Research Topics
| Svenja HappeSummaryCountry: Germany Publications
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Detail Information
Publications
[When the legs have to keep moving at night--the restless legs syndrome]Michael Lanz
Abteilung für Klinische Neurophysiologie, Klinikum Bremen Ost
MMW Fortschr Med 149:42-4. 2007..If therapy-related augmentation occurs while taking levodopa, the medication should be changed to dopamine agonists. If augmentation occurs while taking dopamine agonists, opiates or gabapentin should be taken instead...- Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter bindingSvenja Happe
Department of Clinical Neurology, University of Vienna, Austria
J Neurol 250:83-6. 2003..The reduced striatal [(123)I]beta-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients... - Role of dopamine receptor agonists in the treatment of restless legs syndromeSvenja Happe
Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
CNS Drugs 18:27-36. 2004..Further research should focus on long-term observations and comparisons of different dopamine receptor agonists in RLS... - Growth hormone response to low-dose apomorphine in restless legs syndromeSvenja Happe
Department of Clinical Neurophysiology, University of Gottingen, Germany
Growth Horm IGF Res 17:323-7. 2007..It is therefore the aim of this study to determine whether the GH response to subcutaneously applied low-dose apomorphine is generally altered in patients with RLS as compared to healthy controls... - Perception of dreams and subjective sleep quality in patients with myasthenia gravisSvenja Happe
Department of Clinical Neurology, University of Vienna, Vienna, Austria
Neuropsychobiology 50:21-7. 2004..As the central cholinergic system also plays an important role in sleep/wake rhythms and in the regulation of REM sleep, sleep perception and dreaming may be altered in MG patients... - Dyskinesias due to intravenous apomorphine abuse in a patient without basal ganglia disorderSvenja Happe
Department of Clinical Neurophysiology, University of Gottingen, Germany
Mov Disord 20:105-8. 2005..We describe a patient with psychogenic parkinsonism and intravenous apomorphine abuse leading to subsequent choreatiform dyskinesias... - Levodopa treatment does not affect low-dose apomorphine test in patients with Parkinson's diseaseSvenja Happe
Department of Clinical Neurophysiology, University of Gottingen, Germany
Mov Disord 19:1511-5. 2004..Thus, the low-dose apomorphine test may also be a useful biological marker in the early differential diagnosis of PD patients who have already received levodopa treatment... - Sleep microstructure and neurodegeneration as measured by [123I]beta-CIT SPECT in treated patients with Parkinson's diseaseSvenja Happe
Department of Neurology, University of Vienna, Austria
J Neurol 251:1465-71. 2004..Along with spindles, K-complexes are well known hallmarks of stage 2 (S2) sleep. However, little is known about their quantity in S2 sleep of patients with Parkinson's disease (PD)... - Perception of sleep: subjective versus objective sleep parameters in patients with Parkinson's disease in comparison with healthy elderly controls. Sleep perception in Parkinson's disease and controlsSvenja Happe
Dept of Clinical Neurology, University of Vienna, Vienna, Austria
J Neurol 252:936-43. 2005..Little is known about subjective sleep perception in patients with chronic somatic diseases... - Restless legs syndrome and sleep problems in children and adolescents with insulin-dependent diabetes mellitus type 1S Happe
Department of Clinical Neurophysiology, University of Gottingen, Germany
Neuropediatrics 36:98-103. 2005..However, there is a relationship between diabetes and sleep disturbances and an optimally controlled diabetes mellitus might be an important factor for an improved sleep initiation... - Excessive daytime sleepiness and sleep disturbances in patients with neurological diseases: epidemiology and managementSvenja Happe
Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
Drugs 63:2725-37. 2003..Pharmacological treatment is generally achieved with stimulants such as amphetamine, methylphenidate and pemoline, or newer compounds such as modafinil... - Gabapentin versus ropinirole in the treatment of idiopathic restless legs syndromeSvenja Happe
Department of Clinical Neurology, University of Vienna, Vienna, Austria
Neuropsychobiology 48:82-6. 2003..We conclude that gabapentin and ropinirole provide a similarly well-tolerated and effective treatment of PLMS and sensorimotor symptoms in patients with idiopathic RLS... - The association between caregiver burden and sleep disturbances in partners of patients with Parkinson's diseaseSvenja Happe
Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37 075 Goettingen, Germany
Age Ageing 31:349-54. 2002..These disease-specific characteristics contribute to sleep-related problems in patients. However, little is known about prevalence and causes of sleep disturbances in caregivers of Parkinson's disease patients... - Scalp topography of the spontaneous K-complex and of delta-waves in human sleepSvenja Happe
Department of Neurology, University of Vienna, Austria
Brain Topogr 15:43-9. 2002..Together with spindles, K-complexes are well known hallmarks of stage 2 sleep (S2). However, little is known about their topographical distribution in comparison to delta-waves and to K-complexes superimposed by spindles... - The association between disease severity and sleep-related problems in patients with Parkinson's diseaseSvenja Happe
Department of Neurology, University of Munster, Germany
Neuropsychobiology 46:90-6. 2002.... 
[Sleep and its disorders in the elderly]S Happe
Institut für Klinische Neurophysiologie, Klinikum Bremen Ost, Lehrkrankenhaus der Universität Göttingen, Züricher Strasse 40, Bremen, Germany
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:1311-8. 2011..For the latter, it should be kept in mind that lower doses are needed in the elderly...- Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory perceptsCornelius G Bachmann
Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
Clin Neurophysiol 121:2083-9. 2010..The aim of this single-blinded, complete crossover study was to evaluate the effects of tDCS on thermal and mechanical perception, as assessed by quantitative sensory testing (QST)... - Effects of transcranial direct current stimulation of the primary sensory cortex on somatosensory perceptionLisa Grundmann
Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
Brain Stimul 4:253-60. 2011..Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans... - Health economic burden of patients with restless legs syndrome in a German ambulatory settingRichard Dodel
Department of Neurology, Philipps University Marburg, Marburg, Germany
Pharmacoeconomics 28:381-93. 2010..RLS places a notable financial burden on society as well as on patients and their families. More detailed studies are needed to evaluate the health economic impact of this disorder... - Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson's diseaseSvenja Happe
Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
J Neurol 254:1037-43. 2007..Its etiology, however, is still not fully understood. The aim of this study was to examine if the amount of nigrostriatal dopaminergic degeneration is associated with subjective daytime sleepiness in patients with PD... - Homocysteine in restless legs syndromeCornelius G Bachmann
Department of Clinical Neurophysiology, University of Gottingen, Germany
Sleep Med 9:388-92. 2008..Our objective was to determine whether changes in tHcy are also found in patients with restless legs syndrome (RLS) in relation to levodopa treatment and whether folate and vitamins B6 and B12 play a role in RLS... 
Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center studyBirgit Hogl
Department of Neurology, Innsbruck Medical University, Anichstr 35, 6020, Innsbruck, Austria
J Neurol 257:230-7. 2010..039). Augmentation was common with levodopa, but could be tolerated by most patients during this 6-month trial. Patients should be followed over longer periods to determine if dropout rates increase with time...- Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based surveyMatthias Boentert
Department of Neurology, University Hospital Munster, Albert Schweitzer Str 33, 48129, Munster, Germany
J Neurol 257:646-52. 2010..Since causative treatment for CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life... - Contribution of the premotor cortex to consolidation of motor sequence learning in humans during sleepMichael A Nitsche
Georg August University, Department of Clinical Neurophysiology, Gottingen, Germany
J Neurophysiol 104:2603-14. 2010..In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep... - Assessing health-related quality of life in patients with restless legs syndromeSvenja Happe
Department of Clinical Neurophysiology, Klinikum Bremen Ost, Bremen, Germany
Sleep Med 10:295-305. 2009..Restless Legs Syndrome (RLS) has a substantial impact on normal daily activities. Because of the high prevalence it is necessary to evaluate the impact on the health-related quality of life (HRQoL)... - Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndromeCornelius G Bachmann
Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, D 37075 Goettingen, Germany
Brain 133:762-70. 2010.... - Treatment wish of individuals with known and unknown restless legs syndrome in the communitySvenja Happe
Dept of Clinical Neurophysiology, Klinikum Bremen Ost University of Göttingen, Züricher Strasse 40, 28325, Bremen, Germany
J Neurol 255:1365-71. 2008..The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany... - Perception of sleep and dreams in alcohol-dependent patients during detoxication and abstinenceJana Steinig
Department of Clinical Neurophysiology, Klinikum Bremen Ost University of Göttingen, Züricher St 40, 28325 Bremen, Germany
Alcohol Alcohol 46:143-7. 2011..This study aims to investigate sleep quality and the subjective dream experience in alcohol-dependent patients during withdrawal and abstinence compared with healthy controls... - Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trialClaudia Trenkwalder
Paracelsus Elena Hospital, University of Gottingen, Kassel, Germany
Mov Disord 22:696-703. 2007..0001). This first large-scale active controlled study in RLS showed superior efficacy of cabergoline versus levodopa after a 30-week long-term therapy. Tolerability was found more favorable with levodopa than with cabergoline... - Socio-economic risk factors for incident restless legs syndrome in the general populationAndras Szentkiralyi
Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany
J Sleep Res 21:561-8. 2012..Behavioural variables and co-morbidities did not explain this association, thus further studies are required to reveal the mechanism behind the proposed relationship... - Incidence of restless legs syndrome in two population-based cohort studies in GermanyAndras Szentkiralyi
Institute of Epidemiology and Social Medicine, University of Munster, Germany
Sleep Med 12:815-20. 2011..Prospective data about the new-onset of restless legs syndrome (RLS) are lacking. Our aim was to assess the incidence rate of RLS in the general population... - Transient prosopagnosia after ischemic strokeN Lang
Department of Clinical Neurophysiology, Georg-August University, Robert-Koch-Str. 40, 37075 Goettingen, Germany
Neurology 66:916. 2006 - Modulatory effects of transcranial direct current stimulation on laser-evoked potentialsGabor Csifcsak
Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
Pain Med 10:122-32. 2009..In a separate experiment subjective, pain rating scores of 16 healthy subjects in two perceptual categories (warm sensation, mild pain) were also analyzed... - Actigraphy in irregular sleep-wake rhythmJana Steinig
Department of Clinical Neurophysiology, , Germany
Sleep Med 8:184-5. 2007 - Brain perfusion and VEP reactivity in occipital and parietal areas are associated to recovery from hypoxic vegetative stateHelmut Hildebrandt
Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany University of Oldenburg, Institute of Psychology, Germany
J Neurol Sci 260:150-8. 2007..Although this may just reflect haemodynamics during hypoxia leading to differences in severity of VS, it also may be regarded as a functional precondition for orientation towards stimuli and therefore for conscious actions in general... - Efficacy of cabergoline in restless legs syndrome: a placebo-controlled study with polysomnography (CATOR)W H Oertel
Department of Neurology, Center of Nervous Diseases, Philipps University Marburg, Rudolf Bultmann Str 8, D 35033 Marburg, Germany
Neurology 67:1040-6. 2006..To assess the efficacy and safety of the dopamine agonist cabergoline in the treatment of patients with idiopathic restless legs syndrome (CATOR study)... - Treatment of idiopathic restless legs syndrome (RLS) with gabapentinS Happe
Department of Clinical Neurology, University of Vienna, Austria
Neurology 57:1717-9. 2001..Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS... - The association of dopamine agonists with daytime sleepiness, sleep problems and quality of life in patients with Parkinson's disease--a prospective studyS Happe
Department of Neurology, University of Muenster, Germany
J Neurol 248:1062-7. 2001..The aim of this study was the evaluation of sleep disturbances and the quality of life (QoL) in PD patients with different dopaminergic treatment strategies... - Movement disorders in sleep: Parkinson's disease and restless legs syndromeS Happe
Department of Clinical Neurophysiology, University of Gottingen, Germany
Biomed Tech (Berl) 48:62-7. 2003..The present review focuses on nocturnal motor activity and sleep in Parkinson's disease and RLS... - Sleep disorders and depression in patients with Parkinson's diseaseS Happe
Department of Neurology, University of Vienna, Austria
Acta Neurol Scand 104:275-80. 2001..The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients... - Normal striatal D2 receptor binding in idiopathic restless legs syndrome with periodic leg movements in sleepG G Tribl
Department of Clinical Neurology, University of Vienna, Vienna General Hospital, Austria
Nucl Med Commun 25:55-60. 2004..Structures other than striatal D2 receptors are discussed as possible causes of the treatment effects in RLS... - Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in EuropeWolfgang H Oertel
Department of Neurology, Philipps University, Rudolf Bultmann Strasse 8, D 35039 Marburg, Germany
Sleep Med 9:228-39. 2008..In a pilot placebo-controlled study, low dosages of 0.5-2mg/24h rotigotine showed a dose-dependent beneficial effect in restless legs syndrome (RLS) patients... - Comorbidity of migraine and restless legs syndrome--a case-control studyA M Rhode
Department of Neurology, Klinikum Bremen Ost and University of Göttingen, Gottingen, Germany
Cephalalgia 27:1255-60. 2007..There is an association between RLS and migraine and, in addition, a co-association with depression. The underlying mechanism, however, remains undetermined and might be related to a dysfunction of dopaminergic metabolism in migraine... - The role of opioids in restless legs syndrome: an [11C]diprenorphine PET studySarah von Spiczak
Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
Brain 128:906-17. 2005..We therefore discuss a possible role for opioids in the pathophysiology of RLS with respect to sensory and motor symptoms... - Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndromeDiego Garcia-Borreguero
Fundacion Jimenez Diaz, Madrid, Spain
Sleep Med 8:455-63. 2007..The changes in each dimension are summed to give an ASRS total score... - Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)Claudia Trenkwalder
Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
Mov Disord 22:S495-504. 2007..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols... - Genetics of restless legs syndrome (RLS): State-of-the-art and future directionsJuliane Winkelmann
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:S449-58. 2007..One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies... - Family-based association study of the restless legs syndrome loci 2 and 3 in a European populationDavid Kemlink
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:207-12. 2007..0077, respectively). These results represent the first confirmation of these loci in a mixed European population. Variable results observed in families of different ethnic groups further corroborate the genetic complexity of RLS... - Abnormal cutaneous thermal thresholds in patients with restless legs syndromeSvenja Happe
J Neurol 250:362-5. 2003 - Augmentation as a treatment complication of restless legs syndrome: concept and managementDiego Garcia-Borreguero
Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
Mov Disord 22:S476-84. 2007..The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition...