Rudiger Hardeland

Summary

Country: Germany

Publications

  1. ncbi request reprint C5a anaphylatoxin as a product of complement activation up-regulates the complement inhibitory factor H in rat Kupffer cells
    Gerald Schlaf
    Department of Immunology, Georg August University, Gottingen, Germany
    Eur J Immunol 34:3257-66. 2004
  2. doi request reprint Melatonin--a pleiotropic, orchestrating regulator molecule
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Berliner Str 28, Lower Saxony, D 37073 Goettingen, Germany
    Prog Neurobiol 93:350-84. 2011
  3. ncbi request reprint Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system
    R Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Goettingen, Germany
    Cent Nerv Syst Agents Med Chem 12:189-216. 2012
  4. pmc Melatonin metabolism in the central nervous system
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Goettingen, Germany
    Curr Neuropharmacol 8:168-81. 2010
  5. pmc New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Germany
    Neuropsychiatr Dis Treat 5:341-54. 2009
  6. doi request reprint Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Germany
    J Pineal Res 52:139-66. 2012
  7. pmc Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Georg August University, 37073 Gottingen, Germany
    ScientificWorldJournal 2012:640389. 2012
  8. doi request reprint Neuroprotection by radical avoidance: search for suitable agents
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Berliner Str 28, D 37073 Gottingen, Germany
    Molecules 14:5054-102. 2009
  9. ncbi request reprint Reactions of the NO redox forms NO+, *NO and HNO (protonated NO-) with the melatonin metabolite N1-acetyl-5-methoxykynuramine
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 43:382-8. 2007
  10. ncbi request reprint Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders
    Rudiger Hardeland
    University of Gottingen, Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Berliner Strasse 28, D 37073 Gottingen, Germany
    Curr Opin Investig Drugs 10:691-701. 2009

Collaborators

Detail Information

Publications44

  1. ncbi request reprint C5a anaphylatoxin as a product of complement activation up-regulates the complement inhibitory factor H in rat Kupffer cells
    Gerald Schlaf
    Department of Immunology, Georg August University, Gottingen, Germany
    Eur J Immunol 34:3257-66. 2004
    ..The up-regulation of FH was completely inhibited by the C5a-blocking monoclonal antibody 6-9F. Furthermore, an involvement of LPS and IFN-gamma was excluded, which strongly indicates a direct effect of C5a on the expression of FH in KC...
  2. doi request reprint Melatonin--a pleiotropic, orchestrating regulator molecule
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Berliner Str 28, Lower Saxony, D 37073 Goettingen, Germany
    Prog Neurobiol 93:350-84. 2011
    ..Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis...
  3. ncbi request reprint Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system
    R Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Goettingen, Germany
    Cent Nerv Syst Agents Med Chem 12:189-216. 2012
    ..Indirect antidepressive effects by melatonergic drugs are largely explained by circadian readjustments...
  4. pmc Melatonin metabolism in the central nervous system
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Goettingen, Germany
    Curr Neuropharmacol 8:168-81. 2010
    ....
  5. pmc New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Germany
    Neuropsychiatr Dis Treat 5:341-54. 2009
    ..Problems and limits of melatoninergic hypnotics are compared...
  6. doi request reprint Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Germany
    J Pineal Res 52:139-66. 2012
    ....
  7. pmc Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Georg August University, 37073 Gottingen, Germany
    ScientificWorldJournal 2012:640389. 2012
    ..Therapies with melatonin or synthetic melatonergic drugs have to consider that these agents do not only act on the SCN, but also on numerous organs and cells in which melatonin receptors are also expressed...
  8. doi request reprint Neuroprotection by radical avoidance: search for suitable agents
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Berliner Str 28, D 37073 Gottingen, Germany
    Molecules 14:5054-102. 2009
    ..In this review, the perspectives, problems and limits of drugs are compared which may be suitable for reducing the formation of free radicals...
  9. ncbi request reprint Reactions of the NO redox forms NO+, *NO and HNO (protonated NO-) with the melatonin metabolite N1-acetyl-5-methoxykynuramine
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 43:382-8. 2007
    ..Therefore, all three NO congeners are, in principle, capable of nitrosating AMK and forming AMMC, but in biological material the reaction with NO+ is strongly limited by the extremely short life-time of this redox form...
  10. ncbi request reprint Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders
    Rudiger Hardeland
    University of Gottingen, Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Berliner Strasse 28, D 37073 Gottingen, Germany
    Curr Opin Investig Drugs 10:691-701. 2009
    ..The drug is well tolerated, does not induce impairment of next-day functioning or dependence, and seems to be safe in short-term treatment; however, toxicological data would be required for assessing its long-term safety...
  11. doi request reprint Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, D 37073 Gottingen, Germany
    J Pineal Res 47:109-26. 2009
    ..AMK easily interacts with aromates, forms adducts with tyrosyl and tryptophanyl residues, and may modify proteins...
  12. doi request reprint Melatonin: signaling mechanisms of a pleiotropic agent
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    Biofactors 35:183-92. 2009
    ..Cross-talks between different signaling pathways, including influences of the membrane receptors on nuclear binding sites, are discussed. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc...
  13. doi request reprint Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites
    R Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    Cell Mol Life Sci 65:2001-18. 2008
    ..Moreover, melatonin is a source of bioactive metabolites, such as 5-methoxytryptamine, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine and N(1)-acetyl-5-methoxykynuramine...
  14. doi request reprint Investigational melatonin receptor agonists
    Rudiger Hardeland
    University of Gottingen, Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Gottingen, Germany
    Expert Opin Investig Drugs 19:747-64. 2010
    ..Frequent health problems such as sleep disturbances, neuropsychiatric disorders related to circadian dysphasing, and metabolic diseases associated with insulin resistance are targeted by melatonergic agonists...
  15. ncbi request reprint Melatonin
    Rudiger Hardeland
    Institute of Zoology and Anthropology, University of Goettingen, Berliner Str 28, D 37073 Goettingen, Germany
    Int J Biochem Cell Biol 38:313-6. 2006
    ..Findings are encouraging to use melatonin as a sleep promoter and in preventing progression of neurodegenerative diseases...
  16. ncbi request reprint Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance
    Rudiger Hardeland
    Institute of Zoology, Anthropology and Developmental Biology, University of Gottingen, Gottingen, Germany
    Endocrine 27:119-30. 2005
    ..Radical avoidance is a new line of investigation, which exceeds mitochondrial actions and also comprises antiexcitatory effects and contributions to the maintenance of internal circadian phase relationships...
  17. ncbi request reprint Melatonin and 5-methoxytryptamine in non-metazoans
    R Hardeland
    Institut für Zoologie und Anthropologie, Universitat Gottingen, Germany
    Reprod Nutr Dev 39:399-408. 1999
    ....
  18. ncbi request reprint Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs
    Burkhard Poeggeler
    Institute of Zoology and Anthropology, University of Goettingen, Goettingen, Germany, Department of Pathology, University of South Alabama Medical Center, Mobile, AL, USA
    J Pineal Res 33:20-30. 2002
    ..In this regard, only 6-chloromelatonin equalled melatonin, whereas the efficiency of 2-iodomelatonin was much lower, another indication for the importance of 2,3-dioxygenation...
  19. ncbi request reprint Non-vertebrate melatonin
    Rudiger Hardeland
    Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 34:233-41. 2003
    ..Melatonin can be taken up from the food, findings with possible implications in ecophysiology as well as for human nutrition and, with regard to high levels in medicinal plants, also in pharmacology...
  20. ncbi request reprint Circadian rhythms, oxidative stress, and antioxidative defense mechanisms
    Rudiger Hardeland
    Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    Chronobiol Int 20:921-62. 2003
    ....
  21. ncbi request reprint Oxidation of melatonin by carbonate radicals and chemiluminescence emitted during pyrrole ring cleavage
    Rudiger Hardeland
    Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 34:17-25. 2003
    ..Melatonin's capability of scavenging CO(3)(-) may contribute to its protective potency...
  22. doi request reprint Melatonergic drugs in clinical practice
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Universityof Göttingen, Gottingen, Germany
    Arzneimittelforschung 58:1-10. 2008
    ..g., on reproductive functions. According to current data, both compounds seem to be safe during short-term treatment..
  23. ncbi request reprint Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: destruction of antioxidant vitamins and biogenic amines - implications of organic redox cycling
    Andreas Behrends
    Institut fur Zoologie, Anthropologie und Entwicklungsbiologie, Universitat Gottingen, Gottingen, Germany
    Redox Rep 9:279-88. 2004
    ..Destruction of melatonin may cause deficiencies in circadian physiology, in immune functions and in antioxidative protection...
  24. ncbi request reprint Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction
    Anna Rebekka Ressmeyer
    Institut fur Zoologie, Anthropologie und Entwicklungsbiologie, Universitat Gottingen, Gottingen, Germany
    Redox Rep 8:205-13. 2003
    ..AMK may contribute to the antioxidant properties of the indolic precursor melatonin...
  25. ncbi request reprint Reactions of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK) with the ABTS cation radical: identification of new oxidation products
    Ni Ni Than
    Institute of Organic and Biomolecular Chemistry, University of Gottingen, Gottingen, Germany
    Redox Rep 11:15-24. 2006
    ....
  26. ncbi request reprint Interactions of melatonin and its metabolites with the ABTS cation radical: extension of the radical scavenger cascade and formation of a novel class of oxidation products, C2-substituted 3-indolinones
    Joachim Rosen
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Gottingen, Germany
    J Pineal Res 41:374-81. 2006
    ..Moreover, the aliphatic side chain at C2 is reminiscent of other substances which have been synthesized in the search for melatonin receptor ligands...
  27. ncbi request reprint Photocatalytic mechanisms of indoleamine destruction by the quinalphos metabolite 2-hydroxyquinoxaline: a study on melatonin and its precursors serotonin and N-acetylserotonin
    Andreas Behrends
    Institute of Zoology and Anthropology, University of Goettingen, Goettingen, Germany
    J Environ Sci Health B 42:599-606. 2007
    ..The proportion between products from melatonin is changed by 1,4-diazabicyclo-(2,2,2)-octane: singlet oxygen, also formed under the influence of excited 2-hydroxyquinoxaline, only affects secondary reactions...
  28. ncbi request reprint Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species: formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK
    Anna L Guenther
    Institute of Zoology, Anthropology and Developmental Biology, University of Gottingen, Gottingen, Germany
    J Pineal Res 39:251-60. 2005
    ..Formation of these compounds may contribute to the disappearance of AMK from tissues and body fluids...
  29. ncbi request reprint Reactions of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK) with the tyrosine side-chain fragment, 4-ethylphenol
    Alexandra Nowak
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Goettingen, Germany
    Redox Rep 13:102-8. 2008
    ..The possibility of protein AMKylation may be of interest with regard to an eventual interference with tyrosine nitration or, more importantly, with tyrosine phosphorylation...
  30. ncbi request reprint Toxicity of the quinalphos metabolite 2-hydroxyquinoxaline: growth inhibition, induction of oxidative stress, and genotoxicity in test organisms
    Sonja Riediger
    Institute of Zoology and Anthropology, University of Goettingen, Berliner Str 28, D 37073 Goettingen, Germany
    Environ Toxicol 22:33-43. 2007
    ..In an Ames test of mutagenicity, HQO proved to be genotoxic in both light- and dark-exposed bacteria. HQO appears as a source of secondary quinalphos toxicity, which deserves further attention...
  31. doi request reprint NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides
    Claudia Backhaus
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Berliner Strasse 28, D 37073 Goettingen, Lower Saxony, Germany
    Nitric Oxide 19:237-44. 2008
    ....
  32. ncbi request reprint Mitochondrial medicine: neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent
    Burkhard Poeggeler
    Abteilung fuer Stoffwechselphysiologie, Institut fuer Zoologie, Anthropologie und Entwicklungsbiologie der Georg August Universitaet Goettingen, Goettingen, Germany
    J Neurochem 95:962-73. 2005
    ..These findings indicate that amphiphilic antioxidants have a great potential as neuroprotective agents in preventing the death of cells and organisms exposed to enhanced oxidative stress and damage...
  33. doi request reprint Novel pathway for N1-acetyl-5-methoxykynuramine: UVB-induced liberation of carbon monoxide from precursor N1-acetyl-N2-formyl-5-methoxykynuramine
    Katinka Seever
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 44:450-5. 2008
    ..With regard to the demonstration of melatonin in skin and substantial amounts of AFMK in keratinocytes, these findings may be of dermatologic relevance...
  34. ncbi request reprint Effect of continuous melatonin infusions on steady-state plasma melatonin levels in rats under near physiological conditions
    G Huether
    Psychiatrische Klinik der Universität Göttingen, Germany
    J Pineal Res 24:146-51. 1998
    ....
  35. ncbi request reprint Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 55:325-56. 2013
    ..Although, in mammals, lifetime extension by melatonin has been rarely documented in a fully conclusive way, a support of healthy aging has been observed in rodents and is highly likely in humans. ..
  36. ncbi request reprint Reduced oxidative damage in ALS by high-dose enteral melatonin treatment
    Jochen H Weishaupt
    Department of Neurology, Georg August University, Gottingen, Germany
    J Pineal Res 41:313-23. 2006
    ..This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS...
  37. doi request reprint Reactions of the melatonin metabolite N(1)-acetyl-5-methoxykynuramine with carbamoyl phosphate and related compounds
    Jana T Kuesel
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 48:47-54. 2010
    ....
  38. doi request reprint The melatonin metabolite N-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger
    Meike Schaefer
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    J Pineal Res 46:49-52. 2009
    ..In UV-exposed cells (keratinocytes, plant cells) it is likely to be more rapidly destroyed by singlet oxygen than formed from AFMK...
  39. ncbi request reprint Effects of indoleamines and short photoperiods on the encystment of Gonyaulax polyedra
    I Balzer
    I Zoologisches Institut, Universitat Gottingen, Germany
    Chronobiol Int 9:260-5. 1992
    ....
  40. pmc Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms
    B Poeggeler
    Institute of Zoology, Anthropology and Developmental Biology, University of Gottingen, Gottingen, Germany
    Biomed Pharmacother 59:S220-4. 2005
    ..The 24-h cosine curve of circulating melatonin was found to be in an intermediate phase position. Mechanisms of the phase differences and the contribution of gastrointestinal melatonin to circulating hormone concentrations are discussed...
  41. ncbi request reprint Formation of kynurenic and xanthurenic acids from kynurenine and 3-hydroxykynurenine in the dinoflagellate Lingulodinium polyedrum: role of a novel, oxidative pathway
    B K Zsizsik
    Institut für Zoologie und Anthropologie, Universitat Gottingen, Berliner Str 28, D 37073 Gottingen, Germany
    Comp Biochem Physiol C Toxicol Pharmacol 133:383-92. 2002
    ..A corresponding mechanism may exist for the hydroxylated analogue...