Axel Seltsam

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 48:1151-5. 2008
  2. doi request reprint Rapid detection of anti-Lu(b) with recombinant Lu(b) protein and the particle gel immunoassay
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 48:731-4. 2008
  3. doi request reprint Aberrant intracellular trafficking of a variant B glycosyltransferase
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover the German Red Cross, Center for Transfusion Medicine Hagen, Hagen and Biotest AG, Dreieich, Germany
    Transfusion 48:1898-905. 2008
  4. ncbi request reprint A weak blood group A phenotype caused by a translation-initiator mutation in the ABO gene
    Axel Seltsam
    Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 46:434-40. 2006
  5. doi request reprint Permanent silencing of NKG2A expression for cell-based therapeutics
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    J Mol Med (Berl) 87:199-210. 2009
  6. ncbi request reprint The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens
    Axel Seltsam
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    Transfusion 47:133-46. 2007
  7. ncbi request reprint Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 47:2330-5. 2007
  8. doi request reprint Semaphorin 7A protein variants differentially regulate T-cell activity
    Christiane Gras
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 53:270-83. 2013
  9. doi request reprint Generation of HLA-deficient platelets from hematopoietic progenitor cells
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 50:1690-701. 2010
  10. doi request reprint Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Blood 113:3008-16. 2009

Detail Information

Publications22

  1. ncbi request reprint Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 48:1151-5. 2008
    ..Here, a novel method is described for detection of anti-JMH with particles coated with recombinant semaphorin 7A (Sema7A, CD108), the protein that carries the JMH blood group antigens...
  2. doi request reprint Rapid detection of anti-Lu(b) with recombinant Lu(b) protein and the particle gel immunoassay
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 48:731-4. 2008
    ..Until now, it was not possible to identify antibodies to red blood cells (RBCs) except with pretyped RBCs. Here, a novel method with particles coated with recombinant Lu(b) protein for detection of anti-Lu(b) is described...
  3. doi request reprint Aberrant intracellular trafficking of a variant B glycosyltransferase
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover the German Red Cross, Center for Transfusion Medicine Hagen, Hagen and Biotest AG, Dreieich, Germany
    Transfusion 48:1898-905. 2008
    ..Little is known about the mechanism by which amino acid polymorphisms outside the catalytically active cleft of ABO glycosyltransferases cause weak ABO phenotypes...
  4. ncbi request reprint A weak blood group A phenotype caused by a translation-initiator mutation in the ABO gene
    Axel Seltsam
    Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 46:434-40. 2006
    ..Weak blood group A and B phenotypes are correlated with ABO glycosyltransferases exhibiting single-amino-acid changes and/or C-terminal modifications...
  5. doi request reprint Permanent silencing of NKG2A expression for cell-based therapeutics
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    J Mol Med (Berl) 87:199-210. 2009
    ....
  6. ncbi request reprint The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens
    Axel Seltsam
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    Transfusion 47:133-46. 2007
    ..Because previous serologic studies on red blood cells (RBCs) suggested a considerable diversity of Sema7A, the present study was designed to elucidate the complex picture of the molecular diversity of this protein...
  7. ncbi request reprint Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 47:2330-5. 2007
    ..The common ABO alleles were found to have CBF/NF-Y enhancer regions with specific numbers of 43-bp minisatellite repeats...
  8. doi request reprint Semaphorin 7A protein variants differentially regulate T-cell activity
    Christiane Gras
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 53:270-83. 2013
    ..In this study, the functional role of the R461C Sema7A polymorphism on T-cell responses was investigated...
  9. doi request reprint Generation of HLA-deficient platelets from hematopoietic progenitor cells
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 50:1690-701. 2010
    ..Refractoriness to platelet (PLT) transfusion caused by alloimmunization against HLA Class I antigens constitutes a significant clinical problem...
  10. doi request reprint Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Blood 113:3008-16. 2009
    ..Our data provide novel insights into the role of extracellular HSP70 on T-cell immune response concerning the induction of target-independent T-helper cell cytotoxicity...
  11. ncbi request reprint Missense mutations outside the catalytic domain of the ABO glycosyltransferase can cause weak blood group A and B phenotypes
    Axel Seltsam
    Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 45:1663-9. 2005
    ..Only little is known about the impact of amino acid substitutions outside an enzyme's active site on A and B transferase activity...
  12. pmc The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family
    Christina Bade-Döding
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Haematologica 96:110-8. 2011
    ..Mismatching during allogeneic transplantation can, therefore, lead to immunological reactions...
  13. ncbi request reprint Amino acid 95 causes strong alteration of peptide position Pomega in HLA-B*41 variants
    Christina Bade-Doeding
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    Immunogenetics 59:253-9. 2007
    ....
  14. ncbi request reprint Regulating MHC expression for cellular therapeutics
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    Transfusion 47:18-27. 2007
    ..The lentivirus-mediated delivery of short-hairpin RNAs (shRNAs) has proved to be an efficient method to inhibit the translation of a specific gene...
  15. ncbi request reprint Peptide-binding motif of HLA-A*6603
    Christina Bade-Doeding
    Department of Transfusion Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Immunogenetics 56:769-72. 2005
    ..These data will contribute to both assessing permissive mismatches in the A*66 group and weighting the impact of this individual amino-acid variation for matching and peptide binding algorithms...
  16. ncbi request reprint Prokaryotic versus eukaryotic recombinant Lutheran blood group protein for antibody identification
    Axel Seltsam
    Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 47:1630-6. 2007
    ..Antibodies against Lu(b) are among the most frequent clinically relevant antibody specificities directed against high-frequency antigens...
  17. ncbi request reprint Class-, gene-, and group-specific HLA silencing by lentiviral shRNA delivery
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hanover Medical School, Carl Neuberg Str 1, D 30625, Hanover, Germany
    J Mol Med (Berl) 84:425-37. 2006
    ....
  18. ncbi request reprint ABO glycosyltransferases as potential source of minor histocompatibility antigens in allogeneic peripheral blood progenitor cell transplantation
    Britta Eiz-Vesper
    Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 45:960-8. 2005
    ....
  19. pmc MHC universal cells survive in an allogeneic environment after incompatible transplantation
    Constanca Figueiredo
    Institute for Transfusion Medicine, Hannover Medical School, Lower Saxony, 30625 Hannover, Germany
    Biomed Res Int 2013:796046. 2013
    ..These data suggest that silencing MHC class I expression might overcome the histocompatibility barrier, potentially opening up new avenues in the field of cell transplantation and regenerative medicine...
  20. ncbi request reprint Antibodies to high-frequency antigens may decrease the quality of transfusion support: an observational study
    Axel Seltsam
    Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 43:1563-6. 2003
    ..Maintaining a rapidly accessible stock of just four types of rare blood units would ensure adequate transfusion support for most of these patients...
  21. ncbi request reprint Nondeletional ABO*O alleles express weak blood group A phenotypes
    Axel Seltsam
    Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany
    Transfusion 45:359-65. 2005
    ..Less frequent nondeletional ABO*O alleles such as ABO*O03, in contrast, have nonsynonymous mutations that may abolish the protein's enzyme activity by altering its sugar-binding site...
  22. ncbi request reprint A single amino-acid polymorphism in pocket A of HLA-A*6602 alters the auxiliary anchors compared with HLA-A*6601 ligands
    Christina Bade-Doeding
    Department of Transfusion Medicine, Hannover Medical School, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Immunogenetics 56:83-8. 2004
    ..The change of the auxiliary anchor residue at P1 is likely to alter the spectrum of peptides presented by A*6602 compared with A*6601, which may result in allogenicity in the case of a mismatch in allogeneic stem cell transplantation...