M Hasselblatt

Summary

Country: Germany

Publications

  1. doi request reprint High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Genes Chromosomes Cancer 52:185-90. 2013
  2. ncbi request reprint Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 cases
    M Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Germany
    Neuropathol Appl Neurobiol 31:618-22. 2005
  3. ncbi request reprint Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstrasse 19, 48129 Munster, Germany
    Am J Surg Pathol 30:66-74. 2006
  4. ncbi request reprint Astrocytic gene expression profiling upon hypoxia
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital, Munster, Germany
    Neuroreport 17:51-4. 2006
  5. ncbi request reprint Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region
    M Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Neuropathol Appl Neurobiol 32:278-83. 2006
  6. doi request reprint Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48129, Munster, Germany
    J Neurooncol 91:151-5. 2009
  7. doi request reprint [Molecular diagnostic testing in gliomas]
    M Hasselblatt
    Institut für Neuropathologie, Universitatsklinikum Munster, Domagkstrasse 19, 48129, Munster, Deutschland
    Pathologe 29:422-7. 2008
  8. doi request reprint Hypothalamic papillary tumor in a patient with tuberous sclerosis
    Martin Hasselblatt
    Institutes of Neuropathology, University Hospital Munster, Munster, Germany
    Am J Surg Pathol 32:1578-80. 2008
  9. ncbi request reprint Choroid plexus papilloma with neuropil-like islands
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Germany
    Am J Surg Pathol 32:162-6. 2008
  10. ncbi request reprint Corticobasal degeneration presenting with progressive spasticity
    M Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48129 Munster, Germany
    Neurology 68:791-2. 2007

Detail Information

Publications38

  1. doi request reprint High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Genes Chromosomes Cancer 52:185-90. 2013
    ..In conclusion, these data further suggest the absence of recurrent genomic alterations other than SMARCB1 in AT/RT...
  2. ncbi request reprint Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 cases
    M Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Germany
    Neuropathol Appl Neurobiol 31:618-22. 2005
    ..To conclude, the results from this retrospective study suggest that histological subtyping of haemangioblastomas has prognostic implications and might contribute to identify patients at risk for recurrence...
  3. ncbi request reprint Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstrasse 19, 48129 Munster, Germany
    Am J Surg Pathol 30:66-74. 2006
    ..Our data suggest that antibodies directed against Kir7.1 and stanniocalcin-1 might serve as sensitive and specific diagnostic markers for choroid plexus tumors...
  4. ncbi request reprint Astrocytic gene expression profiling upon hypoxia
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital, Munster, Germany
    Neuroreport 17:51-4. 2006
    ..Further analysis of these genes might provide a better understanding of astrocyte function upon hypoxic conditions...
  5. ncbi request reprint Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region
    M Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Neuropathol Appl Neurobiol 32:278-83. 2006
    ..Antibodies directed against these antigens are thus expected to be valuable markers in the diagnosis of papillary tumours located in the vicinity of the third ventricle...
  6. doi request reprint Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48129, Munster, Germany
    J Neurooncol 91:151-5. 2009
    ..Determination of MGMT promoter methylation status might be useful for the stratification of patients for alkylator-based treatments in future clinical trials...
  7. doi request reprint [Molecular diagnostic testing in gliomas]
    M Hasselblatt
    Institut für Neuropathologie, Universitatsklinikum Munster, Domagkstrasse 19, 48129, Munster, Deutschland
    Pathologe 29:422-7. 2008
    ..This review summarizes methods and rationale for the use of the determination of 1p/19q loss, MGMT promoter methylation and tyrosine kinase receptor expression as diagnostic, prognostic and predictive markers in gliomas...
  8. doi request reprint Hypothalamic papillary tumor in a patient with tuberous sclerosis
    Martin Hasselblatt
    Institutes of Neuropathology, University Hospital Munster, Munster, Germany
    Am J Surg Pathol 32:1578-80. 2008
    ..This hitherto undescribed low-grade hypothalamic tumor extends the spectrum of tumors associated with the tuberous sclerosis complex...
  9. ncbi request reprint Choroid plexus papilloma with neuropil-like islands
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Germany
    Am J Surg Pathol 32:162-6. 2008
    ..This case further emphasizes the capacity of choroid plexus tumor cells toward neuronal differentiation, and expands the spectrum of tumors, which may contain neuropil-like islands...
  10. ncbi request reprint Corticobasal degeneration presenting with progressive spasticity
    M Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48129 Munster, Germany
    Neurology 68:791-2. 2007
  11. doi request reprint TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasion
    Martin Hasselblatt
    Institute of Neuropathology and Integrated Functional Genomics, IZKF, University Hospital Munster, Munster, Germany
    Cancer Res 69:2219-23. 2009
    ..Among those, TWIST1 is highly expressed in choroid plexus papillomas and promotes proliferation and invasion...
  12. ncbi request reprint Juvenile psammomatoid ossifying fibroma of the neurocranium. Report of four cases
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Germany
    J Neurosurg 102:1151-4. 2005
    ..Moreover, the absence of activating missense mutations of the GNAS1 gene in two cases strongly argues against a relationship between JPOF and fibrous dysplasia...
  13. doi request reprint BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults
    M Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Neuropathol Appl Neurobiol 37:803-6. 2011
    ..As data on BRAF-KIAA1549 fusion transcript status remain mainly limited to children, we aimed to examine the diagnostic value of BRAF-KIAA1549 fusion transcripts across all age groups...
  14. ncbi request reprint Sensitivity and specificity of epithelial membrane antigen staining patterns in ependymomas
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48129 Munster, Germany
    Acta Neuropathol 106:385-8. 2003
    ..To conclude, distinct punctate and ring-like EMA staining might serve as sensitive and specific markers of ependymal differentiation in glial tumors and, thus, may aid the diagnosis of ependymoma...
  15. ncbi request reprint Intracranial follicular dendritic cell sarcoma. Case report
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Germany
    J Neurosurg 99:1089-90. 2003
    ..The diagnosis of FDC sarcoma was confirmed by immunohistochemical staining for dendritic cell markers, that is, CD21, CD23, and CD35. Due to some similarities with meningioma, intracranial FDC sarcoma might be an underdiagnosed disease...
  16. ncbi request reprint Familial occurrence of dysembryoplastic neuroepithelial tumor
    M Hasselblatt
    Institute of Neuropathology, Gerhard Domagk Institute of Pathology, University Hospital, Munster, Germany
    Neurology 62:1020-1. 2004
  17. ncbi request reprint Angiomatous meningioma: a clinicopathologic study of 38 cases
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Am J Surg Pathol 28:390-3. 2004
    ..Since all angiomatous meningiomas examined here were grade 1 tumors, the diagnosis of angiomatous meningioma may have prognostic implications. Therefore, the existence of this rare subgroup of meningioma appears justified...
  18. ncbi request reprint Serum S100beta increases in marathon runners reflect extracranial release rather than glial damage
    M Hasselblatt
    Institutes of Neuropathology, University Hospital Munster, Germany
    Neurology 62:1634-6. 2004
    ..001). To conclude, serum S100beta increases after running originate from extracranial sources. CK determination may improve specificity of S100beta as a marker of brain tissue damage in acute trauma...
  19. doi request reprint Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstrasse 19, Munster, Germany
    Am J Surg Pathol 35:933-5. 2011
    ..2032C>T (p.Q678X)]. Our findings highlight the role of SMARCA4 in the pathogenesis of SMARCB1-positive AT/RT and the usefulness of antibodies directed against SMARCA4 in this diagnostic setting...
  20. doi request reprint Cribriform neuroepithelial tumor (CRINET): a nonrhabdoid ventricular tumor with INI1 loss and relatively favorable prognosis
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    J Neuropathol Exp Neurol 68:1249-55. 2009
    ..We suggest that cribriform neuroepithelial tumor (CRINET) is a nonrhabdoid ventricular tumor that shows loss of tumoral INI1 protein and has a relatively favorable prognosis...
  21. doi request reprint Ependymal tumors
    Martin Hasselblatt
    Institute of Neuropathology, University of Munster, Domagkstr 19, Munster, 48129, Germany
    Recent Results Cancer Res 171:51-66. 2009
    ..Furthermore, potential molecular targets for therapy are outlined...
  22. ncbi request reprint Granulocyte-colony stimulating factor (G-CSF) and G-CSF receptor expression in human ischemic stroke
    Martin Hasselblatt
    Institute of Neuropathology, University Hospital Munster, Domagkstr 19, 48129, Munster, Germany
    Acta Neuropathol 113:45-51. 2007
    ..In conclusion, the observed up-regulation of G-CSF receptors and G-CSF points towards a role in the pathophysiology of human ischemic stroke...
  23. ncbi request reprint Platelet-derived growth factor receptor expression and amplification in choroid plexus carcinomas
    Nina N Nupponen
    Molecular Cancer Biology Program, University of Helsinki, Helsinki, Finland
    Mod Pathol 21:265-70. 2008
    ....
  24. ncbi request reprint Prognostic implications of atypical histologic features in choroid plexus papilloma
    Astrid Jeibmann
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    J Neuropathol Exp Neurol 65:1069-73. 2006
    ..Close follow up of patients harboring atypical choroid plexus papillomas may be warranted...
  25. ncbi request reprint Prognosis and histopathologic features in papillary tumors of the pineal region: a retrospective multicenter study of 31 cases
    Michelle Fevre-Montange
    INSERM, U433, Fac Med RTH Laennec, Lyon, France
    J Neuropathol Exp Neurol 65:1004-11. 2006
    ..To conclude, the clinical course of PTPR is characterized by frequent local recurrence, and the value of radiotherapy on disease progression will need to be investigated in future prospective trials...
  26. pmc A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
    Hannelore Ehrenreich
    Max Planck Institute of Experimental Medicine, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 102:862-7. 2005
    ..This effect is not only inhibited by EPO but also by neurotrophins. We suggest that the proapoptotic function of TPO helps to select for neurons that have acquired target-derived neurotrophic support...
  27. ncbi request reprint Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome
    Michael C Frühwald
    University Children s Hospital Muenster, Department of Paediatric Haematology and Oncology, Muenster, Germany
    Pediatr Blood Cancer 47:273-8. 2006
    ..2. Several familial cases have been published and summarized under the term rhabdoid tumor predisposition syndrome. In all of the published familial cases, inactivation of SMARCB1 was detected in tumor tissues...
  28. ncbi request reprint Cytogenetic features of ependymoblastomas
    Christian H Rickert
    Department of Anatomical Pathology, Royal Children s Hospital Melbourne, Flemington Road, Parkville, Vic, 3052, Australia, and Institute of Neuropathology, University Hospital Munster, Germany
    Acta Neuropathol 111:559-62. 2006
    ..All three had died of their disease after a post-operative survival of 9 months (range 6-14 months). Our CGH data suggest that ependymoblastomas show distinct and fairly consistent chromosomal aberrations...
  29. ncbi request reprint Nitric oxide synthase in muscular dystrophies: a re-evaluation
    Igor B Buchwalow
    Gerhard Domagk Institute of Pathology, University of Muenster, Domagkstr 17, 48149, Muenster, Germany
    Acta Neuropathol 111:579-88. 2006
    ....
  30. ncbi request reprint Impact of creatine kinase correction on the predictive value of S-100B after mild traumatic brain injury
    Jeffrey J Bazarian
    Department of Emergency Medicine, University of Rochester School of Medicine, Rochester, NY, USA
    Restor Neurol Neurosci 24:163-72. 2006
    ..To validate a correction factor for the extracranial release of the astroglial protein, S-100B, based on concomitant creatine kinase (CK) levels...
  31. ncbi request reprint Nitric oxide synthase is up-regulated in muscle fibers in muscular dystrophy
    Karla Punkt
    Institute of Anatomy, University of Leipzig, Leipzig, Germany
    Biochem Biophys Res Commun 348:259-64. 2006
    ..These results support the hypothesis that NO deficiency with consequent muscle degeneration in DMD results from NO scavenging by superoxides rather than from reduced NOS expression...
  32. ncbi request reprint No evidence for epidermal growth factor receptor amplification and overexpression in atypical teratoid/rhabdoid tumors
    Astrid Jeibmann
    Acta Neuropathol 112:513-4. 2006
  33. ncbi request reprint Malignant progression in choroid plexus papillomas
    Astrid Jeibmann
    Institute of Neuropathology, University Hospital Munster, Germany
    J Neurosurg 107:199-202. 2007
    ..Malignant progression of choroid plexus papillomas has been occasionally reported, but this issue has not yet been systematically addressed...
  34. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
    ..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...
  35. ncbi request reprint In vitro gender differences in neuronal survival on hypoxia and in 17beta-estradiol-mediated neuroprotection
    Andrea Heyer
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    J Cereb Blood Flow Metab 25:427-30. 2005
    ..Estrogens, acting via membrane receptors, had a higher neuroprotective power in male neurons, explained at least in part by the pronounced increase in estrogen receptor beta/alpha ratio during hypoxia in male cells only...
  36. ncbi request reprint Cellular and reticular variants of hemangioblastoma differ in their cytogenetic profiles
    Christian H Rickert
    Department of Anatomical Pathology, Royal Children s Hospital Melbourne, Parkville, Vic, Australia
    Hum Pathol 37:1452-7. 2006
    ..16). In conclusion, our data may point toward different genetic pathways in the pathogenesis of the 2 histologic subtypes of capillary hemangioblastoma...
  37. ncbi request reprint Effect of endothelin-1 on astrocytic protein content
    Martin Hasselblatt
    Max Planck Institut fur experimentelle Medizin, Gottingen, Germany
    Glia 42:390-7. 2003
    ..This hypertrophic response involves uncoupling of the astrocytic gap junctional network and is not dependent on DNA synthesis...
  38. ncbi request reprint Endothelin B receptor deficiency augments neuronal damage upon exposure to hypoxia-ischemia in vivo
    ANNA LEENA SIREN
    Department of Neurology, Georg August University, and Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Brain Res 945:144-9. 2002
    ..n=5, P=0.0560). To conclude, absence of functional ETB receptors is associated with an increased susceptibility to HI in-vivo, which is not intrinsic to neurons. Antagonism of ETB receptors seems not to be desirable in ischemic stroke...