Gregor Warnecke

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivo
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Transplantation 83:1459-65. 2007
  2. ncbi request reprint Dependency of the trans vivo delayed type hypersensitivity response on the action of regulatory T cells: implications for monitoring transplant tolerance
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Transplantation 84:392-9. 2007
  3. doi request reprint Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients
    Gregor Warnecke
    Division of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hanover Medical School, Hanover, Germany
    Lancet 380:1851-8. 2012
  4. pmc CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Am J Pathol 177:464-72. 2010
  5. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
  6. doi request reprint Correlation of donor leukocyte chimerism with pulmonary allograft survival after immunosuppressive drug withdrawal in a porcine model
    Bianca Kruse
    Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Transplantation 87:1468-77. 2009
  7. ncbi request reprint Surfactant function in lung transplantation after 24 hours of ischemia: advantage of retrograde flush perfusion for preservation
    Martin Struber
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 123:98-103. 2002
  8. doi request reprint Single-centre experience with oral ribavirin in lung transplant recipients with paramyxovirus infections
    Thomas Fuehner
    Department of Respiratory Medicine, Medical School Hannover, Hannover, Germany
    Antivir Ther 16:733-40. 2011
  9. doi request reprint Lymphoscintigraphic localization of a high-output chylus leak after bilateral lung transplantation
    Sven Peterss
    Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Heart Lung Transplant 30:481-3. 2011
  10. doi request reprint Cardiac surgery late after heart transplantation: a safe and effective treatment option
    Heidi Goerler
    Division of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 140:433-9. 2010

Detail Information

Publications17

  1. ncbi request reprint Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivo
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Transplantation 83:1459-65. 2007
    ..CD25+CD4+ regulatory T cells have been shown to suppress alloimmunity in various experimental settings. Here, we hypothesized that alloantigen-reactive regulatory T cells would reduce the severity of transplant arteriosclerosis...
  2. ncbi request reprint Dependency of the trans vivo delayed type hypersensitivity response on the action of regulatory T cells: implications for monitoring transplant tolerance
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Transplantation 84:392-9. 2007
    ..Here we tested the hypothesis that the assay can reveal control of allograft rejection by CD25CD4 regulatory T cells (Treg)...
  3. doi request reprint Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients
    Gregor Warnecke
    Division of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hanover Medical School, Hanover, Germany
    Lancet 380:1851-8. 2012
    ..We report first-in-man experience of the portable Organ Care System (OCS) Lung device for concomitant preservation, assessment, and transport of donor lungs...
  4. pmc CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis
    Gregor Warnecke
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Am J Pathol 177:464-72. 2010
    ..These data illustrate the potential of ex vivo generated regulatory T cells for the inhibition of transplant-associated vasculopathy...
  5. pmc In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    Satish N Nadig
    Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Nat Med 16:809-13. 2010
    ..We anticipate our findings to serve as a foundation for the clinical development of therapeutics targeting transplant arteriosclerosis in both allograft transplantation and other immune-mediated causes of vasculopathy...
  6. doi request reprint Correlation of donor leukocyte chimerism with pulmonary allograft survival after immunosuppressive drug withdrawal in a porcine model
    Bianca Kruse
    Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Transplantation 87:1468-77. 2009
    ..This study was designed to analyze the role of postoperative donor cell chimerism for the induction and maintenance of transplantation tolerance in a porcine lung transplantation model...
  7. ncbi request reprint Surfactant function in lung transplantation after 24 hours of ischemia: advantage of retrograde flush perfusion for preservation
    Martin Struber
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 123:98-103. 2002
    ..This study was designed to define the impact of retrograde flush perfusion on graft and surfactant function after an extended period of ischemia...
  8. doi request reprint Single-centre experience with oral ribavirin in lung transplant recipients with paramyxovirus infections
    Thomas Fuehner
    Department of Respiratory Medicine, Medical School Hannover, Hannover, Germany
    Antivir Ther 16:733-40. 2011
    ..Ribavirin represents a possible treatment option although the outcome on graft function and BOS incidence is unknown...
  9. doi request reprint Lymphoscintigraphic localization of a high-output chylus leak after bilateral lung transplantation
    Sven Peterss
    Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    J Heart Lung Transplant 30:481-3. 2011
    ..This technique is actually an overly complex, time-consuming procedure for proper surgical planning in selected cases...
  10. doi request reprint Cardiac surgery late after heart transplantation: a safe and effective treatment option
    Heidi Goerler
    Division of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 140:433-9. 2010
    ..In this study, we evaluated our results of nonretransplant cardiac surgery in these patients and compared them with those after retransplantation...
  11. doi request reprint Lung and heart-lung transplantation in children and adolescents: a long-term single-center experience
    Heidi Görler
    Department of Cardiothoracic, Hannover Medical School, Germany
    J Heart Lung Transplant 28:243-8. 2009
    ..Therefore, we retrospectively analyzed our experience after 53 lung and heart-lung transplantations (HLTx) in children...
  12. ncbi request reprint Heart-lung transplantation in a 14-year-old boy with Alström syndrome
    Heidi Goerler
    Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    J Heart Lung Transplant 26:1217-8. 2007
    ..The boy underwent successful heart-lung transplantation. We conclude from this report that heart-lung transplantation in patients with Alström syndrome is a viable therapeutic option in select cases...
  13. ncbi request reprint Effects of exogenous surfactant instillation in clinical lung transplantation: a prospective, randomized trial
    Martin Struber
    Hannover Thoracic Transplant Program, Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    J Thorac Cardiovasc Surg 133:1620-5. 2007
    ..We performed a randomized, prospective study investigating the effect of exogenous surfactant instillation into human donor lungs on posttransplant surfactant function and on clinical outcome...
  14. ncbi request reprint Severe right heart failure after heart transplantation. A single-center experience
    Uwe Klima
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
    Transpl Int 18:326-32. 2005
    ..Severe RHF as defined in our study is irreversible in almost every case without differences among therapeutical concepts. Hence, improvement of postoperative outcome necessitates avoidance or aggressive therapy of possible risk factors...
  15. doi request reprint Endoscopic indicators for obstructive airway complications after lung transplantation
    Thomas Fuehner
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Transplantation 90:1210-4. 2010
    ..Obstructive airway complications (OACs) are a significant cause of morbidity after lung transplantation (LTx). Endoscopic evaluation early after LTx may help earlier identification of patients at risk...
  16. doi request reprint Initial topical cooling followed by backtable Celsior flush perfusion provides excellent early graft function in porcine single lung transplantation after 24 hours of cold ischemia
    Bernhard Gohrbandt
    Hannover Thoracic Transplant Program, Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    J Heart Lung Transplant 32:832-8. 2013
    ..Topical in situ cooling of the donor lungs is a prerequisite for procurement of non-heart-beating donor lungs and may be of interest for living related lung donation...
  17. doi request reprint Lung re-transplantation: review
    Gregor Warnecke
    Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Curr Opin Organ Transplant 17:485-9. 2012
    ..Re-transplantation of the lung has come of age. Here, we wish to review the recent literature on the topic and discuss clinical implications...