Julia Skokowa

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    Julia Skokowa
    Department of Pediatric Hematology and Oncology Carl Neuberg Str 1, 30625 Hannover, Germany
    Nat Med 12:1191-7. 2006
  2. doi request reprint NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Med 15:151-8. 2009
  3. doi request reprint Defective G-CSFR signaling pathways in congenital neutropenia
    Julia Skokowa
    Department of Molecular Hematopoiesis, Children s Hospital, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30625, Germany
    Hematol Oncol Clin North Am 27:75-88, viii. 2013
  4. doi request reprint Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Nat Med 18:1550-9. 2012
  5. doi request reprint Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Blood 114:3044-51. 2009
  6. doi request reprint Dysregulation of myeloid-specific transcription factors in congenital neutropenia
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Ann N Y Acad Sci 1176:94-100. 2009
  7. ncbi request reprint Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor
    Gunnar Cario
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 129:275-8. 2005
  8. ncbi request reprint Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation
    Julia Skokowa
    Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
    J Immunol 174:3041-50. 2005
  9. ncbi request reprint LEF-1 is a decisive transcription factor in neutrophil granulopoiesis
    Julia Skokowa
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Ann N Y Acad Sci 1106:143-51. 2007
  10. pmc C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease
    Nelli Shushakova
    Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
    J Clin Invest 110:1823-30. 2002

Detail Information

Publications18

  1. ncbi request reprint LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    Julia Skokowa
    Department of Pediatric Hematology and Oncology Carl Neuberg Str 1, 30625 Hannover, Germany
    Nat Med 12:1191-7. 2006
    ..These observations indicate that LEF-1 is an instructive factor regulating neutrophilic granulopoiesis whose absence plays a critical role in the defective maturation program of myeloid progenitors in individuals with CN...
  2. doi request reprint NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Med 15:151-8. 2009
    ..G-CSF, in turn, further increases NAMPT levels. These results reveal a decisive role of the NAD(+) metabolic pathway in G-CSF-triggered myelopoiesis...
  3. doi request reprint Defective G-CSFR signaling pathways in congenital neutropenia
    Julia Skokowa
    Department of Molecular Hematopoiesis, Children s Hospital, Hannover Medical School, Carl Neuberg Strasse 1, Hannover 30625, Germany
    Hematol Oncol Clin North Am 27:75-88, viii. 2013
    ....
  4. doi request reprint Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Nat Med 18:1550-9. 2012
    ..These data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo...
  5. doi request reprint Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Blood 114:3044-51. 2009
    ..LEF-1 rescue of CD34(+) cells isolated from 2 patients with CN resulted in granulocytic differentiation of the cells which was in line with increased levels of functionally active ELA2/NE...
  6. doi request reprint Dysregulation of myeloid-specific transcription factors in congenital neutropenia
    Julia Skokowa
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Ann N Y Acad Sci 1176:94-100. 2009
    ....
  7. ncbi request reprint Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor
    Gunnar Cario
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 129:275-8. 2005
    ..Caspase 9 was highly expressed in patients and controls after G-CSF administration. Thus, G-CSF acts on apoptosis regulation, but additional mechanisms leading to the increase of neutrophil numbers must be assumed...
  8. ncbi request reprint Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation
    Julia Skokowa
    Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
    J Immunol 174:3041-50. 2005
    ....
  9. ncbi request reprint LEF-1 is a decisive transcription factor in neutrophil granulopoiesis
    Julia Skokowa
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Ann N Y Acad Sci 1106:143-51. 2007
    ..In summary we demonstrated that LEF-1 is not only crucial in lymphopoiesis, but also in myelopoiesis, documenting new functions of LEF-1...
  10. pmc C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease
    Nelli Shushakova
    Department of Clinical Immunology, Medical School Hannover, Hannover, Germany
    J Clin Invest 110:1823-30. 2002
    ..Therefore, C5a, which is a potent chemoattractant, has a broader critical function in regulating the inhibitory/activating FcgammaRII/III receptor pair to connect complement and FcgammaR effector pathways in immune inflammation...
  11. ncbi request reprint Severe congenital neutropenia: inheritance and pathophysiology
    Julia Skokowa
    Department of Pediatric Hematology Oncology, Medical University Hannover, Hannover, Germany
    Curr Opin Hematol 14:22-8. 2007
    ..5 x 10/l. In this review we summarize our current knowledge on inheritance and pathophysiolgy of congenital neutropenia...
  12. doi request reprint NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression
    Basant Kumar Thakur
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Biochem Biophys Res Commun 420:714-20. 2012
    ..This knowledge should contribute to our understanding of the role played by NAMPT and SIRT1 in the regulation of GADD45A expression by FOXO3a...
  13. doi request reprint G-CSF receptor mutations in patients with congenital neutropenia
    Manuela Germeshausen
    Department of Pediatric Hematology Oncology, Medical University Hannover, Hannover, Germany
    Curr Opin Hematol 15:332-7. 2008
    ..Congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10/l...
  14. pmc The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
    Lan Dan
    Department of Molecular Hematopoiesis, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Haematologica 97:551-9. 2012
    ..Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear...
  15. ncbi request reprint Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cells
    Zheng Wang
    Hannover Medical School, Department of Pediatric Hematology and Oncology, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Ann N Y Acad Sci 1044:29-40. 2005
    ..The in vitro differentiation of rhesus monkey ES cells provides an opportunity to better understand the mechanism of TPO function in the early stage of hematopoietic development from ES cells to mature hematopoietic cells...
  16. ncbi request reprint Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis
    Heinfried H Radeke
    Department of Clinical Immunology and Institute of Pharmacology, Medical School of Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 277:27535-44. 2002
    ..Herein is provided the first evidence that glomerular FcgammaRII plays an important immunoregulatory role in the initiation of IC glomerulonephritis...
  17. ncbi request reprint Gene expression profile of the infective murine model for biliary atresia
    Johannes Leonhardt
    Department of Pediatric Surgery, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Pediatr Surg Int 22:84-9. 2006
    ..Of particular interest, very low expression of TIMD2 was observed in BA-positive mice. TIMD2 plays a critical role in the regulation of a Th2-type response through the inhibition of IFN gamma...
  18. doi request reprint High-content cytometry and transcriptomic biomarker profiling of human B-cell activation
    Christian Hennig
    Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany Electronic address
    J Allergy Clin Immunol 133:172-80.e1-10. 2014
    ..Primary antibody deficiencies represent the most prevalent, although very heterogeneous, group of inborn immunodeficiencies, with a puzzling complexity of cellular and molecular processes involved in disease pathogenesis...