Svenja Happe

Summary

Country: Germany

Publications

  1. ncbi request reprint [When the legs have to keep moving at night--the restless legs syndrome]
    Michael Lanz
    Abteilung für Klinische Neurophysiologie, Klinikum Bremen Ost
    MMW Fortschr Med 149:42-4. 2007
  2. ncbi request reprint Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding
    Svenja Happe
    Department of Clinical Neurology, University of Vienna, Austria
    J Neurol 250:83-6. 2003
  3. ncbi request reprint Role of dopamine receptor agonists in the treatment of restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    CNS Drugs 18:27-36. 2004
  4. ncbi request reprint Perception of dreams and subjective sleep quality in patients with myasthenia gravis
    Svenja Happe
    Department of Clinical Neurology, University of Vienna, Vienna, Austria
    Neuropsychobiology 50:21-7. 2004
  5. ncbi request reprint Dyskinesias due to intravenous apomorphine abuse in a patient without basal ganglia disorder
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Mov Disord 20:105-8. 2005
  6. ncbi request reprint Levodopa treatment does not affect low-dose apomorphine test in patients with Parkinson's disease
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Mov Disord 19:1511-5. 2004
  7. ncbi request reprint Sleep microstructure and neurodegeneration as measured by [123I]beta-CIT SPECT in treated patients with Parkinson's disease
    Svenja Happe
    Department of Neurology, University of Vienna, Austria
    J Neurol 251:1465-71. 2004
  8. ncbi request reprint Perception of sleep: subjective versus objective sleep parameters in patients with Parkinson's disease in comparison with healthy elderly controls. Sleep perception in Parkinson's disease and controls
    Svenja Happe
    Dept of Clinical Neurology, University of Vienna, Vienna, Austria
    J Neurol 252:936-43. 2005
  9. ncbi request reprint Restless legs syndrome and sleep problems in children and adolescents with insulin-dependent diabetes mellitus type 1
    S Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Neuropediatrics 36:98-103. 2005
  10. ncbi request reprint Growth hormone response to low-dose apomorphine in restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Growth Horm IGF Res 17:323-7. 2007

Detail Information

Publications51

  1. ncbi request reprint [When the legs have to keep moving at night--the restless legs syndrome]
    Michael Lanz
    Abteilung für Klinische Neurophysiologie, Klinikum Bremen Ost
    MMW Fortschr Med 149:42-4. 2007
    ..If therapy-related augmentation occurs while taking levodopa, the medication should be changed to dopamine agonists. If augmentation occurs while taking dopamine agonists, opiates or gabapentin should be taken instead...
  2. ncbi request reprint Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding
    Svenja Happe
    Department of Clinical Neurology, University of Vienna, Austria
    J Neurol 250:83-6. 2003
    ..The reduced striatal [(123)I]beta-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients...
  3. ncbi request reprint Role of dopamine receptor agonists in the treatment of restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    CNS Drugs 18:27-36. 2004
    ..Further research should focus on long-term observations and comparisons of different dopamine receptor agonists in RLS...
  4. ncbi request reprint Perception of dreams and subjective sleep quality in patients with myasthenia gravis
    Svenja Happe
    Department of Clinical Neurology, University of Vienna, Vienna, Austria
    Neuropsychobiology 50:21-7. 2004
    ..As the central cholinergic system also plays an important role in sleep/wake rhythms and in the regulation of REM sleep, sleep perception and dreaming may be altered in MG patients...
  5. ncbi request reprint Dyskinesias due to intravenous apomorphine abuse in a patient without basal ganglia disorder
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Mov Disord 20:105-8. 2005
    ..We describe a patient with psychogenic parkinsonism and intravenous apomorphine abuse leading to subsequent choreatiform dyskinesias...
  6. ncbi request reprint Levodopa treatment does not affect low-dose apomorphine test in patients with Parkinson's disease
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Mov Disord 19:1511-5. 2004
    ..Thus, the low-dose apomorphine test may also be a useful biological marker in the early differential diagnosis of PD patients who have already received levodopa treatment...
  7. ncbi request reprint Sleep microstructure and neurodegeneration as measured by [123I]beta-CIT SPECT in treated patients with Parkinson's disease
    Svenja Happe
    Department of Neurology, University of Vienna, Austria
    J Neurol 251:1465-71. 2004
    ..Along with spindles, K-complexes are well known hallmarks of stage 2 (S2) sleep. However, little is known about their quantity in S2 sleep of patients with Parkinson's disease (PD)...
  8. ncbi request reprint Perception of sleep: subjective versus objective sleep parameters in patients with Parkinson's disease in comparison with healthy elderly controls. Sleep perception in Parkinson's disease and controls
    Svenja Happe
    Dept of Clinical Neurology, University of Vienna, Vienna, Austria
    J Neurol 252:936-43. 2005
    ..Little is known about subjective sleep perception in patients with chronic somatic diseases...
  9. ncbi request reprint Restless legs syndrome and sleep problems in children and adolescents with insulin-dependent diabetes mellitus type 1
    S Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Neuropediatrics 36:98-103. 2005
    ..However, there is a relationship between diabetes and sleep disturbances and an optimally controlled diabetes mellitus might be an important factor for an improved sleep initiation...
  10. ncbi request reprint Growth hormone response to low-dose apomorphine in restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Growth Horm IGF Res 17:323-7. 2007
    ..It is therefore the aim of this study to determine whether the GH response to subcutaneously applied low-dose apomorphine is generally altered in patients with RLS as compared to healthy controls...
  11. ncbi request reprint Excessive daytime sleepiness and sleep disturbances in patients with neurological diseases: epidemiology and management
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Drugs 63:2725-37. 2003
    ..Pharmacological treatment is generally achieved with stimulants such as amphetamine, methylphenidate and pemoline, or newer compounds such as modafinil...
  12. ncbi request reprint Gabapentin versus ropinirole in the treatment of idiopathic restless legs syndrome
    Svenja Happe
    Department of Clinical Neurology, University of Vienna, Vienna, Austria
    Neuropsychobiology 48:82-6. 2003
    ..We conclude that gabapentin and ropinirole provide a similarly well-tolerated and effective treatment of PLMS and sensorimotor symptoms in patients with idiopathic RLS...
  13. doi request reprint [Sleep and its disorders in the elderly]
    S Happe
    Institut für Klinische Neurophysiologie, Klinikum Bremen Ost, Lehrkrankenhaus der Universität Göttingen, Züricher Strasse 40, Bremen, Germany
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:1311-8. 2011
    ..For the latter, it should be kept in mind that lower doses are needed in the elderly...
  14. ncbi request reprint The association between disease severity and sleep-related problems in patients with Parkinson's disease
    Svenja Happe
    Department of Neurology, University of Munster, Germany
    Neuropsychobiology 46:90-6. 2002
    ....
  15. ncbi request reprint Scalp topography of the spontaneous K-complex and of delta-waves in human sleep
    Svenja Happe
    Department of Neurology, University of Vienna, Austria
    Brain Topogr 15:43-9. 2002
    ..Together with spindles, K-complexes are well known hallmarks of stage 2 sleep (S2). However, little is known about their topographical distribution in comparison to delta-waves and to K-complexes superimposed by spindles...
  16. ncbi request reprint The association between caregiver burden and sleep disturbances in partners of patients with Parkinson's disease
    Svenja Happe
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37 075 Goettingen, Germany
    Age Ageing 31:349-54. 2002
    ..These disease-specific characteristics contribute to sleep-related problems in patients. However, little is known about prevalence and causes of sleep disturbances in caregivers of Parkinson's disease patients...
  17. doi request reprint Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts
    Cornelius G Bachmann
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Clin Neurophysiol 121:2083-9. 2010
    ..The aim of this single-blinded, complete crossover study was to evaluate the effects of tDCS on thermal and mechanical perception, as assessed by quantitative sensory testing (QST)...
  18. doi request reprint Effects of transcranial direct current stimulation of the primary sensory cortex on somatosensory perception
    Lisa Grundmann
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Brain Stimul 4:253-60. 2011
    ..Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans...
  19. doi request reprint Socio-economic risk factors for incident restless legs syndrome in the general population
    Andras Szentkiralyi
    Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany
    J Sleep Res 21:561-8. 2012
    ..Behavioural variables and co-morbidities did not explain this association, thus further studies are required to reveal the mechanism behind the proposed relationship...
  20. doi request reprint Health economic burden of patients with restless legs syndrome in a German ambulatory setting
    Richard Dodel
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Pharmacoeconomics 28:381-93. 2010
    ..RLS places a notable financial burden on society as well as on patients and their families. More detailed studies are needed to evaluate the health economic impact of this disorder...
  21. ncbi request reprint Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson's disease
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 254:1037-43. 2007
    ..Its etiology, however, is still not fully understood. The aim of this study was to examine if the amount of nigrostriatal dopaminergic degeneration is associated with subjective daytime sleepiness in patients with PD...
  22. doi request reprint Contribution of the premotor cortex to consolidation of motor sequence learning in humans during sleep
    Michael A Nitsche
    Georg August University, Department of Clinical Neurophysiology, Gottingen, Germany
    J Neurophysiol 104:2603-14. 2010
    ..In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep...
  23. pmc Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study
    Birgit Hogl
    Department of Neurology, Innsbruck Medical University, Anichstr 35, 6020, Innsbruck, Austria
    J Neurol 257:230-7. 2010
    ..039). Augmentation was common with levodopa, but could be tolerated by most patients during this 6-month trial. Patients should be followed over longer periods to determine if dropout rates increase with time...
  24. pmc Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey
    Matthias Boentert
    Department of Neurology, University Hospital Munster, Albert Schweitzer Str 33, 48129, Munster, Germany
    J Neurol 257:646-52. 2010
    ..Since causative treatment for CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life...
  25. ncbi request reprint Homocysteine in restless legs syndrome
    Cornelius G Bachmann
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Sleep Med 9:388-92. 2008
    ..Our objective was to determine whether changes in tHcy are also found in patients with restless legs syndrome (RLS) in relation to levodopa treatment and whether folate and vitamins B6 and B12 play a role in RLS...
  26. doi request reprint Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome
    Cornelius G Bachmann
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, D 37075 Goettingen, Germany
    Brain 133:762-70. 2010
    ....
  27. doi request reprint Treatment wish of individuals with known and unknown restless legs syndrome in the community
    Svenja Happe
    Dept of Clinical Neurophysiology, Klinikum Bremen Ost University of Göttingen, Züricher Strasse 40, 28325, Bremen, Germany
    J Neurol 255:1365-71. 2008
    ..The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany...
  28. doi request reprint Assessing health-related quality of life in patients with restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, Klinikum Bremen Ost, Bremen, Germany
    Sleep Med 10:295-305. 2009
    ..Restless Legs Syndrome (RLS) has a substantial impact on normal daily activities. Because of the high prevalence it is necessary to evaluate the impact on the health-related quality of life (HRQoL)...
  29. ncbi request reprint Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial
    Claudia Trenkwalder
    Paracelsus Elena Hospital, University of Gottingen, Kassel, Germany
    Mov Disord 22:696-703. 2007
    ..0001). This first large-scale active controlled study in RLS showed superior efficacy of cabergoline versus levodopa after a 30-week long-term therapy. Tolerability was found more favorable with levodopa than with cabergoline...
  30. doi request reprint Perception of sleep and dreams in alcohol-dependent patients during detoxication and abstinence
    Jana Steinig
    Department of Clinical Neurophysiology, Klinikum Bremen Ost University of Göttingen, Züricher St 40, 28325 Bremen, Germany
    Alcohol Alcohol 46:143-7. 2011
    ..This study aims to investigate sleep quality and the subjective dream experience in alcohol-dependent patients during withdrawal and abstinence compared with healthy controls...
  31. ncbi request reprint Actigraphy in irregular sleep-wake rhythm
    Jana Steinig
    Department of Clinical Neurophysiology, Klinikum Bremen Ost University of Göttingen, Germany
    Sleep Med 8:184-5. 2007
  32. doi request reprint Incidence of restless legs syndrome in two population-based cohort studies in Germany
    Andras Szentkiralyi
    Institute of Epidemiology and Social Medicine, University of Munster, Germany
    Sleep Med 12:815-20. 2011
    ..Prospective data about the new-onset of restless legs syndrome (RLS) are lacking. Our aim was to assess the incidence rate of RLS in the general population...
  33. ncbi request reprint Transient prosopagnosia after ischemic stroke
    N Lang
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    Neurology 66:916. 2006
  34. doi request reprint Modulatory effects of transcranial direct current stimulation on laser-evoked potentials
    Gabor Csifcsak
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Pain Med 10:122-32. 2009
    ..In a separate experiment subjective, pain rating scores of 16 healthy subjects in two perceptual categories (warm sensation, mild pain) were also analyzed...
  35. doi request reprint Electrical and transcranial magnetic stimulation of the facial nerve: diagnostic relevance in acute isolated facial nerve palsy
    Svenja Happe
    Department of Clinical Neurophysiology, Klinikum Bremen Ost, University of Gottingen, Bremen, Germany
    Eur Neurol 68:304-9. 2012
    ..Unilateral facial weakness is common. Transcranial magnetic stimulation (TMS) allows identification of a conduction failure at the level of the canalicular portion of the facial nerve and may help to confirm the diagnosis...
  36. ncbi request reprint Brain perfusion and VEP reactivity in occipital and parietal areas are associated to recovery from hypoxic vegetative state
    Helmut Hildebrandt
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany University of Oldenburg, Institute of Psychology, Germany
    J Neurol Sci 260:150-8. 2007
    ..Although this may just reflect haemodynamics during hypoxia leading to differences in severity of VS, it also may be regarded as a functional precondition for orientation towards stimuli and therefore for conscious actions in general...
  37. ncbi request reprint Efficacy of cabergoline in restless legs syndrome: a placebo-controlled study with polysomnography (CATOR)
    W H Oertel
    Department of Neurology, Center of Nervous Diseases, Philipps University Marburg, Rudolf Bultmann Str 8, D 35033 Marburg, Germany
    Neurology 67:1040-6. 2006
    ..To assess the efficacy and safety of the dopamine agonist cabergoline in the treatment of patients with idiopathic restless legs syndrome (CATOR study)...
  38. ncbi request reprint Sleep disorders and depression in patients with Parkinson's disease
    S Happe
    Department of Neurology, University of Vienna, Austria
    Acta Neurol Scand 104:275-80. 2001
    ..The strong association of depression, disease severity and sleep disorders in PD patients underlines the importance of identifying and treating both conditions in these patients...
  39. ncbi request reprint Movement disorders in sleep: Parkinson's disease and restless legs syndrome
    S Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Biomed Tech (Berl) 48:62-7. 2003
    ..The present review focuses on nocturnal motor activity and sleep in Parkinson's disease and RLS...
  40. ncbi request reprint The association of dopamine agonists with daytime sleepiness, sleep problems and quality of life in patients with Parkinson's disease--a prospective study
    S Happe
    Department of Neurology, University of Muenster, Germany
    J Neurol 248:1062-7. 2001
    ..The aim of this study was the evaluation of sleep disturbances and the quality of life (QoL) in PD patients with different dopaminergic treatment strategies...
  41. ncbi request reprint Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe
    Wolfgang H Oertel
    Department of Neurology, Philipps University, Rudolf Bultmann Strasse 8, D 35039 Marburg, Germany
    Sleep Med 9:228-39. 2008
    ..In a pilot placebo-controlled study, low dosages of 0.5-2mg/24h rotigotine showed a dose-dependent beneficial effect in restless legs syndrome (RLS) patients...
  42. ncbi request reprint Treatment of idiopathic restless legs syndrome (RLS) with gabapentin
    S Happe
    Department of Clinical Neurology, University of Vienna, Austria
    Neurology 57:1717-9. 2001
    ..Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS...
  43. ncbi request reprint Comorbidity of migraine and restless legs syndrome--a case-control study
    A M Rhode
    Department of Neurology, Klinikum Bremen Ost and University of Göttingen, Gottingen, Germany
    Cephalalgia 27:1255-60. 2007
    ..There is an association between RLS and migraine and, in addition, a co-association with depression. The underlying mechanism, however, remains undetermined and might be related to a dysfunction of dopaminergic metabolism in migraine...
  44. ncbi request reprint Normal striatal D2 receptor binding in idiopathic restless legs syndrome with periodic leg movements in sleep
    G G Tribl
    Department of Clinical Neurology, University of Vienna, Vienna General Hospital, Austria
    Nucl Med Commun 25:55-60. 2004
    ..Structures other than striatal D2 receptors are discussed as possible causes of the treatment effects in RLS...
  45. ncbi request reprint Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome
    Diego Garcia-Borreguero
    Fundacion Jimenez Diaz, Madrid, Spain
    Sleep Med 8:455-63. 2007
    ..The changes in each dimension are summed to give an ASRS total score...
  46. ncbi request reprint The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study
    Sarah von Spiczak
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    Brain 128:906-17. 2005
    ..We therefore discuss a possible role for opioids in the pathophysiology of RLS with respect to sensory and motor symptoms...
  47. ncbi request reprint Abnormal cutaneous thermal thresholds in patients with restless legs syndrome
    Svenja Happe
    J Neurol 250:362-5. 2003
  48. ncbi request reprint Family-based association study of the restless legs syndrome loci 2 and 3 in a European population
    David Kemlink
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
    Mov Disord 22:207-12. 2007
    ..0077, respectively). These results represent the first confirmation of these loci in a mixed European population. Variable results observed in families of different ethnic groups further corroborate the genetic complexity of RLS...
  49. ncbi request reprint Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
    Mov Disord 22:S495-504. 2007
    ..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols...
  50. ncbi request reprint Genetics of restless legs syndrome (RLS): State-of-the-art and future directions
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
    Mov Disord 22:S449-58. 2007
    ..One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies...
  51. ncbi request reprint Augmentation as a treatment complication of restless legs syndrome: concept and management
    Diego Garcia-Borreguero
    Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
    Mov Disord 22:S476-84. 2007
    ..The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition...