Hans Hauner

Summary

Country: Germany

Publications

  1. ncbi request reprint Constitutive and regulated expression and secretion of interferon-gamma-inducible protein 10 (IP-10/CXCL10) in human adipocytes
    C Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Int J Obes (Lond) 31:403-10. 2007
  2. doi request reprint Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial
    Hans Hauner
    Else Kroner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Clin Nutr 95:383-94. 2012
  3. pmc Dyslipidemia in primary care--prevalence, recognition, treatment and control: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS)
    Elisabeth Steinhagen-Thiessen
    Charite Universitatsmedizin Berlin, Germany
    Cardiovasc Diabetol 7:31. 2008
  4. doi request reprint [Nutritional medicine 2008]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der Technischen Universität München, Ismaninger Str 22, 81675 Munchen
    Dtsch Med Wochenschr 133:1381-3. 2008
  5. ncbi request reprint [Prevalence of diabetes mellitus in Germany 1998-2001. Secondary data analysis of a health insurance sample of the AOK in Hesse/KV in Hesse]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technischen Universität Munich
    Dtsch Med Wochenschr 128:2632-7. 2003
  6. ncbi request reprint [Managing the obese patient]
    Hans Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der Technischen Universität München, Munchen
    Med Klin (Munich) 98:569-76. 2003
  7. doi request reprint The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development. Rationale and design of the INFAT study
    H Hauner
    Else Kroner Fresenius Center for Nutritional Medicine, Technical University Munich, Munich, Germany
    Ann Nutr Metab 54:97-103. 2009
  8. ncbi request reprint [Outpatient care of patients with diabetes mellitus in 2001. Analysis of a health insurance sample of the AOK in Hesse/KV in Hesse]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der Technischen Universität Munich
    Dtsch Med Wochenschr 128:2638-43. 2003
  9. ncbi request reprint [Low-carbohydrate or low-fat diet for weight loss--which is better?]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der TU München, Klinikum rechts der Isar, Ismaninger Str 22, D 81675 Munchen
    MMW Fortschr Med 146:33-5, 37. 2004
  10. ncbi request reprint The new concept of adipose tissue function
    Hans Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munchen, Germany
    Physiol Behav 83:653-8. 2004

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Constitutive and regulated expression and secretion of interferon-gamma-inducible protein 10 (IP-10/CXCL10) in human adipocytes
    C Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Int J Obes (Lond) 31:403-10. 2007
    ..This study investigates whether IP-10 is expressed in human adipocytes and whether its release is regulated by body mass index (BMI) or immunological stimuli...
  2. doi request reprint Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial
    Hans Hauner
    Else Kroner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Clin Nutr 95:383-94. 2012
    ..The composition of long-chain PUFAs (LCPUFAs) in the maternal diet may affect obesity risk in the mother's offspring...
  3. pmc Dyslipidemia in primary care--prevalence, recognition, treatment and control: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS)
    Elisabeth Steinhagen-Thiessen
    Charite Universitatsmedizin Berlin, Germany
    Cardiovasc Diabetol 7:31. 2008
    ..Although being mainly a prevention tool, its thresholds are difficult to meet in clinical practice, especially primary care...
  4. doi request reprint [Nutritional medicine 2008]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der Technischen Universität München, Ismaninger Str 22, 81675 Munchen
    Dtsch Med Wochenschr 133:1381-3. 2008
  5. ncbi request reprint [Prevalence of diabetes mellitus in Germany 1998-2001. Secondary data analysis of a health insurance sample of the AOK in Hesse/KV in Hesse]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technischen Universität Munich
    Dtsch Med Wochenschr 128:2632-7. 2003
    ..The aim of this population-based study was to assess the prevalence of subjects with diabetes mellitus by retrospectively analysing routine health insurance data...
  6. ncbi request reprint [Managing the obese patient]
    Hans Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der Technischen Universität München, Munchen
    Med Klin (Munich) 98:569-76. 2003
  7. doi request reprint The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development. Rationale and design of the INFAT study
    H Hauner
    Else Kroner Fresenius Center for Nutritional Medicine, Technical University Munich, Munich, Germany
    Ann Nutr Metab 54:97-103. 2009
    ..This upcoming study will explore the potential of this dietary approach to limit early adipose tissue growth and may contribute to the development of a new strategy for the primary prevention of childhood obesity...
  8. ncbi request reprint [Outpatient care of patients with diabetes mellitus in 2001. Analysis of a health insurance sample of the AOK in Hesse/KV in Hesse]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der Technischen Universität Munich
    Dtsch Med Wochenschr 128:2638-43. 2003
    ....
  9. ncbi request reprint [Low-carbohydrate or low-fat diet for weight loss--which is better?]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der TU München, Klinikum rechts der Isar, Ismaninger Str 22, D 81675 Munchen
    MMW Fortschr Med 146:33-5, 37. 2004
    ..Successful weight loss largely depends on restricting the intake of calories, but the supply of essential nutrients should be guaranteed...
  10. ncbi request reprint The new concept of adipose tissue function
    Hans Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munchen, Germany
    Physiol Behav 83:653-8. 2004
  11. ncbi request reprint Weight reduction by sibutramine in obese subjects in primary care medicine: the SAT Study
    H Hauner
    German Diabetes Research Institute, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 112:201-7. 2004
    ..Sibutramine is a selective serotonin and noradrenaline reuptake inhibitor that is known to reduce body weight. The efficacy of this drug in primary care medicine is currently unknown...
  12. doi request reprint [Nutritional and psychosomatic aspects of morbid obesity]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar der TU Munchen, Ismaninger Strasse 22, 81675 Munchen, Deutschland
    Chirurg 79:819-25. 2008
    ..Although bariatric surgery produces substantial weight loss and is increasingly recommended, it should be offered only in centers providing multiprofessional care and psychosomatic expertise...
  13. ncbi request reprint Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2-dependent pathway
    Thomas Skurk
    Else Kröner Fresenius Centre for Nutritional Medicine, Technical University Munich, Am Forum 5, 85350 Freising Weihenstephan, Germany
    Obes Res 13:969-73. 2005
    ..The fat cell hormone leptin is known to be implicated in the pathogenesis of hypertension and cardiovascular disease. Here we tested whether angiotensin (Ang) II is involved in the control of leptin release from human adipocytes...
  14. ncbi request reprint Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects
    Vanessa van Harmelen
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technische Universitat Munchen, Freising Weihenstephan, Germany
    Metabolism 53:632-7. 2004
    ....
  15. pmc Prevalence of obesity in primary care using different anthropometric measures--results of the German Metabolic and Cardiovascular Risk Project (GEMCAS)
    Hans Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technical University Munich, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munchen, Germany
    BMC Public Health 8:282. 2008
    ....
  16. doi request reprint The role of dietary fatty acids for early human adipose tissue growth
    Hans Hauner
    Else Kroner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Am J Clin Nutr 98:549S-55S. 2013
    ....
  17. ncbi request reprint Primary culture and differentiation of human adipocyte precursor cells
    Vanessa van Harmelen
    Else Kroner Fresenius Center for Nutritional Medicine, Technical University of Munich, Germany
    Methods Mol Med 107:125-35. 2005
  18. doi request reprint [Obesity]
    Hans Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, TU Munchen, Munchen, Germany
    Med Klin (Munich) 104:851-66. 2009
    ..In addition, the patient should be encouraged to take responsibility for his/her weight management. However, there is urgent need to improve the structural preconditions for effective obesity management in Germany...
  19. ncbi request reprint Managing type 2 diabetes mellitus in patients with obesity
    Hans Hauner
    German Diabetes Research Institute, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Treat Endocrinol 3:223-32. 2004
    ....
  20. doi request reprint Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS
    Christina Holzapfel
    Else Kroener Fresenius Centre for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Universitat Munchen, Munich, Germany
    Eur J Endocrinol 164:205-12. 2011
    ..However, data are rather limited to the adult population and normal-weight children. So far, little is known whether similar associations are present in overweight and obese children and adolescents...
  21. ncbi request reprint Bioappearance and pharmacokinetics of bioactives upon coffee consumption
    Roman Lang
    Chair of Food Chemistry and Molecular Sensory Science, Technische Universitat Munchen, Lise Meitner Str 34, 85354, Freising, Germany
    Anal Bioanal Chem 405:8487-503. 2013
    ....
  22. doi request reprint Breast milk fatty acid profile in relation to infant growth and body composition: results from the INFAT study
    Daniela Much
    Else Kroner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Pediatr Res 74:230-7. 2013
    ..There is some evidence that the n-6/n-3 long-chain polyunsaturated fatty acids (LCPUFAs) ratio in early nutrition, and thus in breast milk, could influence infant body composition...
  23. ncbi request reprint Effect of troglitazone on tumor necrosis factor alpha and transforming growth factor beta expression and action in human adipocyte precursor cells in primary culture
    Thomas Skurk
    Else Kroner Fresenius Center for Nutritional Medicine, Technical University Munich, D 85350 Freising Weihenstephan, Germany
    Metabolism 55:309-16. 2006
    ..In addition, troglitazone improved insulin-stimulated glucose uptake in differentiated fat cells...
  24. doi request reprint Effect of flavonoids on basal and insulin-stimulated 2-deoxyglucose uptake in adipocytes
    Melina Claussnitzer
    Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Freising, Germany
    Mol Nutr Food Res 55:S26-34. 2011
    ..It has been proposed that dietary flavonoids may interfere with glucose transport processes...
  25. doi request reprint Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes
    Gabriele Tiller
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technische Universitat Munchen, 85350 Freising, Germany
    Endocrinology 150:5373-83. 2009
    ....
  26. doi request reprint Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells
    Kerstin Schnäbele
    Chair of the Biofunctionality of Food, Dept of Food and Nutrition, Technische Universitat Munchen, Freising, Germany
    Eur J Nutr 48:154-61. 2009
    ..Both, chronic inflammation and an increased cell proliferation are considered to play an important role in colon carcinogenesis. Diverse phytochemicals were shown to have cell growth inhibiting effects...
  27. ncbi request reprint The proatherogenic cytokine interleukin-18 is secreted by human adipocytes
    Thomas Skurk
    Else Kroner Fresenius Center for Nutritional Medicine, Technical University Munich, D 85350 Weihenstephan, Germany
    Eur J Endocrinol 152:863-8. 2005
    ..The aim of our study was to investigate whether human adipocytes produce IL-18...
  28. doi request reprint Effect of reducing the n-6/n-3 fatty acid ratio on the maternal and fetal leptin axis in relation to infant body composition
    Stefanie Brunner
    Else Kroner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Obesity (Silver Spring) 22:217-24. 2014
    ..To investigate the effect of reducing the n-6/n-3 fatty acid ratio in maternal nutrition on the maternal and cord blood leptin axis and their association with infant body composition up to 2 years...
  29. doi request reprint Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice
    Tobias Ludwig
    Clinical Nutritional Medicine Unit, ZIEL Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, Freising Weihenstephan, Germany
    Am J Physiol Endocrinol Metab 304:E1140-56. 2013
    ..LC-n-3 PUFA effects were pro- and anti-inflammatory and disclose T cell-immunosuppressive potential...
  30. ncbi request reprint The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes
    Helmut Laumen
    Else Kröner Fresenius Centre for Nutritional Medicine, Am Forum 5, D 85350 Freising Weihenstephan, Technische Universitat Munchen, Germany
    Atherosclerosis 196:565-73. 2008
    ..In conclusion our data suggest that rosuvastatin inhibits PAI-1 expression and release from human adipocytes via a MEKK-1-dependent but not a NFkappaB-dependent mechanism...
  31. doi request reprint A novel technique to propagate primary human preadipocytes without loss of differentiation capacity
    Thomas Skurk
    Technische Universitat Munchen, Else Kröner Fresenius Centre for Nutritional Medicine, Am Forum 5, D 85350 Freising Weihenstephan, Germany
    Obesity (Silver Spring) 15:2925-31. 2007
    ..Therefore, we were interested in developing an improved culture system that allows the proliferation of human preadipocytes without loss of differentiation capacity...
  32. ncbi request reprint [Obesity--a somatic or psychological condition or both?]
    Hans Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar der TU Munchen, Munchen, Germany
    Herz 31:207-12. 2006
    ..An effective treatment of this condition may not only significantly improve most somatic and psychological comorbidities of the patients but also prolong life...
  33. ncbi request reprint Albumin inhibits adipogenesis and stimulates cytokine release from human adipocytes
    Janet B Schlesinger
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany
    Am J Physiol Cell Physiol 291:C27-33. 2006
    ..The results of the present study indicate that the presence of BSA in the culture medium has considerable effects on adipocyte function in vitro. These effects should be carefully considered for in vitro studies of adipose tissue...
  34. ncbi request reprint [Adiposis. A somatic or psychic disorder?]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar der TU Munchen
    Chirurg 76:647-52. 2005
    ..For patients with extreme obesity exceeding a BMI of 40 kg/m(2), surgical intervention is the most effective treatment, not only to improve most somatic and psychological comorbidities significantly but also to prolong life...
  35. ncbi request reprint Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients
    T Skurk
    German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany
    Horm Metab Res 34:659-63. 2002
    ..26, p = 0.04, after correction for BMI). In conclusion, our study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans...
  36. ncbi request reprint [Obesity]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar, TU Munchen
    MMW Fortschr Med 149:38-41; quiz 43. 2007
    ..For the treatment of extreme obesity, such surgical procedures as gastric banding or a gastric bypass are also available...
  37. pmc Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146
    Cornelia Then
    Medizinische Klinik und Poliklinik IV, Diabetes Zentrum Campus Innenstadt, Klinikum der Universitat Munchen, Munich, Germany Clinical Cooperation Group Diabetes, Ludwig Maximilians Universität München and Helmholtz Zentrum München, Munich, Germany
    PLoS ONE 8:e78430. 2013
    ..The aim of the present study was to evaluate metabolic alterations in carriers of a common TCF7L2 risk variant...
  38. doi request reprint Primary culture of human adipocyte precursor cells: expansion and differentiation
    Thomas Skurk
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technische Universitat Munchen, Freising Weihenstephan, Germany
    Methods Mol Biol 806:215-26. 2012
    ..Finally, cultures of human adipose precursor cells may also be used as a screening tool for potential novel drug targets to modulate adipocyte differentiation and biology...
  39. doi request reprint Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure
    Isabelle Mack
    Dept of Nutritional Medicine, Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, D 85350 Freising Weihenstephan, Germany
    Am J Physiol Endocrinol Metab 297:E735-48. 2009
    ..This can be enhanced in preadipocytes and induced in adipocytes by TNFalpha and hypoxia in a manner similar to what may occur in WAT in the etiology of obesity...
  40. ncbi request reprint [Clinical advances in "nutritional treatment"]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar der TU Munchen, 81675 Munchen
    Dtsch Med Wochenschr 131:1456-8. 2006
  41. ncbi request reprint Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms
    Melina Claussnitzer
    Chair of Nutritional Medicine, Technische Universitat Munchen, Else Kroner Fresenius Center for Nutritional Medicine, 85350 Freising Weihenstephan, Germany Nutritional Medicine Unit, ZIEL Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany German Center for Diabetes Research DZD, 85764 Neuherberg, Germany Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany and Technische Universität München, 85350 Freising Weihenstephan, Germany Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, MA 02131, USA Electronic address
    Cell 156:343-58. 2014
    ..Thus, cross-species conservation analysis at the level of co-occurring TFBS provides a valuable contribution to the translation of genetic association signals to disease-related molecular mechanisms. ..
  42. doi request reprint Development and application of a stable isotope dilution analysis for the quantitation of advanced glycation end products of creatinine in biofluids of type 2 diabetic patients and healthy volunteers
    Christof Kunert
    Technische Universitat Munchen, Lise Meitner Strasse 34, D 85354 Freising Weihenstephan, Germany
    Anal Chem 85:2961-9. 2013
    ..4), or a more efficient dietary up-take of N-(1-methyl-4-oxoimidazolidin-2-ylidene) α-amino acids in hyperglycemic diabetes patients...
  43. doi request reprint Fate of dietary phytosteryl/-stanyl esters: analysis of individual intact esters in human feces
    Tim Lubinus
    Technische Universitat Munchen, Maximus von Imhof Forum 2, 85350, Freising Weihenstephan, Germany
    Eur J Nutr 52:997-1013. 2013
    ..The objective was to investigate the metabolic fate of phytosteryl/-stanyl fatty acid and ferulic acid esters upon consumption by healthy humans...
  44. doi request reprint Maternal low-dose estradiol-17β exposure during pregnancy impairs postnatal progeny weight development and body composition
    Rainer Werner Fürst
    Physiology Weihenstephan, Technische Universitat Munchen, 85354 Freising Weihenstephan, Germany
    Toxicol Appl Pharmacol 263:338-44. 2012
    ..In line with findings from other obesogens, our data suggest a programming effect during pregnancy for E2 causative for the depicted phenotypes. Therefore, E2 exposure may imply a possible contribution to childhood obesity...
  45. pmc Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data
    Helmut Laumen
    Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    Diabetes 58:984-91. 2009
    ..Hence, we investigated three SNPs (rs16861194, rs17300539, and rs266729) for their influence on adiponectin promoter activity and their association with circulating adiponectin levels...
  46. ncbi request reprint Relationship between adipocyte size and adipokine expression and secretion
    Thomas Skurk
    Else Kröner Fresenius Centre for Nutritional Medicine, Technical University Munich, Am Forum 5, D 85350 Freising Weihenstephan, Germany
    J Clin Endocrinol Metab 92:1023-33. 2007
    ..This secretory function is considered to provide the basis for obesity-related complications such as type 2 diabetes and atherosclerosis...
  47. ncbi request reprint Production and release of macrophage migration inhibitory factor from human adipocytes
    Thomas Skurk
    Else Kröner Fresenius Centre for Nutritional Medicine, Technical University Munich, Hochfeldweg 1, D 85350 Freising Weihenstephan
    Endocrinology 146:1006-11. 2005
    ..We therefore analyzed whether human adipocytes produce MIF, in the search of candidate mediators of macrophage infiltration of obese adipose tissue...
  48. doi request reprint Role of the adipocyte-specific NF-κB activity in the regulation of IP-10 and T cell migration
    Patricia Krinninger
    Else Kröner Fresenius Centre for Nutritional Medicine, Freising, Germany
    Am J Physiol Endocrinol Metab 300:E304-11. 2011
    ..Adipocytes rather than preadipocytes contribute to NF-κB-dependent IP-10 expression and secretion. Furthermore, NF-κB-dependent factors and especially IP-10 represent novel signals from adipocytes to induce T cell migration...
  49. doi request reprint Effect of conditioned media from mature human adipocytes on insulin-stimulated Akt/PKB phosphorylation in human skeletal muscle cells: role of BMI and fat cell size
    T Skurk
    Else Kroner Fresenius Center for Nutritional Medicine, Life Science Center Weihenstephan, Technische Universitat Munchen, Munich, Germany
    Horm Metab Res 41:190-6. 2009
    ....
  50. doi request reprint [Nutrition therapy for gestational diabetes]
    U Amann-Gassner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technische Universitat Munchen, Am Forum 5, 85350 Freising Weihenstephan
    Dtsch Med Wochenschr 133:893-8. 2008
    ..Thus, individualized nutritional treatment together with other specific lifestyle interventions are the principal components in the management of GDM...
  51. doi request reprint Expression and secretion of RANTES (CCL5) in human adipocytes in response to immunological stimuli and hypoxia
    T Skurk
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technische Universitat Munchen, Freising, Germany
    Horm Metab Res 41:183-9. 2009
    ..LPS and IFNgamma do not seem to play a significant role for the expression of RANTES in contrast to moderate hypoxia, which points to a distinct role in the innate immune system...
  52. ncbi request reprint Current pharmacological approaches to the treatment of obesity
    H Hauner
    German Diabetes Research Institute, Heinrich Heine University Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Int J Obes Relat Metab Disord 25:S102-6. 2001
    ..In addition, other current and future pharmacological principles for weight reduction are discussed. There is no doubt that an evidence-based rational pharmacological treatment of obesity is still in an early stage...
  53. doi request reprint [Weight reduction in obese subjects--what role do genes play?]
    C Holzapfel
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar, Technische Universitat Munchen
    Dtsch Med Wochenschr 134:644-9. 2009
    ..However, the identification of gene effects could contribute to offering personalized treatment of obesity and thus achieving greater weight loss...
  54. ncbi request reprint [Epidemiology and costs of diabetes mellitus in Germany]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar der TU Munchen, Munchen
    Dtsch Med Wochenschr 130:S64-5. 2005
  55. doi request reprint [Costs of antihyperglycemic drugs and consumables and treatment satisfaction in patients with type 2 diabetes. Results of the health care research study LIVE-DE (long-acting insulin glargine compared with NPH insulin in Germany)]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technischen Universitat, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich
    Dtsch Med Wochenschr 134:1207-13. 2009
    ....
  56. ncbi request reprint [Secretory activity of the adipocytes and comorbidities of obesity]
    T Skurk
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, TU Munchen
    MMW Fortschr Med 147:41-3. 2005
    ..Further clinical studies are needed...
  57. doi request reprint [Weight maintenance after weight loss - how the body defends its weight]
    C Holzapfel
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar, Technische Universitat Munchen
    Dtsch Med Wochenschr 136:89-94. 2011
    ..Concerning nutrition a fat-reduced diet with a decrease of energy density together with regular eating habits and adequate portion size promises the greatest benefit and is likely to allow sufficient satiety...
  58. ncbi request reprint Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension
    Yu Mi Lee
    Else Kröner Fresenius Centre for Nutritional Medicine, Technical University Munich, Am Forum 5, 85350 Freising, Germany
    Eur J Nutr 46:21-7. 2007
    ..Fermentation of milk proteins was shown to lead to the formation of peptides with ACE-inhibiting activity. Milk products with ACE-inhibiting peptides may provide a useful approach to prevent or treat hypertension...
  59. doi request reprint Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men
    Helga Frank
    Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Am J Clin Nutr 90:1509-16. 2009
    ..High-protein diets are effective for weight reduction; however, little is known about the potential adverse renal effects of such diets...
  60. doi request reprint The dynamic range of the human metabolome revealed by challenges
    Susanne Krug
    Department of Nutritional Medicine, Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, Freising Weihenstephan, Germany
    FASEB J 26:2607-19. 2012
    ..Due to the multitude of analytical methods, challenges and sample types, our freely available metabolomics data set provides a unique reference for future metabolomics studies and for verification of systems biology models...
  61. pmc First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study
    Christina Holzapfel
    Else Kröner Fresenius Centre for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    J Epidemiol Community Health 65:174-6. 2011
    ....
  62. ncbi request reprint Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism
    Hans Hauner
    German Diabetes Research Institute, D 40225 Dusseldorf, Germany
    Pharmacogenetics 13:453-9. 2003
    ..However, a significant variability exists among individuals concerning the response to sibutramine...
  63. ncbi request reprint Secretory factors from human adipose tissue and their functional role
    Hans Hauner
    Else Kröner Fresenius Centre for Nutritional Medicine of the Technical University of Munich, Klinikum rechts der Isar, Germany
    Proc Nutr Soc 64:163-9. 2005
    ..The question arising from these observations is how the secretory pattern of adipose tissue can be modified by dietary and pharmacological measures to reduce the health risks of obesity...
  64. ncbi request reprint The mode of action of thiazolidinediones
    Hans Hauner
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Metab Res Rev 18:S10-5. 2002
    ..Therefore, TZDs may also have potential benefits on the secondary complications of type 2 diabetes, such as cardiovascular disease...
  65. ncbi request reprint Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes
    Daniela Dietze
    Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Research Institute, Dusseldorf, Germany
    Diabetes 51:2369-76. 2002
    ..In conclusion, the release of fat cell factors induces insulin resistance in human skeletal muscle cells; however, TNF-alpha and resistin appear not to be involved in this process...
  66. ncbi request reprint Angiotensin II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB
    Thomas Skurk
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der TU München, Hochfeldweg 1, 85350 Freising Weihenstephan, Germany
    Arterioscler Thromb Vasc Biol 24:1199-203. 2004
    ..Angiotensin (Ang) II, which is also produced by adipocytes, might play a role as a regulator. In the present study, we investigated the effect of Ang II on the production of IL-6 and IL-8 in in vitro differentiated human adipocytes...
  67. ncbi request reprint [The costs of diabetes mellitus and its complications in Germany]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum Rechts der Isar und Wissenschaftszentrum Weihenstephan der TU München, Munchen, Germany
    Dtsch Med Wochenschr 131:S240-2. 2006
    ....
  68. ncbi request reprint Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women
    V van Harmelen
    Deutsches Diabetes Forschungsinstitut, Dusseldorf, Germany
    Int J Obes Relat Metab Disord 27:889-95. 2003
    ..To study the relation between body mass index (BMI) and age on the one hand and total number of human (pre-) adipocytes and preadipocyte differentiation capacity on the other hand...
  69. ncbi request reprint Inhibitor kappaB kinase is involved in the paracrine crosstalk between human fat and muscle cells
    D Dietze
    Department of Clinical Biochemistry and Pathobiochemistry, German Diabetes Research Institute, Dusseldorf, Germany
    Int J Obes Relat Metab Disord 28:985-92. 2004
    ..Here we tested the hypothesis that the crosstalk between fat and muscle involves activation of inhibitor kappaB Kinase (IKK) in the myocytes...
  70. ncbi request reprint Effect of maternal obesity with and without gestational diabetes on offspring subcutaneous and preperitoneal adipose tissue development from birth up to year-1
    Kirsten Uebel
    PhD Graduate School Nutritional adaptation and epigenetic mechanisms, ZIEL Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, Freising Weihenstephan, Germany
    BMC Pregnancy Childbirth 14:138. 2014
    ....
  71. pmc Metabolic effects of replacing sucrose by isomaltulose in subjects with type 2 diabetes: a randomized double-blind trial
    Stefanie Brunner
    Else Kroner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Diabetes Care 35:1249-51. 2012
    ..To test the hypothesis that replacement of sucrose with isomaltulose in sweet foods and beverages improves metabolic control in patients with type 2 diabetes...
  72. doi request reprint Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee
    Roman Lang
    Chair of Food Chemistry and Molecular Sensory Science, Technische Universitat Munchen, Lise Meitner Strasse 34, D 85354 Freising, Germany
    Anal Chem 82:1486-97. 2010
    ..4 +/- 6.9% of trigonelline and 69.1 +/- 6.2% of N-methylpyridinium was found for the male volunteers, whereas females excreted slightly less with 46.2 +/- 7.4% and 61.9 +/- 12.2% of these pyridines...
  73. doi request reprint Effect of Spinacia oleraceae L. and Perilla frutescens L. on antioxidants and lipid peroxidation in an intervention study in healthy individuals
    Georg Schirrmacher
    Center of Greenhouses and Laboratories Dürnast, Quality of Vegetal Foodstuff, Life Science Center Weihenstephan, Technische Universitat Munchen, Freising, Germany
    Plant Foods Hum Nutr 65:71-6. 2010
    ..The high lutein content of perilla caused a more pronounced increase of lutein compared to spinach. Both vegetables seem to be able to influence lipid peroxidation in a beneficial manner...
  74. ncbi request reprint Tissue engineering of white adipose tissue using hyaluronic acid-based scaffolds. I: in vitro differentiation of human adipocyte precursor cells on scaffolds
    Melanie Halbleib
    German Diabetes Research Institute, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Biomaterials 24:3125-32. 2003
    ..Aim of this study was to develop a biohybrid construct consisting of hyaluronic acid-based scaffolds and human adipocyte precursor cells as a soft tissue filler...
  75. ncbi request reprint HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes
    V van Harmelen
    Deutsches Diabetes Forschungsinstitut, Dusseldorf, Germany
    Horm Metab Res 35:466-70. 2003
    ..Our data suggest that cerivastatin exerts an anti-inflammatory effect by down-regulating IL-6 levels in adipocytes, which seems to be mediated by reduced production of GGPP and interference with the NFkappaB pathway...
  76. ncbi request reprint [Prevention of type 2 diabetes mellitus. Position paper of the National Action Forum for Diabetes Mellitus]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der TU München, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munchen
    Dtsch Med Wochenschr 130:1053-4. 2005
  77. ncbi request reprint Effect of angiotensin peptides on PAI-1 expression and production in human adipocytes
    T Skurk
    German Diabetes Research Institute,
    Horm Metab Res 33:196-200. 2001
    ..We conclude that PAI-1 production by adipose tissue may contribute to the elevated thromboembolic risk in obesity...
  78. ncbi request reprint Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000
    W Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center at Heinrich Heine University, Dusseldorf, Germany
    Int J Obes (Lond) 31:770-6. 2007
    ..In men, high adiponectin concentrations were related to a lower risk of myocardial infarction, whereas no association with cardiovascular events was found in women...
  79. ncbi request reprint Prevalence of undiagnosed Type-2-diabetes mellitus and impaired fasting glucose in German primary care: data from the German Metabolic and Cardiovascular Risk Project (GEMCAS)
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technical University Munich, Munchen, Germany
    Exp Clin Endocrinol Diabetes 116:18-25. 2008
    ....
  80. ncbi request reprint [New definition of the metabolic syndrome--where does the disease begin?]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin, Klinikum rechts der Isar der TU Munchen
    MMW Fortschr Med 148:42-4. 2006
  81. pmc Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh--an ethnobotanical survey
    Soeren Ocvirk
    Else Kroener Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, 81675 Munich and ZIEL Research Center for Nutrition and Food Sciences, Technische Universitat Munchen, 85350 Freising Weihenstephan, Germany
    J Ethnobiol Ethnomed 9:43. 2013
    ..We conducted an ethnobotanical survey to identify the traditional medicinal plants being used to treat diabetes in Bangladesh and to critically assess their anti-diabetic potentials with focus on evidence-based criteria...
  82. ncbi request reprint Insulin resistance and the metabolic syndrome-a challenge of the new millennium
    H Hauner
    German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Clin Nutr 56:S25-9. 2002
    ..In its modern meaning this term was propagated by Hanefeld and Leonhardt and by Kaplan, who also called the syndrome the 'deadly quartet' to emphasize its high atherogenic potential...
  83. ncbi request reprint The phosphodiesterase inhibitor IBMX suppresses TNF-alpha expression in human adipocyte precursor cells: a possible explanation for its adipogenic effect
    F Hube
    Diabetes Research Institute at the Heinrich-Heine-University, , Germany
    Horm Metab Res 31:359-62. 1999
    ..These results suggest that the adipogenic effect of IBMX is mediated by suppression of endogenous TNF production...
  84. ncbi request reprint [Nutritional medicine 2007]
    H Hauner
    Else Kröner Fresenius Zentrum für Ernährungsmedizin der TU München, Munchen, Germany
    Dtsch Med Wochenschr 132:1411-3. 2007
  85. ncbi request reprint Effect of the angiotensin II receptor blocker candesartan on fibrinolysis in patients with mild hypertension
    T Skurk
    German Diabetes Research Institute at the Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes Obes Metab 6:56-62. 2004
    ..Impaired fibrinolysis is frequently observed in patients with the metabolic syndrome. Aim of the study was to examine the short-term effect of angiotensin II receptor blockade on the fibrinolytic system...
  86. ncbi request reprint Informatics and medicine--from molecules to populations
    K A Kuhn
    Technische Universitat Munchen, Munich, Germany
    Methods Inf Med 47:283-95. 2008
    ..To clarify challenges and research topics for informatics in health and to describe new approaches for interdisciplinary collaboration and education...
  87. pmc Access technique and its problems in parenteral nutrition - Guidelines on Parenteral Nutrition, Chapter 9
    K W Jauch
    Dept Surgery Grosshadern, University Hospital, Munich, Germany
    Ger Med Sci 7:Doc19. 2009
    ..A peripheral venous catheter (PVC) can remain in situ for as long as it is clinically required unless there are signs of inflammation at the insertion site...
  88. pmc Complications and monitoring - Guidelines on Parenteral Nutrition, Chapter 11
    W H Hartl
    Dept Surgery Grosshadern, University Hospital, Munich, Germany
    Ger Med Sci 7:Doc17. 2009
    ..Monitoring metabolic determinants of bone metabolism is particularly important in patients receiving long-term PN. Markers of intermediary, electrolyte and trace element metabolism require regular checks...
  89. ncbi request reprint Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture
    T Skurk
    Clinical Department, German Diabetes Research Institute, , Germany
    Hypertension 37:1336-40. 2001
    ..AT(1) receptor blockade reduces basal and abolishes Ang II-stimulated PAI-1 release from human adipocytes...
  90. ncbi request reprint Mapping of early signaling events in tumor necrosis factor-alpha -mediated lipolysis in human fat cells
    Mikael Ryden
    Lipid Laboratory, Department of Medicine and Surgery, Karolinska Institute, Huddinge University Hospital, S 141 86 Huddinge, Stockholm, Sweden
    J Biol Chem 277:1085-91. 2002
    ..In conclusion, although TNF-alpha activates all three known MAPK in human preadipocytes, only p44/42 and JNK appear to be involved in the regulation of lipolysis...
  91. ncbi request reprint Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes
    Vanessa van Harmelen
    Department of Medicine, Karolinska Institute and Center for Metabolism and Endocrinology, Huddinge University Hospital, Stockholm, Sweden
    Diabetes 51:2029-36. 2002
    ..e., primary) factors...
  92. ncbi request reprint The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis
    Sucharita Sen Banerjee
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 278:2581-4. 2003
    ..These data identify a novel role for KLF2 as a negative regulator of adipogenesis...
  93. ncbi request reprint A phytosterol-enriched spread improves the lipid profile of subjects with type 2 diabetes mellitus--a randomized controlled trial under free-living conditions
    Yu Mi Lee
    Klinische Abteilung, Deutsches Diabetes Forschungsinstitut, an der Heinrich Heine Universität Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Eur J Nutr 42:111-7. 2003
    ..Phytosterol-enriched margarines are known to significantly lower total and LDL cholesterol, but little is known about the effect of such margarines in subjects with type 2 diabetes...
  94. ncbi request reprint [Lucrative "lipolysis". The spring time diet consultation (interview by Dr. Jochen Aumiller)]
    Hans Hauner
    MMW Fortschr Med 150:7. 2008
  95. ncbi request reprint T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    Ulrich Kintscher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 28:1304-10. 2008
    ..Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue inflammation and IR...
  96. ncbi request reprint [Costs of the treatment of hyperglycemia in patients with diabetes mellitus. The impact of age, type of therapy and complications: results of the German CoDiM study]
    Liselotte von Ferber
    PMV forschungsgruppe an der Klinik und Poliklinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters, Universitätsklinikum Köln, Koln
    Med Klin (Munich) 101:384-93. 2006
    ..However, the specific cost structure is not known. It was the aim of this study to analyze the costs of antihyperglycemic treatment in relation to age, treatment regimen and presence of complications...
  97. ncbi request reprint Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg
    Eva Maria Sedlmeier
    Institute of Epidemiology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Eur J Endocrinol 156:377-85. 2007
    ..The present study investigated the association of nine MCP-1 single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors...
  98. ncbi request reprint Hypoadiponectinemia and proinflammatory state: two sides of the same coin?: results from the Cooperative Health Research in the Region of Augsburg Survey 4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:1626-31. 2006
    ..The major aim of this cross-sectional study was to investigate the interdependence of hypoadiponectinemia and low-grade systemic inflammation...
  99. ncbi request reprint Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes
    Coralie Sengenes
    Obesity Research Unit, INSERM U 586, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, Universite Paul Sabatier, Toulouse, France
    J Biol Chem 278:48617-26. 2003
    ..The present study shows that lipolysis in human adipocytes can be controlled by an independent cGKI-mediated signaling as well as by the classical cAMP/PKA pathway...
  100. ncbi request reprint [HbA1c of 6.5%. A rigid goal in diabetes therapy? (interview by Dr. Dirk Einecke)]
    Hans Hauner
    MMW Fortschr Med 150:16. 2008
  101. ncbi request reprint [Prevention of type 2 diabetes in Germany--a challenge for health professionals]
    Peter E H Schwarz
    Medizinische Klinik III, Universitätsklinikum Carl Gustav Carus der technischen Universität Dresden
    Med Monatsschr Pharm 30:289-96. 2007
    ..This process will be challenging and time consuming, requiring many partners but resulting in a profitable "health" investment...