Frauke Stanke

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Categories of deltaF508 homozygous cystic fibrosis twin and sibling pairs with distinct phenotypic characteristics
    F Mekus
    Department of Pediatrics, Medizinische Hochschule Hannover, Germany
    Twin Res 3:277-93. 2000
  2. ncbi request reprint Genes in the vicinity of CFTR modulate the cystic fibrosis phenotype in highly concordant or discordant F508del homozygous sib pairs
    Frauke Mekus
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Hum Genet 112:1-11. 2003
  3. pmc An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    BMC Med Genet 12:62. 2011
  4. pmc Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Germany
    J Med Genet 48:24-31. 2011
  5. pmc Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 18:553-9. 2010
  6. ncbi request reprint The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis
    Frauke Stanke
    Department of Pediatrics, OE6711, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Hum Genet 119:331-43. 2006
  7. doi request reprint Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Hum Genet 127:383-94. 2010
  8. pmc Very mild disease phenotype of congenic CftrTgH(neoim)Hgu cystic fibrosis mice
    Balazs Toth
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    BMC Genet 9:28. 2008
  9. doi request reprint Functional analysis of F508del CFTR in native human colon
    Andrea van Barneveld
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Hannover, Germany
    Biochim Biophys Acta 1802:1062-9. 2010
  10. pmc Spontaneous rescue from cystic fibrosis in a mouse model
    Nikoletta Charizopoulou
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Genet 7:18. 2006

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Categories of deltaF508 homozygous cystic fibrosis twin and sibling pairs with distinct phenotypic characteristics
    F Mekus
    Department of Pediatrics, Medizinische Hochschule Hannover, Germany
    Twin Res 3:277-93. 2000
    ..The selected pairs from these categories demonstrated non-overlapping properties for wfh%, FEVPerc and the intra-pair difference of both parameters...
  2. ncbi request reprint Genes in the vicinity of CFTR modulate the cystic fibrosis phenotype in highly concordant or discordant F508del homozygous sib pairs
    Frauke Mekus
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Hum Genet 112:1-11. 2003
    ..We conclude that disease manifestation in CF is modulated by loci in the partially imprinted region 3' of CFTR that determine stature, food intake and energy homeostasis, such as the Silver-Russel-Syndrome candidate gene region and LEP...
  3. pmc An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    BMC Med Genet 12:62. 2011
    ....
  4. pmc Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Germany
    J Med Genet 48:24-31. 2011
    ..The cystic fibrosis (CF) basic defect, caused by dysfunction of the apical chloride channel CFTR in the gastrointestinal and respiratory tract epithelia, has not been employed so far to support the role of CF modifier genes...
  5. pmc Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 18:553-9. 2010
    ....
  6. ncbi request reprint The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis
    Frauke Stanke
    Department of Pediatrics, OE6711, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Hum Genet 119:331-43. 2006
    ....
  7. doi request reprint Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6
    Frauke Stanke
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Hum Genet 127:383-94. 2010
    ....
  8. pmc Very mild disease phenotype of congenic CftrTgH(neoim)Hgu cystic fibrosis mice
    Balazs Toth
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    BMC Genet 9:28. 2008
    ..Clinical and electrophysiological features of the two congenic strains were compared with those of CF/1-CftrTgH(neoim)Hgu and CF/3-CftrTgH(neoim)Hgu and wild type controls...
  9. doi request reprint Functional analysis of F508del CFTR in native human colon
    Andrea van Barneveld
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, Hannover, Germany
    Biochim Biophys Acta 1802:1062-9. 2010
    ..The finding that some F508del CFTR escapes the ER quality control in vivo substantiates the hope that the defective processing and trafficking of F508del CFTR can be corrected by pharmacological agents...
  10. pmc Spontaneous rescue from cystic fibrosis in a mouse model
    Nikoletta Charizopoulou
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Genet 7:18. 2006
    ..In order to further investigate whether these genetic differences have an impact on the disease phenotype of cystic fibrosis we characterised the phenotype of the two inbred strains...
  11. pmc CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine
    Ernst Wolfgang Kolbe
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 21:691-4. 2013
    ..The latter finding is in consistency with the now favored role of the CLCA proteins in signal transduction in epithelial cells...
  12. pmc Initial interrogation, confirmation and fine mapping of modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation
    Heike Labenski
    Department of Pediatrics, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Eur J Hum Genet 19:1281-8. 2011
    ....
  13. ncbi request reprint The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis
    Margit Ritzka
    Department of Pediatrics and Clinical CF Research Group, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Hum Genet 115:483-91. 2004
    ..The CLCA gene region was identified to encode mediators of DIDS-sensitive anion conductance in the human gastrointestinal tract that modulate the CF basic defect...
  14. ncbi request reprint CFTR protein analysis of splice site mutation 2789+5 G-A
    Andrea van Barneveld
    Department of Pediatric Pneumology and Neonatology, OE 6710, Medizinische Hochschule Hannover, D30625 Hannover, Germany
    J Cyst Fibros 7:165-7. 2008
    ....
  15. pmc Instability of the insertional mutation in CftrTgH(neoim)Hgu cystic fibrosis mouse model
    Nikoletta Charizopoulou
    Klinische Forschergruppe, OE 6710, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    BMC Genet 5:6. 2004
    ....
  16. ncbi request reprint Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated residual chloride secretion does not protect against early chronic Pseudomonas aeruginosa infection in F508del homozygous cystic fibrosis patients
    Nico Derichs
    Medizinische Hochschule Hannover, Department of Pediatrics, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Pediatr Res 55:69-75. 2004
    ..These results demonstrate the presence of some active F508del-CFTR in the apical cell membrane and imply that factors other than the CFTR-mediated residual Cl- secretion determine the age of onset of PA colonization...
  17. doi request reprint Head-out spirometry accurately monitors the course of Pseudomonas aeruginosa lung infection in mice
    Florian Wölbeling
    Pediatric Pulmonology and Neonatology, Hannover Medical School, Hannover, Germany woelbeling florian mh hannover de
    Respiration 80:340-6. 2010
    ..Longitudinal parameters such as temperature appear to have a relatively low accuracy. Spirometry might be an accurate method to assess the course of a bacterial lung infection without the necessity to sacrifice the animals...
  18. pmc Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis
    Daniel Kahlmann
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    BMC Genet 8:33. 2007
    ..However, it is unknown whether mutations of CCR7 are linked to autoimmunity in humans...
  19. ncbi request reprint Ex vivo biochemical analysis of CFTR in human rectal biopsies
    Andrea van Barneveld
    Klinische Forschergruppe, OE 6711, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30623 Hannover, Germany
    Biochim Biophys Acta 1762:393-7. 2006
    ..Interestingly, maturation of CFTR increases substantially in tissue incubated at 26 degrees C. Our data provide a solid basis for future studies on the characterisation of CFTR in pathological cases...
  20. pmc Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains
    Jens Klockgether
    Klinische Forschergruppe, Medizinische Hochschule Hannover, Hannover, Germany
    J Bacteriol 192:1113-21. 2010
    ..High-throughput genome resequencing will resolve more cases and could become a proper quality control for strain collections...