Sebastian Suerbaum

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc The nucleotide excision repair (NER) system of Helicobacter pylori: role in mutation prevention and chromosomal import patterns after natural transformation
    Claudia Moccia
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    BMC Microbiol 12:67. 2012
  2. pmc The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1
    Sya N Ukena
    German Research Centre for Biotechnology, Mucosal Immunity Group, Mascheroder Weg 1, 38124 Braunschweig, Germany
    BMC Med Genet 6:43. 2005
  3. ncbi request reprint Helicobacter pylori: recombination, population structure and human migrations
    Sebastian Suerbaum
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Int J Med Microbiol 294:133-9. 2004
  4. ncbi request reprint Helicobacter pylori evolution and phenotypic diversification in a changing host
    Sebastian Suerbaum
    Medizinische Hochschule Hannover, Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Microbiol 5:441-52. 2007
  5. ncbi request reprint Epidemiology of multi-drug-resistant gram-negative bacteria: data from an university hospital over a 36-month period
    Ralf Peter Vonberg
    Institute for Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Street 1, 30625 Hannover, Germany
    Int J Hyg Environ Health 211:251-7. 2008
  6. pmc In vivo sequence variation in HopZ, a phase-variable outer membrane protein of Helicobacter pylori
    Lynn Kennemann
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    Infect Immun 80:4364-73. 2012
  7. pmc A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island
    Patrick Olbermann
    Institute for Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS Genet 6:e1001069. 2010
  8. pmc The Helicobacter pylori anti-sigma factor FlgM is predominantly cytoplasmic and cooperates with the flagellar basal body protein FlhA
    Melanie Rust
    Hannover Medical School, Department for Medical Microbiology and Hospital Epidemiology, Hannover, Germany
    J Bacteriol 191:4824-34. 2009
  9. pmc Role of the Helicobacter hepaticus flagellar sigma factor FliA in gene regulation and murine colonization
    Torsten Sterzenbach
    Hannover Medical School, Institute for Medical Microbiology and Hospital Epidemiology, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Bacteriol 190:6398-408. 2008
  10. pmc Mosaic DNA imports with interspersions of recipient sequence after natural transformation of Helicobacter pylori
    Stefan Kulick
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 3:e3797. 2008

Detail Information

Publications64

  1. pmc The nucleotide excision repair (NER) system of Helicobacter pylori: role in mutation prevention and chromosomal import patterns after natural transformation
    Claudia Moccia
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    BMC Microbiol 12:67. 2012
    ..In this study, we used a genetic approach to investigate the roles of nucleotide excision repair (NER) pathway components in H. pylori mutation and recombination...
  2. pmc The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1
    Sya N Ukena
    German Research Centre for Biotechnology, Mucosal Immunity Group, Mascheroder Weg 1, 38124 Braunschweig, Germany
    BMC Med Genet 6:43. 2005
    ..The aim of this study was to improve our understanding of the E. coli Nissle 1917-host interaction by analyzing the gene expression pattern initiated by this probiotic in human intestinal epithelial cells...
  3. ncbi request reprint Helicobacter pylori: recombination, population structure and human migrations
    Sebastian Suerbaum
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Int J Med Microbiol 294:133-9. 2004
    ..This review article summarizes recent developments in this rapidly moving field...
  4. ncbi request reprint Helicobacter pylori evolution and phenotypic diversification in a changing host
    Sebastian Suerbaum
    Medizinische Hochschule Hannover, Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Microbiol 5:441-52. 2007
    ..Finally, we put forward the hypothesis that the lack of opportunity for intraspecies recombination as a result of the decreasing prevalence of H. pylori could accelerate its disappearance from Western populations...
  5. ncbi request reprint Epidemiology of multi-drug-resistant gram-negative bacteria: data from an university hospital over a 36-month period
    Ralf Peter Vonberg
    Institute for Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Street 1, 30625 Hannover, Germany
    Int J Hyg Environ Health 211:251-7. 2008
    ..Because there are many immunocompromised patients in our facility we will continue our current infection control management until more data concerning MRGN are available...
  6. pmc In vivo sequence variation in HopZ, a phase-variable outer membrane protein of Helicobacter pylori
    Lynn Kennemann
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    Infect Immun 80:4364-73. 2012
    ..pylori strains. All H. pylori populations contained hopZ-positive isolates. The data suggest that hopZ has been acquired and split into the two variants before the human migration out of Africa...
  7. pmc A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island
    Patrick Olbermann
    Institute for Medical Microbiology and Hospital Epidemiology, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS Genet 6:e1001069. 2010
    ..Our study provides a resource that can guide future research on the biological roles and host interactions of cagPAI proteins, including several whose function is still unknown...
  8. pmc The Helicobacter pylori anti-sigma factor FlgM is predominantly cytoplasmic and cooperates with the flagellar basal body protein FlhA
    Melanie Rust
    Hannover Medical School, Department for Medical Microbiology and Hospital Epidemiology, Hannover, Germany
    J Bacteriol 191:4824-34. 2009
    ..We suggest that, in H. pylori, FlgM secretion may not be paramount for its regulatory function and that protein interactions at the flagellar basal body may determine the turnover and localization of functional FlgM...
  9. pmc Role of the Helicobacter hepaticus flagellar sigma factor FliA in gene regulation and murine colonization
    Torsten Sterzenbach
    Hannover Medical School, Institute for Medical Microbiology and Hospital Epidemiology, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Bacteriol 190:6398-408. 2008
    ..flaA_1 mutants which had flagella but displayed reduced motility did not colonize mice, indicating that motility is required for intestinal colonization by H. hepaticus and that the presence of flagella alone is not sufficient...
  10. pmc Mosaic DNA imports with interspersions of recipient sequence after natural transformation of Helicobacter pylori
    Stefan Kulick
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 3:e3797. 2008
    ..The formation of ISR in H. pylori increases allelic diversity, and contributes to the uniquely low linkage disequilibrium characteristic of this pathogen...
  11. ncbi request reprint The Helicobacter pylori mutY homologue HP0142 is an antimutator gene that prevents specific C to A transversions
    Stefan Kulick
    Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Arch Microbiol 189:263-70. 2008
    ..Inactivation of mutY was associated with a stationary phase fitness deficit in competitive cultures with the wild type strain...
  12. ncbi request reprint Pathogenomics of helicobacter
    Christine Josenhans
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Street 1, D 30625 Hannover, Germany
    Int J Med Microbiol 297:589-600. 2007
    ..pylori infection. This review summarizes the available information, emphasizing work performed in the framework of the PathoGenoMik funding initiative (2001-2006) of the German Ministry of Education and Research...
  13. pmc Characterization of the pilin ortholog of the Helicobacter pylori type IV cag pathogenicity apparatus, a surface-associated protein expressed during infection
    Joanna Andrzejewska
    Hannover Medical School, Institute for Medical Microbiology, Carl Neuberg Strasse 1, Hannover 30625, Germany
    J Bacteriol 188:5865-77. 2006
    ..Pronounced strain-to-strain variability of this predicted surface-exposed part of HP0546 indicates a strong selective pressure for variation in vivo...
  14. pmc Genomic changes during chronic Helicobacter pylori infection
    Christian Kraft
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Bacteriol 188:249-54. 2006
    ..These results suggest that adaptation of H. pylori to the host individual may principally occur through sequence changes rather than loss or gain of genes...
  15. pmc Intestinal Microbiota Composition of Interleukin-10 Deficient C57BL/6J Mice and Susceptibility to Helicobacter hepaticus-Induced Colitis
    Ines Yang
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany DZIF German Center for Infection Research, Hannover Braunschweig Site, Hannover, Germany
    PLoS ONE 8:e70783. 2013
    ..This was associated with significant differences in microbiota composition, highlighting the importance of characterizing the intestinal microbiome when studying murine models of IBD. ..
  16. doi request reprint Hcp and VgrG1 are secreted components of the Helicobacter hepaticus type VI secretion system and VgrG1 increases the bacterial colitogenic potential
    Lucie Bartonickova
    Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Cell Microbiol 15:992-1011. 2013
    ..We therefore concluded that the type VI secretion component VgrG1 can modulate and specifically exacerbate the innate pro-inflammatory effect of the chronic H. hepaticus infection...
  17. doi request reprint Impact of routine surgical ward and intensive care unit admission surveillance cultures on hospital-wide nosocomial methicillin-resistant Staphylococcus aureus infections in a university hospital: an interrupted time-series analysis
    Iris F Chaberny
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    J Antimicrob Chemother 62:1422-9. 2008
    ....
  18. ncbi request reprint Flagellar and global gene regulation in Helicobacter pylori modulated by changes in DNA supercoiling
    Fang Ye
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hanover, Germany
    Int J Med Microbiol 297:65-81. 2007
    ..These data indicate that global supercoiling changes may help coordinate temporal (growth phase-related) regulation of flagellar biosynthesis and other cellular functions in Helicobacter...
  19. pmc Helicobacter pylori genome evolution during human infection
    Lynn Kennemann
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 108:5033-8. 2011
    ..pylori genome is stable in the absence of mixed infection. Among these few differences was an OFF/ON switch in the phase-variable adhesin gene hopZ, suggesting strong in vivo selection for this putative adhesin during early colonization...
  20. pmc Horizontal versus familial transmission of Helicobacter pylori
    Sandra Schwarz
    Institute of Medical Microbiology and Hospital Epidemiology, Hanover Medical School, Hanover, Germany
    PLoS Pathog 4:e1000180. 2008
    ..The patterns observed in rural South African families may be representative of large parts of the developing world...
  21. pmc Genome sequence of Helicobacter pylori hpEurope strain N6
    Wiebke Behrens
    Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    J Bacteriol 194:3725-6. 2012
    ..It is a causative agent of stomach diseases, including malignant tumors. We report the genome sequence of strain N6, which is widely used in H. pylori research and appreciated for its large cell size and high transformation efficiency...
  22. pmc Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells
    Torsten Sterzenbach
    Hannover Medical School, Institute for Medical Microbiology and Hospital Epidemiology, 30625 Hannover, Germany
    Infect Immun 75:2717-28. 2007
    ..Suppression of innate immune responses by H. hepaticus LPS thus may affect intestinal responses to the resident microbial flora, epithelial homeostasis, and intestinal inflammatory conditions...
  23. pmc Closely related Campylobacter jejuni strains from different sources reveal a generalist rather than a specialist lifestyle
    Eugenia Gripp
    Institute for Medical Microbiology, Hannover Medical School, Hannover, Germany
    BMC Genomics 12:584. 2011
    ..In certain hosts, Campylobacter species colonize persistently and do not cause disease, while they cause acute intestinal disease in humans...
  24. ncbi request reprint Mutation and recombination in Helicobacter pylori: mechanisms and role in generating strain diversity
    Christian Kraft
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Int J Med Microbiol 295:299-305. 2005
    ..In this review article, we discuss the genetic variability of H. pylori, the mechanisms that generate diversity, and the potential relevance of genetic variability to colonization and pathogenicity...
  25. ncbi request reprint Risk of rabies infection and adverse effects of postexposure prophylaxis in healthcare workers and other patient contacts exposed to a rabies virus-infected lung transplant recipient
    Frauke Mattner
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    Infect Control Hosp Epidemiol 28:513-8. 2007
    ..The patient was given ventilatory assistance and cared for postoperatively for 6 weeks before a diagnosis of rabies virus infection was made. Postexposure prophylaxis (PEP) was offered to potentially exposed healthcare workers (HCWs)...
  26. pmc Functional characterization and mutagenesis of the proposed behavioral sensor TlpD of Helicobacter pylori
    Tobias Schweinitzer
    Institute for Medical Microbiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Bacteriol 190:3244-55. 2008
    ..The proposed energy sensor TlpD was found to mediate a repellent tactic response away from conditions of reduced electron transport...
  27. doi request reprint The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models
    Sandra Nell
    Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Microbiol 8:564-77. 2010
    ..In this Review, we focus on the impact of pathogenic and commensal bacteria on IBD-like pathogenesis in mouse infection models and summarize important recent developments...
  28. ncbi request reprint A German external quality survey of diagnostic microbiology of respiratory tract infections in patients with cystic fibrosis
    Beate Balke
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hanover, Germany
    J Cyst Fibros 7:7-14. 2008
    ..Therefore, a multicentre study of 18 German CF laboratories was performed to evaluate their proficiency in analyzing CF respiratory secretions...
  29. doi request reprint Routine bile collection for microbiological analysis during cholangiography and its impact on the management of cholangitis
    Ahmed A Negm
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Gastrointest Endosc 72:284-91. 2010
    ..Antibiotic treatment of cholangitis is often insufficient because of inappropriate antibiotic use or bacterial resistance...
  30. pmc Standardized, App-Based Disinfection of iPads in a Clinical and Nonclinical Setting: Comparative Analysis
    Urs Vito Albrecht
    PL Reichertz Institute for Medical Informatics, Hannover Medical School, Hannover, Germany
    J Med Internet Res 15:e176. 2013
    ..Since manufacturers do not allow cleaning methods that make use of anything but a dry fleece, other approaches have to be established to ensure patient safety and to minimize risks posed by microbiological contamination...
  31. doi request reprint Survival in hostile territory: the microbiota of the stomach
    Ines Yang
    Hannover Medical School, Institute of Medical Microbiology and Hospital Epidemiology, Hannover, Germany
    FEMS Microbiol Rev 37:736-61. 2013
    ....
  32. pmc Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine
    Cornelia Lindner
    Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany
    J Exp Med 209:365-77. 2012
    ..These data provide a conceptual framework to understand the dynamic changes in the IgA repertoires to match environmental and intrinsic stimuli...
  33. pmc Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution
    Anna Potapova
    Institute of Pathology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Biotechnol 11:6. 2011
    ..Therefore, a systematic cross-validation of 454 sequencing and conventional pyrosequencing, both of which offer exact quantification of methylation levels with a single CpG dinucleotide resolution, was performed...
  34. doi request reprint Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease
    Kay Johswich
    Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 15:1812-23. 2009
    ..In this study, mouse models of acute and chronic dextran sulfate-induced colitis were used to further elucidate the impact of C5a and its receptor (C5aR) on disease development...
  35. ncbi request reprint An infection with linezolid-resistant S. aureus in a patient with left ventricular assist system
    Axel Kola
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover, Germany
    Scand J Infect Dis 39:463-5. 2007
    ..Linezolid should be used with caution when invasive devices or foreign materials are in place or therapeutic courses last longer than 14 d. Previous cases of linezolid-resistant S. aureus are summarized...
  36. ncbi request reprint In the European population HLA-class II genes are not associated with Helicobacter pylori infection
    Erdmute Kunstmann
    Department of Molecular Human Genetics, Ruhr University, Bochum, Germany
    Eur J Gastroenterol Hepatol 14:49-53. 2002
    ..Certain HLA-DQA1 alleles have been reported to be associated with gastric and duodenal ulcer disease in infected patients in the Japanese population. But conflicting results were reported on European and Japanese populations...
  37. ncbi request reprint Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host
    Erdmute Kunstmann
    Department of Human Genetics, Ruhr University, Bochum, Germany
    Int J Med Microbiol 292:537-40. 2003
    ..There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations...
  38. ncbi request reprint Traces of human migrations in Helicobacter pylori populations
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, 10117 Berlin, Germany
    Science 299:1582-5. 2003
    ..Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade...
  39. ncbi request reprint Helicobacter pylori infection
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 347:1175-86. 2002
  40. ncbi request reprint Helicobacter pylori--23 years on
    Sebastian Suerbaum
    Int J Med Microbiol 295:297-8. 2005
  41. pmc Gain and loss of multiple genes during the evolution of Helicobacter pylori
    Helga Gressmann
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Berlin, Germany
    PLoS Genet 1:e43. 2005
    ..Thus, the use of microarrays can reveal patterns of gene gain or loss when examined within a phylogenetic context that is based on sequences of core genes...
  42. pmc An African origin for the intimate association between humans and Helicobacter pylori
    Bodo Linz
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, D 10117 Berlin, Germany
    Nature 445:915-8. 2007
    ..pylori before their migrations from Africa and demonstrate that H. pylori has remained intimately associated with their human host populations ever since...
  43. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
    ....
  44. ncbi request reprint Bacterial genomics: seven years on
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, D 97080, Wurzburg, Germany
    Trends Microbiol 10:351-3. 2002
  45. ncbi request reprint Fatal Clostridium tertium septicemia in a nonneutropenic patient
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    J Infect 50:76-80. 2005
    ..As C. tertium is aerotolerant, often gram-variable and mostly resistant to broad-spectrum cephalosporins, differentiation is difficult and empirical therapeutic strategies may fail...
  46. pmc Rapid loss of motility of Helicobacter pylori in the gastric lumen in vivo
    Sören Schreiber
    Institut fur Physiologie, MA 2 149, Ruhr Universitaet Bochum, Universitaetsstrasse 150, D 44801 Bochum, Germany
    Infect Immun 73:1584-9. 2005
    ..pylori in the gastric chymus to only a few minutes by rapidly inhibiting active motility. It is therefore likely that this short period of resistance in the gastric lumen is one of the most critical phases of Helicobacter infection...
  47. ncbi request reprint The neuA/flmD gene cluster of Helicobacter pylori is involved in flagellar biosynthesis and flagellin glycosylation
    Christine Josenhans
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    FEMS Microbiol Lett 210:165-72. 2002
    ..Together with other genes in the H. pylori genome, a proposed function of the neuA/flmD gene products could be to provide a pathway for glycosylation of flagellin and other extracytoplasmic molecules during type III secretion...
  48. ncbi request reprint The role of motility as a virulence factor in bacteria
    Christine Josenhans
    Institute for Hygiene and Microbiology, Wurzburg University, Germany
    Int J Med Microbiol 291:605-14. 2002
    ..Possibilities to exploit bacterial motility as a specific therapeutic antibacterial target to cure or prevent disease are discussed...
  49. ncbi request reprint Functional characterization of the antagonistic flagellar late regulators FliA and FlgM of Helicobacter pylori and their effects on the H. pylori transcriptome
    Christine Josenhans
    Institute for Hygiene and Microbiology, University of Wuerzburg, Germany
    Mol Microbiol 43:307-22. 2002
    ..Like other motile bacteria, H. pylori has a FliA/FlgM pair of sigma and anti-sigma factors, but the genes controlled by these differ markedly from the Salmonella/Escherichia coli paradigm...
  50. ncbi request reprint Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pylori
    Sebastian Suerbaum
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
    Int J Syst Evol Microbiol 52:437-9. 2002
    ..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...
  51. ncbi request reprint Gastric antibacterial efficiency is different for pepsin A and C
    Sören Schreiber
    Institut fur Physiologie, MA 2 149, Ruhr Universitat Bochum, Universitatsstrasse 150, 44801, Bochum, Germany
    Arch Microbiol 184:335-40. 2006
    ..We found that pepsin C completely inactivates H. pylori at proteolytic activities of 2 (pH 5) and 20 (pH 2) U/ml. In contrast, the activities of pepsin A and chymosin required to affect Helicobacter motility were ten times higher...
  52. pmc Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16 825C, Cambridge, MA 02139, USA
    Infect Immun 73:8449-52. 2005
    ..Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1...
  53. pmc Downregulation of CXCR1 and CXCR2 expression on human neutrophils by Helicobacter pylori: a new pathomechanism in H. pylori infection?
    Bernd Schmausser
    Institut fur Pathologie, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Infect Immun 72:6773-9. 2004
    ..pylori infection. Downregulation of CXCR1 and CXCR2 expression on neutrophils in H. pylori infection by H. pylori itself may represent a new mechanism of modulating neutrophil migration and activation in the gastric mucosa...
  54. ncbi request reprint Hepatic temporal gene expression profiling in Helicobacter hepaticus-infected A/JCr mice
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:678-93. 2004
    ....
  55. ncbi request reprint Identification of disulfide reductases in Campylobacterales: a bioinformatics investigation
    Nadeem O Kaakoush
    School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    Antonie Van Leeuwenhoek 92:429-41. 2007
    ..The phylogenetic features of the Campylobacterales thioredoxin reductases suggested a special role for these enzymes in the physiology of these bacteria...
  56. pmc Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Microbes Infect 10:726-33. 2008
    ..05) at 13 WPI. These results demonstrate that genes in the HHGI1 contribute to the pathogenicity of H. hepaticus, at least in part via up-regulation of proinflammatory mediators IFN-gamma, TNF-alpha and IL-17a...
  57. pmc The spatial orientation of Helicobacter pylori in the gastric mucus
    Sören Schreiber
    Institut fur Physiologie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Proc Natl Acad Sci U S A 101:5024-9. 2004
    ..H. pylori thus uses the gastric mucus pH gradient for chemotactic orientation...
  58. ncbi request reprint Multilocus sequence analysis of Porphyromonas gingivalis indicates frequent recombination
    Andreas Koehler
    Institut für Hygiene und Mikrobiologie der Bayerischen Julius Maximilians Universität, 97080 Wurzburg, Germany
    Microbiology 149:2407-15. 2003
    ..gingivalis. A standardized index of association of 0.0898 indicates that the P. gingivalis genes analysed are close to linkage equilibrium...
  59. pmc The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:7901-6. 2003
    ....
  60. ncbi request reprint The diversity within an expanded and redefined repertoire of phase-variable genes in Helicobacter pylori
    Laurence Salaun
    The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Microbiology 150:817-30. 2004
    ..This study extends and provides new evidence for variation of this type in H. pylori, and of the high degree of diversity of the repertoire of genes which display phase-variable switching within individual strains...
  61. ncbi request reprint Growth phase-dependent and differential transcriptional control of flagellar genes in Helicobacter pylori
    Eike Niehus
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Microbiology 148:3827-37. 2002
    ..Growth phase in vitro had the strongest influence on transcriptional control of H. pylori flaA and flaB, while differences in supplements to a rich culture medium had only a modest modulatory effect on flagellin gene transcription...
  62. ncbi request reprint Helicobacter hepaticus catalase shares surface-predicted epitopes with mammalian catalases
    Essam J Alyamani
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 01225, USA
    Microbiology 153:1006-16. 2007
    ..hepaticus catalase. Catalases are highly conserved enzymes in bacteria and mammals that may contribute to autoimmune responses in animals infected with catalase-producing pathogens...
  63. ncbi request reprint Genome-wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pylori
    Eike Niehus
    Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    Mol Microbiol 52:947-61. 2004
    ..A true master regulator of flagellar biosynthesis is absent in H. pylori, consistent with the essential role of flagellar motility and chemotaxis for this organism...
  64. ncbi request reprint Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5
    Sae Kyung Lee
    Institute for Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Microbes Infect 5:1345-56. 2003
    ..pylori to preserve the essential function of its flagella during chronic colonization of the stomach and to evade the deleterious host immune responses...