Stefanie M Hauck

Summary

Country: Germany

Publications

  1. Grosche A, Hauser A, Lepper M, Mayo R, von Toerne C, Merl Pham J, et al. The Proteome of Native Adult Müller Glial Cells From Murine Retina. Mol Cell Proteomics. 2016;15:462-80 pubmed publisher
    ..This provides the basis to allow the discovery of novel glial specializations and will enable us to elucidate the role of Müller cells in retinal pathologies - a topic still controversially discussed. ..
  2. von Toerne C, Menzler J, Ly A, Senninger N, Ueffing M, Hauck S. Identification of a novel neurotrophic factor from primary retinal Müller cells using stable isotope labeling by amino acids in cell culture (SILAC). Mol Cell Proteomics. 2014;13:2371-81 pubmed publisher
    ..These findings suggest that CXCL10 contributes to the supportive potential of RMGs toward retinal neurons. ..
  3. Uhl P, Amann B, Hauck S, Deeg C. Novel localization of peripherin 2, the photoreceptor-specific retinal degeneration slow protein, in retinal pigment epithelium. Int J Mol Sci. 2015;16:2678-92 pubmed publisher
    ..Our novel findings are very promising for better understanding the molecular mechanisms taking place on RPE in uveitis. ..
  4. Schäfer A, Neschen S, Kahle M, Sarioglu H, Gaisbauer T, Imhof A, et al. The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and is Repressed in Insulin-Resistant Mouse Liver. Mol Cell Proteomics. 2015;14:2764-74 pubmed publisher
    ..The stimulation of insulin signaling by EETs and depression of the pathway in insulin resistant liver suggest a likely role in hepatic insulin resistance. Our findings support therapeutic potential for inhibiting EET degradation. ..
  5. Reagan A, Gu X, Hauck S, Ash J, Cao G, Thompson T, et al. Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol. 2016;854:411-8 pubmed publisher
    ..Thus, Cav-1 modulates neuroprotective signaling by regulating the endogenous production of neuroprotective factors. ..
  6. Merl Pham J, Gruhn F, Hauck S. Proteomic Profiling of Cigarette Smoke Induced Changes in Retinal Pigment Epithelium Cells. Adv Exp Med Biol. 2016;854:785-91 pubmed publisher
    ..The analysis of associated biological processes revealed an alteration of proteins involved in RNA processing and transport as well as extracellular matrix remodelling in response to cigarette smoke treatment. ..
  7. Pao P, Emri E, Abdirahman S, Soorma T, Zeng H, Hauck S, et al. The effects of zinc supplementation on primary human retinal pigment epithelium. J Trace Elem Med Biol. 2018;49:184-191 pubmed publisher
    ..The results also highlight that determining and controlling of available, as opposed to total added, zinc will be essential to be able to compare results obtained in different laboratories. ..
  8. Walker A, Russmann V, Deeg C, von Toerne C, Kleinwort K, Szober C, et al. Proteomic profiling of epileptogenesis in a rat model: Focus on inflammation. Brain Behav Immun. 2016;53:138-158 pubmed publisher
    ..Taken together, the findings deepen our understanding of modulation of inflammatory signaling during epileptogenesis providing an excellent and comprehensive basis for the identification of target and biomarker candidates. ..
  9. Amann B, Kleinwort K, Hirmer S, Sekundo W, Kremmer E, Hauck S, et al. Expression and Distribution Pattern of Aquaporin 4, 5 and 11 in Retinas of 15 Different Species. Int J Mol Sci. 2016;17: pubmed publisher
    ..Our data indicate a disparity in aquaporin distribution in retinas of various animals, especially for AQP5 and 11. ..

More Information

Publications12

  1. von Toerne C, Laimighofer M, Achenbach P, Beyerlein A, de Las Heras Gala T, Krumsiek J, et al. Peptide serum markers in islet autoantibody-positive children. Diabetologia. 2017;60:287-295 pubmed publisher
    ..Distinct peptide signatures indicate islet autoimmunity prior to the clinical manifestation of type 1 diabetes and enable refined staging of the presymptomatic disease period. ..
  2. Hauck S, Hofmaier F, Dietter J, Swadzba M, Blindert M, Amann B, et al. Label-free LC-MSMS analysis of vitreous from autoimmune uveitis reveals a significant decrease in secreted Wnt signalling inhibitors DKK3 and SFRP2. J Proteomics. 2012;75:4545-54 pubmed publisher
    ..Furthermore, retinal expression levels and patterns of DKK3 change in response to ERU. Since many other regulated proteins identified here are associated with RMG cells, these cells qualify as the prime responders to autoimmune triggers...
  3. Obermann J, Priglinger C, Merl Pham J, Geerlof A, Priglinger S, Gotz M, et al. Proteome-wide Identification of Glycosylation-dependent Interactors of Galectin-1 and Galectin-3 on Mesenchymal Retinal Pigment Epithelial (RPE) Cells. Mol Cell Proteomics. 2017;16:1528-1546 pubmed publisher
    ..In conclusion, the identified specific glycoprotein ligands shed light into the highly specific binding of galectins to dedifferentiated RPE cells and the resulting prevention of PVR-associated cellular events. ..