Research Topics
| Hans WorthmannSummaryAffiliation: Hannover Medical School Country: Germany Publications
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Detail Information
Publications
Monocyte chemotactic protein-1 as a potential biomarker for early anti-thrombotic therapy after ischemic strokeHans Worthmann
Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany E Mails H W R D W G E
Int J Mol Sci 13:8670-8. 2012..However, MCP-1 may be a useful biomarker for deciding on early stroke therapy, as patients with high MCP-1 at baseline appear to benefit from early treatment with ASA + ER-DP...
The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcomeH Worthmann
Department of Neurology, Medical School of Hannover, Hannover, Germany
Cerebrovasc Dis 30:85-92. 2010..The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage...- Linking infection and inflammation in acute ischemic strokeH Worthmann
Department of Neurology, Medical School of Hannover, Germany
Ann N Y Acad Sci 1207:116-22. 2010..Thus, sequential dynamics of early inflammation must be considered in the development of both mechanism-targeting anti-inflammatory and anti-infectious treatment strategies in ischemic brain damage... 
High plasma dimethylarginine levels are associated with adverse clinical outcome after strokeHans Worthmann
Department of Neurology, Hannover Medical School, Hannover, Germany
J Atheroscler Thromb 18:753-61. 2011..We hypothesized that plasma dimethylarginine levels increase in the hyper-acute phase after ischemic stroke and that their time course is related to stroke outcome...- Association of dimethylarginines and mediators of inflammation after acute ischemic strokeShufen Chen
Department of Neurology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30623, Germany
J Neuroinflammation 9:251. 2012..We sought to investigate the association between dimethylarginines and inflammatory mediators in patients with acute ischemic stroke... - Growth differentiation factor 15 plasma levels and outcome after ischemic strokeHans Worthmann
Department of Neurology, Hannover Medical School, Hannover, Germany
Cerebrovasc Dis 32:72-8. 2011..We hypothesized that the circulating levels of GDF-15 are increased and associated with neurological outcome in patients with ischemic stroke... - Nitric oxide (NO) and asymmetric dimethylarginine (ADMA): their pathophysiological role and involvement in intracerebral hemorrhageNa Li
Department of Neurology, Hannover Medical School, Germany
Neurol Res 33:541-8. 2011..This article aims to review the current knowledge about the role and metabolism of NO and ADMA. It will also address the role of the NO-NOS-ADMA pathway in ICH and delineate some questions that should be addressed by future studies... - Anticoagulants affect matrix metalloproteinase 9 levels in blood samples of stroke patients and healthy controlsMunir Rababah
Department of Neurology, Hannover Medical School, Carl Neuberg Strase 1, 30623 Hannover, Germany
Clin Biochem 45:483-9. 2012..In clinical studies MMP-9 has been quantified by ELISA using differing protocols. We aimed to establish a valid protocol by evaluation of preanalytics... - IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-FosAxel Lorentz
Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Germany
J Immunol 174:6751-6. 2005..In summary, our data show that the IL-4 effects on human intestinal mast cell functions are reversible and accompanied by an increased activity of ERK1/2 and c-Fos... - Circulating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndromeJohan M Lorenzen
Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover, Germany
PLoS ONE 7:e47215. 2012..MicroRNAs are small ribonucleotides orchestrating gene expression. We tested whether circulating microRNAs in serum of HUS patients during the 2011 epidemics are altered in this patient cohort and related to clinical manifestations... - Neurologic manifestations of E coli infection-induced hemolytic-uremic syndrome in adultsKarin Weissenborn
Hannover Medical School, Hannover, Germany
Neurology 79:1466-73. 2012..To describe the neurologic and neuroradiologic complications of Shiga toxin producing Escherichia coli infection (STEC)-associated hemolytic-uremic syndrome (HUS) in adults... - Hepatic encephalopathy after treatment with temozolomideAnnemarie Goldbecker
Department of Neurology and Clinical Neurophysiology, Hannover Medical School, 30623 Hannover, Germany
J Neurooncol 103:163-6. 2011..Furthermore, new side effects of drugs have to be considered. At least this case might lead to a closer monitoring of liver enzymes during temozolomide therapy... - Diagnostic accuracy of plasma glial fibrillary acidic protein for differentiating intracerebral hemorrhage and cerebral ischemia in patients with symptoms of acute strokeChristian Foerch
Department of Neurology, Goethe University, Frankfurt am Main, Germany
Clin Chem 58:237-45. 2012..In this study the diagnostic accuracy of plasma GFAP was determined in a prospective multicenter approach... - Hepatitis C virus infection and the brainKarin Weissenborn
Department of Neurology, Hannover Medical School, 30623 Hannover, Germany
Metab Brain Dis 24:197-210. 2009..Therefore, the Trojan horse hypothesis emerged: HCV-infected mononuclear blood cells enter the brain, enabling the virus to reside within the brain (probably in microglia) and to infect brain cells, especially astrocytes...