Andreas Tiede

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Management of acquired haemophilia A
    A Tiede
    Andreas Tiede, MD, PhD, Hannover Medical School, Dept Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Carl Neuberg Str 1, 30625 Hannover, Germany, E mail
    Hamostaseologie 35:311-8. 2015
  2. doi request reprint Turoctocog alfa (recombinant factor VIII). Manufacturing, characteristics and clinical trial results
    A Tiede
    Prof Dr med Andreas Tiede, Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany Tel 49 0 511 532 84 88, Fax 49 0 511 532 41 46
    Hamostaseologie 35:364-71. 2015
  3. doi request reprint The use of recombinant activated factor VII in patients with acquired haemophilia
    Andreas Tiede
    Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany Electronic address
    Blood Rev 29:S19-25. 2015
  4. doi request reprint Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A
    A Tiede
    Hannover Medical School, Hannover, Germany
    J Thromb Haemost 11:670-8. 2013
  5. doi request reprint Diagnosis and treatment of acquired von Willebrand syndrome
    Andreas Tiede
    Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Thromb Res 130:S2-6. 2012
  6. doi request reprint Acquired haemophilia caused by non-haemophilic factor VIII gene variants
    Andreas Tiede
    Department of Haematology, Hannover Medical School, Feodor Lynen Str 5, 30625 Hannover, Germany
    Ann Hematol 89:607-12. 2010
  7. doi request reprint Immunosuppressive treatment for acquired haemophilia: current practice and future directions in Germany, Austria and Switzerland
    Andreas Tiede
    Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Ann Hematol 88:365-70. 2009
  8. doi request reprint Diagnostic workup of patients with acquired von Willebrand syndrome: a retrospective single-centre cohort study
    A Tiede
    Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    J Thromb Haemost 6:569-76. 2008
  9. doi request reprint Antithrombin alfa in hereditary antithrombin deficient patients: A phase 3 study of prophylactic intravenous administration in high risk situations
    Andreas Tiede
    Hannover Medical School, Dept of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Germany
    Thromb Haemost 99:616-22. 2008
  10. ncbi request reprint [Perioperative hemostasis management]
    A Tiede
    Abteilung Hamatologie, Hämostaseologie und Onkologie, Medizinische Hochschule Hannover, Feodor Lynen Strasse 5, 30625 Hannover, Germany
    Chirurg 78:69-79; quiz 80-1. 2007

Collaborators

Detail Information

Publications27

  1. doi request reprint Management of acquired haemophilia A
    A Tiede
    Andreas Tiede, MD, PhD, Hannover Medical School, Dept Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Carl Neuberg Str 1, 30625 Hannover, Germany, E mail
    Hamostaseologie 35:311-8. 2015
    ..However, an ideal IST regimen has not been established so far. Adverse events of IST, including infections as the foremost cause death, are frequent complications in AHA. ..
  2. doi request reprint Turoctocog alfa (recombinant factor VIII). Manufacturing, characteristics and clinical trial results
    A Tiede
    Prof Dr med Andreas Tiede, Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany Tel 49 0 511 532 84 88, Fax 49 0 511 532 41 46
    Hamostaseologie 35:364-71. 2015
    ..A total of 41 surgical procedures (15 major, 26 minor) were performed in 33 patients, with a successful haemostatic response reported in all cases. No patient developed confirmed inhibitors in any of the trials. ..
  3. doi request reprint The use of recombinant activated factor VII in patients with acquired haemophilia
    Andreas Tiede
    Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany Electronic address
    Blood Rev 29:S19-25. 2015
    ..In surgical procedures, rFVIIa also provided high rates of control. In patients with AH, rFVIIa has a high rate of haemostatic efficacy in acute and surgical bleeding episodes. ..
  4. doi request reprint Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A
    A Tiede
    Hannover Medical School, Hannover, Germany
    J Thromb Haemost 11:670-8. 2013
    ..N8-GP is a recombinant factor VIII (FVIII) with a site-directed glycoPEGylation for the purpose of half-life prolongation...
  5. doi request reprint Diagnosis and treatment of acquired von Willebrand syndrome
    Andreas Tiede
    Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Thromb Res 130:S2-6. 2012
    ..Treatment success will depend largely on the underlying pathogenesis of the disorder...
  6. doi request reprint Acquired haemophilia caused by non-haemophilic factor VIII gene variants
    Andreas Tiede
    Department of Haematology, Hannover Medical School, Feodor Lynen Str 5, 30625 Hannover, Germany
    Ann Hematol 89:607-12. 2010
    ..The expected frequency in the general Caucasoid population undergoing transfusion is 3% to 4%. In conclusion, encounter of variant allogeneic FVIII presented on a suitable MHC background could be a risk factor for inhibitor formation...
  7. doi request reprint Immunosuppressive treatment for acquired haemophilia: current practice and future directions in Germany, Austria and Switzerland
    Andreas Tiede
    Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Ann Hematol 88:365-70. 2009
    ..Immunoadsorption was preferred for first- and second-line treatment by 10% and 9% of participants, respectively. These results highlight critical issues in the field. Open questions and directions for future research are discussed...
  8. doi request reprint Diagnostic workup of patients with acquired von Willebrand syndrome: a retrospective single-centre cohort study
    A Tiede
    Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    J Thromb Haemost 6:569-76. 2008
    ....
  9. doi request reprint Antithrombin alfa in hereditary antithrombin deficient patients: A phase 3 study of prophylactic intravenous administration in high risk situations
    Andreas Tiede
    Hannover Medical School, Dept of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Germany
    Thromb Haemost 99:616-22. 2008
    ..In conclusion, this study suggests that antithrombin alfa is a safe and effective alternative to human plasma-derived AT for treating hereditary AT deficiency patients at high risk for thromboembolic events...
  10. ncbi request reprint [Perioperative hemostasis management]
    A Tiede
    Abteilung Hamatologie, Hämostaseologie und Onkologie, Medizinische Hochschule Hannover, Feodor Lynen Strasse 5, 30625 Hannover, Germany
    Chirurg 78:69-79; quiz 80-1. 2007
    ..However, physicians should be aware of the limitations of these methods, and a full diagnostic workup should be done in order to uncover hemorrhagic diatheses not detected by point of care testing...
  11. doi request reprint How I treat the acquired von Willebrand syndrome
    Andreas Tiede
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Blood 117:6777-85. 2011
    ..Here, we review the management of AVWS with an overview on the currently available evidence and additional considerations for typical treatment situations...
  12. doi request reprint Effect of TNF-alpha blockade on coagulopathy and endothelial cell activation in xenoperfused porcine kidneys
    Wolf Ramackers
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
    Xenotransplantation 22:284-94. 2015
    ..In this study, we examined the effect of a TNF-receptor fusion protein (TNF-RFP) on endothelial cell activation and coagulopathy utilizing an appropriate ex vivo perfusion system...
  13. doi request reprint Ovine blood: establishment of a list of reference values relevant for blood coagulation in sheep
    Mathias H Wilhelmi
    Department for Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Germany
    ASAIO J 58:79-82. 2012
    ..We established a reference list of ovine blood count and blood coagulation parameters. Because of some peculiarities of the ovine blood, this list may have implications for the interpretation of experimental data...
  14. doi request reprint Deletion or inhibition of Fc gamma receptor 2B (CD32) prevents FVIII-specific activation of memory B cells in vitro
    Sonja Werwitzke
    Sonja Werwitzke, MD, PhD, Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, D 30625 Hannover, Germany, Tel 49 511 532 8377, Fax 49 511 18524, E mail
    Thromb Haemost 114:1127-35. 2015
    ..We conclude that CD32 is a crucial regulator of FVIII-specific B cells and is required for the differentiation of MBCs into ASCs. Inhibition of CD32 could potentially improve the efficacy of FVIII in the context of ITT. ..
  15. doi request reprint Recovery and composition of microparticles after snap-freezing depends on thawing temperature
    Arne Trummer
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Blood Coagul Fibrinolysis 20:52-6. 2009
    ..07). For microparticle detection thawing of snap-frozen, platelet-free plasma samples should be carried out at room temperature or at 37 degrees C in a water bath but not on ice...
  16. pmc Prognostic factors for remission of and survival in acquired hemophilia A (AHA): results from the GTH-AH 01/2010 study
    Andreas Tiede
    Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Blood 125:1091-7. 2015
    ..2, P < .0001). Low FVIII was also associated with a lower rate of complete remission and decreased survival. In conclusion, presenting FVIII and inhibitor concentration are potentially useful to tailor IST in AHA. ..
  17. doi request reprint Recombinant human antithrombin prevents xenogenic activation of hemostasis in a model of pig-to-human kidney transplantation
    Wolf Ramackers
    Department of General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany
    Xenotransplantation 21:367-75. 2014
    ..However, the use of rhAPC may not be feasible in a perioperative setting due to possible bleeding complications...
  18. doi request reprint Addition of in-vitro generated endothelial microparticles to von-Willebrand plasma improves primary and secondary hemostasis
    Arne Trummer
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany Electronic address
    Thromb Res 133:445-50. 2014
    ....
  19. doi request reprint DNA analysis from stool samples: a fast and reliable method avoiding invasive sampling methods in mouse models of bleeding disorders
    Katy Kalippke
    Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Feodor Lynen Str 5, 30625 Hannover, Germany
    Lab Anim 43:390-3. 2009
    ..Avoiding loss of animals due to bleeding implies a substantial improvement in animal welfare by reducing the number of animals used and may also advance the effectiveness of breeding programmes in these disease models...
  20. ncbi request reprint Inhibitor-Immunology-Study. Different HLA-types seem to be involved in the inhibitor development in haemophilia A
    I Wieland
    Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Germany
    Hamostaseologie 28:S26-8. 2008
    ..We performed HLA typing in 50 patients with haemophilia A in an effort to find associations with inhibitor development...
  21. doi request reprint Isotype controls in phenotyping and quantification of microparticles: a major source of error and how to evade it
    Arne Trummer
    Department of Hematology, Hemostasis and Oncology, Hannover Medical School, Hannover, Germany
    Thromb Res 122:691-700. 2008
    ..Fluorescence-labelled isotype controls (ICs) are commonly used to set limits for the discrimination of antigen positive vs. negative events...
  22. doi request reprint Effects of pharmacological intervention on coagulopathy and organ function in xenoperfused kidneys
    Wolf Ramackers
    Klinik für Sllgemein, Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Xenotransplantation 15:46-55. 2008
    ..Following pig to primate kidney transplantation, xenogenic activation of the coagulation (XAC) system of the recipient eventually leading to organ dysfunction and disseminated intravascular coagulation (DIC) can be observed...
  23. doi request reprint Laboratory diagnosis of acquired hemophilia A: limitations, consequences, and challenges
    Andreas Tiede
    Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Semin Thromb Hemost 40:803-11. 2014
    ..This article reviews the diagnostic approach to AHA, discusses assay-specific limitations and addresses some of the challenges for future research. ..
  24. doi request reprint Legionnaires' disease in immunocompromised patients: a case report of Legionella longbeachae pneumonia and review of the literature
    Philipp Kümpers
    Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    J Med Microbiol 57:384-7. 2008
    ..The features of Legionnaires' disease in immunocompromised patients with special emphasis on significance and detection of non-pneumophila species are reviewed...
  25. ncbi request reprint Cardiac surgery in a patient with paroxysmal nocturnal hemoglobinuria
    Karsten Knobloch
    Division of Cardiothoracic and Vascular Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Haematologica 87:ECR29. 2002
  26. doi request reprint Thrombelastographic monitoring of recombinant factor VIIa in acquired haemophilia
    H Dehmel
    Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Feodor Lynen Strasse 5, Hannover, Germany
    Haemophilia 14:736-42. 2008
    ..In the limited number of patients studied here, a better clotting profile during steady-state dosing was associated with a better clinical treatment response...
  27. ncbi request reprint Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction
    A Tiede
    Department of Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Gene Ther 10:1917-25. 2003
    ..Our results show for the first time that transplantation of transduced CD34(+) progenitors may give rise to differentiated hematopoietic cells secreting a nonhematopoietic recombinant protein...