Klikovits T, Lohinai Z, Fabian K, Gyulai M, Szilasi M, Varga J, et al
. New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study. Lung Cancer. 2018;126:139-148 pubmed publisher
..Central LADC is associated with early metastatic disease, bone involvement and, consequently, decreased survival. ..
László V, Valkó Z, Ozsvar J, Kovacs I, Garay T, Hoda M, et al
. The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma. J Mol Med (Berl). 2018;: pubmed publisher
..KEY MESSAGES: Response to FAK inhibition in MPM is independent of NF2 expression or histotype. FAK inhibition strongly interfered with MPM spheroid formation. BI 853520 has been shown to exert anti-tumor effect in MPM. ..
Molnar E, Rittler D, Baranyi M, Grusch M, Berger W, Dome B, et al
. Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells. BMC Cancer. 2018;18:542 pubmed publisher
..Our data suggests that combined blocking of RAF and MEK may achieve increased therapeutic response in non-V600 BRAF mutant tumors. ..