A Hartwig

Summary

Country: Germany

Publications

  1. ncbi Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications
    Andrea Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, Germany
    Toxicol Lett 127:47-54. 2002
  2. ncbi Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells
    Andrea Hartwig
    Universitat Karlsruhe, Institut für Lebensmittelchemie und Toxikologie, Karlsruhe, Germany
    Int J Cancer 104:1-6. 2003
  3. ncbi Carcinogenicity of metal compounds: possible role of DNA repair inhibition
    A Hartwig
    University of Karlsruhe, Institute of Food Chemistry, Germany
    Toxicol Lett 102:235-9. 1998
  4. ncbi The potential use of mutation spectra in cancer related genes in genetic toxicology: a statement of a GUM working group
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Mutat Res 473:263-7. 2001
  5. ncbi Modulation of DNA repair processes by arsenic and selenium compounds
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Toxicology 193:161-9. 2003
  6. ncbi Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function
    A Hartwig
    University of Karlsruhe, Institute of Food Chemistry and Toxicology, Germany
    Antioxid Redox Signal 3:625-34. 2001
  7. pmc Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Environ Health Perspect 110:797-9. 2002
  8. ncbi Role of DNA repair in particle- and fiber-induced lung injury
    Andrea Hartwig
    Institute of Food Chemistry and Toxicology, University of Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Inhal Toxicol 14:91-100. 2002
  9. ncbi Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128, Karlsruhe, Germany
    Food Chem Toxicol 40:1179-84. 2002
  10. ncbi Role of magnesium in genomic stability
    A Hartwig
    Department of Food Chemistry and Toxicology, University of Karlsruhe, Profach 6980, D 76128, Karlsruhe, Germany
    Mutat Res 475:113-21. 2001

Collaborators

Detail Information

Publications25

  1. ncbi Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications
    Andrea Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, Germany
    Toxicol Lett 127:47-54. 2002
    ....
  2. ncbi Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells
    Andrea Hartwig
    Universitat Karlsruhe, Institut für Lebensmittelchemie und Toxikologie, Karlsruhe, Germany
    Int J Cancer 104:1-6. 2003
    ....
  3. ncbi Carcinogenicity of metal compounds: possible role of DNA repair inhibition
    A Hartwig
    University of Karlsruhe, Institute of Food Chemistry, Germany
    Toxicol Lett 102:235-9. 1998
    ..Nevertheless, the underlying mechanisms are quite different, depending for example on the ability of toxic metal ions to compete with magnesium ions or to displace zinc ions in zinc finger structures of DNA repair enzymes...
  4. ncbi The potential use of mutation spectra in cancer related genes in genetic toxicology: a statement of a GUM working group
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Mutat Res 473:263-7. 2001
    ..Nevertheless, on the individual level, the presence or absence of defined mutations in cancer-related genes in human tumors does not permit a definite conclusion about the causative agent...
  5. ncbi Modulation of DNA repair processes by arsenic and selenium compounds
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Toxicology 193:161-9. 2003
    ....
  6. ncbi Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function
    A Hartwig
    University of Karlsruhe, Institute of Food Chemistry and Toxicology, Germany
    Antioxid Redox Signal 3:625-34. 2001
    ....
  7. pmc Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Environ Health Perspect 110:797-9. 2002
    ....
  8. ncbi Role of DNA repair in particle- and fiber-induced lung injury
    Andrea Hartwig
    Institute of Food Chemistry and Toxicology, University of Karlsruhe, Postfach 6980, D 76128 Karlsruhe, Germany
    Inhal Toxicol 14:91-100. 2002
    ..Taken together, the extent of DNA repair is an important determinant in particle-induced genotoxicity and carcinogenicity...
  9. ncbi Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability
    A Hartwig
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Postfach 6980, D 76128, Karlsruhe, Germany
    Food Chem Toxicol 40:1179-84. 2002
    ..Relevant mechanisms of inhibition appear to be the displacement of zinc by other transition metals as well as redox reactions leading to thiol/disulfide interchange...
  10. ncbi Role of magnesium in genomic stability
    A Hartwig
    Department of Food Chemistry and Toxicology, University of Karlsruhe, Profach 6980, D 76128, Karlsruhe, Germany
    Mutat Res 475:113-21. 2001
    ..With respect to the magnesium status in humans, the daily intake in most industrialized countries does not reach the current recommended daily dietary allowances (RDA) values, and thus marginal magnesium deficiencies are very common...
  11. ncbi Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg
    Tanja Schwerdtle
    Institute of Food Chemistry and Toxicology, University of Karlsruhe, Postfach 6980, D 76128, Karlsruhe, Germany
    DNA Repair (Amst) 2:1449-63. 2003
    ..Altogether the results suggest that besides arsenite, especially the trivalent methylated metabolites may contribute to diminished NER at low concentrations...
  12. ncbi Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA
    Tanja Schwerdtle
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, Germany
    Carcinogenesis 24:967-74. 2003
    ..Thus, biomethylation of inorganic arsenic may be involved in inorganic arsenic-induced genotoxicity/carcinogenicity...
  13. ncbi Effect of soluble and particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells
    Tanja Schwerdtle
    Institut für Lebensmittelchemie und Toxikologie, Universitat Karlsruhe, D 76128 Karlsruhe, Germany
    Carcinogenesis 23:47-53. 2002
    ....
  14. doi No differences in DNA damage and antioxidant capacity between intervention groups of healthy, nonsmoking men receiving 2, 5, or 8 servings/day of vegetables and fruit
    Karlis Briviba
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Karlsruhe, Germany
    Nutr Cancer 60:164-70. 2008
    ....
  15. ncbi Interaction of selenium compounds with zinc finger proteins involved in DNA repair
    Holger Blessing
    Institute of Food Chemistry and Toxicology, University of Karlsruhe, Germany
    Eur J Biochem 271:3190-9. 2004
    ..Altogether, the results indicate that zinc finger motifs are highly reactive towards oxidizing selenium compounds. This could affect gene expression, DNA repair and, thus, genomic stability...
  16. doi Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms
    Detmar Beyersmann
    Biochemistry, Department of Biology and Chemistry, University of Bremen, Bremen, Germany
    Arch Toxicol 82:493-512. 2008
    ....
  17. doi Monomethylarsonous acid destroys a tetrathiolate zinc finger much more efficiently than inorganic arsenite: mechanistic considerations and consequences for DNA repair inhibition
    Katarzyna Piatek
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Chem Res Toxicol 21:600-6. 2008
    ..These results indicate a particular susceptibility of tetrathiolate zinc fingers to MMA (III), thereby providing a novel molecular pathway in arsenic carcinogenesis...
  18. ncbi Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity
    Tanja Schwerdtle
    Institut für Lebensmitteltechnologie und Lebensmittelchemie, Technische Universitat Berlin, Berlin, Germany
    Mol Nutr Food Res 51:201-10. 2007
    ..Hence, a balance needs to be maintained to ensure sufficient uptake and to prevent overload...
  19. ncbi Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells
    Ingo Walter
    Institut für Lebensmitteltechnologie und Lebensmittelchemie, Technische Universitat Berlin, 13355 Berlin, Germany
    DNA Repair (Amst) 6:61-70. 2007
    ....
  20. ncbi Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity
    Edyta Kopera
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Chem Res Toxicol 17:1452-8. 2004
    ..The Cd(II)-saturated XPAzf is very resistant to oxidation by H2O2. Overall, our results indicate that XPAzf can undergo Co(II) and Cd(II) assault under specific conditions...
  21. ncbi Mechanism of nickel assault on the zinc finger of DNA repair protein XPA
    Wojciech Bal
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Chem Res Toxicol 16:242-8. 2003
    ..Overall, our results indicate that XPAzf can undergo Ni(II) assault in specific conditions...
  22. ncbi Quantitative electrospray ionization mass spectrometry of zinc finger oxidation: the reaction of XPA zinc finger with H(2)O(2)
    Julia Smirnova
    Institute of Gene Technology, Tallinn Technical University, 12618 Tallinn, Estonia
    Anal Biochem 369:226-31. 2007
    ..The comparison of experimental information demonstrated that the formation of the Cys5-Cys8 single disulfide was responsible for zinc release...
  23. ncbi Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53
    Sarah L Hockley
    Section of Molecular Carcinogenesis, The Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Carcinogenesis 29:202-10. 2008
    ..Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP...
  24. doi Reaction of the XPA zinc finger with S-nitrosoglutathione
    Julia Smirnova
    Department of Gene Technology, Tallinn Technical University, Akadeemia tee 15, 12618 Tallinn, Estonia
    Chem Res Toxicol 21:386-92. 2008
    ..In the case of XPA, this may lead to DNA repair inhibition...
  25. ncbi Food-borne radiolytic compounds (2-alkylcyclobutanones)may promote experimental colon carcinogenesis
    Francis Raul
    Laboratoire d Oncologie Nutritionnelle, F 67000 Strasbourg, France
    Nutr Cancer 44:189-91. 2002
    ..This is the first demonstration that a compound found exclusively in irradiated dietary fats may promote colon carcinogenesis in animals treated with a chemical carcinogen...