Heiner Wedemeyer

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Sustained HCV-RNA response and hepatitis Bs seroconversion after individualized antiviral therapy with pegylated interferon alpha plus ribavirin and active vaccination in a hepatitis C virus/hepatitis B virus-coinfected patient
    Andrej Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Eur J Gastroenterol Hepatol 19:906-9. 2007
  2. pmc Structural barriers in the context of opiate substitution treatment in Germany--a survey among physicians in primary care
    Bernd Schulte
    Centre for Interdisciplinary Addiction Research, Hamburg University, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg, D 20246, Germany
    Subst Abuse Treat Prev Policy 8:26. 2013
  3. doi request reprint Immunopathogenesis of hepatitis E virus infection
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Semin Liver Dis 33:71-8. 2013
  4. doi request reprint Pathogenesis and treatment of hepatitis e virus infection
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Gastroenterology 142:1388-1397.e1. 2012
  5. doi request reprint Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients
    Karsten Wursthorn
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 52:1611-20. 2010
  6. doi request reprint Hepatitis D revival
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Liver Int 31:140-4. 2011
  7. ncbi request reprint [German guidelines on diagnosis and therapy of hepatitis B]
    H Wedemeyer
    Medizinische Hochschule Hannover, Germany
    Dtsch Med Wochenschr 132:1775-82. 2007
  8. ncbi request reprint [Hepatitis (Hep-Net) competence network]
    H Wedemeyer
    Kompetenznetz Hepatitis, c o Medizinische Hochschule Hannover
    Internist (Berl) 45:415-21. 2004
  9. ncbi request reprint Isolated anti-HBV core phenotype in anti-HCV-positive patients is associated with hepatitis C virus replication
    H Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany
    Clin Microbiol Infect 10:70-2. 2004
  10. doi request reprint Performance and clinical utility of a novel fully automated quantitative HCV-core antigen assay
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Clin Virol 46:210-5. 2009

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint Sustained HCV-RNA response and hepatitis Bs seroconversion after individualized antiviral therapy with pegylated interferon alpha plus ribavirin and active vaccination in a hepatitis C virus/hepatitis B virus-coinfected patient
    Andrej Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Eur J Gastroenterol Hepatol 19:906-9. 2007
    ..Monitoring of HBsAg levels can be useful in individualizing optimal treatment duration in HBV-infected patients...
  2. pmc Structural barriers in the context of opiate substitution treatment in Germany--a survey among physicians in primary care
    Bernd Schulte
    Centre for Interdisciplinary Addiction Research, Hamburg University, University Medical Centre Hamburg Eppendorf, Martinistrasse 52, Hamburg, D 20246, Germany
    Subst Abuse Treat Prev Policy 8:26. 2013
    ..The present survey among a sample of primary care physicians in Germany aimed to identify and assess potential structural barriers for the provision of health care in the context of OST...
  3. doi request reprint Immunopathogenesis of hepatitis E virus infection
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Semin Liver Dis 33:71-8. 2013
    ..Recent studies were able to associate T-cell responses, activation of the interferon system and viral evolution with severity or chronicity of hepatitis E. We here summarize the emerging data on the immunopathogenesis of HEV infection...
  4. doi request reprint Pathogenesis and treatment of hepatitis e virus infection
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Gastroenterology 142:1388-1397.e1. 2012
    ....
  5. doi request reprint Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients
    Karsten Wursthorn
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 52:1611-20. 2010
    ..In patients with subsequent HBsAg loss, viral antigens were already undetectable in liver biopsy samples after 1 year of treatment. This was associated with markedly enhanced antiviral T cell reactivity...
  6. doi request reprint Hepatitis D revival
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Liver Int 31:140-4. 2011
    ..Novel treatment options include prenylation inhibitors and HBV entry inhibitors which are currently in early clinical development...
  7. ncbi request reprint [German guidelines on diagnosis and therapy of hepatitis B]
    H Wedemeyer
    Medizinische Hochschule Hannover, Germany
    Dtsch Med Wochenschr 132:1775-82. 2007
    ..Finally, the importance of HBV in the context of organ and bone marrow transplantation, treatment of coinfections and children and prophylaxis of HBV is covered...
  8. ncbi request reprint [Hepatitis (Hep-Net) competence network]
    H Wedemeyer
    Kompetenznetz Hepatitis, c o Medizinische Hochschule Hannover
    Internist (Berl) 45:415-21. 2004
    ..Further, basic questions in the fields of epidemiology, virology and immunology are processed in cooperative research projects within the network...
  9. ncbi request reprint Isolated anti-HBV core phenotype in anti-HCV-positive patients is associated with hepatitis C virus replication
    H Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany
    Clin Microbiol Infect 10:70-2. 2004
    ..This finding represents new information regarding the immunopathogenesis of chronic HCV infection and supports previous data indicating impaired humoral immune responses in HCV infection...
  10. doi request reprint Performance and clinical utility of a novel fully automated quantitative HCV-core antigen assay
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Clin Virol 46:210-5. 2009
    ..Recently, a novel quantitative HCVcoreAg immunoassay developed for commercialisation by Abbott has become available in Europe and Asia...
  11. doi request reprint Peginterferon plus adefovir versus either drug alone for hepatitis delta
    Heiner Wedemeyer
    Hannover Medical School, Hannover, Germany
    N Engl J Med 364:322-31. 2011
    ..There is no currently approved treatment. We investigated the safety and efficacy of 48 weeks of treatment with peginterferon alfa-2a plus adefovir dipivoxil, peginterferon alfa-2a alone, and adefovir dipivoxil alone...
  12. ncbi request reprint Fate and function of hepatitis-C-virus-specific T-cells during peginterferon-alpha2b therapy for acute hepatitis C
    Johannes Wiegand
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Antivir Ther 12:303-16. 2007
    ..However, recent studies described a decline in HCV-specific CD8+ T-cells during interferon treatment, suggesting that the success of acute HCV therapy might be independent of adaptive immunity...
  13. doi request reprint Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: a European perspective
    Jerzy Jaroszewicz
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, Hannover, Germany
    J Hepatol 52:514-22. 2010
    ..However, there is limited information on HBsAg levels considering the dynamic natural course of HBV-infection. This study aimed to determine HBsAg levels in the different phases of HBV-infection in European HBsAg-positive patients...
  14. doi request reprint Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-α2a treatment
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Antivir Ther 17:305-12. 2012
    ..We performed anti-HDV IgM testing in a well defined cohort of HDV-infected patients who were treated with pegylated interferon-α2a plus adefovir, or either drug alone...
  15. doi request reprint Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment
    Jan Grabowski
    Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany
    Liver Int 31:1395-405. 2011
    ..The role of the adaptive immune system in controlling HDV infection during spontaneous or treatment-induced viral clearance is not well understood...
  16. doi request reprint Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection
    Kerstin A Stegmann
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Gastroenterology 138:1885-97. 2010
    ..Natural killer (NK) cells might be associated with control of HCV infection. We examined the effects of IFNalpha on human NK cells and its relevance to HCV infection...
  17. doi request reprint Correlation between the Elecsys HBsAg II assay and the Architect assay for the quantification of hepatitis B surface antigen (HBsAg) in the serum
    Karsten Wursthorn
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Clin Virol 50:292-6. 2011
    ..Studies have shown that serum HBsAg quantification during, and at end of, treatment may predict long-term HBsAg loss...
  18. doi request reprint HCV core antigen testing in HIV- and HBV-coinfected patients, and in HCV-infected patients on hemodialysis
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Clin Virol 53:110-5. 2012
    ..A quantitative HCV core antigen (HCVcoreAg) immunoassay has been developed for the confirmation of viremia in patients with hepatitis C...
  19. doi request reprint Delayed versus immediate treatment for patients with acute hepatitis C: a randomised controlled non-inferiority trial
    Katja Deterding
    Hep Net German Network of Competence on Viral Hepatitis, Hannover, Germany
    Lancet Infect Dis 13:497-506. 2013
    ..We aimed to assess an alternative treatment strategy of delayed antiviral therapy in patients who do not eliminate the virus spontaneously compared with immediate treatment...
  20. doi request reprint Different kinetics of HBV and HCV during haemodialysis and absence of seronegative viral hepatitis in patients with end-stage renal disease
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, D 30625 Hannover, Germany
    Nephrol Dial Transplant 26:2648-56. 2011
    ..Moreover, some studies reported seronegative cases of viral hepatitis. We and others have previously shown an HCV RNA decline during haemodialysis; however, limited data on HBV viraemia during haemodialysis are available...
  21. ncbi request reprint A decline in hepatitis B virus surface antigen (hbsag) predicts clearance, but does not correlate with quantitative hbeag or HBV DNA levels
    Johannes Wiegand
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany
    Antivir Ther 13:547-54. 2008
    ..As quantitative assays for HBsAg recently became available, we have investigated whether quantitative HBsAg measurements can substitute for hepatitis B virus (HBV) DNA quantification in treatment monitoring...
  22. doi request reprint Results of single-center screening for chronic hepatitis E in children after liver transplantation and report on successful treatment with ribavirin
    Norman Junge
    Pediatric Gastroenterology and Hepatology, Children s Hospital, Hannover Medical School, Hannover, Germany
    Pediatr Transplant 17:343-7. 2013
    ..Therefore, the most reliably screening method is screening for HEV-RNA. Chronic HEV infection in children can successfully be treated with ribavirin...
  23. ncbi request reprint Gilbert's syndrome and antiviral therapy of hepatitis C
    Katja Deterding
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Ann Hepatol 8:246-50. 2009
    ..Of note, both patients recovered from their initial unconjugated hyperbilirubinemia despite continuation of ribavirin therapy, which indicates that compensatory mechanisms leading to a normalization of UGT1A1 activity are likely...
  24. doi request reprint Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis
    Chun Wang
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Med Virol 81:2079-88. 2009
    ..These results indicate that B19V can persist in the liver. However, there is no evidence that B19V is a "hepatitis virus" worsening liver disease in European patients with chronic hepatitis C...
  25. pmc Interferon α-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-1
    Kerstin A Stegmann
    Department for Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    J Infect Dis 205:1351-62. 2012
    ..We used this system to characterize interactions of HCV-infected Huh-7.5 cells and NK cells from healthy controls and patients with acute HCV infection...
  26. doi request reprint Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical University of Hannover, Germany
    Vaccine 27:5142-51. 2009
    ..Optimized vaccine responses may enhance sustained virologic response rates obtained with standard treatment of chronic hepatitis C...
  27. doi request reprint Persistence of occult hepatitis B after removal of the hepatitis B virus-infected liver
    Sandra Ciesek
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    J Infect Dis 197:355-60. 2008
    ..Thus, these data indicate that a long-term extrahepatic HBV reservoir exists, which is relevant not only for liver transplantation but also for other types of transplantations, including bone marrow grafting...
  28. doi request reprint Natural history: the importance of viral load, liver damage and HCC
    Karsten Wursthorn
    Clinic for Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Best Pract Res Clin Gastroenterol 22:1063-79. 2008
    ..In addition to the better-known factors- including coinfections with HBV and HIV- progression of liver disease is adversely affected by smoking, hepatic steatosis and insulin resistance...
  29. doi request reprint The HEP-NET B/C co-infection trial: A prospective multicenter study to investigate the efficacy of pegylated interferon-alpha2b and ribavirin in patients with HBV/HCV co-infection
    Andrej Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    J Hepatol 49:688-94. 2008
    ..The efficacy of pegylated interferon alpha and ribavirin in HBV/HCV co-infected patients is unknown...
  30. doi request reprint High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis
    Sven Pischke
    Department for Gastroenterology, Hannover Medical School, Hannover, Germany
    J Hepatol 56:1063-9. 2012
    ..In liver transplant recipients with graft hepatitis, the relevance of herpesviruses is not well defined...
  31. doi request reprint Improved immune status corresponds with long-term decline of quantitative serum hepatitis B surface antigen in HBV/HIV co-infected patients
    Eduard Arendt
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany
    Viral Immunol 25:442-7. 2012
    ..Increasing CD4 counts indicating the restoration of immune competence in HBV/HIV-co-infected patients is associated with a stronger HBsAg decline...
  32. doi request reprint Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication
    Thomas von Hahn
    Medizinische Hochschule Hannover, Hannover, Germany
    Gastroenterology 143:439-47.e1. 2012
    ..We investigated the effects of nonsynonymous single nucleotide polymorphisms (SNPs) in the region of peptidyl-prolyl isomerase A (PPIA) that encodes CypA on HCV infection and replication of human hepatocytes...
  33. doi request reprint Effect of peptide pools on effector functions of antigen-specific CD8+ T cells
    Pothakamuri Venkata Suneetha
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Immunol Methods 342:33-48. 2009
    ..5%. Thus, peptide-specific CD8 T-cell proliferation but not cytokine production may be largely underestimated when using a peptide pool which warrants caution in immunomonitoring during clinical trials and in epitope discovery studies...
  34. doi request reprint Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection
    Pothakamuri Venkata Suneetha
    Department of Gastroenterology Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 55:695-708. 2012
    ..We conclude that chronic hepatitis E is associated with impaired HEV-specific T-cell responses and suggest that enhancing adaptive cellular immunity against HEV might prevent persistent HEV infections...
  35. doi request reprint Reduced dose and duration of peginterferon alfa-2b and weight-based ribavirin in patients with genotype 2 and 3 chronic hepatitis C
    Michael Manns
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Hepatol 55:554-63. 2011
    ..There is increasing interest in identifying patients with chronic hepatitis C genotype 2 or 3 infection in whom it is possible to lower the burden of therapy while retaining high levels of efficacy...
  36. ncbi request reprint Hepatitis A virus infection suppresses hepatitis C virus replication and may lead to clearance of HCV
    Katja Deterding
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Hepatol 45:770-8. 2006
    ..While some studies suggested an incidence of fulminant hepatitis A of up to 35%, this could not be confirmed by others...
  37. pmc Establishment of a novel quantitative hepatitis D virus (HDV) RNA assay using the Cobas TaqMan platform to study HDV RNA kinetics
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, Hannover D 30625, Germany
    J Clin Microbiol 48:2022-9. 2010
    ..In conclusion, this novel automated HDV RNA assay is a useful tool for monitoring HDV-infected patients both before and during antiviral therapy...
  38. doi request reprint Prognostic implications of lactate, bilirubin, and etiology in German patients with acute liver failure
    Johannes Hadem
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Clin Gastroenterol Hepatol 6:339-45. 2008
    ..The accuracy of these parameters in predicting transplantation or death shows significant variation in different countries...
  39. pmc Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting
    Benjamin Maasoumy
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e55285. 2013
    ..The aim of our study was to analyze the eligibility and safety of P/R/PI treatment in a real world setting of a tertiary referral center...
  40. doi request reprint Hepatitis delta and HIV infection
    Beatriz Calle Serrano
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Semin Liver Dis 32:120-9. 2012
    ..Early initiation of anti-HIV therapy seems to be reasonable in patients with hepatitis delta - even though controlled studies are not available...
  41. doi request reprint Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients
    Sven Pischke
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Transpl 16:74-82. 2010
    ..The diagnosis of HEV infection should be based on HEV RNA determination in immunosuppressed patients. We suggest that immunocompromised individuals should avoid eating uncooked meat and contact with possibly HEV-infected animals...
  42. doi request reprint Rapid early HDV RNA decline in the peripheral blood but prolonged intrahepatic hepatitis delta antigen persistence after liver transplantation
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Hepatol 56:115-22. 2012
    ..The aims of this study were to investigate kinetics of HDV RNA and HBsAg early after LTX, to apply the data to a mathematical model and to study long-term persistence of HDV after LTX...
  43. pmc Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
    Manuela F Meyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Virol J 4:58. 2007
    ..Thus, these cases highlight that clearance of low levels of HCV viremia is possible in the absence of a strong adaptive immune response which might explain the low seroconversion rate after occupational exposure to HCV...
  44. ncbi request reprint Polyethylene glycol-interferon: current status in hepatitis C virus therapy
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Gastroenterol Hepatol 17:S344-50. 2002
    ..The combination of PEG-interferon and ribavirin improves the overall sustained response rates to 54-56% and represents the new standard therapy for patients with chronic hepatitis C infection in most patients...
  45. doi request reprint Clinical feasibility of liver elastography by acoustic radiation force impulse imaging (ARFI)
    Kinan Rifai
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Dig Liver Dis 43:491-7. 2011
    ..Transient elastography is increasingly used for assessment of liver fibrosis. Acoustic radiation force impulse imaging (ARFI) is a new technology to perform liver elastography...
  46. ncbi request reprint Treatment with daily consensus interferon (CIFN) plus ribavirin in non-responder patients with chronic hepatitis C: a randomized open-label pilot study
    Markus Cornberg
    Abt Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany
    J Hepatol 44:291-301. 2006
    ..Therapeutic options for hepatitis C non-responder patients are limited...
  47. pmc Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells
    Verena Schlaphoff
    Department for Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS Pathog 7:e1002045. 2011
    ..Understanding in more detail how 2B4 exerts its differential effects could have implications for the development of novel immunotherapies of HCV infection aiming to achieve immune control...
  48. doi request reprint Treatment of HBV/HCV coinfection
    Andrej Potthoff
    Hannover Medical School, Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology and Endocrinology, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Expert Opin Pharmacother 11:919-28. 2010
    ..HBV/HCV coinfection is not uncommon with an estimated 7 - 20 million individuals affected worldwide. Patients with HBV/HCV coinfection have an increased risk for cirrhosis, hepatocellular carcinoma (HCC) and even death...
  49. ncbi request reprint Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection
    Xandra Volkmann
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 43:1311-6. 2006
    ..845; 95% CI). In conclusion, hepatic caspase activity might play a role in HCV clearance and could also predict the efficacy of antiviral therapy...
  50. ncbi request reprint Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma
    Lars A Ormandy
    Department of Gastroenterology, Hepatology und Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    World J Gastroenterol 12:3275-82. 2006
    ..To analyze the phenotype and function of dendritic cells (DC) from patients with hepatocellular carcinoma (HCC) in order to understand their role in this disease...
  51. doi request reprint HBeAg-positive hepatitis delta: virological patterns and clinical long-term outcome
    Benjamin Heidrich
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Int 32:1415-25. 2012
    ..The aim of this study was to investigate the role of HBeAg in patients co-infected with the hepatitis D virus (HDV)...
  52. ncbi request reprint Long-term follow-up after successful interferon therapy of acute hepatitis C
    Johannes Wiegand
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Hepatology 40:98-107. 2004
    ..Waning of anti-HCV humoral immunity and presence of HCV-specific CD8(+) (but not CD4(+)) T cells highlights the complexity of T-cell and B-cell memory to HCV, which might be significantly altered by IFN treatment...
  53. doi request reprint Managing HBV in patients with impaired immunity
    Karsten Wursthorn
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Gut 59:1430-45. 2010
    ..This review will summarise the current knowledge on pathogenesis, frequency and treatment options of HBV reactivations in patients with impaired immunity...
  54. ncbi request reprint Longer survival of liver transplant recipients with hepatitis virus coinfections
    Kinan Rifai
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Clin Transplant 21:258-64. 2007
    ..Thus, viral coinfections may be associated with ameliorated courses of diseases under certain conditions...
  55. doi request reprint Hepatitis B surface antigen (HBsAg) decrease and serum interferon-inducible protein-10 levels as predictive markers for HBsAg loss during treatment with nucleoside/nucleotide analogues
    Jerzy Jaroszewicz
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Antivir Ther 16:915-24. 2011
    ..Serum interferon-inducible protein-10 (IP-10) has been associated with treatment response in hepatitis C, but data in chronic hepatitis B are lacking. Here, we aimed to investigate potential factors predictive for HBsAg loss...
  56. doi request reprint Glucocorticosteroids increase cell entry by hepatitis C virus
    Sandra Ciesek
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Gastroenterology 138:1875-84. 2010
    ..However, these drugs worsen hepatitis C virus (HCV) recurrence after liver transplantation, suggesting that they may directly exacerbate HCV infection...
  57. pmc Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles
    Sandra Ciesek
    Medizinische Hochschule Hannover, Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Virol 85:7613-21. 2011
    ..Finally, we use the Huh-7.5/OCLN(low) cell line to show that HCV spread between neighboring cells is strictly dependent on OCLN...
  58. pmc Hepatitis B surface antigen concentrations in patients with HIV/HBV co-infection
    Jerzy Jaroszewicz
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e43143. 2012
    ..In conclusion, HBsAg decline is dependent on an effective immune status. Restoration of CD4 T-cells during treatment with cART including nucleos(t)ide analogues seems to be important for HBsAg decrease and subsequent HBsAg loss...
  59. doi request reprint Anti-retroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro
    Lisa Sandmann
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany
    Antiviral Res 96:51-8. 2012
    ..In conclusion, commonly used HAART agents do not specifically enhance HCV replication. Thus recent epidemic outbreaks of acute HCV in HIV-infected MSM are unlikely to be related to enhancing effects of HAART drugs...
  60. doi request reprint Angiopoietin-2 in acute liver failure
    Johannes Hadem
    Department of Gastroenterology, Hepatology, and Endocrinology, The Institute of Pathology, Hannover Medical School, Hannover, Germany
    Crit Care Med 40:1499-505. 2012
    ..We examined whether the release of Angiopoietin-2 correlates with surrogates of organ dysfunction and outcome in patients with acute liver failure...
  61. doi request reprint The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry
    Sandra Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 54:1947-55. 2011
    ..Conclusion: The green tea molecule, EGCG, potently inhibits HCV entry and could be part of an antiviral strategy aimed at the prevention of HCV reinfection after liver transplantation...
  62. ncbi request reprint Evaluation of sound speed for detection of liver fibrosis: prospective comparison with transient dynamic elastography and histology
    Bita Boozari
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Ultrasound Med 29:1581-8. 2010
    ..The aim of this pilot study was to evaluate whether SV estimation of liver tissue allows the determination of fibrosis stages in patients with chronic viral hepatitis...
  63. ncbi request reprint Treatment of hepatitis C virus-associated inflammatory polyneuropathy with pegylated interferon-alpha and ribavirin
    Corinna Trebst
    Department of Neurology, Medical School Hannover, Hannover, Germany
    Eur J Gastroenterol Hepatol 19:91-2. 2007
    ..Treatment of hepatitis C virus-cryoglobulinemia-associated neuropathy should therefore be continued even if response of viral replication is lacking or delayed as long as a clinical benefit can be observed...
  64. doi request reprint Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis
    Kalliopi Zachou
    Department of Gastroenterology, Hepatology and Endocrinology, Hanover Medical School, Hanover, Germany
    Liver Int 30:430-7. 2010
    ..ii) Biochemical parameters did not accurately indicate the stage and grade of liver disease in chronic HDV and thus liver biopsy seems to remain the major tool for the evaluation of delta hepatitis patients...
  65. doi request reprint Food intake increases liver stiffness in patients with chronic or resolved hepatitis C virus infection
    Ingmar Mederacke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Int 29:1500-6. 2009
    ..Parameters influencing liver stiffness may include food intake that increases liver blood flow...
  66. doi request reprint Late hepatitis B virus relapse in patients co-infected with hepatitis B virus and hepatitis C virus after antiviral treatment with pegylated interferon-a2b and ribavirin
    A Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Scand J Gastroenterol 44:1487-90. 2009
    ..In contrast, a sustained response concerning HCV is durable. We recommend long-term monitoring of HBV/HCV-co-infected patients after IFN a-based therapies...
  67. doi request reprint Natural history of acute and chronic hepatitis C
    Benjamin Maasoumy
    Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Best Pract Res Clin Gastroenterol 26:401-12. 2012
    ..Personalized treatment approaches for HCV infection should consider individual risk profiles to avoid both under- and over-treatment - which will remain important also in upcoming era of interferon-free treatment of hepatitis C...
  68. ncbi request reprint Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients
    Verena Schlaphoff
    Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Carl Neuberg Str 1, 30625 Hannover, Germany
    Vaccine 25:6793-806. 2007
    ..Thus, this study suggests that HCV-specific memory cells can be induced by peptide vaccination and that a reversion of functional impaired phenotypes by therapeutic vaccination is possible in chronic HCV infection...
  69. doi request reprint Epidemiological trends in incidence and mortality of hepatobiliary cancers in Germany
    Thomas von Hahn
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule, Hannover Medical School, Hannover, Germany
    Scand J Gastroenterol 46:1092-8. 2011
    ..We aimed to provide epidemiological data on recent trends in liver-related mortality, specifically mortality from hepatobiliary malignancies, in Germany...
  70. ncbi request reprint Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA
    Christian Klein
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Germany
    Gastroenterology 125:9-18. 2003
    ..Animal models to study new treatment options in vivo have several drawbacks. Therefore, we were interested to establish a new small animal model in which HBV replication and especially new treatment options can be studied easily...
  71. doi request reprint Monocytes transduced with lentiviral vectors expressing hepatitis C virus non-structural proteins and differentiated into dendritic cells stimulate multi-antigenic CD8(+) T cell responses
    Adan C Jirmo
    Lymphatic Cell Therapy Laboratory, Clinic of Hematology, Hannover Medical School, Hannover, Germany
    Vaccine 28:922-33. 2010
    ..Hence, lentiviral-mediated expression of the multi-antigenic HCV-NS cluster in monocytes subsequently differentiated into DC is a novel potential anti-HCV vaccine modality...
  72. doi request reprint Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A
    Sandra Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Hepatology 50:1638-45. 2009
    ..NS2 is either an additional target for CsA-dependent inhibition or modulates the antiviral activity against NS3 to NS5B proteins. CsA is thus the first anti-HCV drug shown to act through NS2...
  73. doi request reprint Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
    Bastian Hoechst
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School, Hannover, Germany
    Hepatology 50:799-807. 2009
    ..These findings have important implications when designing immunotherapy protocols...
  74. doi request reprint How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides
    Sandra Ciesek
    Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Joint venture between Hannover Medical School, Hannover, Germany
    J Infect Dis 201:1859-66. 2010
    ..The recent development of an HCV infection system allowed the direct assessment of environmental stability and susceptibility to chemical disinfectants...
  75. doi request reprint Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Nat Rev Gastroenterol Hepatol 7:31-40. 2010
    ..Novel alternative treatment options including prenylation inhibitors are awaiting clinical development for use in hepatitis D...
  76. ncbi request reprint Treatment of chronic hepatitis C with PEGylated interferon and ribavirin
    Markus Cornberg
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Carl Neuberg Strasse 1, D 30623 Hannover, Germany
    Curr Gastroenterol Rep 4:23-30. 2002
    ..This review describes recent advances in the treatment of HCV infection with PEGylated interferon (interferon modified with polyethylene glycol [PEG] ) combined with ribavirin...
  77. doi request reprint Membranous Budd-Chiari syndrome in Caucasians
    Sandra Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Scand J Gastroenterol 45:226-34. 2010
    ..To date, there is only very limited information on membranous BCS in the Western world. We here report the diagnosis and management of five Caucasian patients with membranous BCS...
  78. ncbi request reprint Hepatitis B virus immunization with an adjuvant containing vaccine after liver transplantation for hepatitis B-related disease: failure of humoral and cellular immune response
    Jens Rosenau
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Transpl Int 19:828-33. 2006
    ..Patient-related preconditions and concomitant HBIG administration should be further investigated as possible predictors for response...
  79. ncbi request reprint Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: the HEP-NET acute-HCV-II study
    Johannes Wiegand
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 43:250-6. 2006
    ..The high number of dropouts underlines the importance of thorough patient selection and close monitoring during therapy. Thus, future studies should identify factors predicting spontaneous viral clearance to avoid unnecessary therapy...
  80. doi request reprint Prevalence of alpha-fodrin antibodies in patients with chronic hepatitis C infection and Sjögren syndrome
    Andrej Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Germany
    Scand J Gastroenterol 44:994-1003. 2009
    ..The frequency and role of alpha-fodrin antibodies in patients with chronic HCV infection are unknown. The aim of this study was to investigate the prevalence of alpha-fodrin antibodies in HCV-infected patients with SS...
  81. ncbi request reprint Frequency of very low HCV viremia detected by a highly sensitive HCV-RNA assay
    P Fytili
    Medizinische Hochschule Hannover, Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Clin Virol 39:308-11. 2007
    ..Only limited data is available on the frequency and clinical significance of very low hepatitis C viremia (<600 IU/ml) determined by novel sensitive methods for HCV quantification...
  82. ncbi request reprint Liver transplantation: A new risk factor for intestinal intussusceptions
    Sven Pischke
    Hannover Medical School, Gastroenterology, Hepatology and Endocrinology, Germany
    Ann Hepatol 10:38-42. 2011
    ..Intestinal intussusception in adults is associated with chronic inflammatory bowel disease, celiac disease, abdominal tumors or previous abdominal surgery but most often of unknown origin...
  83. doi request reprint Adenosine and IFN-{alpha} synergistically increase IFN-gamma production of human NK cells
    Florian Jeffe
    Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    J Leukoc Biol 85:452-61. 2009
    ..Future studies need to define the role of the different adenosine receptors in more detail...
  84. ncbi request reprint Hepatitis B virus: where are we and where are we going?
    Michael P Manns
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Methods Mol Med 96:415-43. 2004
  85. ncbi request reprint Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    Lars A Ormandy
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Cancer Res 65:2457-64. 2005
    ..Our data suggest that the increase in frequency of regulatory T cells might play a role in modulation of the immune response against HCC and could be important in design of immunotherapeutic approaches...
  86. ncbi request reprint Epigenetic defects of hepatocellular carcinoma are already found in non-neoplastic liver cells from patients with hereditary haemochromatosis
    Ulrich Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Germany
    Hum Mol Genet 16:1335-42. 2007
    ..Thus, changes in DNA methylation patterns are an early event preceding morphological alterations of malignant transformation and represent promising targets for early detection...
  87. ncbi request reprint Republished paper: Managing HBV in patients with impaired immunity
    Karsten Wursthorn
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Postgrad Med J 87:223-38. 2011
    ..This review will summarise the current knowledge on pathogenesis, frequency and treatment options of HBV reactivations in patients with impaired immunity...
  88. ncbi request reprint Peptide-beta2-microglobulin-MHC fusion molecules bind antigen-specific T cells and can be used for multivalent MHC-Ig complexes
    Tim F Greten
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, FZ Oststadt, Raum 310, Pasteurallee 5, Germany
    J Immunol Methods 271:125-35. 2002
    ..These molecules bind antigen-specific T cells with high specificity and sensitivity, therefore, providing a valuable tool for detection as well as enrichment of antigen-specific T cells...
  89. ncbi request reprint Viral hepatitis after liver transplantation. Which immunosuppressive drugs should be recommended?
    S Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Minerva Gastroenterol Dietol 53:337-50. 2007
    ..Further trials are urgently needed to clarify the role of different immunosuppressive compounds in hepatitis C after transplantation...
  90. doi request reprint [Hepatitis E virus infection: a paradigm shift?]
    S Pischke
    Gastroenterologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 135:1129-33. 2010
    ..In this review we summarize the current state-of-the-art on the knowledge of HEV-infections in industrialised countries...
  91. ncbi request reprint Treatment of chronic hepatitis B
    M Cornberg
    Department of Gastroenterology, Medizinische Hochschule Hannover, Germany
    Minerva Gastroenterol Dietol 56:451-65. 2010
    ..Still, whom to treat, which therapy regimen to use, and when to begin treatment remain the challenges in the management HBV-infected patients. This review focuses on the current treatment concepts for chronic hepatitis B...
  92. ncbi request reprint Current and future treatment of hepatitis C
    M P Manns
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Hannover, Germany
    Indian J Gastroenterol 20:C47-51. 2001
    ..Hopefully, new treatment modalities will be available in the near future. Helicase, protease and the RNA polymerase are potential targets to suppress HCV replication and several immunotherapeutic approaches are explored...
  93. ncbi request reprint Chronic hepatitis E in liver transplant recipients: a significant clinical problem?
    S Pischke
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Minerva Gastroenterol Dietol 56:121-8. 2010
    ..In this review we summarize the recent data on hepatitis E with a particular focus on the importance of persistent HEV infections in liver transplant recipients...
  94. ncbi request reprint Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy
    A Widjaja
    Dept. of Gastroenterology and Hepatology, Hannover Medical School, Germany
    Scand J Gastroenterol 36:426-31. 2001
    ....
  95. doi request reprint Virological and clinical characteristics of delta hepatitis in Central Europe
    B Heidrich
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Viral Hepat 16:883-94. 2009
    ....
  96. ncbi request reprint [Standard treatment of chronic hepatitis B]
    M P Manns
    Medizinische Hochschule Hannover, Abt Gastroenterologie, Hepatologie und Endokrinologie, Hannover
    Z Gastroenterol 42:687-91. 2004
  97. ncbi request reprint [Injuries from needles contaminated with hepatitis C virus: how high is the risk of seroconversion for medical personnel really?]
    A Kubitschke
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    Internist (Berl) 48:1165-72. 2007
    ..Future studies should address not only the frequency of acute hepatitis but also factors associated with a higher risk of becoming HCV infected...
  98. doi request reprint The German guideline for the management of hepatitis B virus infection: short version
    M Cornberg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Viral Hepat 15:1-21. 2008
  99. pmc Treating viral hepatitis C: efficacy, side effects, and complications
    M P Manns
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Gut 55:1350-9. 2006
    ..This review describes the efficacy and optimisation of the current standard therapy of hepatitis C and its problems in special patient populations. New treatment directions beyond interferon alpha based therapies are on the horizon...
  100. doi request reprint [Interferon-alfa induced reactivation of sarcoidosis in a patient with chronic hepatitis C]
    I Mederacke
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 51:522-7. 2010
    ..The antiviral therapy was continued until week 48 without administration of systemic steroids. Six month after the end of antiviral treatment the sarcoidosis was in remission and the hepatitis C was cured...
  101. ncbi request reprint [Diagnosis, progression and therapy of hepatitis-B-virus infection--results of an evidenced based consensus conference of the German Society for Alimentary Metabolic Disorders and and in cooperation with the Hepatitis Competence Network]
    M P Manns
    Medizinische Hochschule Hannover, Abt Gastroenterologie, Hepatologie und Endokrinologie, Hannover
    Z Gastroenterol 42:677-8. 2004