- [AT(1) blocker for post-infarct therapy. VALIANT Study]G Hasenfuss
Zentrum Innere Medizin, Kardiologie und Pneumologie, Georg August Universitat, Robert Koch Strasse 40, 37075 Gottingen
Internist (Berl) 45:946-8. 2004
- Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardiumG Hasenfuss
Zentrum Innere Medizin, Abteilung für Kardiologie und Pneumologie, Universitat Gottingen, Germany
Circulation 98:2141-7. 1998..Levosimendan was shown to increase calcium sensitivity by a novel mechanism and to inhibit phosphodiesterase III activity in animal myocardium...
- [Acute cor pulmonale in pulmonary embolism. An important prognostic factor and a critical parameter for the choice of a therapeutic strategy]S Konstantinides
Abteilung Kardiologie und Pneumologie, Klinikum der Georg August Universität Göttingen
Internist (Berl) 45:1155-62. 2004..Rapid identification of acute cor pulmonale with echocardiography and cardiac biomarkers has recently proven to be especially helpful in this regard...
- Angiotensin II blockers in obstructive pulmonary disease: a randomised controlled trialS Andreas
Lungenfachklinik Immenhausen, Robert Koch Str 3, 34376 Immenhausen, Germany
Eur Respir J 27:972-9. 2006..However, the changes in haematocrit and total lung capacity following irbesartan raise the possibility that well-known cardiovascular drugs can produce unanticipated beneficial effects in chronic obstructive pulmonary disease patients...
- Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractilityJ Prestle
Department of Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany
Circ Res 88:188-94. 2001..Taken together, these data suggest that FKBP12.6 stabilizes the closed conformation state of RyR2. This may reduce diastolic SR-Ca(2+) leak and consequently increase SR-Ca(2+) release and myocyte shortening...
- Preservation of myocardial function after adenoviral gene transfer in isolated myocardiumS E Lehnart
Abteilung Kardiologie und Pneumologie, Universitat Gottingen, D 37075 Gottingen, Germany
Am J Physiol Heart Circ Physiol 279:H986-91. 2000..005). Our results demonstrate a new ex vivo approach to achieve homogenous and high-level expression of recombinant adenoviral genes in contracting myocardium without adverse functional effects...
- Impact of beta-adrenoceptor antagonists on myofilament calcium sensitivity of rabbit and human myocardiumO Zeitz
Department of Cardiology and Pneumology, University of Gottingen, Germany
J Cardiovasc Pharmacol 36:126-31. 2000..1 +/- 0.9 to 1.7 +/- 0.4 mN/mm2. We conclude that nebivolol desensitizes cardiac myofilaments slightly, whereas neither propranolol nor carvedilol had an effect...
- Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardiumP M Janssen
Abt Kardiologie und Pneumologie, Universitat Gottingen, Gottingen, Germany
Cardiovasc Res 47:99-107. 2000..We investigated the direct effects of CsA on myocardial function, because these are largely unknown...
- [Pathophysiological basis of heart failure]B Pieske
Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen
Ther Umsch 57:284-92. 2000..Endothelin and angiotensin may contribute to the regulation of myocardial contractility in the human heart, but their functional relevance in the regulation of myocardial contractility under clinical conditions remains to be evaluated...
- Mechanism of action of the new anti-ischemia drug ranolazineG Hasenfuss
Dept of Cardiology and Pneumology, Heart Center Göttingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
Clin Res Cardiol 97:222-6. 2008..In the present article, we review the relevant pathophysiological concepts for the role of late sodium inhibition and summarize the most recent data from basic as well as clinical studies...
- Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivololP M Janssen
Medizinische Klinik III, Universitat Freiburg, Germany
Eur J Pharmacol 366:223-32. 1999..The results indicate that hydroxyl radical injury induces systolic and diastolic dysfunction, and that nebivolol can effectively prevent a large part of this *OH injury...
- Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardiumG Hasenfuss
Zentrum Innere Medizin, Abteilung Kardiologie und Pneumologie, Universitat Gottingen, Germany
Circulation 99:641-8. 1999..In the failing human heart, sarcoplasmic reticulum (SR) calcium handling is impaired, and therefore, calcium elimination and diastolic function may depend on the expression of sarcolemmal Na+-Ca2+ exchanger...
- The functional effect of adenoviral Na+/Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+-ATPaseW Schillinger
Herzzentrum Göttingen, Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
Cardiovasc Res 57:996-1003. 2003..The functional consequences of Na+/Ca2+ exchanger (NCX) overexpression in heart failure have been controversially discussed. NCX function strongly depends on intracellular sodium which has been shown to be increased in heart failure...
- Effects of different proton pump inhibitors on cardiac contractility in isolated human failing myocardiumS Sossalla
Department of Cardiology and Pneumology, Heart Center, Georg August University Göttingen Germany
J Cardiovasc Surg (Torino) 52:437-44. 2011..Therefore, in western industrial countries they play a major economic role, representing one of the most important drugs in open heart cardiac surgery...
- The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effectsH Knauf
Department of Medicine 1, St Berward Krankenhaus, Hildesheim, Germany
Eur J Clin Pharmacol 62:885-92. 2006..Cardiovascular and antiinflammatory therapeutics may interfere with TGF and thereby influence the effect of thiazides once co-administration is clinically indicated...
- Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytesC M Loughrey
Institute of Comparative Medicine, University of Glasgow Veterinary School, University of Glasgow, Glasgow G61 1QH, UK
J Physiol 556:919-34. 2004..6 over-expression enhances Ca(2+) transient amplitude predominately by increasing SR Ca(2+) content. Moreover, there is also evidence that FKBP12.6 can enhance the coupling between SR Ca(2+) release sites independently of SR content...
- [Differential therapy of heart failure. Which drug for which patient?]W Schillinger
Herzzentrum, Georg August Universitat Gottingen
Internist (Berl) 45:1378-87. 2004..We therefore discuss the differential therapy of heart failure in view of particular patient subgroups...
- The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction - baseline characteristics of the study populationR Ferrari
Royal Brompton Hospital, London, UK
Cardiology 110:271-82. 2008..This report describes the study population at baseline...
- Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trialKim Fox
Royal Brompton Hospital, London, UK
Lancet 372:807-16. 2008..We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction...
- Slow breathing reduces sympathoexcitation in COPDT Raupach
Dept of Cardiology and Pneumology, Georg August University Gottingen, Gottingen, Germany
Eur Respir J 32:387-92. 2008..In conclusion, sympathovagal imbalance is present in normoxic chronic obstructive pulmonary disease patients. The possibility of modifying these changes by slow breathing may help to better understand and influence this systemic disease...
- Heterogeneous transmural gene expression of calcium-handling proteins and natriuretic peptides in the failing human heartJ Prestle
Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
Cardiovasc Res 43:323-31. 1999..In the present study, we analyzed the transmural protein and/or mRNA levels of SERCA2a, other Ca(2+)-handling proteins, and of atrial and brain natriuretic peptides (ANP and BNP) in the human heart...
- Protective role of nebivolol in hydroxyl radical induced injuryP M Janssen
Department of Cardiology and Pneumology, , Germany
J Cardiovasc Pharmacol 38:S17-23. 2001....
- [Symptoms of primary endocardial fibroelastosis in a young adult]T Meyer
Abteilung Kardiologie und Pulmonologie,
Dtsch Med Wochenschr 126:168-71. 2001..CONCLUSION: Primary endocardial fibroelastosis of the contracted type must be included in the differential diagnosis of heart failure occurring in young adults...
- Influence of mild hypothermia on myocardial contractility and circulatory functionJ Weisser
Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, , Germany
Basic Res Cardiol 96:198-205. 2001..These effects translate into improved hemodynamic parameters of left ventricular function...
- Load-dependent induction of apoptosis in multicellular myocardial preparationsP M L Janssen
Abteilung Kardiologie und Pneumologie, Universitat Gottingen, Göttingen D 37075, Germany
Am J Physiol Heart Circ Physiol 282:H349-56. 2002..9 +/- 5.9 DLI) and very similar to those contracting unloaded isotonic (6.1 +/- 5.1 DLI). We conclude that load-dependent apoptosis can occur at sarcomere lengths achievable in vivo and may mainly result from increased preload...
- The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human heartsJ van der Velden
Laboratory for Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Cardiovasc Res 57:505-14. 2003..1+/-2.0%) compared to donor (31.9+/-4.8%) hearts. To assess the functional implications of this change, we compared the effects of MLC-2 dephosphorylation on force development in failing and non-failing (donor) human hearts...