint Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells
    Thomas Hehlgans
    Department of Pathology, Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany
    Eur Cytokine Netw 14:103-7. 2003
    ..MIP-2 and IL-6 secretion was NFkappaB-dependent because IkappaB-transfected cells released significantly reduced amounts of both mediators...
  7. ncbi request reprint The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5210-8. 2003
    ..tuberculosis infection as wild-type mice, these data demonstrate that signaling of LT alpha(1)beta(2) heterotrimers via the LT beta R is an essential prerequisite for containment of intracellular pathogens...
  8. ncbi request reprint The TNF-TNF receptor system
    Thomas Hehlgans
    Department of Pathology Tumor Immunology, University of Regensburg, D 93042 Regensburg, Germany
    Biol Chem 383:1581-5. 2002
    ..This makes the TNF-TNFR system very complex. The dual TNF function for either cell death or survival upon interaction of members of the TNF ligand family with members of the TNF receptor family will be discussed...
  9. pmc Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria
    Benjamin Stoelcker
    Institute of Pathology Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany
    Infect Immun 70:5857-9. 2002
    ..Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria...
  10. doi request reprint Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3
    Johann Röhrl
    Institute of Immunology University of Regensburg, D 93042 Regensburg, Germany
    J Biol Chem 283:5414-9. 2008
    ..In addition, both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3...