Ursula Seidler

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathways
    Ursula E Seidler
    Department of Gastroenterology, Hannover Medical School, Hannover, Germany Electronic address
    Curr Opin Pharmacol 13:900-8. 2013
  2. pmc Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo
    Anurag Kumar Singh
    Prof Dr U Seidler Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strase 1, D 30625 Germany
    J Physiol 591:5377-91. 2013
  3. ncbi request reprint Molecular mechanisms of disturbed electrolyte transport in intestinal inflammation
    Ursula Seidler
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Ann N Y Acad Sci 1072:262-75. 2006
  4. doi request reprint The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport
    Ursula Seidler
    Department of Gastroenterology, Hannover Medical School, Hannover, Germany
    Ann N Y Acad Sci 1165:249-60. 2009
  5. ncbi request reprint Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice
    Ursula Seidler
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Pflugers Arch 455:757-66. 2008
  6. doi request reprint Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells
    U Seidler
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Germany
    Acta Physiol (Oxf) 201:3-20. 2011
  7. doi request reprint Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension
    Ursula Seidler
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Exp Physiol 94:175-9. 2009
  8. pmc The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function
    Anurag Kumar Singh
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Am J Physiol Cell Physiol 298:C1057-65. 2010
  9. ncbi request reprint Gene ablation for PEPT1 in mice abolishes the effects of dipeptides on small intestinal fluid absorption, short-circuit current, and intracellular pH
    Mingmin Chen
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Am J Physiol Gastrointest Liver Physiol 299:G265-74. 2010
  10. pmc NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes
    Ayhan Cinar
    Hannover Medical School, Department of Gastroenterology and Hepatology, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Physiol 581:1235-46. 2007

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathways
    Ursula E Seidler
    Department of Gastroenterology, Hannover Medical School, Hannover, Germany Electronic address
    Curr Opin Pharmacol 13:900-8. 2013
    ..New information about HCO3(-) transport pathways, and emerging concepts about the intricate regulatory network that governs duodenal HCO3(-) secretion are described, and new perspectives for drug therapy discussed. ..
  2. pmc Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo
    Anurag Kumar Singh
    Prof Dr U Seidler Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strase 1, D 30625 Germany
    J Physiol 591:5377-91. 2013
    ..We conclude that the long-lasting DBS-R to luminal acid exposure activates multiple duodenocyte signalling pathways and involves changes in trafficking and/or activity of CFTR, Slc26 isoforms Slc26a3 and Slc26a9, and NHE3...
  3. ncbi request reprint Molecular mechanisms of disturbed electrolyte transport in intestinal inflammation
    Ursula Seidler
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Ann N Y Acad Sci 1072:262-75. 2006
    ....
  4. doi request reprint The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport
    Ursula Seidler
    Department of Gastroenterology, Hannover Medical School, Hannover, Germany
    Ann N Y Acad Sci 1165:249-60. 2009
    ..Recently, NHERF1, 2, and 3 knockout mice have become available, and this review summarizes the reports on electrolyte and fluid transport regulation in the native intestine of these mice...
  5. ncbi request reprint Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice
    Ursula Seidler
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Pflugers Arch 455:757-66. 2008
    ..The data strongly suggests that Slc26a6 acts in concert with NHE3 in electroneutral salt absorption in the small intestine. Slc26a6 also serves to absorb Cl(-) during glucose-driven salt absorption...
  6. doi request reprint Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells
    U Seidler
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Germany
    Acta Physiol (Oxf) 201:3-20. 2011
    ..The purpose of this review is to summarize current knowledge on the molecular identity and cellular function of basolateral ion transporters in the gastric and duodenal epithelium...
  7. doi request reprint Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension
    Ursula Seidler
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Exp Physiol 94:175-9. 2009
    ....
  8. pmc The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function
    Anurag Kumar Singh
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Am J Physiol Cell Physiol 298:C1057-65. 2010
    ..This suggests that Slc26a6 and Slc26a3 need proton recycling via NHE3 to operate in the Cl(-) absorptive mode and Cl(-) exit via CFTR to operate in the HCO(3)(-) secretory mode...
  9. ncbi request reprint Gene ablation for PEPT1 in mice abolishes the effects of dipeptides on small intestinal fluid absorption, short-circuit current, and intracellular pH
    Mingmin Chen
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Am J Physiol Gastrointest Liver Physiol 299:G265-74. 2010
    ....
  10. pmc NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes
    Ayhan Cinar
    Hannover Medical School, Department of Gastroenterology and Hepatology, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Physiol 581:1235-46. 2007
    ..It leaves NHE3 inhibition by hyperosmolarity intact, suggesting an important and selective role for PDZK1 in the agonist-mediated regulation of intestinal NHE3 activity...
  11. pmc Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine
    Mingmin Chen
    Department of Gastroenterology, Hannover Medical School, Hannover 30625, Germany
    J Physiol 588:5049-63. 2010
    ....
  12. pmc Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice
    Anurag Kumar Singh
    Department of Gastroenterology, Hepatology, and Endocrinology, Carl Neuberg Strasse 1, Hannover Medical School, Hannover, Germany
    J Clin Invest 119:540-50. 2009
    ..These data suggest that the NHERF proteins differentially modulate duodenal HCO3- secretion: while NHERF1 is an obligatory linker for beta2-AR stimulation of CFTR, NHERF2 confers inhibitory signals by coupling the LPA receptor to CFTR...
  13. pmc Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo
    Anurag Kumar Singh
    Department of Gastroenterology, Hannover Medical School, Hannover, Germany
    J Physiol 591:2189-204. 2013
    ....
  14. pmc Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del
    Fang Xiao
    Department of Gastoenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Physiol 590:5317-34. 2012
    ..This suggests that therapeutic strategies which deliver F508del to the apical membrane have the potential to significantly enhance epithelial HCO(3)(-) secretion...
  15. ncbi request reprint Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice
    Jutta Hillesheim
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Pflugers Arch 454:575-86. 2007
    ..Lack of the PDZ-adapter protein PDZK1 in murine small intestine causes a mild reduction in maximal CFTR activation, but a severe defect in electroneutral Na(+) absorption...
  16. pmc Kir4.1 channel expression is essential for parietal cell control of acid secretion
    Penghong Song
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, D 30625 Hannover, Germany
    J Biol Chem 286:14120-8. 2011
    ..Our results demonstrate that Kir4.1 channels are involved in the control of acid secretion and suggest that they may also affect secretory membrane recycling...
  17. ncbi request reprint Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion
    Biguang Tuo
    Department of Gastroenterology and Hepatology, Hannover Medical School, Germany
    Gastroenterology 130:349-58. 2006
    ..The present study was designed to examine the role of SLC26A6 in prostaglandin E(2) (PGE(2))-, forskolin-, and carbachol-induced duodenal HCO(3)(-) secretion...
  18. pmc The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum
    Mingmin Chen
    Department of Gastroenterology, Hannover Medical School, Carl Neuberg Strase 1, Hannover, D 30625, Germany
    J Physiol 590:3317-33. 2012
    ..The electroneutral Na+:HCO3 − cotransporter NBCn1 (slc4a7) is a major duodenal HCO3 − importer that supplies HCO3 − during basal and FSK-stimulated HCO3 − secretion...
  19. pmc Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression
    Markus Sjöblom
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany
    Proc Natl Acad Sci U S A 106:13094-9. 2009
    ..The results suggest that CA II is important for duodenocyte acidification by low luminal pH and for eliciting the acid-mediated HCO(3)(-) secretory response, but is not important in the generation of the secreted HCO(3)(-) ions...
  20. doi request reprint Localization, trafficking, and significance for acid secretion of parietal cell Kir4.1 and KCNQ1 K+ channels
    Marc André Kaufhold
    Department of Gastroenterology, Hannover Medical School, Hannover, Germany
    Gastroenterology 134:1058-69. 2008
    ..This study addresses the subcellular localization, trafficking, and potential functional significance of KCNQ1 and Kir4.1 channels during stimulated acid secretion...
  21. pmc cAMP-dependent and cholinergic regulation of the electrogenic intestinal/pancreatic Na+/HCO3- cotransporter pNBC1 in human embryonic kidney (HEK293) cells
    Oliver Bachmann
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    BMC Cell Biol 9:70. 2008
    ..After having shown activation of NBC by carbachol and forskolin in murine colon, we now investigated these pathways in HEK293 cells transiently expressing a GFP-tagged pNBC1 construct...
  22. ncbi request reprint Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis
    Sunil Yeruva
    Department of Gastroenterology, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 16:1149-61. 2010
    ..We therefore studied the expression, brush border membrane (BBM) localization, and transport capacity of the major intestinal Na(+) absorptive protein, the Na(+)/H(+) exchanger isoform 3 (NHE3) in biopsies from UC patients...
  23. pmc Downregulation of the NHE3-binding PDZ-adaptor protein PDZK1 expression during cytokine-induced inflammation in interleukin-10-deficient mice
    Henrike Lenzen
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e40657. 2012
    ....
  24. pmc KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion
    Penghong Song
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625, Germany
    J Physiol 587:3955-65. 2009
    ..The study demonstrates that the KCNQ1 channel provides K(+) to the extracellular K(+) binding site of the H(+)/K(+)-ATPase during acid secretion, and no other gastric K(+) channel can substitute for this function...
  25. doi request reprint Increased epithelial permeability is the primary cause for bicarbonate loss in inflamed murine colon
    Marina Jurić
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Inflamm Bowel Dis 19:904-11. 2013
    ..However, candidate pathways like CFTR or DRA are inhibited in the inflamed gut. This study addressed the question whether and how inflammation-associated increased intestinal permeability may result in epithelial HCO(3)(-) loss...
  26. doi request reprint Loss of downregulated in adenoma (DRA) impairs mucosal HCO3(-) secretion in murine ileocolonic inflammation
    Fang Xiao
    Department of Gastroenterology, Hannover Medical School, Germany
    Inflamm Bowel Dis 18:101-11. 2012
    ..Disturbances in J(HCO3)(-) may occur due to inflammation-induced changes in the crypt and villous architecture, or due to the effect of proinflammatory cytokines on epithelial ion transporters...
  27. doi request reprint Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5
    Anurag Kumar Singh
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Kidney Int 74:438-47. 2008
    ..We suggest that fructose-induced hypertension is likely caused by increased salt absorption by the intestine and kidney and the transporters Slc26a6 and Slc2a5 are essential in this process...
  28. doi request reprint The role of pancreatic ductal secretion in protection against acute pancreatitis in mice*
    Petra Pallagi
    1First Department of Medicine, University of Szeged, Szeged, Hungary 2Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany 3Department of Pathology, University of Szeged, Szeged, Hungary 4Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary 5Department of Microbiology, University of Szeged, Szeged, Hungary 6Institute of Surgical Research, University of Szeged, Szeged, Hungary 7Department of Surgery, Tufts Medical Center, Boston, MA 8Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary 9Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    Crit Care Med 42:e177-88. 2014
    ....
  29. doi request reprint Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid
    Anurag Kumar Singh
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    FASEB J 26:1745-54. 2012
    ..vagus elicited a similar HCO(3)(-) secretory response in cGKI(-/-), ncGKI(-/-) and wild-type mice. These findings show that protection of the duodenum from acid injury requires neuronal cGKI...
  30. ncbi request reprint Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion
    Bi guang Tuo
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Am J Physiol Gastrointest Liver Physiol 293:G279-87. 2007
    ..These results demonstrated that PGE(2) activates PI3K in duodenal mucosa and stimulates duodenal HCO(3)(-) secretion via cAMP-, Ca(2+)-, and PI3K-dependent signaling pathways...
  31. ncbi request reprint News from the end of the gut--how the highly segmental pattern of colonic HCO₃⁻ transport relates to absorptive function and mucosal integrity
    Oliver Bachmann
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Biol Pharm Bull 34:794-802. 2011
    ....
  32. pmc Short-term regulation of murine colonic NBCe1-B (electrogenic Na+/HCO3(-) cotransporter) membrane expression and activity by protein kinase C
    Oliver May
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 9:e92275. 2014
    ....
  33. doi request reprint Cytoprotective effects of acidosis via heat shock protein HSP27 against the anticancer drug doxorubicin
    Anurag Kumar Singh
    Department of Gastroenterolgy, Hepatology and Endocrinology, Hannover Medical School, Germany
    Cell Mol Life Sci 68:1041-51. 2011
    ..In conclusion, acidic pH causes less accumulation of cytotoxic drug in the nucleus of adeno gastric carcinoma (AGS) cells and HSP27-dependent decrease in FasR-mediated gastric epithelial tumour cell apoptosis...
  34. ncbi request reprint Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells
    Oliver Bachmann
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Am J Physiol Gastrointest Liver Physiol 292:G711-7. 2007
    ..K(+), Cl(-), and water secretion into the secretory canaliculi is thus one likely mechanism of stimulation-associated cell shrinkage in cultured parietal cells. The observed RVI is predominantly mediated by NHE1...
  35. pmc Protein kinase C-alpha attenuates cholinergically stimulated gastric acid secretion of rabbit parietal cells
    Michael Fährmann
    Institut für Zoophysiologie der Westfälischen Wilhelms Universität Münster, Hindenburgplatz 55, D 48143 Munster, Germany
    Br J Pharmacol 139:545-54. 2003
    ..We assume that in cholinergically stimulated parietal cells PKC-alpha transinhibits CaMKII activity, resulting in an attenuation of acid secretion...
  36. pmc Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
    Sya N Ukena
    Department of Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 2:e1308. 2007
    ..Disruption of this border alters paracellular permeability and is a key mechanism for the development of enteric infections and inflammatory bowel diseases (IBDs)...
  37. ncbi request reprint Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells
    Snezana Petrovic
    Department of Medicine, University of Cincinnati, Cincinnati 45267, USA
    Am J Physiol Gastrointest Liver Physiol 284:G1093-103. 2003
    ..On the basis of its unique expression pattern and function, we propose that SLC26A7 is a basolateral Cl(-)/HCO(3)(-) exchanger in gastric parietal cells and plays a major role in gastric acid secretion...
  38. ncbi request reprint The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange
    Georg Lamprecht
    1st Medical Department and Medical and Natural Sciences Research Center, University of Tuebingen, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    Biochemistry 41:12336-42. 2002
    ..In such a model, the first PDZ domain would remain available for instance for signal transduction proteins...
  39. ncbi request reprint Colocalization of the apical Cl-/HCO3- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells
    Snezana Petrovic
    Department of Medicine, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1207-16. 2002
    ....
  40. ncbi request reprint Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum
    Petra Jacob
    Department of Medicine, University of Tubingen, Tubingen, Germany
    Gastroenterology 122:709-24. 2002
    ..The recently discovered dra (down-regulated in adenoma) gene encodes a transport protein (DRA) for SO4(2-), Cl-, and HCO3-. The aim of this study was to investigate whether DRA may be the duodenal apical Cl-/HCO3- exchanger...
  41. ncbi request reprint Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains
    Hannes Lohi
    Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland
    Am J Physiol Cell Physiol 284:C769-79. 2003
    ..Our results support the general concept of microdomain organization for ion transport and suggest a mechanism for cystic fibrosis transmembrane regulator (CFTR)-mediated SLC26A6 upregulation in pancreatic duct cells...
  42. ncbi request reprint CaMKII is activated and translocated to the secretory apical membrane during cholinergically conveyed gastric acid secretion
    Michael Fährmann
    Institut für Zoophysiologie der Westfälischen Wilhelms Universität Münster, Hindenburgplatz 55, D 48143 Munster, Germany
    Cell Signal 14:161-8. 2002
    ..These findings contribute to the model implicating an involvement for CaMKII in the intracellular dynamics of the acid secretion...
  43. ncbi request reprint Renal and intestinal transport defects in Slc26a6-null mice
    Zhaohui Wang
    Department of Internal Medicine, Division of Nephrology and Hypertension, Univ of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati OH 45267 0585, USA
    Am J Physiol Cell Physiol 288:C957-65. 2005
    ..We conclude that Slc26a6 mediates oxalate-stimulated NaCl absorption, contributes to apical membrane Cl-/base exchange in the kidney proximal tubule, and also plays an important role in HCO3- secretion in the duodenum...
  44. ncbi request reprint The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa
    Heidi Rossmann
    Department of Clinical Chemistry and Laboratory Medicine, University of Mainz, Mainz, Germany
    Biochemistry 44:4477-87. 2005
    ..Its restricted expression shows that it cannot be involved in NaCl absorption in the proximal colon. We suggest that CAP70 mediates regulatory functions specific to the small intestine...
  45. pmc Different actions of protein kinase C isoforms alpha and epsilon on gastric acid secretion
    Michael Fährmann
    Institut für Zoophysiologie der Westfälischen Wilhelms Universität Münster, Hindenburgplatz 55, D 48143 Munster, Germany
    Br J Pharmacol 136:938-46. 2002
    ..In contrast, PKC-alpha activation attenuates acid secretion accompanied by a down-regulation of CaMKII activity...
  46. ncbi request reprint Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice
    Nellie Broere
    Department of Biochemistry, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands
    J Biol Chem 282:37575-84. 2007
    ....
  47. doi request reprint Controversies in the role of SLC26 anion exchangers in pancreatic ductal bicarbonate secretion
    Peter Hegyi
    Pancreas 37:232-4. 2008
  48. ncbi request reprint Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus
    Rakhilya Murtazina
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 282:25141-51. 2007
    ....
  49. ncbi request reprint Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study
    Oliver Schroder
    First Department of Internal Medicine, Division of Gastroenterology, ZAFES, Johann Wolfgang Goethe University, Frankfurt, Germany
    Am J Gastroenterol 100:2503-9. 2005
    ..We therefore evaluated the efficacy and safety of intravenous iron sucrose as compared with oral iron sulfate for the treatment of iron deficiency anemia (IDA) in patients with IBD...
  50. ncbi request reprint Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation
    Leif E Sander
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    J Immunol 181:3586-94. 2008
    ..We provide evidence that IL-6 cytokines acting via gp130 are required in the acute stages of intestinal inflammation by modulating the dynamics of innate immune cell recruitment and activation...
  51. ncbi request reprint Identification of an apical Cl-/HCO3- exchanger in gastric surface mucous and duodenal villus cells
    Jie Xu
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1225-34. 2003
    ..These data show that AE4 is an apical Cl-/HCO3- exchanger in gastric mucous cells and duodenal villus cells. On the basis of its function and location, we propose that AE4 may play an important role in mucosal protection...
  52. ncbi request reprint Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen
    Nichole McDaniel
    Div of Biomedical Sciences, 2226 Webber Hall, Univ of California, Riverside, CA 92521, USA
    Am J Physiol Gastrointest Liver Physiol 289:G550-60. 2005
    ..The observed dependence of pepsinogen secretion on NKCC supports the concept that a nonacidic secretory stream elaborated from parietal cells facilitates flushing of the proenzyme from the gastric gland lumen...