Research Topics
| D O StichtenothSummaryAffiliation: Hannover Medical School Country: Germany Publications
| Collaborators
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Detail Information
Publications
Blood donors on medication. Are deferral periods necessary?D O Stichtenoth
Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Germany
Eur J Clin Pharmacol 57:433-40. 2001..A guideline for 191 drugs and drug classes has been elaborated accordingly...- [Prescription of rimonabant in the early stage of pregnancy?]Gesine Picksak
Zentralapotheke, Medizinische Hochschule Hannover, 30623 Hannover
Med Monatsschr Pharm 31:107-8. 2008..A preventive termination of pregnancy is not indicated. Women in childbearing age should take only low-risk drugs. Otherwise dedicated information, in doubt pregnancy test, and strict contraception is required... - Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial diseaseD O Stichtenoth
Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623, Germany
Prostaglandins Leukot Essent Fatty Acids 65:211-4. 2001..Our data demonstrate a shift of the prostacyclin/thromboxane ratio toward prostacyclin by oxygen infusion. Thus, a mechanism of action is provided and clinical trials with intravenous oxygen find a rational basis... - Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteersDirk O Stichtenoth
Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Germany
Kidney Int 68:2197-207. 2005..The renin-angiotensin system plays a critical role in cardiovascular function, but little is known about the effects of specific cyclooxygenase 2 (COX-2) inhibition on this system in healthy humans under physiologic conditions... - The second generation of COX-2 inhibitors: what advantages do the newest offer?Dirk O Stichtenoth
Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Hannover, Germany
Drugs 63:33-45. 2003.... - The second generation of COX-2 inhibitors: clinical pharmacological point of viewD O Stichtenoth
Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
Mini Rev Med Chem 4:617-24. 2004..In comparison to the first generation, they show an at least equivalent efficacy in the treatment of pain and inflammation. However, the postulated gain of safety is yet difficult to determine and seems to be, if any, small... - Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. II. Quantitative determination of S-nitrosoalbumin in human plasma using S-[15N]nitrosoalbumin as internal standardD Tsikas
Institute of Clinical Pharmacology, Hannover Medical School, Germany
J Chromatogr B Biomed Sci Appl 726:13-24. 1999..Our results show that SNALB occurs in human plasma at concentrations at least one-order of magnitude smaller than those reported in the literature from measurements using chemiluminescence... 
[Placebo therapy. Analysis of extent and expectations in a tertiary referral center]M Bernateck
Bereich Schmerzmedizin, Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, 30625 Hannover, Deutschland
Schmerz 23:47-53. 2009..The aim of this report was to examine the frequency, indications and the intentions of placebo use at the Medical University of Hannover (MHH)...- S-Transnitrosylation of albumin in human plasma and blood in vitro and in vivo in the ratD Tsikas
Institute of Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625, Hannover, Germany
Biochim Biophys Acta 1546:422-34. 2001..Our results suggest that S-transnitrosylation of albumin by SNOC and GSNO could be a more favored mechanism for the formation of SNOALB in the circulation in vivo than S-nitrosation of albumin by NO itself... - [What significance has the C(2) value in the treatment with cyclosporin A?]V V Pham
Institut fur Klinische Pharmakologie, Universitatsklinikum, Hannover, Germany
Dtsch Med Wochenschr 129:706. 2004 - Knowledge on drug dosages of ward physiciansJ U Schnurrer
Department of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
Eur J Clin Pharmacol 58:65-7. 2002..Dosing errors are a common source for preventable adverse drug events. This study evaluated the knowledge of German hospital physicians with respect to the daily dosage of frequently used drugs... - [To give or not to give? Towards the indication of CSE inhibitors ("statins")]Matthias Teichert
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Hannover
Med Monatsschr Pharm 31:184-5. 2008..For this, the PROCAM and SCORE risk scores offer validated, hands on decision support tools. In patients with manifest atherosclerosis and diabetes mellitus statins are indicated regardless of the serum cholesterol level... - [Are AT1 receptor antagonists an alternative to ACE inhibitors in angioedema?]Gesine Picksak
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Hannover
Med Monatsschr Pharm 30:415-7. 2007..In patients with an anamnestic angioedema or ACE-induced angioedema AT1 receptor antagonists can be given under close monitoring provided that there is strong indication for inhibition of the renin-angiotensin system... - [Splitting of tablets: small pieces a risk]Gesine Picksak
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30623 Hannover
Med Monatsschr Pharm 30:340-2. 2007..Since exact dosing is guaranteed only if tablets are divided properly, information and guidance of the patients by the physician and pharmacist is of critical importance... - GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo inKristine Chobanyan
Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 858:32-41. 2007..The GC-MS assay reported here should be suitable to probe for DDAH activity in various disease models... - [Aerosol administration-- appropriate treatment for asthma in a "recovered alcoholic"?]Gesine Picksak
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, 30623 Hannover
Med Monatsschr Pharm 30:187-9. 2007 - Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC-MS and GC-tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization modeKristine Chobanyan
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 851:240-9. 2007..The present GC-MS method should be useful for the determination of systemic and whole body DDAH activity by measuring circulating and excretory DMA in experimental and clinical studies... - Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and diseaseDimitrios Tsikas
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 851:229-39. 2007..17+/-4.2) being insignificantly lower (P=0.46). Between urinary DMA and ADMA there was a positive correlation (R=0.6655, P<0.0001) in coronary artery disease, but no correlation (R=0.27339) was found in end-stage liver disease... - [Use of pharmaceuticals after the expiration date?]Jessica Y Lachmuth
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover
Dtsch Med Wochenschr 130:2596-7. 2005 - Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteersStefanie A Fahlbusch
Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, 30623 Hannover, Germany
Eur J Clin Pharmacol 60:83-8. 2004..CONCLUSIONS: In vitro, the antioxidative potential of carvedilol was confirmed. In healthy men, antihypertensive doses of carvedilol exert no specific inhibition of oxidative stress... - Determination of 3-nitrotyrosine in human urine at the basal state by gas chromatography-tandem mass spectrometry and evaluation of the excretion after oral intakeDimitrios Tsikas
Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
J Chromatogr B Analyt Technol Biomed Life Sci 827:146-56. 2005..The suitability of the non-invasive measurement of urinary 3-nitrotyrosine as a method of assessment of oxidative stress in humans remains to be established... - Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-IThomas Thum
Universitatsklinikum, Medizinische Klinik I Kardiologie, 97080 Wurzburg, Germany
J Clin Endocrinol Metab 92:4172-9. 2007..Animal data demonstrate increased NO availability to be mediated via an increase in IGF-I plasma levels. Thus, GH treatment enhances systemic NO bioavailability via IGF-I and may be beneficial in certain cardiovascular diseases... - [New substances need critical appraisal, unequivocal information and time. COX-2-inhibitors between cold facts and media hype]Dirk O Stichtenoth
MMW Fortschr Med 147:23-4. 2005 - Comment on Jüni P, Dieppe P. Older people should NOT be prescribed 'coxibs' in place of conventional NSAIDsDirk O Stichtenoth
Age Ageing 33:521. 2004 - [Creatine kinase increase under simvastatin--therapeutic consequences?]Celine C Rasche-Schürmann
Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover
Med Monatsschr Pharm 31:25-7. 2008..In case of an asymptomatic CK increase below 5 times the upper limits of normal, therapy can be continued with CK monitoring...