Alkomiet Hasan

Summary

Country: Germany

Publications

  1. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
  2. doi request reprint Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors
    Alkomiet Hasan
    Deparment of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:273-84. 2013
  3. ncbi request reprint Transcranial brain stimulation in schizophrenia: targeting cortical excitability, connectivity and plasticity
    A Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    Curr Med Chem 20:405-13. 2013
  4. doi request reprint Impaired long-term depression in schizophrenia: a cathodal tDCS pilot study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Brain Stimul 5:475-83. 2012
  5. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 13:318-78. 2012
  6. pmc Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:415-23. 2012
  7. pmc Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortex
    Alkomiet Hasan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Room 3 10, 33 Queen Square, Box 146, London, WC1N 3BG, UK
    Exp Brain Res 217:15-23. 2012
  8. pmc Prefrontal cortex gyrification index in twins: an MRI study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:459-65. 2011
  9. doi request reprint Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Strasse 5, D 37075, Goettingen, Germany
    Behav Brain Res 224:15-22. 2011
  10. ncbi request reprint Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia
    Berend Malchow
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University LMU Munich, Nußbaumstraße 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:S155-68. 2013

Detail Information

Publications30

  1. pmc Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:23-31. 2012
    ..BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus...
  2. doi request reprint Epigenetic dysregulation in schizophrenia: molecular and clinical aspects of histone deacetylase inhibitors
    Alkomiet Hasan
    Deparment of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:273-84. 2013
    ..Additional investigations are required in order to fully evaluate the potential of HDACi and similar "epigenetic therapies" as novel treatment options for schizophrenia and other psychotic disease...
  3. ncbi request reprint Transcranial brain stimulation in schizophrenia: targeting cortical excitability, connectivity and plasticity
    A Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    Curr Med Chem 20:405-13. 2013
    ..This review will discuss this issue with regard to the available treatment options and will give implications for future research and therapeutic strategies regarding disinhibition and neuroplasticity in schizophrenia...
  4. doi request reprint Impaired long-term depression in schizophrenia: a cathodal tDCS pilot study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Brain Stimul 5:475-83. 2012
    ..However, glutamate-dependent long-term depression (LTD)-like cortical plasticity has not yet been investigated...
  5. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 13:318-78. 2012
    ..This first part of the updated guidelines covers the general descriptions of antipsychotics and their side effects, the biological treatment of acute schizophrenia and the management of treatment-resistant schizophrenia...
  6. pmc Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 262:415-23. 2012
    ..Dysfunctional N-methyl D-aspartate receptors or modulation of dopaminergic transmission can explain these findings. Nevertheless, the effects of antipsychotic medication still need to be considered...
  7. pmc Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortex
    Alkomiet Hasan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Room 3 10, 33 Queen Square, Box 146, London, WC1N 3BG, UK
    Exp Brain Res 217:15-23. 2012
    ..The data show that it may be possible to enhance LTP-like plasticity after TBS in the human cortex...
  8. pmc Prefrontal cortex gyrification index in twins: an MRI study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Str 5, 37075, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:459-65. 2011
    ..The nonexistence of a pronounced similarity in MZ twins compared to DZ twins concerning prefrontal GI raises questions about the extent of genetic influence on GI...
  9. doi request reprint Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Strasse 5, D 37075, Goettingen, Germany
    Behav Brain Res 224:15-22. 2011
    ..Disturbances of N-methyl-d-aspartate, gamma-aminobutyric acid and dopamine receptors may account for this plasticity deficit. LTP-like plasticity deficits might be related to disturbed information processing in schizophrenia patients...
  10. ncbi request reprint Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia
    Berend Malchow
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University LMU Munich, Nußbaumstraße 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:S155-68. 2013
    ..Future longitudinal studies in first-episode patients with quantification of cannabis abuse and assessment of schizophrenia risk genes are warranted...
  11. doi request reprint Deficient inhibitory cortical networks in antipsychotic-naive subjects at risk of developing first-episode psychosis and first-episode schizophrenia patients: a cross-sectional study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    Biol Psychiatry 72:744-51. 2012
    ..However, there have been no previous studies investigating cortical excitability with particular regard to intracortical inhibitory networks in antipsychotic-naive subjects at risk of developing first-episode psychosis...
  12. doi request reprint Planum temporale asymmetry to the right hemisphere in first-episode schizophrenia
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Von Siebold Street 5, 37075 Goettingen, Germany
    Psychiatry Res 193:56-9. 2011
    ..We investigated planum temporale (PT) volume and asymmetry in 23 first-episode schizophrenia patients compared to healthy controls and found for the first time an in vivo volume asymmetry of PT to the right hemisphere...
  13. doi request reprint A similar but distinctive pattern of impaired cortical excitability in first-episode schizophrenia and ADHD
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    Neuropsychobiology 67:74-83. 2013
    ..Studies on cortical excitability comparing these two diseases directly are lacking...
  14. pmc Muscle and timing-specific functional connectivity between the dorsolateral prefrontal cortex and the primary motor cortex
    Alkomiet Hasan
    University College London, London, UK
    J Cogn Neurosci 25:558-70. 2013
    ..These results reveal temporally and spatially selective interactions between BA 46 and M1 that are both task and muscle specific...
  15. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 14:2-44. 2013
    ..These guidelines are primarily concerned with the biological treatment (including antipsychotic medication and other pharmacological treatment options) of adults suffering from schizophrenia...
  16. pmc Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Strasse 5, 37075 Gottingen, Germany
    Psychopharmacology (Berl) 208:353-63. 2010
    ..Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking...
  17. doi request reprint Impaired motor cortex responses in non-psychotic first-degree relatives of schizophrenia patients: a cathodal tDCS pilot study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany Electronic address
    Brain Stimul 6:821-9. 2013
    ..Little is known about the impact of genetic liability on cortical plasticity and connectivity in schizophrenia...
  18. doi request reprint Hippocampal integrity and neurocognition in first-episode schizophrenia: a multidimensional study
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University, Gottingen, Germany
    World J Biol Psychiatry 15:188-99. 2014
    ..However, the association between hippocampal morphometry, neurochemistry and function is controversial. Therefore, we aimed to investigate the relationship between hippocampal anomalies and their functional relevance...
  19. pmc Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence
    Berend Malchow
    Department of Psychiatry and Psychotherapy, University Medical Center Gottingen, Georg August University, Germany
    Eur Arch Psychiatry Clin Neurosci 263:3-13. 2013
    ..There is some weak evidence that cannabis abuse could affect brain structures in high-risk subjects, but replication of these studies is needed...
  20. doi request reprint The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls--a randomized placebo-controlled, double-blind fMRI study
    Birgit Guse
    University Medical Centre, Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Von Siebold Str 5, D 37075 Gottingen, Germany
    Behav Brain Res 237:300-7. 2013
    ..This is the first fMRI study that has systematically investigated this topic within a randomized, placebo-controlled, double-blind design, contrasting the effects in schizophrenia patients and healthy controls...
  21. doi request reprint The role of interneuron networks in driving human motor cortical plasticity
    Masashi Hamada
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Cereb Cortex 23:1593-605. 2013
    ..Our results are consistent with the idea that variation in response to rTMS plasticity probing protocols is strongly influenced by which interneuron networks are recruited by the TMS pulse...
  22. doi request reprint Reduction of gyrification index in the cerebellar vermis in schizophrenia: a post-mortem study
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    World J Biol Psychiatry 12:99-103. 2011
    ..Cerebellar regions have been implicated in the pathophysiology of schizophrenia; however, the GI has not been investigated here so far...
  23. pmc Schizophrenia as a disorder of disconnectivity
    Andrea Schmitt
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S150-4. 2011
    ..The specificity and the neurobiological origin of these connectivity deficits and the relation to the symptom complex of schizophrenia and the glutamatergic and GABAergic system are discussed...
  24. ncbi request reprint Modulating neural plasticity with non-invasive brain stimulation in schizophrenia
    Alkomiet Hasan
    Deparment of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:621-31. 2013
    ..Additional investigation is required to improve the response rates to non-invasive brain stimulation, to reduce the interindividual variability and to improve the understanding of non-invasive brain stimulation in schizophrenia...
  25. doi request reprint The effects of physical exercise in schizophrenia and affective disorders
    Berend Malchow
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nußbaumstraße 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:451-67. 2013
    ....
  26. ncbi request reprint Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report
    Alkomiet Hasan
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    J Clin Psychopharmacol 30:190-2. 2010
    ....
  27. ncbi request reprint Pregabalin exerts oppositional effects on different inhibitory circuits in human motor cortex: a double-blind, placebo-controlled transcranial magnetic stimulation study
    Nicolas Lang
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Epilepsia 47:813-9. 2006
    ..To explore acute effects of pregabalin (PGB) on human motor cortex excitability with transcranial magnetic stimulation (TMS)...
  28. doi request reprint Motor cortical excitability assessed by transcranial magnetic stimulation in psychiatric disorders: a systematic review
    Tilmann Bunse
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    Brain Stimul 7:158-69. 2014
    ..However, little is known about the overlap and specificity of these findings across these conditions...
  29. ncbi request reprint Cortical hypoexcitability in chronic smokers? A transcranial magnetic stimulation study
    Nicolas Lang
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Neuropsychopharmacology 33:2517-23. 2008
    ..These changes may form a physiological basis for neurobiological and behavioral variations associated with chronic smoking...
  30. pmc Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosi
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Bull 37:S111-21. 2011
    ..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...