Nicole Happel

Summary

Country: Germany

Publications

  1. ncbi Topoisomerase inhibitor induced dephosphorylation of H1 and H3 histones as a consequence of cell cycle arrest
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Cell Biochem 95:1235-47. 2005
  2. ncbi Arabidopsis mu A-adaptin interacts with the tyrosine motif of the vacuolar sorting receptor VSR-PS1
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, D 37073 Gottingen, Germany
    Plant J 37:678-93. 2004
  3. ncbi Characterisation of human histone H1x
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Biol Chem 386:541-51. 2005
  4. ncbi H1 subtype expression during cell proliferation and growth arrest
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Gottingen, Germany
    Cell Cycle 8:2226-32. 2009
  5. doi M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, Department of Molecular Biology, University of Gottingen, Germany
    J Mol Biol 386:339-50. 2009
  6. doi H1 histone subtype constitution and phosphorylation state of the ageing cell system of human peripheral blood lymphocytes
    Nicole Happel
    Institute of Biochemistry and Molecular Cell Biology, University of Gottingen, Gottingen, Germany
    Exp Gerontol 43:184-99. 2008
  7. doi Expression of p16INK4A in gastrointestinal stromal tumours (GISTs): two different forms exist that independently correlate with poor prognosis
    Florian Haller
    Department of Pathology, Georg August University, Gottingen, Germany
    Histopathology 56:305-18. 2010
  8. ncbi Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors
    Florian Haller
    Department of Pathology, Georg August University, Gottingen, Germany
    Mod Pathol 20:1103-11. 2007
  9. pmc Histone H1x is highly expressed in human neuroendocrine cells and tumours
    Julia Warneboldt
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    BMC Cancer 8:388. 2008
  10. ncbi G1 phase-dependent nucleolar accumulation of human histone H1x
    Stefan Stoldt
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Biol Cell 99:541-52. 2007

Collaborators

Detail Information

Publications16

  1. ncbi Topoisomerase inhibitor induced dephosphorylation of H1 and H3 histones as a consequence of cell cycle arrest
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Cell Biochem 95:1235-47. 2005
    ....
  2. ncbi Arabidopsis mu A-adaptin interacts with the tyrosine motif of the vacuolar sorting receptor VSR-PS1
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, D 37073 Gottingen, Germany
    Plant J 37:678-93. 2004
    ..The trans-Golgi localization of the mu A-adaptin strongly suggests its involvement in Golgi- to vacuole-trafficking events...
  3. ncbi Characterisation of human histone H1x
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Biol Chem 386:541-51. 2005
    ..However, comparison of the inducibility of their expression revealed that their genes are regulated differentially...
  4. ncbi H1 subtype expression during cell proliferation and growth arrest
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Gottingen, Germany
    Cell Cycle 8:2226-32. 2009
    ..The results of the present study demonstrate that the cell cycle-dependent mRNA and protein expression of various H1 subtypes is differentially regulated, supporting the hypothesis of a functional heterogeneity...
  5. doi M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3
    Nicole Happel
    Institute for Biochemistry and Molecular Cell Biology, Department of Molecular Biology, University of Gottingen, Germany
    J Mol Biol 386:339-50. 2009
    ..Furthermore, addition of specific glycogen synthase kinase-3 inhibitors led to a reduction in phosphorylation at this site both in vivo and in vitro...
  6. doi H1 histone subtype constitution and phosphorylation state of the ageing cell system of human peripheral blood lymphocytes
    Nicole Happel
    Institute of Biochemistry and Molecular Cell Biology, University of Gottingen, Gottingen, Germany
    Exp Gerontol 43:184-99. 2008
    ..These results indicate that dephosphorylation of H1 histones may be related to an increase in senescence-associated heterochromatin formation during the in vivo ageing of human peripheral blood lymphocytes...
  7. doi Expression of p16INK4A in gastrointestinal stromal tumours (GISTs): two different forms exist that independently correlate with poor prognosis
    Florian Haller
    Department of Pathology, Georg August University, Gottingen, Germany
    Histopathology 56:305-18. 2010
    ..To determine the prognostic impact of p16INK4A expression in gastrointestinal stromal tumours (GISTs), which is currently being questioned, with both loss and overexpression said to be correlated with poor prognosis...
  8. ncbi Site-dependent differential KIT and PDGFRA expression in gastric and intestinal gastrointestinal stromal tumors
    Florian Haller
    Department of Pathology, Georg August University, Gottingen, Germany
    Mod Pathol 20:1103-11. 2007
    ..The higher PDGFRA expression in gastric GISTs possibly contributes to the well-known site-dependent clinical behavior...
  9. pmc Histone H1x is highly expressed in human neuroendocrine cells and tumours
    Julia Warneboldt
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    BMC Cancer 8:388. 2008
    ..The epigenetic contribution of H1 histones to these mechanisms makes it conceivable that they also take part in malignant transformation...
  10. ncbi G1 phase-dependent nucleolar accumulation of human histone H1x
    Stefan Stoldt
    Institute for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Biol Cell 99:541-52. 2007
    ....
  11. pmc Regulation of geminin functions by cell cycle-dependent nuclear-cytoplasmic shuttling
    Lingfei Luo
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Mol Cell Biol 27:4737-44. 2007
    ..This mechanism for regulating the functions of geminin adds to distinct mechanisms, such as protein degradation and ubiquitination, applied in other vertebrates...
  12. ncbi Development of starburst cholinergic amacrine cells in the retina of Tupaia belangeri
    Wolfgang Knabe
    Department of Anatomy and Embryology, Georg August University, D 37075 Gottingen, Germany
    J Comp Neurol 502:584-97. 2007
    ....
  13. doi Diversity in mammalian chiasmatic architecture: ipsilateral axons are deflected at glial arches in the prechiasmatic optic nerve of the eutherian Tupaia belangeri
    Wolfgang Knabe
    Department of Anatomy and Embryology, Georg August University, D 37075 Gottingen, Germany
    J Comp Neurol 508:437-57. 2008
    ....
  14. doi Histone H1 and its isoforms: contribution to chromatin structure and function
    Nicole Happel
    Institute of Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Gene 431:1-12. 2009
    ..On the other hand, studies on the role of particular subtypes at specific developmental stages in lower eukaryotes, but also in vertebrates suggest that specific subtypes of H1 participate in particular systems of gene regulation...
  15. ncbi Surgical management after neoadjuvant imatinib therapy in gastrointestinal stromal tumours (GISTs) with respect to imatinib resistance caused by secondary KIT mutations
    Florian Haller
    Department of Pathology, Georg August University, Robert Koch Str 40, 37099, Gottingen, Germany
    Ann Surg Oncol 14:526-32. 2007
    ..The aim of the current study was to evaluate the tumour response and observance of secondary KIT mutations in a case of GIST undergoing neoadjuvant imatinib therapy...
  16. ncbi HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding
    Sylvain Daujat
    Max Planck Institute for Immunobiology, Freiburg, Germany
    J Biol Chem 280:38090-5. 2005
    ..Our results provide the first experimental evidence for a "phospho switch" model in which neighboring phosphorylation reverts the effect of histone lysine methylation...