K Weissenborn

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Portosystemic encephalopathy
    Karin Weissenborn
    Department of Neurology, Hanover Medical School, Hanover, Germany Electronic address
    Handb Clin Neurol 120:661-74. 2014
  2. pmc Association of dimethylarginines and mediators of inflammation after acute ischemic stroke
    Shufen Chen
    Department of Neurology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30623, Germany
    J Neuroinflammation 9:251. 2012
  3. doi request reprint Quantitative MRI shows cerebral microstructural damage in hemolytic-uremic syndrome patients with severe neurological symptoms but no changes in conventional MRI
    Karin Weissenborn
    Clinic for Neurology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Neuroradiology 55:819-25. 2013
  4. doi request reprint Psychometric tests for diagnosing minimal hepatic encephalopathy
    Karin Weissenborn
    Department of Neurology, Hannover Medical School, 30623 Hannover, Germany
    Metab Brain Dis 28:227-9. 2013
  5. doi request reprint Neurologic manifestations of E coli infection-induced hemolytic-uremic syndrome in adults
    Karin Weissenborn
    Hannover Medical School, Hannover, Germany
    Neurology 79:1466-73. 2012
  6. ncbi request reprint Functional imaging of the brain in patients with liver cirrhosis
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Metab Brain Dis 19:269-80. 2004
  7. ncbi request reprint Neurological and neuropsychiatric syndromes associated with liver disease
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    AIDS 19:S93-8. 2005
  8. pmc Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment
    K Weissenborn
    Neurologische Klinik, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Gut 55:1624-30. 2006
  9. pmc Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Gut 56:1736-42. 2007
  10. doi request reprint Hepatitis C virus infection and the brain
    Karin Weissenborn
    Department of Neurology, Hannover Medical School, 30623 Hannover, Germany
    Metab Brain Dis 24:197-210. 2009

Detail Information

Publications49

  1. doi request reprint Portosystemic encephalopathy
    Karin Weissenborn
    Department of Neurology, Hanover Medical School, Hanover, Germany Electronic address
    Handb Clin Neurol 120:661-74. 2014
    ..Of note, this approach does not work in acquired hepatocerebral degeneration and hepatic myelopathy. Here liver transplantation should be considered early in the course of the disease. ..
  2. pmc Association of dimethylarginines and mediators of inflammation after acute ischemic stroke
    Shufen Chen
    Department of Neurology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30623, Germany
    J Neuroinflammation 9:251. 2012
    ..We sought to investigate the association between dimethylarginines and inflammatory mediators in patients with acute ischemic stroke...
  3. doi request reprint Quantitative MRI shows cerebral microstructural damage in hemolytic-uremic syndrome patients with severe neurological symptoms but no changes in conventional MRI
    Karin Weissenborn
    Clinic for Neurology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Neuroradiology 55:819-25. 2013
    ..This study aims to analyze if quantitative MRI is able to reveal cerebral pathological alterations invisible for conventional MRI...
  4. doi request reprint Psychometric tests for diagnosing minimal hepatic encephalopathy
    Karin Weissenborn
    Department of Neurology, Hannover Medical School, 30623 Hannover, Germany
    Metab Brain Dis 28:227-9. 2013
    ..Future studies must address these questions to improve diagnosis of mHE...
  5. doi request reprint Neurologic manifestations of E coli infection-induced hemolytic-uremic syndrome in adults
    Karin Weissenborn
    Hannover Medical School, Hannover, Germany
    Neurology 79:1466-73. 2012
    ..To describe the neurologic and neuroradiologic complications of Shiga toxin producing Escherichia coli infection (STEC)-associated hemolytic-uremic syndrome (HUS) in adults...
  6. ncbi request reprint Functional imaging of the brain in patients with liver cirrhosis
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Metab Brain Dis 19:269-80. 2004
    ..These findings fit well with the clinical characteristics of early stages of HE such as deficits in attention, visuo-spatial orientation, visuo-constructive abilities, motor speed, and accuracy...
  7. ncbi request reprint Neurological and neuropsychiatric syndromes associated with liver disease
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    AIDS 19:S93-8. 2005
    ..In contrast to patients with HE, HCV-infected patients did not show motor symptoms or deficits in visual perception, but considerable deficits in attention and concentration ability...
  8. pmc Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment
    K Weissenborn
    Neurologische Klinik, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Gut 55:1624-30. 2006
    ..This observation indicates alteration of serotonergic neurotransmission in HCV infected patients with chronic fatigue...
  9. pmc Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Gut 56:1736-42. 2007
    ....
  10. doi request reprint Hepatitis C virus infection and the brain
    Karin Weissenborn
    Department of Neurology, Hannover Medical School, 30623 Hannover, Germany
    Metab Brain Dis 24:197-210. 2009
    ..Therefore, the Trojan horse hypothesis emerged: HCV-infected mononuclear blood cells enter the brain, enabling the virus to reside within the brain (probably in microglia) and to infect brain cells, especially astrocytes...
  11. ncbi request reprint Hepatitis C virus infection affects the brain-evidence from psychometric studies and magnetic resonance spectroscopy
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    J Hepatol 41:845-51. 2004
    ..The aim of the present study was to seek evidence for the presence of central nervous system involvement in HCV infected patients with only mild liver disease...
  12. ncbi request reprint Memory function in early hepatic encephalopathy
    Karin Weissenborn
    Neurologische Klinik, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    J Hepatol 39:320-5. 2003
    ..Early hepatic encephalopathy (HE) is characterized by deficits in motor performance, visual perception, visuo-constructive abilities and attention. Whether defective memory is a feature of early HE is controversial...
  13. ncbi request reprint [Concepts for stroke therapy]
    K Weissenborn
    Neurologische Klinik, Medizinische Hochschule Hannover
    Anasthesiol Intensivmed Notfallmed Schmerzther 34:110-4. 1999
    ....
  14. ncbi request reprint The basal ganglia and portal-systemic encephalopathy
    K Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Germany
    Metab Brain Dis 13:261-72. 1998
    ..The symptoms of PSE - whether cognitive, emotional or motor - are proposed to be a consequence of basal ganglia dysfunction...
  15. ncbi request reprint Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy
    K Weissenborn
    Department of Neurology, Medizinische, Hochschule Hannover, Germany
    Metab Brain Dis 15:173-8. 2000
    ..It is suggested that the alteration of the dopamine re-uptake in cirrhotics may be the cause of an increased catabolism of dopamine in HE...
  16. ncbi request reprint Liver transplantation improves hepatic myelopathy: evidence by three cases
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Germany
    Gastroenterology 124:346-51. 2003
    ..The aim of this study was to find out whether orthotopic liver transplantation (OLT) may improve hepatic myelopathy...
  17. doi request reprint Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy
    M Bokemeyer
    Institute for Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany
    Gut 60:370-7. 2011
    ....
  18. doi request reprint Recurrent stroke after lobar and deep intracerebral hemorrhage: a hospital-based cohort study
    C Weimar
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cerebrovasc Dis 32:283-8. 2011
    ..We therefore aimed to assess the patient characteristics and prognosis after deep and lobar ICH in a well-characterized, multicenter, hospital-based cohort...
  19. doi request reprint The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome
    H Worthmann
    Department of Neurology, Medical School of Hannover, Hannover, Germany
    Cerebrovasc Dis 30:85-92. 2010
    ..The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage...
  20. ncbi request reprint Attention deficits in minimal hepatic encephalopathy
    K Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Germany
    Metab Brain Dis 16:13-9. 2001
    ..Thus, the PSE-Test results represent attention deficits as well as deficits in motor skills, visuo-spatial orientation, and visual construction...
  21. doi request reprint Quality of life in patients with various liver diseases: patients with HCV show greater mental impairment, while patients with PBC have greater physical impairment
    H L Tillmann
    Medizinische Hochschule Hannover, Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Hannover, Germany
    J Viral Hepat 18:252-61. 2011
    ..This may suggest that HCV either may not be involved in QoL impairment or may induce a process which persists after viral clearance in some patients...
  22. doi request reprint The role of cerebrospinal fluid S100 and lactate to predict clinically evident spinal cord ischaemia in thoraco-abdominal aortic surgery
    N Khaladj
    Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Eur J Vasc Endovasc Surg 36:11-9. 2008
    ..In a high risk population, we have re-evaluated the potential impact of ischaemia/damage markers (S100, lactate) in the peripheral blood and CSF for perioperative patient management...
  23. ncbi request reprint Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and/or posterior cerebral circulation
    Argyro Tountopoulou
    Department of Neurology and Clinical Neurophysiology, Hannover Medical School, 30623, Hannover, Germany
    Neuroradiology 50:75-83. 2008
    ..The aim of our study was to evaluate the safety and efficacy of intra-arterial (IA) thrombolysis using recombinant tissue plasminogen activator (rt-PA) in patients with acute stroke due to occlusion in the anterior or posterior circulation...
  24. doi request reprint Spontaneous recovery from progressive multifocal leukoencephalopathy in a patient with non-active sarcoidosis
    Annemarie Goldbecker
    Department of Neurology and Neurophysiology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Int J Infect Dis 14:e313-6. 2010
    ..This is the first case of a patient with no sign of active sarcoidosis and without immunosuppressive therapy who recovered spontaneously with a follow-up time of nearly 3 years...
  25. doi request reprint Hepatic encephalopathy after treatment with temozolomide
    Annemarie Goldbecker
    Department of Neurology and Clinical Neurophysiology, Hannover Medical School, 30623 Hannover, Germany
    J Neurooncol 103:163-6. 2011
    ..Furthermore, new side effects of drugs have to be considered. At least this case might lead to a closer monitoring of liver enzymes during temozolomide therapy...
  26. pmc Blood-brain barrier permeability for ammonia in patients with different grades of liver fibrosis is not different from healthy controls
    Annemarie Goldbecker
    Department of Neurology and Clinical Neurophysiology, Hannover Medical School, Hannover, Germany
    J Cereb Blood Flow Metab 30:1384-93. 2010
    ..The hypothesis that increased permeability of the BBB for ammonia in patients with liver fibrosis contributes to the later development of HE could not be supported by this study...
  27. ncbi request reprint Attention, memory, and cognitive function in hepatic encephalopathy
    Karin Weissenborn
    Department of Neurology, Medizinische Hochschule Hannover, Hannover
    Metab Brain Dis 20:359-67. 2005
    ..The present paper summarizes some findings about attentional and memory dysfunction in hepatic encephalopathy, with reference to basic knowledge about normal attention and memory function and their cerebral representation...
  28. ncbi request reprint Decrease of middle cerebral artery blood flow velocity after low-frequency repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex
    Jens D Rollnik
    Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Clin Neurophysiol 113:951-5. 2002
    ..Both, inhibition and activation of cortical areas may be achieved using different stimulation parameters. Using low-frequency rTMS (0.9 Hz), inhibition of cortical areas can be observed...
  29. doi request reprint Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial
    Reinhard Dengler
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Lancet Neurol 9:159-66. 2010
    ..The EARLY trial aimed to compare outcome in patients given aspirin plus extended-release dipyridamole twice daily either within 24 h of stroke or TIA or after 7 days of aspirin monotherapy...
  30. doi request reprint Symptomatic intracranial atherosclerotic stenoses: prevalence and prognosis in patients with acute cerebral ischemia
    R Weber
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Cerebrovasc Dis 30:188-93. 2010
    ..In view of the increasing options for endovascular interventions, we sought to investigate the prevalence, risk for recurrent stroke and mortality in these patients...
  31. ncbi request reprint Regional differences in cerebral blood flow and cerebral ammonia metabolism in patients with cirrhosis
    Bjorn Ahl
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 40:73-9. 2004
    ....
  32. doi request reprint Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration
    B Burgel
    Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Medical School Hannover MHH and Helmholtz Centre for Infection Research HZI, Hannover, Germany
    J Viral Hepat 18:562-70. 2011
    ..However, productive viral entry into the peripheral neuroblastoma cell line SKNMC indicates that HCV may penetrate into certain nonhepatic cell types which may serve as viral reservoirs and could modulate viral pathogenesis...
  33. doi request reprint Current management and risk of recurrent stroke in cerebrovascular patients with right-to-left cardiac shunt
    C Weimar
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Cerebrovasc Dis 28:349-56. 2009
    ..We aimed to investigate the current management and prognosis in consecutive patients with RLS and otherwise cryptogenic cerebrovascular events...
  34. pmc Dissection of the brain supplying arteries over the life span
    B Ahl
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    J Neurol Neurosurg Psychiatry 75:1194-6. 2004
    ..The results show that CAD is a possible cause of cerebral ischemia in the elderly and thus has also to be considered in the diagnostic investigation in this patient group...
  35. ncbi request reprint Bradykinesia in cirrhotic patients with early hepatic encephalopathy is related to a decreased glucose uptake of frontomesial cortical areas relevant for movement initiation
    Kathrin Giewekemeyer
    Department of Neurology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    J Hepatol 46:1034-9. 2007
    ..The present study aimed to test the hypothesis that bradykinesia in HE is due to a functional disturbance of these areas...
  36. doi request reprint Linking infection and inflammation in acute ischemic stroke
    H Worthmann
    Department of Neurology, Medical School of Hannover, Germany
    Ann N Y Acad Sci 1207:116-22. 2010
    ..Thus, sequential dynamics of early inflammation must be considered in the development of both mechanism-targeting anti-inflammatory and anti-infectious treatment strategies in ischemic brain damage...
  37. doi request reprint Prediction of recurrent stroke and vascular death in patients with transient ischemic attack or nondisabling stroke: a prospective comparison of validated prognostic scores
    Christian Weimar
    Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Stroke 41:487-93. 2010
    ..We aimed to prospectively compare the predictive accuracy of the Essen Stroke Risk Score, Stroke Prognostic Instrument, Hankey score, and the Life Long After Cerebral ischemia score...
  38. doi request reprint Prognosis after cryptogenic cerebral ischemia in patients with coagulopathies
    Ralph Weber
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Cerebrovasc Dis 28:611-7. 2009
    ..The goal of this prospective observational multicenter study was to determine the risk of recurrence in cryptogenic stroke patients with either no or defined coagulopathies under various prevention regimens...
  39. ncbi request reprint Comparison of perfusion computed tomography with diffusion-weighted magnetic resonance imaging in hyperacute ischemic stroke
    Sotirios Bisdas
    Department of Neuroradiology, Hannover Medical School, Hannover, Germany
    J Comput Assist Tomogr 28:747-55. 2004
    ..In this study, perfusion CT and diffusion-weighted magnetic resonance imaging (DWI) were compared as means of assessing the ischemic brain in hyperacute stroke...
  40. ncbi request reprint Effect of sildenafil (Viagra) on cerebral blood flow velocity: a pilot study
    Anouscheh Arnavaz
    Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, 30625 Hannover, Germany
    Psychiatry Res 122:207-9. 2003
    ....
  41. ncbi request reprint [Lipomatosis dolorosa--a frequently overlooked disease picture]
    J Steiner
    Neurologische Klinik, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Nervenarzt 73:183-7. 2002
    ..Surgical excision or liposuction of these fatty tissue deposits have shown significant reduction of pain. However, this effect reduces over time and recurrences often develop...
  42. ncbi request reprint Bradykinesia in minimal hepatic encephalopathy is due to disturbances in movement initiation
    E Michael Joebges
    Department of Neurology and Clinical Neurophysiology, Medizinische Hochschule, Hannover, Germany
    J Hepatol 38:273-80. 2003
    ..One of the predominant symptoms of early stages of hepatic encephalopathy (HE) is bradykinesia...
  43. ncbi request reprint Video documented follow-up of liver transplantation in Wilson's disease with predominant neurological manifestation
    Thorsten Suess
    Department of Neurology, Medizinische Hochschule Hannover, Hannover, Germany
    Mov Disord 22:1036-8. 2007
    ..In this case report, we document the follow up of neurological symptoms in WD after LT for the first time on video...
  44. ncbi request reprint Minimal hepatic encephalopathy: a permanent source of discussion
    Karin Weissenborn
    Hepatology 35:494-6. 2002
  45. ncbi request reprint Correlations between cerebral glucose metabolism and neuropsychological test performance in nonalcoholic cirrhotics
    Alan H Lockwood
    Center for Positron Emission Tomography, Veterans Affairs Western New York Healthcare System, Buffalo 14215, USA
    Metab Brain Dis 17:29-40. 2002
    ..Metabolic abnormalities in the anterior attention system and association cortices mediating executive and integrative function form the pathophysiological basis for mild hepatic encephalopathy...
  46. ncbi request reprint Malnutrition and hypermetabolism are not risk factors for the presence of hepatic encephalopathy: a cross-sectional study
    Peter Soros
    Department of Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Gastroenterol Hepatol 23:606-10. 2008
    ..We tested the hypothesis that reduced nutritional status or the degree of tissue catabolism are associated with the presence of hepatic encephalopathy...
  47. ncbi request reprint The treatment of hepatic encephalopathy
    Marsha Y Morgan
    Centre for Hepatology, Division of Medicine, Royal Free Campus, Royal Free and University College Medical School, University College London, London, UK
    Metab Brain Dis 22:389-405. 2007
    ..The content of this discussion is summarized...
  48. ncbi request reprint Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998
    Peter Ferenci
    Department of Internal Medicine IV, Gastroenterology and Hepatology, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Hepatology 35:716-21. 2002
    ..Finally, the need for a careful evaluation of the newer neuroimaging modalities for the diagnosis of hepatic encephalopathy was stressed...
  49. ncbi request reprint Correlative assessment of cerebral blood flow obtained with perfusion CT and positron emission tomography in symptomatic stenotic carotid disease
    Sotirios Bisdas
    Department of Diagnostic and Interventional Radiology, JWG University Hospital, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Eur Radiol 16:2220-8. 2006
    ..In conclusion, the perfusion CT-CBF measurements correlate significantly with the PET-CBF measurements in chronic carotid stenotic disease and contribute useful information to the evaluation of the altered cerebral hemodynamics...