Martin Stanulla

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes
    Eckart Schnakenberg
    Institute for Pharmacogenetic and Genetic Disposition, Ostpassage 7, D 30853 Langenhagen, Germany
    Environ Health 6:6. 2007
  2. ncbi request reprint Integrating molecular information into treatment of childhood acute lymphoblastic leukemia--a perspective from the BFM Study Group
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Blood Cells Mol Dis 39:160-3. 2007
  3. ncbi request reprint High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS
    Gunnar Cario
    Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
    J Clin Oncol 25:4813-20. 2007
  4. pmc Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
    Eckart Schnakenberg
    Institute for Pharmacogenetic and Genetic Disposition, Langenhagen, Germany
    BMC Med Genet 6:23. 2005
  5. ncbi request reprint No evidence for a major role of heterozygous deletion 657del5 within the NBS1 gene in the pathogenesis of non-Hodgkin's lymphoma of childhood and adolescence
    M Stanulla
    Department of Paediatric Haematology and Oncology, Children s Hospital, Hannover Medical School, Germany
    Br J Haematol 109:117-20. 2000
  6. ncbi request reprint Thioguanine versus mercaptopurine in childhood ALL
    Martin Stanulla
    Department of Paediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany
    Lancet 368:1304-6. 2006
  7. ncbi request reprint Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    JAMA 293:1485-9. 2005
  8. ncbi request reprint GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Int J Hematol 81:39-44. 2005
  9. doi request reprint Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study
    Ekaterini Kidas
    Department of Paediatric Haematology and Oncology, OE 6780, Medizinische Hochschule Hannover, Hannover, Germany
    Int J Hematol 89:584-91. 2009
  10. ncbi request reprint MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95
    Kathrin Seidemann
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, D 30625, Hannover, Germany
    Ann Hematol 85:291-300. 2006

Collaborators

Detail Information

Publications30

  1. pmc A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes
    Eckart Schnakenberg
    Institute for Pharmacogenetic and Genetic Disposition, Ostpassage 7, D 30853 Langenhagen, Germany
    Environ Health 6:6. 2007
    ....
  2. ncbi request reprint Integrating molecular information into treatment of childhood acute lymphoblastic leukemia--a perspective from the BFM Study Group
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Blood Cells Mol Dis 39:160-3. 2007
    ....
  3. ncbi request reprint High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS
    Gunnar Cario
    Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
    J Clin Oncol 25:4813-20. 2007
    ....
  4. pmc Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
    Eckart Schnakenberg
    Institute for Pharmacogenetic and Genetic Disposition, Langenhagen, Germany
    BMC Med Genet 6:23. 2005
    ..Studies on the role of these polymorphisms in the susceptibility to acute lymphoblastic leukemia (ALL) led to discrepant results...
  5. ncbi request reprint No evidence for a major role of heterozygous deletion 657del5 within the NBS1 gene in the pathogenesis of non-Hodgkin's lymphoma of childhood and adolescence
    M Stanulla
    Department of Paediatric Haematology and Oncology, Children s Hospital, Hannover Medical School, Germany
    Br J Haematol 109:117-20. 2000
    ..None of the patients analysed carried a NBS1 allele with the 657del5 mutation, suggesting that this mutation does not play a major role in the pathogenesis of NHL of childhood and adolescence...
  6. ncbi request reprint Thioguanine versus mercaptopurine in childhood ALL
    Martin Stanulla
    Department of Paediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany
    Lancet 368:1304-6. 2006
  7. ncbi request reprint Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    JAMA 293:1485-9. 2005
    ..Thiopurine methyltransferase (TPMT) is involved in the metabolism of mercaptopurine and subject to genetic polymorphism, with heterozygous individuals having intermediate and homozygous mutant individuals having very low TPMT activity...
  8. ncbi request reprint GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Int J Hematol 81:39-44. 2005
    ..These results suggested a modulating role for host genetic variation in the development of CNS relapse in childhood ALL treated according to Berlin-Frankfurt-Münster protocols...
  9. doi request reprint Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study
    Ekaterini Kidas
    Department of Paediatric Haematology and Oncology, OE 6780, Medizinische Hochschule Hannover, Hannover, Germany
    Int J Hematol 89:584-91. 2009
    ..98, CI 0.98-9.01, P = 0.05). These results support a role of specific genetic polymorphisms on lethal infections during induction chemotherapy of ALL treatment...
  10. ncbi request reprint MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95
    Kathrin Seidemann
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, D 30625, Hannover, Germany
    Ann Hematol 85:291-300. 2006
    ..Therefore, we conclude that the MTHFR 677 C-->T polymorphism does not appear to influence outcome or therapy-associated toxicity in pediatric patients with NHL treated on BFM protocols...
  11. ncbi request reprint Polymorphisms within glutathione S-transferase genes in pediatric non-Hodgkin's lymphoma
    Björn Ole Dieckvoss
    Department of Pediatric Hematology and Oncology, Children s Hospital, Hannover Medical School, Hannover, Germany
    Haematologica 87:709-13; discussion 713. 2002
    ..Certain members within the GST superfamily exhibit phenotypically relevant genetic polymorphisms which have been associated with outcome in hematologic malignant disease...
  12. doi request reprint Quantification of free total plasma DNA and minimal residual disease detection in the plasma of children with acute lymphoblastic leukemia
    Arne Kristian Schwarz
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hanover, Germany
    Ann Hematol 88:897-905. 2009
    ..Despite low concentrations of DNA, it is feasible to measure MRD kinetics in plasma DNA during ALL induction therapy by adapted real-time PCR methodologies...
  13. ncbi request reprint Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia
    Gunnar Cario
    Department of Pediatric Hematology and Oncology, Institute for Cell and Molecular Pathology, Hannover Medical School, Germany
    Blood 105:821-6. 2005
    ..Because treatment response could be predicted with high accuracy, gene expression profiling could become a clinically relevant tool for treatment stratification in the early course of childhood ALL...
  14. ncbi request reprint Tumor necrosis factor and lymphotoxin alfa genetic polymorphisms and outcome in pediatric patients with non-Hodgkin's lymphoma: results from Berlin-Frankfurt-Münster Trial NHL-BFM 95
    Kathrin Seidemann
    Department of Pediatric Hematology and Oncology, Children s Hospital, Hannover Medical School, Hannover, Germany
    J Clin Oncol 23:8414-21. 2005
    ..To analyze the association of genetic variation within the tumor necrosis factor (TNF -308 [G-->A]) and lymphotoxin alfa (LT-a +252 [A-->G]) genes with outcome in non-Hodgkin's lymphoma of childhood and adolescence...
  15. doi request reprint Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease
    Doris Steinemann
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 47:471-80. 2008
    ..This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  16. pmc Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome
    Lutz Zeidler
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Haematologica 97:402-9. 2012
    ..In contrast, little is known about the prognostic relevance of normal blood counts in this setting...
  17. doi request reprint NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Med 15:151-8. 2009
    ..G-CSF, in turn, further increases NAMPT levels. These results reveal a decisive role of the NAD(+) metabolic pathway in G-CSF-triggered myelopoiesis...
  18. ncbi request reprint LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    Julia Skokowa
    Department of Pediatric Hematology and Oncology Carl Neuberg Str 1, 30625 Hannover, Germany
    Nat Med 12:1191-7. 2006
    ..These observations indicate that LEF-1 is an instructive factor regulating neutrophilic granulopoiesis whose absence plays a critical role in the defective maturation program of myeloid progenitors in individuals with CN...
  19. ncbi request reprint Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor
    Gunnar Cario
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 129:275-8. 2005
    ..Caspase 9 was highly expressed in patients and controls after G-CSF administration. Thus, G-CSF acts on apoptosis regulation, but additional mechanisms leading to the increase of neutrophil numbers must be assumed...
  20. ncbi request reprint Gene expression profile of the infective murine model for biliary atresia
    Johannes Leonhardt
    Department of Pediatric Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Pediatr Surg Int 22:84-9. 2006
    ..Of particular interest, very low expression of TIMD2 was observed in BA-positive mice. TIMD2 plays a critical role in the regulation of a Th2-type response through the inhibition of IFN gamma...
  21. ncbi request reprint Gene expression profiles and risk stratification in childhood acute lymphoblastic leukemia
    Oliver Teuffel
    Department of Oncology University Children s Hospital Zurich, Switzerland
    Haematologica 89:801-8. 2004
    ..However, it has not yet been reported whether gene expression profiles can predict risk group stratification already at the time of diagnosis...
  22. doi request reprint Anemia and survival in childhood acute lymphoblastic leukemia
    Oliver Teuffel
    University Children s Hospital Zurich, Steinwiesstrasse 75 Zurich, 8032 Switzerland
    Haematologica 93:1652-7. 2008
    ..However, it has not been reported whether there is any correlation between degree of anemia and leukemia subtype...
  23. doi request reprint Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
    Dani Bercovich
    Human Molecular Genetics and Pharmacogenetics Laboratory, Migal Galilee Biotechnology Centre, Kiryat Shmona, and Tel Hai Academic College, Israel
    Lancet 372:1484-92. 2008
    ..We tested the hypothesis that mutations in JAK2 might be a common molecular event in acute lymphoblastic leukaemia associated with Down's syndrome...
  24. pmc Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray
    Norihiko Kawamata
    Hematology Oncology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 105:11921-6. 2008
    ..PAX5-fusion proteins may contribute to leukemogenesis by blocking differentiation of hematopoietic cells into mature B cells. SNP-chip is a powerful tool to identify fusion genes in human cancers...
  25. ncbi request reprint Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia
    Bernard M Fine
    Division of Hematology, 269 Campus Dr, CCSR 1155, Stanford University School of Medicine, Stanford, CA 94305 5156, USA
    Blood 103:1043-9. 2004
    ..Notably, we found that the erythropoietin receptor (EPOR) is consistently highly expressed in TEL/AML1 ALL compared with BCR/ABL or MLL...
  26. doi request reprint Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95
    Anja Möricke
    Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Blood 111:4477-89. 2008
    ..2% (+/- 3.2%). Compared without previous trial ALL-BFM 90, consistently favorable results in non-HR patients were achieved with significant treatment reduction in the majority of these patients...
  27. pmc Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray
    Norihiko Kawamata
    Department of Hematology, Oncology, Cedars Sinai Medical Center University of California at Los Angeles School of Medicine 90048, USA
    Blood 111:776-84. 2008
    ..This technique was able to detect subgroups with a poor prognosis based on their genetic status...
  28. ncbi request reprint Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    Stephen Breit
    Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Blood 108:1151-7. 2006
    ..These findings indicate that in the context of the ALL-BFM 2000 treatment strategy, NOTCH1 mutations predict a more rapid early treatment response and a favorable long-term outcome in children with T-ALL...
  29. ncbi request reprint Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia
    Melchior Lauten
    Haematologica 88:353-4. 2003
  30. ncbi request reprint NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms
    Thorben Kracht
    Pediatric Hematology Oncology, Medical School of Hannover, Germany
    Haematologica 89:1492-7. 2004
    ..In the present study, we investigated this association in our population and extended the analysis to other subgroups of pediatric hematologic neoplasms characterized by specific fusion genes...