Reiner F Haseloff

Summary

Country: Germany

Publications

  1. ncbi request reprint Differential protein expression in brain capillary endothelial cells induced by hypoxia and posthypoxic reoxygenation
    Reiner F Haseloff
    Institute of Molecular Pharmacology, Berlin, Germany
    Proteomics 6:1803-9. 2006
  2. ncbi request reprint Cytotoxicity of spin trapping compounds
    R F Haseloff
    Research Institute of Molecular Pharmacology, Berlin, Germany
    FEBS Lett 418:73-5. 1997
  3. ncbi request reprint In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro
    R F Haseloff
    Forschungsinstitut fur Molekulare Pharmakologie, Robert Rossle Str 10, D 13125 Berlin, Germany
    Cell Mol Neurobiol 25:25-39. 2005
  4. pmc A strategy for enrichment of claudins based on their affinity to Clostridium perfringens enterotoxin
    Dörte Lohrberg
    Leibniz Institut fur Molekulare Pharmakologie FMP, Berlin, Germany
    BMC Mol Biol 10:61. 2009
  5. ncbi request reprint Superoxide-mediated reduction of the nitroxide group can prevent detection of nitric oxide by nitronyl nitroxides
    R F Haseloff
    Institute of Molecular Pharmacology, Berlin, Germany
    Free Radic Res 26:7-17. 1997
  6. ncbi request reprint Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier
    I E Blasig
    Forschungsinstitut fur Molekulare Pharmakologie, Delbrück Zentrum für Molekulare Medizin, Robert Rossle Str 10, 13125 Berlin, Germany
    Neuropharmacology 43:1006-14. 2002
  7. ncbi request reprint *NO and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier
    I E Blasig
    Forschungsinstitut fur Molekulare Pharmakologie, Robert Rossle Str 10, 10315, Berlin, Germany
    Microvasc Res 62:114-27. 2001
  8. ncbi request reprint Proteomics of brain endothelium. Separation of proteins by two-dimensional gel electrophoresis and identification by mass spectrometry
    Reiner F Haseloff
    Institute of Molecular Pharmacology, Berlin, Germany
    Methods Mol Med 89:465-77. 2003
  9. ncbi request reprint Structure and function of claudins
    Gerd Krause
    Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Str 10, 13125 Berlin, Germany
    Biochim Biophys Acta 1778:631-45. 2008
  10. ncbi request reprint Tight junctions and tissue barriers
    Ingolf E Blasig
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    Antioxid Redox Signal 15:1163-6. 2011

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Differential protein expression in brain capillary endothelial cells induced by hypoxia and posthypoxic reoxygenation
    Reiner F Haseloff
    Institute of Molecular Pharmacology, Berlin, Germany
    Proteomics 6:1803-9. 2006
    ..g., calreticulin), and cytoskeletal (e.g., vimentin) proteins. The results indicate that BCEC respond to hypoxia/reoxygenation by adaptive up-regulation of proteins involved in the glycolysis, protein synthesis, and stress response...
  2. ncbi request reprint Cytotoxicity of spin trapping compounds
    R F Haseloff
    Research Institute of Molecular Pharmacology, Berlin, Germany
    FEBS Lett 418:73-5. 1997
    ..The results of this study indicate that most spin traps can be used in cell cultures at customary (i.e. millimolar) concentrations; caution is recommended when nitroso spin traps are applied to cells...
  3. ncbi request reprint In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro
    R F Haseloff
    Forschungsinstitut fur Molekulare Pharmakologie, Robert Rossle Str 10, D 13125 Berlin, Germany
    Cell Mol Neurobiol 25:25-39. 2005
    ..4) In conclusion, it is expected that the present and future research focused on molecular mechanisms and signaling pathways will produce new and exciting insights into the complex network of BBB regulation: the cornerstone is laid...
  4. pmc A strategy for enrichment of claudins based on their affinity to Clostridium perfringens enterotoxin
    Dörte Lohrberg
    Leibniz Institut fur Molekulare Pharmakologie FMP, Berlin, Germany
    BMC Mol Biol 10:61. 2009
    ..The interaction of several claudins with Clostridium perfringens enterotoxin (CPE) has been exploited for an affinity-based enrichment of CPE-binding claudins from lysates of normal rat cholangiocytes...
  5. ncbi request reprint Superoxide-mediated reduction of the nitroxide group can prevent detection of nitric oxide by nitronyl nitroxides
    R F Haseloff
    Institute of Molecular Pharmacology, Berlin, Germany
    Free Radic Res 26:7-17. 1997
    ..The results indicate that in biological systems (in addition to other reducing agents) the presence of superoxide can prevent the detection of nitric oxide using nitronyl nitroxides...
  6. ncbi request reprint Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier
    I E Blasig
    Forschungsinstitut fur Molekulare Pharmakologie, Delbrück Zentrum für Molekulare Medizin, Robert Rossle Str 10, 13125 Berlin, Germany
    Neuropharmacology 43:1006-14. 2002
    ..NN represent a new group of antioxdatively acting cytoprotectiva improving the survival and function of the endothelium against oxidative stress...
  7. ncbi request reprint *NO and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier
    I E Blasig
    Forschungsinstitut fur Molekulare Pharmakologie, Robert Rossle Str 10, 10315, Berlin, Germany
    Microvasc Res 62:114-27. 2001
    ..These cells can be subcultivated in large amounts and, hence, they are suitable to study the role of radical metabolism in the BBB and in the cerebral microvasculature...
  8. ncbi request reprint Proteomics of brain endothelium. Separation of proteins by two-dimensional gel electrophoresis and identification by mass spectrometry
    Reiner F Haseloff
    Institute of Molecular Pharmacology, Berlin, Germany
    Methods Mol Med 89:465-77. 2003
  9. ncbi request reprint Structure and function of claudins
    Gerd Krause
    Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Str 10, 13125 Berlin, Germany
    Biochim Biophys Acta 1778:631-45. 2008
    ..The concepts evolved from these findings and first tentative molecular models for homophilic interactions may explain the different functional contribution of the two extracellular loops at tight junctions...
  10. ncbi request reprint Tight junctions and tissue barriers
    Ingolf E Blasig
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    Antioxid Redox Signal 15:1163-6. 2011
    ..However, our knowledge of the molecular basis of the specific mechanisms responsible for functional disturbances remains limited and needs further investigations. Antioxid. Redox Signal. 15, 1163-1166...
  11. ncbi request reprint Synthesis and spin trapping applications of 2,2-dimethyl-d6-4-methyl-2H-imidazole-1-oxide-1-15N
    R F Haseloff
    Institute of Molecular Pharmacology, Berlin, Germany
    Free Radic Res 26:159-68. 1997
    ..The pKa was found to be 5.8 +/- 0.3. In comparison to other nitrones, application of this spin trap provides more detailed information on the structure of the species trapped, especially for carbon-centered radicals...
  12. ncbi request reprint Evaluation of the titanium dioxide approach for MS analysis of phosphopeptides
    Clementine Klemm
    Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Str 10, 13125 Berlin, Germany
    J Mass Spectrom 41:1623-32. 2006
    ..Drastically reduced recovery was observed for phosphopeptides with multiple basic amino acids. Nonspecific binding of nonphosphorylated peptides and sample loss of phosphopeptides must also be taken into account...
  13. ncbi request reprint Protein markers of ischemic insult in brain endothelial cells identified using 2D gel electrophoresis and ICAT-based quantitative proteomics
    Arsalan S Haqqani
    Cerebrovascular Research and Genomics and Proteomics Groups, Institute for Biological Sciences, National Research Council of Canada, Ottawa, ON, Canada K1A 0R6
    J Proteome Res 6:226-39. 2007
    ..The comparative analyses of protein changes between the in vitro and in vivo models demonstrated a significant correlative relationship, emphasizing the 'translational' value of in vitro endothelial models in neurovascular research...
  14. doi request reprint Protective effects of peroxiredoxin-1 at the injured blood-brain barrier
    Gerty Schreibelt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 45:256-64. 2008
    ..On the other hand, it may function as an endogenous defense mechanism to inhibit leukocyte infiltration and counteract ROS-induced cellular injury...