Martin Schrappe

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. pmc Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
    Eckart Schnakenberg
    Institute for Pharmacogenetic and Genetic Disposition, Langenhagen, Germany
    BMC Med Genet 6:23. 2005
  2. ncbi request reprint Prognostic factors in childhood acute lymphoblastic leukemia
    Martin Schrappe
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Indian J Pediatr 70:817-24. 2003
  3. ncbi request reprint Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome
    M Schrappe
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany
    Blood 92:2730-41. 1998
  4. ncbi request reprint Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group
    M Schrappe
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Federal Republic of Germany FRG
    Blood 95:3310-22. 2000
  5. ncbi request reprint Impact of cranial radiotherapy on central nervous system prophylaxis in children and adolescents with central nervous system-negative stage III or IV lymphoblastic lymphoma
    Birgit Burkhardt
    Department of Pediatric Hematology and Oncology, Children s University Hospital, Giessen, Germany
    J Clin Oncol 24:491-9. 2006
  6. ncbi request reprint Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    JAMA 293:1485-9. 2005
  7. ncbi request reprint Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia
    Melchior Lauten
    Hannover Medical School, Pediatric Hematology and Oncology, 30625 Hannover, Germany
    Haematologica 88:1253-8. 2003
  8. pmc In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties
    Christoph le Viseur
    Department of Pediatric Hematology and Oncology, University Children s Hospital Munster, 48129 Munster, Germany
    Cancer Cell 14:47-58. 2008
  9. ncbi request reprint Osteonecrosis: a treatment related toxicity in childhood acute lymphoblastic leukemia (ALL)--experiences from trial ALL-BFM 95
    Britta Bürger
    Hannover Medical School, Department of Pediatric Hematology and Oncology, Hannover, Germany
    Pediatr Blood Cancer 44:220-5. 2005
  10. doi request reprint Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations
    Heidrun Gerr
    Department of Paediatric Haematology Oncology, Hannover Medical School, Germany
    Br J Haematol 149:84-92. 2010

Detail Information

Publications66

  1. pmc Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
    Eckart Schnakenberg
    Institute for Pharmacogenetic and Genetic Disposition, Langenhagen, Germany
    BMC Med Genet 6:23. 2005
    ..Studies on the role of these polymorphisms in the susceptibility to acute lymphoblastic leukemia (ALL) led to discrepant results...
  2. ncbi request reprint Prognostic factors in childhood acute lymphoblastic leukemia
    Martin Schrappe
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Indian J Pediatr 70:817-24. 2003
    ..If standardized tools are used for treatment response evaluation, logistics and quality controls are demanding but essential for the reliable conduct of such clinical studies...
  3. ncbi request reprint Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome
    M Schrappe
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany
    Blood 92:2730-41. 1998
    ..55 (SE, 0.08) compared with 0.10 (SE, 0.07) in patients with PPR (P = .0001). PGR is also an indicator for treatment responsiveness and durable second remission after relapse, which in turn may provide a second chance for BMT...
  4. ncbi request reprint Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group
    M Schrappe
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Federal Republic of Germany FRG
    Blood 95:3310-22. 2000
    ..In multivariate analysis, inadequate in vivo response emerged as the strongest adverse prognostic variable...
  5. ncbi request reprint Impact of cranial radiotherapy on central nervous system prophylaxis in children and adolescents with central nervous system-negative stage III or IV lymphoblastic lymphoma
    Birgit Burkhardt
    Department of Pediatric Hematology and Oncology, Children s University Hospital, Giessen, Germany
    J Clin Oncol 24:491-9. 2006
    ....
  6. ncbi request reprint Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    JAMA 293:1485-9. 2005
    ..Thiopurine methyltransferase (TPMT) is involved in the metabolism of mercaptopurine and subject to genetic polymorphism, with heterozygous individuals having intermediate and homozygous mutant individuals having very low TPMT activity...
  7. ncbi request reprint Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia
    Melchior Lauten
    Hannover Medical School, Pediatric Hematology and Oncology, 30625 Hannover, Germany
    Haematologica 88:1253-8. 2003
    ..The protein expression of the GR has been linked to in vivo and in vitro GC resistance in various diseases treated with GC. However, existing data are conflicting...
  8. pmc In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties
    Christoph le Viseur
    Department of Pediatric Hematology and Oncology, University Children s Hospital Munster, 48129 Munster, Germany
    Cancer Cell 14:47-58. 2008
    ..Sorted blast populations mirrored normal B precursor cells with transcription of a number of stage-appropriate genes. These observations inform a model for leukemia-propagating stem cells in childhood ALL...
  9. ncbi request reprint Osteonecrosis: a treatment related toxicity in childhood acute lymphoblastic leukemia (ALL)--experiences from trial ALL-BFM 95
    Britta Bürger
    Hannover Medical School, Department of Pediatric Hematology and Oncology, Hannover, Germany
    Pediatr Blood Cancer 44:220-5. 2005
    ..Due to spontaneous reporting of affected patients with ON, a group-wide evaluation was performed to determine incidence, risk factors, and morbidity for ON...
  10. doi request reprint Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations
    Heidrun Gerr
    Department of Paediatric Haematology Oncology, Hannover Medical School, Germany
    Br J Haematol 149:84-92. 2010
    ....
  11. doi request reprint Anti-Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials
    Andrea Willer
    Department of Pediatric Hematology and Oncology, University Children s Hospital of Muenster, Muenster, Germany
    Blood 118:5774-82. 2011
    ..This retrospective analysis is the first to describe the relationship between the level of anti-E coli ASE Abs and serum activity of pegylated E coli ASE used second-line after native E coli ASE...
  12. doi request reprint Pediatric precursor T lymphoblastic leukemia and lymphoblastic lymphoma: Differences in the common regions with loss of heterozygosity at chromosome 6q and their prognostic impact
    Birgit Burkhardt
    Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany
    Leuk Lymphoma 49:451-61. 2008
    ..Therefore patterns of LOH at 6q and the prognostic impact of LOH differ between T-ALL and T-LBL. These results hint at biologic differences between the two diseases...
  13. doi request reprint Quantification of free total plasma DNA and minimal residual disease detection in the plasma of children with acute lymphoblastic leukemia
    Arne Kristian Schwarz
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hanover, Germany
    Ann Hematol 88:897-905. 2009
    ..Despite low concentrations of DNA, it is feasible to measure MRD kinetics in plasma DNA during ALL induction therapy by adapted real-time PCR methodologies...
  14. pmc Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia
    David Krieger
    Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany
    Haematologica 95:158-62. 2010
    ..A tendency for favorable event-free-survival was observed in LOH 9p positive T-LBL. The frequency of LOH at chromosomes 11q and 17p was 5% or less for both diseases...
  15. doi request reprint Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease
    Doris Steinemann
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Genes Chromosomes Cancer 47:471-80. 2008
    ..This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
  16. ncbi request reprint Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor
    Gunnar Cario
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 129:275-8. 2005
    ..Caspase 9 was highly expressed in patients and controls after G-CSF administration. Thus, G-CSF acts on apoptosis regulation, but additional mechanisms leading to the increase of neutrophil numbers must be assumed...
  17. ncbi request reprint Prevalence, clinical pattern, and outcome of CNS involvement in childhood and adolescent non-Hodgkin's lymphoma differ by non-Hodgkin's lymphoma subtype: a Berlin-Frankfurt-Munster Group Report
    Janina Salzburg
    Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany
    J Clin Oncol 25:3915-22. 2007
    ....
  18. ncbi request reprint Integrating molecular information into treatment of childhood acute lymphoblastic leukemia--a perspective from the BFM Study Group
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Blood Cells Mol Dis 39:160-3. 2007
    ....
  19. ncbi request reprint Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia
    Gunnar Cario
    Department of Pediatric Hematology and Oncology, Institute for Cell and Molecular Pathology, Hannover Medical School, Germany
    Blood 105:821-6. 2005
    ..Because treatment response could be predicted with high accuracy, gene expression profiling could become a clinically relevant tool for treatment stratification in the early course of childhood ALL...
  20. doi request reprint Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study
    Ekaterini Kidas
    Department of Paediatric Haematology and Oncology, OE 6780, Medizinische Hochschule Hannover, Hannover, Germany
    Int J Hematol 89:584-91. 2009
    ..98, CI 0.98-9.01, P = 0.05). These results support a role of specific genetic polymorphisms on lethal infections during induction chemotherapy of ALL treatment...
  21. pmc Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome
    Lutz Zeidler
    Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany
    Haematologica 97:402-9. 2012
    ..In contrast, little is known about the prognostic relevance of normal blood counts in this setting...
  22. ncbi request reprint The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95
    Wilhelm Woessmann
    Department of Pediatric Hematology and Oncology, Justus Liebig University, D 35385 Giessen, Germany
    Blood 105:948-58. 2005
    ..In conclusion, MTX-4h was less toxic than MTX-24h. MTX-4h was noninferior to MTX-24h for limited stage B-cell non-Hodgkin lymphoma (B-NHL) but not for advanced disease. For limited disease, MTX 1 g/m(2) is noninferior to 5 g/m(2)...
  23. ncbi request reprint GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia
    Martin Stanulla
    Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
    Int J Hematol 81:39-44. 2005
    ..These results suggested a modulating role for host genetic variation in the development of CNS relapse in childhood ALL treated according to Berlin-Frankfurt-Münster protocols...
  24. ncbi request reprint New treatment strategies in childhood acute lymphoblastic leukaemia
    Martin Schrappe
    Department of Paediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Best Pract Res Clin Haematol 15:729-40. 2002
    ..Persistent disease is an indication for treatment modification and intensification. Logistics and quality control are demanding but are essential for the introduction of this new technology into clinical practice...
  25. ncbi request reprint Polymorphisms within glutathione S-transferase genes in pediatric non-Hodgkin's lymphoma
    Björn Ole Dieckvoss
    Department of Pediatric Hematology and Oncology, Children s Hospital, Hannover Medical School, Hannover, Germany
    Haematologica 87:709-13; discussion 713. 2002
    ..Certain members within the GST superfamily exhibit phenotypically relevant genetic polymorphisms which have been associated with outcome in hematologic malignant disease...
  26. ncbi request reprint Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture
    Britta Bürger
    Department of Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany
    J Clin Oncol 21:184-8. 2003
    ..To determine the significance of leukemic blasts or traumatic lumbar puncture (TLP) in diagnostic CSF of children enrolled in the Berlin-Frankfurt-Münster (BFM) Acute Lymphoblastic Leukemia-BFM-95 trial...
  27. ncbi request reprint Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform-specific real-time polymerase chain reaction approach
    Carmela Beger
    Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
    Br J Haematol 122:245-52. 2003
    ..These data were correlated with cell survival, demonstrating a more pronounced induction of apoptosis in cells from patients with PGR as compared with PPR...
  28. ncbi request reprint Leukemic stem cells in childhood high-risk ALL/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+CD19- cells
    Marc Hotfilder
    Department of Pediatric Hematology and Oncology, University Children s Hospital Munster, Munster, Germany
    Cancer Res 65:1442-9. 2005
    ..In conclusion, we show that childhood high-risk ALL/t(9;22) and t(4;11) originate in a primitive CD34(+)CD19(-) progenitor/stem cell without a myeloerythroid developmental potential...
  29. ncbi request reprint Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?
    Peter Bader
    Department of Pediatric Hematology and Oncology, University Children s Hospital, and Department of Medical Biometry, University of Tubingen, Tuebingen, Germany
    J Clin Oncol 22:1696-705. 2004
    ....
  30. ncbi request reprint A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial
    Rob Pieters
    Dutch Childhood Oncology Group DCOG, Netherlands Erasmus MC Sophia Children s Hospital, Rotterdam, Netherlands
    Lancet 370:240-50. 2007
    ..We also did a randomised trial to establish the value of a late intensification course...
  31. ncbi request reprint Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway
    Beat C Bornhauser
    Department of Oncology, Children s Hospital, University of Zurich, Zurich, Switzerland
    Blood 110:2084-91. 2007
    ..These data suggest that the combination of ATO and glucocorticoids could be advantageous in GC-resistant ALL and reveal additional targets for the evaluation of new antileukemic agents...
  32. ncbi request reprint Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implicat
    Paul Krappmann
    Department of Pediatric Hematology and Oncology, University Hospital for Children and Adolescents Erlangen Germany
    Pediatr Hematol Oncol 24:101-9. 2007
    ..Thus, neurocognitive examination should focus on younger ALL patients and girls...
  33. ncbi request reprint High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS
    Gunnar Cario
    Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
    J Clin Oncol 25:4813-20. 2007
    ....
  34. ncbi request reprint Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children
    Leo Kager
    Department of Hematology and Oncology, St Anna Children s Hospital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Haematologica 92:1561-4. 2007
    ..These data document that contemporary ALL-BFM treatment is highly effective in children with TCF3-PBX1 ALL. Implementation of early dose-intensified remission induction may be an essential treatment component...
  35. doi request reprint Eligibility for allogeneic transplantation in very high risk childhood acute lymphoblastic leukemia: the impact of the waiting time
    Adriana Balduzzi
    Clinica Pediatrica Università degli Studi di Milano Bicocca, Ospedale San Gerardo, Via Pergolesi 33, 20052 Monza, Milan, Italy
    Haematologica 93:925-9. 2008
    ..The relative advantage of transplant from compatible related donors in very-high-risk childhood acute lymphoblastic leukemia was consistent for any time elapsed in first remission...
  36. ncbi request reprint The NQO1 C609T polymorphism is associated with risk of secondary malignant neoplasms after treatment for childhood acute lymphoblastic leukemia: a matched-pair analysis from the ALL-BFM study group
    Martin Stanulla
    Haematologica 92:1581-2. 2007
    ..Patients carrying a variant low-activity NQO1 allele had a significantly increased risk of developing a SMN. The observed effect was restricted to solid tumors...
  37. doi request reprint Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95
    Anja Möricke
    Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Blood 111:4477-89. 2008
    ..2% (+/- 3.2%). Compared without previous trial ALL-BFM 90, consistently favorable results in non-HR patients were achieved with significant treatment reduction in the majority of these patients...
  38. doi request reprint Minimal residual disease values discriminate between low and high relapse risk in children with B-cell precursor acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21: the Austrian and German acute lymphoblastic leukemia Berl
    Andishe Attarbaschi
    Department of Pediatric Hematology and Oncology, St Anna Children s Hospital, Vienna, Austria
    J Clin Oncol 26:3046-50. 2008
    ..We aimed to identify relapse predictors in children with a B-cell precursor acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21), a novel genetic entity associated with poor outcome...
  39. doi request reprint Initial leukemic gene expression profiles of patients with poor in vivo prednisone response are similar to those of blasts persisting under prednisone treatment in childhood acute lymphoblastic leukemia
    Gunnar Cario
    Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 20, 24105 Kiel, Germany
    Ann Hematol 87:709-16. 2008
    ..Leukemic cells of patients with PPR are characterized by gene expression pattern which are similar to those of resistant cells persisting under glucocorticoid treatment...
  40. ncbi request reprint Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial
    Valentino Conter
    Department of Paediatrics, University of Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Lancet 369:123-31. 2007
    ....
  41. ncbi request reprint Superiority of allogeneic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: results from ALL-BFM 90 and 95
    Andre Schrauder
    Department of Pediatrics, University Medical Center Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Clin Oncol 24:5742-9. 2006
    ..The role of hematopoietic stem-cell transplantation (SCT) in first complete remission (CR1) for children with very high-risk (VHR) acute lymphoblastic leukemia (ALL) is still under critical discussion...
  42. ncbi request reprint Chemotherapy versus allogeneic transplantation for very-high-risk childhood acute lymphoblastic leukaemia in first complete remission: comparison by genetic randomisation in an international prospective study
    Adriana Balduzzi
    Clinica Pediatrica dell Università degli Studi di Milano Bicocca, Ospedale San Gerardo Via Pergolesi 33, 20052 Monza, Milan, Italy
    Lancet 366:635-42. 2005
    ..We compared this strategy with intensified chemotherapy protocols, with the aim to improve the outcome of children with very-high-risk acute lymphoblastic leukaemia in first complete remission...
  43. ncbi request reprint Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial
    Frank Berthold
    Children s Hospital and Centre for Molecular Medicine, University of Cologne, Cologne, Germany
    Lancet Oncol 6:649-58. 2005
    ..We aimed to assess whether megatherapy with autologous stem-cell transplantation could increase event-free survival and overall survival compared with maintenance chemotherapy...
  44. ncbi request reprint The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence
    Birgit Burkhardt
    Department of Paediatric Haematology and Oncology, Children s University Hospital, Giessen, Germany
    Br J Haematol 131:39-49. 2005
    ..The impact of gender on outcome differed between NHL subgroups. The prognostic impact of age differed not only by NHL-subtype but also according to gender in some subtypes...
  45. ncbi request reprint Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL
    Marja J Willemse
    Department of Immunology, University Hospital Rotterdam Erasmus University Rotterdam, The Netherlands
    Blood 99:4386-93. 2002
    ....
  46. ncbi request reprint Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87
    Hagen Graf Einsiedel
    Department of Pediatric Oncology Hematology, Charite Universitatsmedizin Berlin, Germany
    J Clin Oncol 23:7942-50. 2005
    ..Between 1987 and 1990, the multicenter trial Acute Lymphoblastic Leukemia-Relapse Study of the Berlin-Frankfurt-Münster Group (ALL-REZ BFM) 87 was conducted to establish a uniform treatment for these children in Germany and Austria...
  47. ncbi request reprint Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    Stephen Breit
    Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Blood 108:1151-7. 2006
    ..These findings indicate that in the context of the ALL-BFM 2000 treatment strategy, NOTCH1 mutations predict a more rapid early treatment response and a favorable long-term outcome in children with T-ALL...
  48. ncbi request reprint Minimal residual disease analysis in children with t(12;21)-positive acute lymphoblastic leukemia: comparison of Ig/TCR rearrangements and the genomic fusion gene
    Markus Metzler
    Dept of Paediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Haematologica 91:683-6. 2006
    ..These patients have remained in complete remission for 38 and 41 months, so far, indicating that a small ETV6-RUNX1-positive clone is not detrimental to the short-term prognosis of affected children...
  49. ncbi request reprint In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia
    Christian Wuchter
    Department of Hematology, Oncology, and Tumor Immunology, Robert Rössle Cancer Center, Charite, Humboldt University of Berlin, Germany
    Blood 99:4109-15. 2002
    ..The enhanced sensitivity to both drugs in cortical T-ALL might account for the better in vivo treatment response of this prognostically favorable T-ALL subgroup...
  50. ncbi request reprint Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia
    Melchior Lauten
    Haematologica 88:353-4. 2003
  51. doi request reprint Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
    Dani Bercovich
    Human Molecular Genetics and Pharmacogenetics Laboratory, Migal Galilee Biotechnology Centre, Kiryat Shmona, and Tel Hai Academic College, Israel
    Lancet 372:1484-92. 2008
    ..We tested the hypothesis that mutations in JAK2 might be a common molecular event in acute lymphoblastic leukaemia associated with Down's syndrome...
  52. doi request reprint Anemia and survival in childhood acute lymphoblastic leukemia
    Oliver Teuffel
    University Children s Hospital Zurich, Steinwiesstrasse 75 Zurich, 8032 Switzerland
    Haematologica 93:1652-7. 2008
    ..However, it has not been reported whether there is any correlation between degree of anemia and leukemia subtype...
  53. ncbi request reprint Mediastinal mass in childhood T-cell acute lymphoblastic leukemia: significance and therapy response
    Andishe Attarbaschi
    St Anna Children s Hospital, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Med Pediatr Oncol 39:558-65. 2002
    ..However, 30-40% of patients still relapse, so that additional prognostic factors such as the local response of the mediastinal mass to therapy might allow defining the patients at risk in a better manner...
  54. ncbi request reprint Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region
    Ching Hon Pui
    St Jude Children s Research Hospital and the University of Tennessee, College of Medicine, Memphis, TN 38105, USA
    Lancet 359:1909-15. 2002
    ....
  55. ncbi request reprint PEG-asparaginase (Oncaspar) 2500 U/m(2) BSA in reinduction and relapse treatment in the ALL/NHL-BFM protocols
    Hans Joachim Müller
    Department of Pediatric Hematology Oncology, University of Munster, Germany
    Cancer Chemother Pharmacol 49:149-54. 2002
    ..coli asparaginase in induction treatment of acute lymphoblastic leukaemia (ALL), drug monitoring was performed with the use of a higher dose...
  56. ncbi request reprint Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia
    Bernard M Fine
    Division of Hematology, 269 Campus Dr, CCSR 1155, Stanford University School of Medicine, Stanford, CA 94305 5156, USA
    Blood 103:1043-9. 2004
    ..Notably, we found that the erythropoietin receptor (EPOR) is consistently highly expressed in TEL/AML1 ALL compared with BCR/ABL or MLL...
  57. ncbi request reprint Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia
    Seisho Takeuchi
    Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, USA
    Br J Haematol 119:985-7. 2002
    ..These data suggest that genetic polymorphisms in the TNF locus have a limited effect on the outcome of childhood ALL...
  58. ncbi request reprint Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL
    Lüder Hinrich Meyer
    Universitätsklinik für Kinder und Jugendmedizin, University of Ulm, Germany
    Blood 107:4524-31. 2006
    ..019). CRAC may serve as a functionally defined risk factor for treatment stratification...
  59. ncbi request reprint Rituximab plus chemotherapy in children with relapsed or refractory CD20-positive B-cell precursor acute lymphoblastic leukemia
    Alexander Claviez
    Haematologica 91:272-3. 2006
    ..Two children subsequently underwent allogeneic stem cell transplantation and remain in complete remission at days +399 and +332...
  60. pmc Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray
    Norihiko Kawamata
    Department of Hematology, Oncology, Cedars Sinai Medical Center University of California at Los Angeles School of Medicine 90048, USA
    Blood 111:776-84. 2008
    ..This technique was able to detect subgroups with a poor prognosis based on their genetic status...
  61. ncbi request reprint Acute lymphoblastic leukemia and Klinefelter syndrome in children: two cases and review of the literature
    Jan Nicolas Machatschek
    Department of Pediatrics, University of Munster, Munster, Germany
    Pediatr Hematol Oncol 21:621-6. 2004
    ..In contrast to other chromosomal aberrations, the incidence of ALL does not seem to be increased in pediatric patients with KS...
  62. ncbi request reprint NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms
    Thorben Kracht
    Pediatric Hematology Oncology, Medical School of Hannover, Germany
    Haematologica 89:1492-7. 2004
    ..In the present study, we investigated this association in our population and extended the analysis to other subgroups of pediatric hematologic neoplasms characterized by specific fusion genes...
  63. ncbi request reprint Consolidation treatment with chimeric anti-GD2-antibody ch14.18 in children older than 1 year with metastatic neuroblastoma
    Thorsten Simon
    Children s Hospital, Department of Pediatric Oncology and Hematology, University of Cologne, Germany
    J Clin Oncol 22:3549-57. 2004
    ..We have analyzed stage 4 neuroblastoma patients older than 1 year who underwent consolidation treatment with the chimeric monoclonal anti-GD2-antibody ch14.18...
  64. ncbi request reprint Emergence of translocation t(9;11)-positive leukemia during treatment of childhood acute lymphoblastic leukemia
    Markus Metzler
    Department of Pediatrics, University of Erlangen Nuremberg, Nuremberg, Germany
    Genes Chromosomes Cancer 41:291-6. 2004
    ..The time course and characteristics of the genomic breakpoints in the present t-AML cases support the hypothesis of translocation formation as a result of defective breakage repair after topoisomerase II cleavage...
  65. ncbi request reprint Gene expression profiles and risk stratification in childhood acute lymphoblastic leukemia
    Oliver Teuffel
    Department of Oncology University Children s Hospital Zurich, Switzerland
    Haematologica 89:801-8. 2004
    ..However, it has not yet been reported whether gene expression profiles can predict risk group stratification already at the time of diagnosis...
  66. pmc Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray
    Norihiko Kawamata
    Hematology Oncology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 105:11921-6. 2008
    ..PAX5-fusion proteins may contribute to leukemogenesis by blocking differentiation of hematopoietic cells into mature B cells. SNP-chip is a powerful tool to identify fusion genes in human cancers...