K Wewetzer

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint The monoclonal antibody 23E9 defines a novel developmentally-regulated Schwann cell surface antigen
    K Wewetzer
    Hannover Medical School, Center of Anatomy, Germany
    Int J Dev Neurosci 17:715-25. 1999
  2. ncbi request reprint Macrowell cultures identify a subpopulation of neonatal rat dorsal root ganglionic neurons displaying nerve growth factor independent survival
    K Wewetzer
    Hannover Medical School, Center of Anatomy, Germany
    Neurosci Lett 276:9-12. 1999
  3. ncbi request reprint In vitro expression and regulation of ciliary neurotrophic factor and its alpha receptor subunit in neonatal rat olfactory ensheathing cells
    K Wewetzer
    Hannover Medical School, Center of Anatomy OE4140, Carl Neuberg Strasse 1, D 30623 Hannover, Germany
    Neurosci Lett 306:165-8. 2001
  4. ncbi request reprint Phagocytosis of O4+ axonal fragments in vitro by p75- neonatal rat olfactory ensheathing cells
    Konstantin Wewetzer
    Department of Pathology, Veterinary School Hannover, Hannover, Germany
    Glia 49:577-87. 2005
  5. ncbi request reprint Exposure to dimethyl sulfoxide at 37 degrees C prior to freezing significantly improves the recovery of cryopreserved hybridoma cells
    K Wewetzer
    Center of Anatomy OE4140, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Cryobiology 43:288-92. 2001
  6. ncbi request reprint Olfactory ensheathing glia and Schwann cells: two of a kind?
    Konstantin Wewetzer
    Hannover Medical School, Center of Anatomy Neuroanatomy OE4140, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Cell Tissue Res 309:337-45. 2002
  7. ncbi request reprint The high molecular weight fibroblast growth factor-2 isoforms (21,000 mol. wt and 23,000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro
    C Grothe
    Hannover Medical School, Center of Anatomy, OE 4140, D 30623, Hannover, Germany
    Neuroscience 100:73-86. 2000
  8. doi request reprint Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro
    I Gerhauser
    Department of Pathology, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    J Neuroimmunol 252:49-55. 2012
  9. ncbi request reprint Expression of interleukin-6 and its receptor in the sciatic nerve and cultured Schwann cells: relation to 18-kD fibroblast growth factor-2
    C Grothe
    Hannover Medical School, Center of Anatomy, OE 4140, D 30623 Hannover, Germany
    Brain Res 885:172-81. 2000
  10. ncbi request reprint Differential expression of HNK-1 and p75(NTR) in adult canine Schwann cells and olfactory ensheathing cells in situ but not in vitro
    Patricia Bock
    Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
    J Comp Neurol 505:572-85. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint The monoclonal antibody 23E9 defines a novel developmentally-regulated Schwann cell surface antigen
    K Wewetzer
    Hannover Medical School, Center of Anatomy, Germany
    Int J Dev Neurosci 17:715-25. 1999
    ..To clarify the molecular identity of the antigen and define its physiological relevance, the antibody will be used in future studies for immunoprecipitation and functional in vitro assays...
  2. ncbi request reprint Macrowell cultures identify a subpopulation of neonatal rat dorsal root ganglionic neurons displaying nerve growth factor independent survival
    K Wewetzer
    Hannover Medical School, Center of Anatomy, Germany
    Neurosci Lett 276:9-12. 1999
    ..Addition of NGF to these cultures increased survival up to 65%. Neurons surviving independent of NGF in macrowell culture were heterogeneous in size and were lacking the low-affinity NGF receptor...
  3. ncbi request reprint In vitro expression and regulation of ciliary neurotrophic factor and its alpha receptor subunit in neonatal rat olfactory ensheathing cells
    K Wewetzer
    Hannover Medical School, Center of Anatomy OE4140, Carl Neuberg Strasse 1, D 30623 Hannover, Germany
    Neurosci Lett 306:165-8. 2001
    ..The observation that OECs express both the ligand and part of its receptor complex may indicate that CNTF exerts paracrine and/or autocrine effects in vivo, which apparently do not include the regulation of cell division...
  4. ncbi request reprint Phagocytosis of O4+ axonal fragments in vitro by p75- neonatal rat olfactory ensheathing cells
    Konstantin Wewetzer
    Department of Pathology, Veterinary School Hannover, Hannover, Germany
    Glia 49:577-87. 2005
    ..The strong phagocytic activity of OECs in vitro may reflect one important aspect of their physiological function...
  5. ncbi request reprint Exposure to dimethyl sulfoxide at 37 degrees C prior to freezing significantly improves the recovery of cryopreserved hybridoma cells
    K Wewetzer
    Center of Anatomy OE4140, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Cryobiology 43:288-92. 2001
    ..We conclude that the exposure of cells to Me2SO at elevated temperatures does not necessarily reduce cell viability and that contrary to this, cell type-specific, beneficial effects of Me2SO could be observed...
  6. ncbi request reprint Olfactory ensheathing glia and Schwann cells: two of a kind?
    Konstantin Wewetzer
    Hannover Medical School, Center of Anatomy Neuroanatomy OE4140, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Cell Tissue Res 309:337-45. 2002
    ..The present review summarizes recent data on the in vitro and in vivo properties of OECs and critically compares the analogies and differences in the biology of both cell types relevant in the above-mentioned context...
  7. ncbi request reprint The high molecular weight fibroblast growth factor-2 isoforms (21,000 mol. wt and 23,000 mol. wt) mediate neurotrophic activity on rat embryonic mesencephalic dopaminergic neurons in vitro
    C Grothe
    Hannover Medical School, Center of Anatomy, OE 4140, D 30623, Hannover, Germany
    Neuroscience 100:73-86. 2000
    ..These results suggest that the high molecular weight fibroblast growth factor-2 isoforms may serve as a new tool for the treatment of Parkinson's disease...
  8. doi request reprint Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro
    I Gerhauser
    Department of Pathology, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    J Neuroimmunol 252:49-55. 2012
    ..The simultaneous expression of TNF and its receptors by both cell types might generate autocrine feedback loops possibly associated with pro-inflammatory actions of astrocytes via TNFR1...
  9. ncbi request reprint Expression of interleukin-6 and its receptor in the sciatic nerve and cultured Schwann cells: relation to 18-kD fibroblast growth factor-2
    C Grothe
    Hannover Medical School, Center of Anatomy, OE 4140, D 30623 Hannover, Germany
    Brain Res 885:172-81. 2000
    ..These results are consistent with the idea of a functional coupling of FGF-2 and the IL-6 system in the early reaction of Schwann cells to nerve injury...
  10. ncbi request reprint Differential expression of HNK-1 and p75(NTR) in adult canine Schwann cells and olfactory ensheathing cells in situ but not in vitro
    Patricia Bock
    Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
    J Comp Neurol 505:572-85. 2007
    ..This is reminiscent of humans and differs from rodents; it also underscores the importance of large animal models for translational research...
  11. doi request reprint In vitro characterization and preferential infection by canine distemper virus of glial precursors with Schwann cell characteristics from adult canine brain
    E A Orlando
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    Neuropathol Appl Neurobiol 34:621-37. 2008
    ..The aim of this study was to establish primary glial cell cultures from adult canine brain for the analysis of CDV spread and cell tropism...
  12. ncbi request reprint Immunohistochemical characterization of axonal sprouting and reactive tissue changes after long-term implantation of a polyimide sieve electrode to the transected adult rat sciatic nerve
    P M Klinge
    Department of Neurosurgery, Hannover Medical School, Germany
    Biomaterials 22:2333-43. 2001
    ..It is concluded that the introduced flexible polyimide electrode is suitable for contacting peripheral nerves since it permits substantial neurite growth and offers excellent long-term stability...
  13. ncbi request reprint Purification and in vitro characterization of adult canine olfactory ensheathing cells
    Christiane Krudewig
    Department of Pathology, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Cell Tissue Res 326:687-96. 2006
    ..CaOECs therefore represent a suitable model system relevant for humOECs in neural repair studies...
  14. doi request reprint Transfection of adult canine Schwann cells and olfactory ensheathing cells at early and late passage with human TERT differentially affects growth factor responsiveness and in vitro growth
    Somporn Techangamsuwan
    Department of Pathology, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany Center for Systems Neuroscience, Hannover, Germany
    J Neurosci Methods 176:112-20. 2009
    ..Taken together, we established a stable source of adult canine Schwann cells and OECs and demonstrated that the effects of hTERT expression on in vitro growth and growth factor responsiveness depend on the replicative age...
  15. doi request reprint In vitro characterization of a murine oligodendrocyte precursor cell line (BO-1) following spontaneous immortalization
    Kidsadagon Pringproa
    Institute of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    Int J Dev Neurosci 26:283-91. 2008
    ..In summary, the novel murine BO-1 cell line shares several characteristics with oligodendrocyte precursor cells but displays a restricted differentiation into mature oligodendrocytes...
  16. doi request reprint Similar behaviour and primate-like properties of adult canine Schwann cells and olfactory ensheathing cells in long-term culture
    Somporn Techangamsuwan
    Department of Pathology, University of Veterinary Medicine, Hannover, Germany
    Brain Res 1240:31-8. 2008
    ..This underscores the relevance of the dog as a translational species between rodents and humans...
  17. doi request reprint Theiler's murine encephalomyelitis virus preferentially infects immature stages of the murine oligodendrocyte precursor cell line BO-1 and blocks oligodendrocytic differentiation in vitro
    Kidsadagon Pringproa
    Department of Pathology, University of Veterinary Medicine Hannover, D 30559 Hannover, Germany
    Brain Res 1327:24-37. 2010
    ..The first demonstration of TMEV-mediated effects on OPC differentiation may shed new light on the pathogenesis of TMEV-induced demyelination and offers an explanation for the limited remyelination observed in vivo...
  18. doi request reprint Differential transcription of matrix-metalloproteinase genes in primary mouse astrocytes and microglia infected with Theiler's murine encephalomyelitis virus
    Jirawat Kumnok
    Department of Pathology, University of Veterinary Medicine, Hannover, Germany
    J Neurovirol 14:205-17. 2008
    ..Conclusively, in addition to inflammatory infiltrates, TMEV-induced astrocytic MMPs might trigger a proteolysis cascade leading to an opening of the blood-brain barrier and demyelination in vivo...
  19. pmc Site-specific population dynamics and variable olfactory marker protein expression in the postnatal canine olfactory epithelium
    Patricia Bock
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    J Anat 215:522-35. 2009
    ..Whether the site-specific population dynamics in the postnatal canine olfactory epithelium revealed in the present study are modulated by physiological parameters, such as airflow, has to be clarified in future studies...
  20. ncbi request reprint Vimentin-positive astrocytes in canine distemper: a target for canine distemper virus especially in chronic demyelinating lesions?
    Frauke Seehusen
    Department of Pathology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hannover, Germany
    Acta Neuropathol 114:597-608. 2007
    ..To conclude, the present findings indicate a change in cell tropism of CDV and/or the occurrence of less differentiated astrocytes representing a permanent source for virus infection and spread in advanced lesions of DL...
  21. doi request reprint Distinct cell tropism of canine distemper virus strains to adult olfactory ensheathing cells and Schwann cells in vitro
    Somporn Techangamsuwan
    Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
    Virus Res 144:195-201. 2009
    ..Whether these differences are either related to strain-specific distemper pathogenesis or support a role of OECs during CDV infection and virus spread needs to be addressed in future studies...
  22. doi request reprint Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
    Maria Grosheva
    Department of Otorhinolaryngology, University of Cologne, Cologne, Germany
    Biol Chem 389:873-88. 2008
    ..Furthermore, such deleterious effects cannot be overridden by manual stimulation. We conclude that entubulation with BM-MSCs is not beneficial for facial nerve repair...
  23. pmc Remyelination of the nonhuman primate spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cells
    Christine Radtke
    Department of Neurology, Yale University School of Medicine, New Haven, an Neuroscience Research Center, VA Medical Center, West Haven, Connecticut 06516, USA
    FASEB J 18:335-7. 2004
    ..This is the first demonstration that xenotransplantation of characterized OECs into the primate spinal cord results in remyelination...
  24. ncbi request reprint Transplantation of olfactory mucosa minimizes axonal branching and promotes the recovery of vibrissae motor performance after facial nerve repair in rats
    Orlando Guntinas-Lichius
    Department of Oto Rhino Laryngology, University of Cologne, 50931 Cologne, Germany
    J Neurosci 22:7121-31. 2002
    ..It is concluded that transplantation of OM to the transected facial nerve significantly improves nerve regeneration...