D O Stichtenoth

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Blood donors on medication. Are deferral periods necessary?
    D O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Germany
    Eur J Clin Pharmacol 57:433-40. 2001
  2. ncbi request reprint [Prescription of rimonabant in the early stage of pregnancy?]
    Gesine Picksak
    Zentralapotheke, Medizinische Hochschule Hannover, 30623 Hannover
    Med Monatsschr Pharm 31:107-8. 2008
  3. ncbi request reprint Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease
    D O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623, Germany
    Prostaglandins Leukot Essent Fatty Acids 65:211-4. 2001
  4. ncbi request reprint Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers
    Dirk O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Germany
    Kidney Int 68:2197-207. 2005
  5. ncbi request reprint The second generation of COX-2 inhibitors: what advantages do the newest offer?
    Dirk O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Hannover, Germany
    Drugs 63:33-45. 2003
  6. ncbi request reprint The second generation of COX-2 inhibitors: clinical pharmacological point of view
    D O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Mini Rev Med Chem 4:617-24. 2004
  7. ncbi request reprint Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. II. Quantitative determination of S-nitrosoalbumin in human plasma using S-[15N]nitrosoalbumin as internal standard
    D Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Germany
    J Chromatogr B Biomed Sci Appl 726:13-24. 1999
  8. doi request reprint [Placebo therapy. Analysis of extent and expectations in a tertiary referral center]
    M Bernateck
    Bereich Schmerzmedizin, Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, 30625 Hannover, Deutschland
    Schmerz 23:47-53. 2009
  9. ncbi request reprint S-Transnitrosylation of albumin in human plasma and blood in vitro and in vivo in the rat
    D Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625, Hannover, Germany
    Biochim Biophys Acta 1546:422-34. 2001
  10. ncbi request reprint [What significance has the C(2) value in the treatment with cyclosporin A?]
    V V Pham
    Institut fur Klinische Pharmakologie, Universitatsklinikum, Hannover, Germany
    Dtsch Med Wochenschr 129:706. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Blood donors on medication. Are deferral periods necessary?
    D O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Germany
    Eur J Clin Pharmacol 57:433-40. 2001
    ..If the treated disorder is not to be regarded as an exclusion criterion from blood donation, donors on medication should be deferred for a period consistent with the drug's pharmacokinetics...
  2. ncbi request reprint [Prescription of rimonabant in the early stage of pregnancy?]
    Gesine Picksak
    Zentralapotheke, Medizinische Hochschule Hannover, 30623 Hannover
    Med Monatsschr Pharm 31:107-8. 2008
    ..A preventive termination of pregnancy is not indicated. Women in childbearing age should take only low-risk drugs. Otherwise dedicated information, in doubt pregnancy test, and strict contraception is required...
  3. ncbi request reprint Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease
    D O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623, Germany
    Prostaglandins Leukot Essent Fatty Acids 65:211-4. 2001
    ..Our data demonstrate a shift of the prostacyclin/thromboxane ratio toward prostacyclin by oxygen infusion. Thus, a mechanism of action is provided and clinical trials with intravenous oxygen find a rational basis...
  4. ncbi request reprint Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers
    Dirk O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Germany
    Kidney Int 68:2197-207. 2005
    ..The renin-angiotensin system plays a critical role in cardiovascular function, but little is known about the effects of specific cyclooxygenase 2 (COX-2) inhibition on this system in healthy humans under physiologic conditions...
  5. ncbi request reprint The second generation of COX-2 inhibitors: what advantages do the newest offer?
    Dirk O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Hannover, Germany
    Drugs 63:33-45. 2003
    ....
  6. ncbi request reprint The second generation of COX-2 inhibitors: clinical pharmacological point of view
    D O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Mini Rev Med Chem 4:617-24. 2004
    ..In comparison to the first generation, they show an at least equivalent efficacy in the treatment of pain and inflammation. However, the postulated gain of safety is yet difficult to determine and seems to be, if any, small...
  7. ncbi request reprint Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. II. Quantitative determination of S-nitrosoalbumin in human plasma using S-[15N]nitrosoalbumin as internal standard
    D Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Germany
    J Chromatogr B Biomed Sci Appl 726:13-24. 1999
    ..Our results show that SNALB occurs in human plasma at concentrations at least one-order of magnitude smaller than those reported in the literature from measurements using chemiluminescence...
  8. doi request reprint [Placebo therapy. Analysis of extent and expectations in a tertiary referral center]
    M Bernateck
    Bereich Schmerzmedizin, Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, 30625 Hannover, Deutschland
    Schmerz 23:47-53. 2009
    ..The aim of this report was to examine the frequency, indications and the intentions of placebo use at the Medical University of Hannover (MHH)...
  9. ncbi request reprint S-Transnitrosylation of albumin in human plasma and blood in vitro and in vivo in the rat
    D Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625, Hannover, Germany
    Biochim Biophys Acta 1546:422-34. 2001
    ..Our results suggest that S-transnitrosylation of albumin by SNOC and GSNO could be a more favored mechanism for the formation of SNOALB in the circulation in vivo than S-nitrosation of albumin by NO itself...
  10. ncbi request reprint [What significance has the C(2) value in the treatment with cyclosporin A?]
    V V Pham
    Institut fur Klinische Pharmakologie, Universitatsklinikum, Hannover, Germany
    Dtsch Med Wochenschr 129:706. 2004
  11. ncbi request reprint Knowledge on drug dosages of ward physicians
    J U Schnurrer
    Department of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Eur J Clin Pharmacol 58:65-7. 2002
    ..Dosing errors are a common source for preventable adverse drug events. This study evaluated the knowledge of German hospital physicians with respect to the daily dosage of frequently used drugs...
  12. ncbi request reprint [To give or not to give? Towards the indication of CSE inhibitors ("statins")]
    Matthias Teichert
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Hannover
    Med Monatsschr Pharm 31:184-5. 2008
    ..For this, the PROCAM and SCORE risk scores offer validated, hands on decision support tools. In patients with manifest atherosclerosis and diabetes mellitus statins are indicated regardless of the serum cholesterol level...
  13. ncbi request reprint [Are AT1 receptor antagonists an alternative to ACE inhibitors in angioedema?]
    Gesine Picksak
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Hannover
    Med Monatsschr Pharm 30:415-7. 2007
    ..In patients with an anamnestic angioedema or ACE-induced angioedema AT1 receptor antagonists can be given under close monitoring provided that there is strong indication for inhibition of the renin-angiotensin system...
  14. ncbi request reprint [Splitting of tablets: small pieces a risk]
    Gesine Picksak
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30623 Hannover
    Med Monatsschr Pharm 30:340-2. 2007
    ..Since exact dosing is guaranteed only if tablets are divided properly, information and guidance of the patients by the physician and pharmacist is of critical importance...
  15. ncbi request reprint GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
    Kristine Chobanyan
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 858:32-41. 2007
    ..The GC-MS assay reported here should be suitable to probe for DDAH activity in various disease models...
  16. ncbi request reprint [Aerosol administration-- appropriate treatment for asthma in a "recovered alcoholic"?]
    Gesine Picksak
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, 30623 Hannover
    Med Monatsschr Pharm 30:187-9. 2007
  17. ncbi request reprint Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC-MS and GC-tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode
    Kristine Chobanyan
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:240-9. 2007
    ..The present GC-MS method should be useful for the determination of systemic and whole body DDAH activity by measuring circulating and excretory DMA in experimental and clinical studies...
  18. ncbi request reprint Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease
    Dimitrios Tsikas
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:229-39. 2007
    ..17+/-4.2) being insignificantly lower (P=0.46). Between urinary DMA and ADMA there was a positive correlation (R=0.6655, P<0.0001) in coronary artery disease, but no correlation (R=0.27339) was found in end-stage liver disease...
  19. ncbi request reprint [Use of pharmaceuticals after the expiration date?]
    Jessica Y Lachmuth
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 130:2596-7. 2005
  20. ncbi request reprint Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers
    Stefanie A Fahlbusch
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Eur J Clin Pharmacol 60:83-8. 2004
    ..In this study, we assessed the antioxidative potential of carvedilol in cell culture and in antihypertensive doses in healthy men...
  21. ncbi request reprint Determination of 3-nitrotyrosine in human urine at the basal state by gas chromatography-tandem mass spectrometry and evaluation of the excretion after oral intake
    Dimitrios Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 827:146-56. 2005
    ..The suitability of the non-invasive measurement of urinary 3-nitrotyrosine as a method of assessment of oxidative stress in humans remains to be established...
  22. ncbi request reprint Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I Kardiologie, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 92:4172-9. 2007
    ..We investigated whether improved systemic NO bioavailability and increased levels of EPC after GH treatment are related and mediated by the IGF-I...
  23. ncbi request reprint [New substances need critical appraisal, unequivocal information and time. COX-2-inhibitors between cold facts and media hype]
    Dirk O Stichtenoth
    Komm Leiter des Instituts für Klinische Pharmakologie Medizinische Hochschule Hannover
    MMW Fortschr Med 147:23-4. 2005
  24. ncbi request reprint Comment on Jüni P, Dieppe P. Older people should NOT be prescribed 'coxibs' in place of conventional NSAIDs
    Dirk O Stichtenoth
    Age Ageing 33:521. 2004
  25. ncbi request reprint [Creatine kinase increase under simvastatin--therapeutic consequences?]
    Celine C Rasche-Schürmann
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
    Med Monatsschr Pharm 31:25-7. 2008
    ..In case of an asymptomatic CK increase below 5 times the upper limits of normal, therapy can be continued with CK monitoring...