Ch P Strassburg

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi Hepatitis B virus immunization with an adjuvant containing vaccine after liver transplantation for hepatitis B-related disease: failure of humoral and cellular immune response
    Jens Rosenau
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Transpl Int 19:828-33. 2006
  2. doi Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Arch Toxicol 82:573-82. 2008
  3. ncbi Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
    C P Strassburg
    Department of Gastroenterology and Hepatology, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 275:36164-71. 2000
  4. doi Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Arch Toxicol 82:415-33. 2008
  5. doi [Liver transplantation: indications and results]
    C P Strassburg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover
    Internist (Berl) 50:550-60. 2009
  6. doi [Progress in immunosuppression]
    C P Strassburg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Chirurg 79:149-56. 2008
  7. ncbi [Diagnosis and therapy: autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 130:S202-4. 2005
  8. ncbi [Partial liver transplantation and living donation from the viewpoint of internal medicine]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 43:1551-8. 2002
  9. ncbi [Diagnosis and therapy of inheritable liver diseases: hemochromatisis, Wilson's disease and alpha-1-antitrypsin deficiency]
    Ch P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Praxis (Bern 1994) 94:73-81. 2005
  10. ncbi Gastrointestinal disorders of the critically ill. Shock liver
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Best Pract Res Clin Gastroenterol 17:369-81. 2003

Detail Information

Publications80

  1. ncbi Hepatitis B virus immunization with an adjuvant containing vaccine after liver transplantation for hepatitis B-related disease: failure of humoral and cellular immune response
    Jens Rosenau
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Transpl Int 19:828-33. 2006
    ..Patient-related preconditions and concomitant HBIG administration should be further investigated as possible predictors for response...
  2. doi Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Arch Toxicol 82:573-82. 2008
    ..UGT1A3 transcription was reduced in the presence of promoter SNPs. These data demonstrate xenobiotic induced regulation of the UGT1A3 gene by the AhR, which shows genetic variability...
  3. ncbi Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
    C P Strassburg
    Department of Gastroenterology and Hepatology, Hannover Medical School, 30625 Hannover, Germany
    J Biol Chem 275:36164-71. 2000
    ....
  4. doi Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Arch Toxicol 82:415-33. 2008
    ..Glucuronidation and its variability are likely to represent an important factor for individualized drug therapy and risk prediction impacting the drug development and licensing processes...
  5. doi [Liver transplantation: indications and results]
    C P Strassburg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover
    Internist (Berl) 50:550-60. 2009
    ..As a consequence of these developments indications, selection of recipients and the management of the waiting list have seen profound change...
  6. doi [Progress in immunosuppression]
    C P Strassburg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Chirurg 79:149-56. 2008
    ..Novel drugs and strategies for the induction of tolerance are under development...
  7. ncbi [Diagnosis and therapy: autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 130:S202-4. 2005
  8. ncbi [Partial liver transplantation and living donation from the viewpoint of internal medicine]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 43:1551-8. 2002
  9. ncbi [Diagnosis and therapy of inheritable liver diseases: hemochromatisis, Wilson's disease and alpha-1-antitrypsin deficiency]
    Ch P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Praxis (Bern 1994) 94:73-81. 2005
    ..Foremost the diagnosis of the three diseases is reached by clinical, biochemical and in some instances also histological means which are supplemented and confirmed by the use of appropriate genetic tests...
  10. ncbi Gastrointestinal disorders of the critically ill. Shock liver
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Best Pract Res Clin Gastroenterol 17:369-81. 2003
    ....
  11. ncbi [Liver transplantation: deciding between need and donor allocation]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Internist (Berl) 45:1233-45. 2004
    ..Fair allocation and medical necessity therefore define the challenges surrounding the indications for liver transplantation...
  12. ncbi [Autoimmune liver diseases and their overlap syndromes]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Praxis (Bern 1994) 95:1363-81. 2006
    ..AIH, PBC and PSC are well established indications for liver transplantation with good results. Transplantation is required when cirrhosis is progressive despite therapy and is likely to lead to liver failure...
  13. ncbi [Primary biliary liver cirrhosis and overlap syndrome. Diagnosis and therapy]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Internist (Berl) 45:16-26. 2004
    ..The only curative option is liver transplantation which should be considered when bilirubin levels exceed 100 microM/l...
  14. ncbi [Diagnosis and therapy of primary biliary cirrhosis and primary sclerosing cholangitis]
    C P Strassburg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 128:S96-8. 2003
  15. doi Pharmacogenetics of Gilbert's syndrome
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Pharmacogenomics 9:703-15. 2008
    ..The prediction of unwanted drug reactions associated with Gilbert's syndrome will improve drug safety, therapeutic individualization and impact the drug-development process...
  16. ncbi Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A)
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Crit Rev Clin Lab Sci 45:485-530. 2008
    ....
  17. doi [Treatment of autoimmune liver diseases. Autoimmune hepatitis and primary sclerosing cholangitis]
    C P Strassburg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Internist (Berl) 52:1394-406. 2011
    ..IgG4-associated cholangitis can mimic primary sclerosing cholangitis but--in contrast-- can respond to the administration of steroid-containing immunosuppression...
  18. doi Autoimmune hepatitis
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Best Pract Res Clin Gastroenterol 24:667-82. 2010
    ....
  19. ncbi Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7
    C P Strassburg
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    J Hepatol 34:865-72. 2001
    ..Hepatic and extrahepatic metabolism of cyclosporine A and tacrolimus by cytochrome P450 proteins has been analyzed but metabolism and inactivation by glucuronidation has not been investigated...
  20. doi Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome)
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Best Pract Res Clin Gastroenterol 24:555-71. 2010
    ..In addition, the precise diagnosis of these inherited hyperbilirubinemic syndromes avoids unnecessary invasive procedures for suspected more severe hepatobiliary disease...
  21. doi Therapeutic options to treat autoimmune hepatitis in 2009
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Dig Dis 28:93-8. 2010
    ..Although only 4% of transplant patients are transplanted with the diagnosis AIH, the risk for graft loss because of recurrence has to be considered and recurrent AIH treated after transplantation...
  22. doi Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?
    Christian P Strassburg
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Drug Metab Rev 42:168-81. 2010
    ..The complexity hidden behind this pharmacogenetic abnormality is of profound significance for drug development and therapy...
  23. pmc Developmental aspects of human hepatic drug glucuronidation in young children and adults
    C P Strassburg
    Department of Gastroenterology and Hepatology, Hannover Medical School, Germany
    Gut 50:259-65. 2002
    ..Hepatic glucuronidation undergoes significant changes during fetal and neonatal development requiring age adapted drug therapy. Regulation of individual UGT genes during hepatic development has not been defined...
  24. ncbi [Clubbed fingers and dysphagia in a 38-year-old patient]
    C P Strassburg
    Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Internist (Berl) 43:99-104. 2002
  25. doi [Diagnostics and therapy of hepatitis]
    C P Strassburg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover, Deutschland
    Internist (Berl) 50:1358-68. 2009
    ..Hepatitis A does not lead to chronic infection. This was also assumed for hepatitis E. However, reports indicate chronic courses in selected patient groups. A vaccine for hepatitis E is currently not yet available...
  26. pmc Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
    C P Strassburg
    Department of Gastroenterology and Hepatology, Hannover Medical School, 30625 Hannover, Germany
    Gut 50:851-6. 2002
    ..A silent mutation at codon 11 and missense mutations at codons 129, 131, and 208 lead to the description of three polymorphic alleles designated UGT1A7*2, UGT1A7*3, and UGT1A7*4...
  27. doi Treatment of autoimmune hepatitis
    Christian P Strassburg
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, 30625 Hannover, Germany
    Semin Liver Dis 29:273-85. 2009
    ..Although only 4% of transplant candidates are AIH patients, the risk for graft loss because of recurrence has to be considered, and recurrent AIH should be treated after transplantation...
  28. ncbi Autoimmunity and hepatitis C
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Autoimmun Rev 2:322-31. 2003
    ..Virus infection remains at the center of molecular and cellular research aimed at identifying the forces driving human autoimmunity and autoimmune diseases...
  29. doi Therapy of autoimmune hepatitis
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Best Pract Res Clin Gastroenterol 25:673-87. 2011
    ..Only four percent of transplant candidates are transplanted for AIH but the risk for graft loss because of recurrence has to be considered and recurrent AIH treated after transplantation...
  30. ncbi Retrospective analysis of the impact of immunosuppression on the course of recurrent hepatitis C after liver transplantation
    M J Bahr
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Transplant Proc 37:1703-4. 2005
    ..In a substantial proportion of patients, recurrent hepatitis C after liver transplantation (OLT) rapidly progresses to graft cirrhosis. The role of different immunosuppressive schemes is not well evaluated...
  31. ncbi Polymorphisms of the carcinogen detoxifying UDP-glucuronosyltransferase UGT1A7 in proximal digestive tract cancer
    A Vogel
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Z Gastroenterol 40:497-502. 2002
    ..33-3.07)). We identify the significant association of the UGT1A7*3 allele encoding a low catalytic activity protein as a risk gene in proximal digestive tract cancer and as a potential marker for cancer susceptibility...
  32. ncbi Severe hearing loss after liver transplantation
    K Rifai
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany
    Transplant Proc 37:1918-9. 2005
    ..In most patients, onset of hearing loss is early and bilateral, suggesting a dose-dependent toxicity. The pathogenetic role of different immunosuppressants remains to be evaluated...
  33. doi Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation: role of rituximab
    M A Stange
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Z Gastroenterol 48:258-63. 2010
    ..Pre-emptive antiviral treatments should be administered since delayed antiviral treatment is frequently unable to prevent liver failure...
  34. ncbi Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene
    A Vogel
    Department of Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany
    Gastroenterology 121:1136-44. 2001
    ..This study examines the association of UGT1A7 and UGT1A9 gene polymorphisms with hepatocellular carcinoma...
  35. ncbi Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    P Obermayer-Straub
    Department of Gastroenterology and Hepatology, Hanover Medical School, Germany
    Gastroenterology 121:668-77. 2001
    ..No clinical correlation was observed for anti-CYP2A6. Autoimmune hepatitis and APECED hepatitis are characterized by different molecular targets of autoantibodies with no overlap...
  36. ncbi [Autoimmune hepatitis]
    M P Manns
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Z Gastroenterol 40:39-42. 2002
  37. doi [Long-term results after liver transplantation]
    H Schrem
    Allgemein, Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Chirurg 79:121-9. 2008
    ..4% for PSC, 78.5% for biliary atresia, 70% for acute liver failure, 69.1% for HBV-related cirrhosis, 61.3% for hepatocellular carcinoma, and 56% for HCV-related cirrhosis...
  38. ncbi Autoimmune regulator AIRE: evidence for genetic differences between autoimmune hepatitis and hepatitis as part of the autoimmune polyglandular syndrome type 1
    A Vogel
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany
    Hepatology 33:1047-52. 2001
    ..However, the Aire gene defect showed that genes involved in the induction of immunologic tolerance provide candidates for etiologic factors in autoimmune liver diseases...
  39. ncbi Immunosuppression and the prognosis of patients suffering from myeloproliferative disorders after liver transplantation
    Matthias J Bahr
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Carl Neuberg Strasse 1, 30623 Hannover, Germany
    Transplant Proc 34:1493-4. 2002
  40. ncbi [Autoimmune polyglandular syndromes]
    T O Lankisch
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Internist (Berl) 46:750-8. 2005
    ..Therapy consists of hormone replacement therapy and treatment of clinical symptoms. In some APECED patients immunosuppressive therapy seems to be promising...
  41. ncbi Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases
    P Obermayer-Straub
    Medizinische Hochschule Hannover, Hannover, Germany
    Can J Gastroenterol 14:429-39. 2000
    ..In idiopathic Addison disease, CYP21 is the major autoantigen...
  42. ncbi Effects of cyclosporine on human dendritic cell subsets
    S Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule, Hannover, Germany
    Transplant Proc 37:20-4. 2005
    ..In conclusion, cyclosporine differentially alters function and phenotype of myeloid dendritic cells leading to a partially impaired capacity to stimulate allogenic and autologous T cells...
  43. ncbi Steroid treatment for severe acute cryptogenic hepatitis
    A Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Z Gastroenterol 45:15-9. 2007
    ..Acute cryptogenic hepatitis may represent both a self-limited disease as well as the onset of chronic hepatitis. The aim of this analysis was to evaluate the effect of steroid treatment in patients with acute cryptogenic hepatitis...
  44. ncbi A novel AIRE mutation in an APECED patient with candidiasis, adrenal failure, hepatitis, diabetes mellitus and osteosclerosis
    A Vogel
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany
    Exp Clin Endocrinol Diabetes 111:174-6. 2003
    ..The frame shift mutation G263fsX377 in exon 6 results in a protein lacking both PHD zinc-finger domains similar to the R257 X mutation. This novel mutation was not found in 50 German controls...
  45. doi Of guinea pigs and men--an unusual case of jaundice
    S Pischke
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Z Gastroenterol 48:33-7. 2010
    ..Bacterial culture was not successful, and also PCR tests remained negative. The clinical symptoms quickly resolved after the initiation of antibiotic therapy with amoxicillin...
  46. ncbi 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link
    A Vogel
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, D 30625 Hannover, Germany
    Genes Immun 4:79-81. 2003
    ..Our data identify CD45 as a gene associated with AIH, and further substantiates the hypothesis that CD45 represents a modifier gene of human autoimmunity...
  47. ncbi Autoimmunity and viruses
    Arndt Vogel
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30623, Hannover, Germany
    Clin Liver Dis 6:739-53. 2002
    ..Future studies must differentiate the targets of pathologic immunity and distinguish self-antigens from infectious nonself-antigens. Transgenic animal models of AIH are needed to assess the pathogenicity of the antigenic targets...
  48. doi Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene
    Thomas J Erichsen
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Medical School, Hannover, Germany
    Toxicol Appl Pharmacol 230:252-60. 2008
    ..AhR-mediated regulation of the human UGT1A4 gene by two XRE and a modulation by naturally occurring genetic variability by SNPs is demonstrated, which indicates gene-environment interaction with potential relevance for drug metabolism...
  49. doi Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cancer Epidemiol Biomarkers Prev 17:695-701. 2008
    ....
  50. ncbi Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity
    Robert H Tukey
    Department of Pharmacology, Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    Mol Pharmacol 62:446-50. 2002
  51. ncbi Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis
    Arndt Vogel
    Department of Gastroenterology and Hepatology, Medical School of Hannover, Hannover, Germany
    Hepatology 35:126-31. 2002
    ..Further studies are needed to elucidate the mechanisms by which the vitamin D receptor contributes to the development of autoimmune diseases...
  52. doi Persistence of occult hepatitis B after removal of the hepatitis B virus-infected liver
    Sandra Ciesek
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    J Infect Dis 197:355-60. 2008
    ..Thus, these data indicate that a long-term extrahepatic HBV reservoir exists, which is relevant not only for liver transplantation but also for other types of transplantations, including bone marrow grafting...
  53. ncbi Longer survival of liver transplant recipients with hepatitis virus coinfections
    Kinan Rifai
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Clin Transplant 21:258-64. 2007
    ..Thus, viral coinfections may be associated with ameliorated courses of diseases under certain conditions...
  54. ncbi Failure of hepatitis B vaccination with conventional HBsAg vaccine in patients with continuous HBIG prophylaxis after liver transplantation
    Jens Rosenau
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Liver Transpl 13:367-73. 2007
    ..Further studies should address the question, of whether the use of potent adjuvant systems results in higher response rates...
  55. doi Indications for and outcomes after combined lung and liver transplantation: a single-center experience on 13 consecutive cases
    Gerrit Grannas
    Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany
    Transplantation 85:524-31. 2008
    ..For several reasons, Lu-LTx is performed in few centers and information about the technical issues, posttransplant management and long-term outcomes associated with this procedure is limited...
  56. ncbi UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer
    Johann Ockenga
    Department of Gastroenterology, Hepatology and Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Gastroenterology 124:1802-8. 2003
    ..Uridine 5'-diphosphate glucuronosyltransferases are phase II detoxifying enzymes capable of tobacco-borne toxicant inactivation and cellular protection. This study analyzes UGT1A7 gene polymorphisms in pancreatic diseases...
  57. ncbi A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens
    T Sugimura
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neubergstr 1, 30625 Hannover, Germany
    Autoimmunity 35:501-13. 2002
    ..This epitope is homologous to three-dimensional epitopes detected by autoantibodies directed against hepatic cytochromes P450s in drug induced hepatitis and to an autoepitope on CYP21B associated with adrenal failure...
  58. ncbi Detection of autoimmune regulator gene mutations in children with type 2 autoimmune hepatitis and extrahepatic immune-mediated diseases
    Tim O Lankisch
    Department of Gastroenterlogy, Hannover Medical School, Hanover, Germany
    J Pediatr 146:839-42. 2005
    ..These findings suggest that autoimmune regulator gene variants might predispose children to systemic autoimmune disease, a recurrence of immune disease, or both...
  59. ncbi Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin
    Ewa Ellis
    Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital Huddinge K63, S 141 86 Stockholm, Sweden
    J Hepatol 44:243-5. 2006
    ..Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes...
  60. ncbi A new side effect of immunosuppression: high incidence of hearing impairment after liver transplantation
    Kinan Rifai
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Hannover, Germany
    Liver Transpl 12:411-5. 2006
    ..Calcineurin inhibitor-related neurotoxicity appears as a possible mechanism. Further prospective investigations with objective hearing tests are necessary to confirm these results and to evaluate the role of immunosuppression...
  61. ncbi Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 44:1324-32. 2006
    ..This haplotype predisposes to hyperbilirubinemia in ATV treatment and may have an additional role as a pharmacogenomic risk factor for drug therapy...
  62. ncbi Recurrence of Budd-Chiari syndrome after liver transplantation in paroxysmal nocturnal hemoglobinuria
    Matthias J Bahr
    Department of Gastroenterology, Hepatology and Endocrinology, Hanover University Medical School, Carl Neuberg Strasse 1, 30623 Hanover, Germany
    Transpl Int 16:890-4. 2003
    ..In conclusion, patients afflicted with PNH appear to be at high risk of incurring complications after liver transplantation...
  63. ncbi Portopulmonary hypertension and hepatopulmonary syndrome
    Marius M Hoeper
    Department of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
    Lancet 363:1461-8. 2004
    ..Data from several centres have contributed to provide criteria that allow improved prediction of which patients may, or may not, benefit from liver transplantation alone...
  64. ncbi Long-term outcome of liver transplantation for autoimmune hepatitis
    Arndt Vogel
    Department of a Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Clin Transplant 18:62-9. 2004
    ..The aim of this study was to evaluate the long-term outcome in serologically defined subgroups of AIH after transplantation...
  65. ncbi Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4
    Ursula Ehmer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 39:970-7. 2004
    ..Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification...
  66. pmc Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched-chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitis
    Antal Csepregi
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Street 1, 30625 Hannover, Germany
    Clin Dev Immunol 10:173-81. 2003
    ..In the present study, immunoreactivities and disease associations of AMA against BCKADC-E2 were analyzed. B-cell autoepitopes on BCKADC-E2 were mapped by immunoprecipitation assay...
  67. ncbi Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury
    Heike Bantel
    Institute of Molecular Medicine, University of Dusseldorf, Dusseldorf, Germany
    Hepatology 40:1078-87. 2004
    ..Thus, measurement of caspase activity might provide a novel diagnostic tool, especially for patients with normal aminotransferases but otherwise undiagnosed histologically active hepatitis and progressive fibrosis...
  68. ncbi A rare cause of nonalcoholic fatty liver disease
    Sandra Ciesek
    Ann Intern Med 145:154-5. 2006
  69. ncbi The genetic background of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy and its autoimmune disease components
    Arndt Vogel
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hanover Carl Neubergstrasse 1, 30625 Hanover, Germany
    J Mol Med (Berl) 80:201-11. 2002
    ..Here we provide an overview of the current clinical and genetic features of APECED in comparison to the genetic background of the frequently associated disease components of APECED...
  70. ncbi Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Mol Pharmacol 67:1732-9. 2005
    ..Our finding emphasizes the importance of combinations of structural and regulatory gene polymorphisms that may be useful as markers of drug toxicity...
  71. ncbi Transition of care between paediatric and adult gastroenterology. Autoimmune hepatitis
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Best Pract Res Clin Gastroenterol 17:291-306. 2003
    ..In Europe, about 4% of cirrhotic patients with the diagnosis of AIH undergo transplantation. The diagnosis and awareness of the disease is designed to reduce mortality and morbidity...
  72. ncbi Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis
    Jens J W Tischendorf
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany
    Scand J Gastroenterol 41:1227-34. 2006
    ..Primary sclerosing cholangitis (PSC) confers a high risk of development of hepatobiliary carcinoma (HBC). The aim of the study was to identify indicators and risk factors for developing HBC in PSC patients...
  73. ncbi Autoimmune hepatitis in the elderly: what is the difference?
    Christian P Strassburg
    J Hepatol 45:480-2. 2006
  74. ncbi Autoantibodies and autoantigens in autoimmune hepatitis
    Christian P Strassburg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Semin Liver Dis 22:339-52. 2002
    ..Autoantibodies and their corresponding autoantigens are intensively studied to provide clues to the understanding of disease initiation, tissue specificity, and propagation of hepatic autoimmune diseases...
  75. doi The challenges in primary sclerosing cholangitis--aetiopathogenesis, autoimmunity, management and malignancy
    Tobias J Weismüller
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30655 Hannover, Germany
    J Hepatol 48:S38-57. 2008
    ..Primary sclerosing cholangitis is a disease of unknown aetiology and without any further curative treatment options apart from liver transplantation. Therefore it may be regarded as the greatest challenge in hepatology today...
  76. ncbi Autoimmune hepatitis and overlap syndromes
    Arndt Vogel
    Department of Hepatology, Gastroenterology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Gastroenterol Hepatol 17:S389-98. 2002
    ..These yet incompletely defined syndromes are an important differential diagnosis in the difficult-to-treat patient with autoimmune hepatitis...
  77. doi Prediction of survival after liver transplantation by pre-transplant parameters
    Tobias J Weismüller
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Scand J Gastroenterol 43:736-46. 2008
    ..A prediction of outcome would improve preoperative patient selection and management...
  78. ncbi UGT1A7 polymorphisms, polycyclic aromatic hydrocarbons and the development of hepatocellular cancer
    Florian Kuchenbauer
    Hepatology 40:1021. 2004
  79. ncbi Autoimmune hepatitis
    Heike Bantel
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Germany
    Curr Gastroenterol Rep 7:81-3. 2005
  80. ncbi Approaches to liver biopsy techniques--revisited
    Christian P Strassburg
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Semin Liver Dis 26:318-27. 2006
    ..This requires a detailed consideration of the differences of biopsy techniques currently available to the clinical hepatologist...